Deliriant poison

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Deliriant poison

  1. 1. Dhatura,Atropa Belladonna,Hyoscyamus Niger, Cannabis Indica and Cocaine
  2. 4. DATURA (Jimson weed, Thorn apple) <ul><li>Toxic principles: Hyoscine,hyoscymine, atropine </li></ul><ul><li>Mode of action: competitively inhibit muscarinic effects of acetylcholine </li></ul>
  3. 5. Toxic effects <ul><li>Blind as a bat, </li></ul><ul><li>hot as a hare, </li></ul><ul><li>dry as a bone, </li></ul><ul><li>red as a beet, </li></ul><ul><li>and mad as a wet hen </li></ul>
  4. 6. Important manifestations <ul><li>Dryness of mouth, thirst, slurred speech </li></ul><ul><li>Dysphagia </li></ul><ul><li>Dilated pupils </li></ul><ul><li>Diploplia </li></ul><ul><li>Dry hot skin </li></ul><ul><li>Dysuria </li></ul><ul><li>Drunken gait </li></ul><ul><li>Delirium </li></ul><ul><li>Death </li></ul>
  5. 7. Datura <ul><li>Fatal Dose-100-125(60mg ,4mg). </li></ul><ul><li>Fatal period. </li></ul><ul><li>Treatment </li></ul><ul><li>Stomach wash (potasium,tannic) </li></ul><ul><li>Decontamination </li></ul><ul><li>Physostigmine- 2mg IV or Neostigmine </li></ul><ul><li>Forensic significance(MEDICOLEGAL IMPORTANCE) </li></ul><ul><li>Accidental </li></ul><ul><li>Suicidal </li></ul><ul><li>Homicidal </li></ul><ul><li>Stupefaction </li></ul>
  6. 9. Cannabis <ul><li>Cannabis Sativa – flowering tops & leaves </li></ul><ul><li>Uses: Antiemetic </li></ul><ul><li>Convulsions, anxiety, pain & inflammation </li></ul><ul><li>Active principle: </li></ul><ul><li>Tetra hydro cannabinol- THC </li></ul>
  7. 10. <ul><li>PREPARATIONS </li></ul><ul><li>Marijuana- any part of plant / its extract </li></ul><ul><li>Hashish (Charas)- dried resin from flowery tops </li></ul><ul><li> (40% ACTIVE PRINCIPLE ) </li></ul><ul><li>Ganja- resinous extract of crushed leaves of female plant (25% OF ACTIVE PRINCIPLE)) </li></ul><ul><li>Bhang- dried mature leaves & flower stems(15%) </li></ul><ul><li>Sinsemilla- seedless unpollinated female plant (50% THC) </li></ul>
  8. 11. Acute poisoning <ul><li>Euphoria </li></ul><ul><li>Temporal & spatial disorientation with intensification of sensation & increased clarity of perception </li></ul><ul><li>Hallucinations, sedation, dysphoria </li></ul><ul><li>Acute toxic psychosis </li></ul><ul><li>Tachycardia, palpitations, hypotension </li></ul><ul><li>Stimulation of appetite </li></ul>
  9. 12. Chronic poisoning <ul><li>Amotivational syndrome – lethargic, apathetic, disinterested, poor concentration </li></ul><ul><li>Manic / paranoid psychosis </li></ul><ul><li>(Running amok) </li></ul><ul><li>Treatment: </li></ul><ul><li>Decontamination, benzodiazipines, psycho social </li></ul><ul><li>therapy </li></ul><ul><li>Medicosocial & Forensic issues: Drug of abuse </li></ul>
  10. 14. Cocaine (Coke, snow, cadillac, crack) <ul><li>Alkaloid from Erythroxylon coca </li></ul><ul><li>Occurs as white, shiny crystals with bitter taste & numbing taste </li></ul><ul><li>Uses: </li></ul><ul><li>Topical anaesthetic for cornea </li></ul><ul><li>Brompton’s cocktail </li></ul><ul><li>(cocaine, morphine, chlorpromazine, alcohol) </li></ul>
  11. 15. Cocaine <ul><li>One of the most powerful stimulants of CNS </li></ul><ul><li>Whole sale price in USA- 25,000-35,000 $/ kg </li></ul><ul><li>India, cocaine powder- Rs 3000- 5000/gm </li></ul>
  12. 16. Acute poisoning <ul><li>Stage of early stimulation: </li></ul><ul><li>Euphoria, excitement, mydriasis, increased HR, BP, RR </li></ul><ul><li>Stage of advanced stimulation: </li></ul><ul><li>Vomiting, muscle twitching, dyspnoea, hyperthermia, hallucinations, convulsions </li></ul><ul><li>Stage of depression: </li></ul><ul><li>Paralysis of muscles, loss of reflexes, coma & death </li></ul>
  13. 17. <ul><li>Body packer syndrome (body stuffing): </li></ul><ul><li>Seen in smugglers (body stuffer / mules) </li></ul><ul><li>Massive over dosage & death </li></ul>
  14. 18. Cocaine addict <ul><li>Loses interest in family, friends, food, sexual activity </li></ul><ul><li>Emaciated & physically exhausted </li></ul><ul><li>Mydriasis, anorexia, hyperactivity, tachycardia, tachypnoea, insomnia </li></ul><ul><li>Manic, paranoid or depressive psychosis </li></ul><ul><li>Tactile hallucinations (coke bug, formication, Magnan’s sign) </li></ul>
  15. 19. <ul><li>Treatment: </li></ul><ul><li>Stomach wash, activated charcoal </li></ul><ul><li>Symptomatic </li></ul><ul><li>Psychotherapy </li></ul><ul><li>Medicolegal importance </li></ul><ul><li>Rich man’s drug </li></ul><ul><li>Champagne drug </li></ul><ul><li>Body packing </li></ul>
  16. 20. Psychotropics <ul><li>Antidepressants- Amphetamine (Designer drugs) </li></ul><ul><li>Neuroleptics- Chlorpromazine </li></ul><ul><li>Hallucinogens- LSD (Lysergic Acid Diethylamide) </li></ul>
  17. 21. <ul><li>THANK YOU </li></ul>

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