• Share
  • Email
  • Embed
  • Like
  • Save
  • Private Content
Zimmer cancer 2013 talk
 

Zimmer cancer 2013 talk

on

  • 4,423 views

 

Statistics

Views

Total Views
4,423
Views on SlideShare
866
Embed Views
3,557

Actions

Likes
1
Downloads
11
Comments
0

15 Embeds 3,557

http://phenomena.nationalgeographic.com 3098
http://cloud.feedly.com 296
http://www.newsblur.com 95
http://digg.com 22
http://newsblur.com 22
http://flavors.me 6
http://www.feedly.com 4
http://www.redtreereader.com 3
http://www.digg.com 3
http://translate.googleusercontent.com 2
http://hivereader.com 2
http://www.ighome.com 1
http://www-ig-opensocial.googleusercontent.com 1
http://dwarf.guruj.net 1
http://www.feedspot.com 1
More...

Accessibility

Upload Details

Uploaded via as Adobe PDF

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

    Zimmer cancer 2013 talk Zimmer cancer 2013 talk Presentation Transcript

    • The Devil’s Tumor June 14, 2013 Carl Zimmer Friday, June 14, 13
    • Disclosures • I  have  no  conflicts  of  interest  to  disclose Friday, June 14, 13
    • Causes of death in the United States, 2010 http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6208a8.htm?s_cid=mm6208a8_w, http://who.int Worldwide, 7.8 million deaths from cancer each year (A San Francisco every month) Friday, June 14, 13
    • Rick Eh/Flicker via Creative Commons http://www.flickr.com/photos/rick-in-rio Friday, June 14, 13
    • Friday, June 14, 13
    • Friday, June 14, 13
    • Friday, June 14, 13
    • George von Dassow, University of Oregon http://www.cell.com/cell_picture_show-cellcycle Friday, June 14, 13
    • x Mutations that speed up growth Friday, June 14, 13
    • x x x x Mutations that speed up growth Friday, June 14, 13
    • x x x x x x x xx Mutations that speed up growth Friday, June 14, 13
    • x x x x x x x xx x xx x xx x xxx xx x xx x xx x xx x xx x xx x xx x xx Mutations that speed up growth Friday, June 14, 13
    • Prostate cancer cells Friday, June 14, 13
    • Cancer Evolves Charles Darwin Friday, June 14, 13
    • Based on Gregory, Evo Edu Outreach (2009) 2:156–175 Natural Selection Friday, June 14, 13
    • Generation 1 Based on Gregory, Evo Edu Outreach (2009) 2:156–175 Natural Selection Friday, June 14, 13
    • Generation 1 Based on Gregory, Evo Edu Outreach (2009) 2:156–175 X X Non-random survival X X Natural Selection Friday, June 14, 13
    • Generation 1 Reproduction and mutation Generation 2 Based on Gregory, Evo Edu Outreach (2009) 2:156–175 X X Non-random survival X X Natural Selection Friday, June 14, 13
    • Generation 1 Reproduction and mutation Generation 2 Based on Gregory, Evo Edu Outreach (2009) 2:156–175 X X Non-random survival X X Non-random survival XXX X Natural Selection Friday, June 14, 13
    • Generation 1 Reproduction and mutation Generation 2 Based on Gregory, Evo Edu Outreach (2009) 2:156–175 X X Non-random survival X X Generation 3 Reproduction and mutation Non-random survival XXX X Natural Selection Friday, June 14, 13
    • Generation 1 Reproduction and mutation Generation 2 Based on Gregory, Evo Edu Outreach (2009) 2:156–175 Many generations of mutation and natural selection Generation X X X Non-random survival X X Generation 3 Reproduction and mutation Non-random survival XXX X Natural Selection Friday, June 14, 13
    • Friday, June 14, 13
    • Ding, Li, et al. Nature 2012 481: 506-510 Friday, June 14, 13
    • Therapy Relapse resistant sub-clone Aktipis & Nesse, 2013 Evolution:Why Chemotherapy Fails Friday, June 14, 13
    • J. Baylor Roberts/National Geographic Friday, June 14, 13
    • Friday, June 14, 13
    • http://en.wikipedia.org/wiki/Humphrey_Bogart Friday, June 14, 13
