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Deliriant poison

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About deliriant poison.

About deliriant poison.


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  • 1. Dhatura,Atropa Belladonna,Hyoscyamus Niger, Cannabis Indica and Cocaine
  • 2.  
  • 3.  
  • 4. DATURA (Jimson weed, Thorn apple)
    • Toxic principles: Hyoscine,hyoscymine, atropine
    • Mode of action: competitively inhibit muscarinic effects of acetylcholine
  • 5. Toxic effects
    • Blind as a bat,
    • hot as a hare,
    • dry as a bone,
    • red as a beet,
    • and mad as a wet hen
  • 6. Important manifestations
    • Dryness of mouth, thirst, slurred speech
    • Dysphagia
    • Dilated pupils
    • Diploplia
    • Dry hot skin
    • Dysuria
    • Drunken gait
    • Delirium
    • Death
  • 7. Datura
    • Fatal Dose-100-125(60mg ,4mg).
    • Fatal period.
    • Treatment
    • Stomach wash (potasium,tannic)
    • Decontamination
    • Physostigmine- 2mg IV or Neostigmine
    • Forensic significance(MEDICOLEGAL IMPORTANCE)
    • Accidental
    • Suicidal
    • Homicidal
    • Stupefaction
  • 8.  
  • 9. Cannabis
    • Cannabis Sativa – flowering tops & leaves
    • Uses: Antiemetic
    • Convulsions, anxiety, pain & inflammation
    • Active principle:
    • Tetra hydro cannabinol- THC
  • 10.
    • PREPARATIONS
    • Marijuana- any part of plant / its extract
    • Hashish (Charas)- dried resin from flowery tops
    • (40% ACTIVE PRINCIPLE )
    • Ganja- resinous extract of crushed leaves of female plant (25% OF ACTIVE PRINCIPLE))
    • Bhang- dried mature leaves & flower stems(15%)
    • Sinsemilla- seedless unpollinated female plant (50% THC)
  • 11. Acute poisoning
    • Euphoria
    • Temporal & spatial disorientation with intensification of sensation & increased clarity of perception
    • Hallucinations, sedation, dysphoria
    • Acute toxic psychosis
    • Tachycardia, palpitations, hypotension
    • Stimulation of appetite
  • 12. Chronic poisoning
    • Amotivational syndrome – lethargic, apathetic, disinterested, poor concentration
    • Manic / paranoid psychosis
    • (Running amok)
    • Treatment:
    • Decontamination, benzodiazipines, psycho social
    • therapy
    • Medicosocial & Forensic issues: Drug of abuse
  • 13.  
  • 14. Cocaine (Coke, snow, cadillac, crack)
    • Alkaloid from Erythroxylon coca
    • Occurs as white, shiny crystals with bitter taste & numbing taste
    • Uses:
    • Topical anaesthetic for cornea
    • Brompton’s cocktail
    • (cocaine, morphine, chlorpromazine, alcohol)
  • 15. Cocaine
    • One of the most powerful stimulants of CNS
    • Whole sale price in USA- 25,000-35,000 $/ kg
    • India, cocaine powder- Rs 3000- 5000/gm
  • 16. Acute poisoning
    • Stage of early stimulation:
    • Euphoria, excitement, mydriasis, increased HR, BP, RR
    • Stage of advanced stimulation:
    • Vomiting, muscle twitching, dyspnoea, hyperthermia, hallucinations, convulsions
    • Stage of depression:
    • Paralysis of muscles, loss of reflexes, coma & death
  • 17.
    • Body packer syndrome (body stuffing):
    • Seen in smugglers (body stuffer / mules)
    • Massive over dosage & death
  • 18. Cocaine addict
    • Loses interest in family, friends, food, sexual activity
    • Emaciated & physically exhausted
    • Mydriasis, anorexia, hyperactivity, tachycardia, tachypnoea, insomnia
    • Manic, paranoid or depressive psychosis
    • Tactile hallucinations (coke bug, formication, Magnan’s sign)
  • 19.
    • Treatment:
    • Stomach wash, activated charcoal
    • Symptomatic
    • Psychotherapy
    • Medicolegal importance
    • Rich man’s drug
    • Champagne drug
    • Body packing
  • 20. Psychotropics
    • Antidepressants- Amphetamine (Designer drugs)
    • Neuroleptics- Chlorpromazine
    • Hallucinogens- LSD (Lysergic Acid Diethylamide)
  • 21.
    • THANK YOU