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Project – Brain Simulator<br />May 1st, 2010<br />Speaker : Tony Tseng<br />Advisor : Hsing Mei<br />Web Computing Laborat...
Outline<br />Introduction<br />Brain Network<br />The Theory of Neuronal Group Selection<br />Case Study - Alzheimer's dis...
Introduction<br />Web Intelligence<br />Understand Human Intelligence<br />Brain Informatics<br />Simulate Brain Models fo...
Brain Network<br />Thalamo-cortical motif<br />Polysynaptic loop structure<br />Diffuse ascending projections<br />4<br />...
Thalamo-cortical motif<br />Thalamocortical radiations<br />Directions<br />Thalamus – Cortex<br />Cortex – Cortex<br />Co...
Diffuse ascending projections<br />Value System<br />Neurotransmitters<br />6<br />08:29<br />WECO Lab, CSIE Dept., FJU<br...
The Theory of Neuronal Group Selection<br />Developmental Selection<br />The formation during brain development<br />Neuro...
The Theory of Neuronal Group Selection<br />Experiential Selection<br />Synaptic selection<br />Refining brain maps into i...
The Theory of Neuronal Group Selection<br />Reentrant Mapping<br />This is the process of neuronal integration<br />The th...
Case Study - Alzheimer's disease<br />The most common form of dementia<br />Affect 1 in 85 people globally by 2050<br />Ca...
Case Study - Alzheimer's disease<br />Comparison of a normal aged brain (left) and an Alzheimer's patient's brain (right)<...
Case Study - Alzheimer's disease<br />The acetylcholine pathway<br />12<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />htt...
Ideas of Brain Simulator<br />13<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />
Ideas of Brain Simulator<br />Macro (Global)<br />Dynamic Core<br />Spatial<br />Temporal<br />Integration of Brian Maps<b...
Ideas of Brain Simulator<br />Analysis of Brain Simulator<br />Simulate Brain Models for new Web Intelligence<br />15<br /...
Conclusion and Future Work<br />Brain Network<br />TNGS<br />Ideas of Brain Simulator<br />Future Work<br />Polysynaptic l...
17<br />~END~<br />THANK YOU<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />
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Brain Simulator

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Transcript of "Brain Simulator"

  1. 1. Project – Brain Simulator<br />May 1st, 2010<br />Speaker : Tony Tseng<br />Advisor : Hsing Mei<br />Web Computing Laboratory<br />Computer Science and Information Engineering Department <br />Fu Jen Catholic University<br />
  2. 2. Outline<br />Introduction<br />Brain Network<br />The Theory of Neuronal Group Selection<br />Case Study - Alzheimer's disease<br />Ideas of Brain Simulator<br />Conclusion and Future Work<br />2<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />
  3. 3. Introduction<br />Web Intelligence<br />Understand Human Intelligence<br />Brain Informatics<br />Simulate Brain Models for new Web Intelligence<br />Step One<br />Brain Simulator<br />3<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />
  4. 4. Brain Network<br />Thalamo-cortical motif<br />Polysynaptic loop structure<br />Diffuse ascending projections<br />4<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />
  5. 5. Thalamo-cortical motif<br />Thalamocortical radiations<br />Directions<br />Thalamus – Cortex<br />Cortex – Cortex<br />Cortex – Thalamus<br />Reentrant mapping<br />Small World Network<br />5<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />from Edelman & Tononi, 2000<br />
  6. 6. Diffuse ascending projections<br />Value System<br />Neurotransmitters<br />6<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />from Edelman & Tononi, 2000<br />
  7. 7. The Theory of Neuronal Group Selection<br />Developmental Selection<br />The formation during brain development<br />Neurons fire together wire together<br />7<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />from Edelman & Tononi, 2000<br />
  8. 8. The Theory of Neuronal Group Selection<br />Experiential Selection<br />Synaptic selection<br />Refining brain maps into internal representations<br />8<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />from Edelman & Tononi, 2000<br />
  9. 9. The Theory of Neuronal Group Selection<br />Reentrant Mapping<br />This is the process of neuronal integration<br />The thalamo-cortical system<br />9<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />from Edelman & Tononi, 2000<br />
  10. 10. Case Study - Alzheimer's disease<br />The most common form of dementia<br />Affect 1 in 85 people globally by 2050<br />Causes<br />Tangles<br />Plaques<br />The neurotransmitter acetylcholine<br />10<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />from AHAF<br />
  11. 11. Case Study - Alzheimer's disease<br />Comparison of a normal aged brain (left) and an Alzheimer's patient's brain (right)<br />11<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />from wikipedia<br />
  12. 12. Case Study - Alzheimer's disease<br />The acetylcholine pathway<br />12<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />from thebrain<br />
  13. 13. Ideas of Brain Simulator<br />13<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />
  14. 14. Ideas of Brain Simulator<br />Macro (Global)<br />Dynamic Core<br />Spatial<br />Temporal<br />Integration of Brian Maps<br />Mesco (Intermediate)<br />Neural Migration<br />Degeneracy<br />Micro (Local)<br />Neurogenesis<br />Synaptogenesis / Synaptic Prunning<br />Myelination<br />14<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />
  15. 15. Ideas of Brain Simulator<br />Analysis of Brain Simulator<br />Simulate Brain Models for new Web Intelligence<br />15<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />
  16. 16. Conclusion and Future Work<br />Brain Network<br />TNGS<br />Ideas of Brain Simulator<br />Future Work<br />Polysynaptic loop structure<br />Results of AD related experiments<br />Modeling our brain simulator<br />Brain-Oriented SLS<br />16<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />
  17. 17. 17<br />~END~<br />THANK YOU<br />08:29<br />WECO Lab, CSIE Dept., FJU<br />http://www.weco.net<br />
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