    • img.photobucket.com/albums/v382/Matthoggua/Dimfuture/jackalope-1.jpg Friday, June 14, 13
    • kuleuven.be/rega/mvr/research.html Friday, June 14, 13
    • Papillomavirus Friday, June 14, 13
    • Friday, June 14, 13
    • HeLa cells Landry, Jonathan JM, et al. G3: Genes| Genomes| Genetics (2013) Friday, June 14, 13
    • LeighVanValen Van Valen LM, Maiorana VC 1991. Hela, a new microbial species. Evol. Theory 10: 71-74. Friday, June 14, 13
    • HeLa cells Friday, June 14, 13
    • Helacyton gartleri? Friday, June 14, 13
    • Lactobacillus bulgaricus van de Guchte et al, PNAS 2006 103:9274-9 Friday, June 14, 13
    • Glassy-winged sharpshooter (with residents) Nancy Moran PNAS 2007 (104) Suppl 1 8627-8633 Friday, June 14, 13
    • http://www.tassiedevil.com.au Friday, June 14, 13
    • en.wikipedia.org/wiki/File:Taz-Looney_Tunes.svg Friday, June 14, 13
    • Courtesy Kathy Belov Friday, June 14, 13
    • tassiedevil.com.au Devil’s Facial Tumor Disease Friday, June 14, 13
    • Friday, June 14, 13
    • Friday, June 14, 13
    • WhatYou’d Expect From Normal Cancer... Host DNA Tumor DNA Friday, June 14, 13
    • WhatYou’d Expect From Normal Cancer... Friday, June 14, 13
    • Friday, June 14, 13
    • Friday, June 14, 13
    • Friday, June 14, 13
    • Murchison et al. Cell 2012 148: 780-791 Friday, June 14, 13
    • Tony Pappenfuss Walter & Eliza Hall Institute of Medical Research Melbourne,Australia Murchison et al Science. 2010 327:84-7 Friday, June 14, 13
    • www.tassiedevil.com.au Friday, June 14, 13
    • Image: en.wikipedia.org/wiki/File:MHC_expression.svg See: Siddle et al, PNAS 2013 110:5103-8 Friday, June 14, 13
    • flickr.com/photos/australianshepherds/3212875937/ K. Belov, Bioessays. 2012 34:285-92, Rebbeck et al, Science. 2011 331:303 Canine TransmissibleVenereal Tumor Friday, June 14, 13
    • Friday, June 14, 13
    • Friday, June 14, 13
    • Maria Island Paul Benjamin, Flickr, Creative Commons http://www.flickr.com/photos/paul_benjamin Friday, June 14, 13
    • Friday, June 14, 13
    • Ali and Lear, Journal of Skin Cancer 2012 doi:10.1155/2012/404615 Friday, June 14, 13
    • Friday, June 14, 13
    • Friday, June 14, 13
    • Friday, June 14, 13
    • See Magee et al, Cancer Cell 2012 3:283, & I. O'Neill Stem Cells 2011 29:1909-1914 Friday, June 14, 13
    • See Magee et al, Cancer Cell 2012 3:283, & I. O'Neill Stem Cells 2011 29:1909-1914 Friday, June 14, 13
    • X X See Magee et al, Cancer Cell 2012 3:283, & I. O'Neill Stem Cells 2011 29:1909-1914 Friday, June 14, 13
    • X X X X See Magee et al, Cancer Cell 2012 3:283, & I. O'Neill Stem Cells 2011 29:1909-1914 Friday, June 14, 13
    • Gilbertson and Graham, Nature 2012 488, 462–463 Curing Cancer:All Cancer Cells Are Not Equal Friday, June 14, 13
    • Friday, June 14, 13
    • Friday, June 14, 13
    • Thanks to Carlo Maley, Athena Aktipis, Rebecca Skloot, Beata Ujvari, and Kathy Belov For more information, please visit carlzimmer.com Friday, June 14, 13
    • Friday, June 14, 13
    • Opportunity for Somatic Evolution in a Human Lifetime • Mutation rate: • Point mutations: 10-11 – 10-7 bp/cell generation • Chromosomal abnormalities: 10-6 per cell generation • Methylation changes: ~10-3 per CpG/cell generation • Number of mutations detected: 101 – 105 • Generation time: 1 – 3 days • Time from initiation to malignancy: decades (3 – 60 years) • Number of generations: 102 – 104 • Population size: 109 – 1012 cells • Rate of clonal expansions: unknown More potential for evolution than the history of H. sapiens Note: uncertainty about all these parameters Friday, June 14, 13