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Brain Simulator

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  • 1. Project – Brain Simulator
    May 1st, 2010
    Speaker : Tony Tseng
    Advisor : Hsing Mei
    Web Computing Laboratory
    Computer Science and Information Engineering Department
    Fu Jen Catholic University
  • 2. Outline
    Introduction
    Brain Network
    The Theory of Neuronal Group Selection
    Case Study - Alzheimer's disease
    Ideas of Brain Simulator
    Conclusion and Future Work
    2
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
  • 3. Introduction
    Web Intelligence
    Understand Human Intelligence
    Brain Informatics
    Simulate Brain Models for new Web Intelligence
    Step One
    Brain Simulator
    3
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
  • 4. Brain Network
    Thalamo-cortical motif
    Polysynaptic loop structure
    Diffuse ascending projections
    4
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
  • 5. Thalamo-cortical motif
    Thalamocortical radiations
    Directions
    Thalamus – Cortex
    Cortex – Cortex
    Cortex – Thalamus
    Reentrant mapping
    Small World Network
    5
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
    from Edelman & Tononi, 2000
  • 6. Diffuse ascending projections
    Value System
    Neurotransmitters
    6
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
    from Edelman & Tononi, 2000
  • 7. The Theory of Neuronal Group Selection
    Developmental Selection
    The formation during brain development
    Neurons fire together wire together
    7
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
    from Edelman & Tononi, 2000
  • 8. The Theory of Neuronal Group Selection
    Experiential Selection
    Synaptic selection
    Refining brain maps into internal representations
    8
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
    from Edelman & Tononi, 2000
  • 9. The Theory of Neuronal Group Selection
    Reentrant Mapping
    This is the process of neuronal integration
    The thalamo-cortical system
    9
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
    from Edelman & Tononi, 2000
  • 10. Case Study - Alzheimer's disease
    The most common form of dementia
    Affect 1 in 85 people globally by 2050
    Causes
    Tangles
    Plaques
    The neurotransmitter acetylcholine
    10
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
    from AHAF
  • 11. Case Study - Alzheimer's disease
    Comparison of a normal aged brain (left) and an Alzheimer's patient's brain (right)
    11
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
    from wikipedia
  • 12. Case Study - Alzheimer's disease
    The acetylcholine pathway
    12
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
    from thebrain
  • 13. Ideas of Brain Simulator
    13
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
  • 14. Ideas of Brain Simulator
    Macro (Global)
    Dynamic Core
    Spatial
    Temporal
    Integration of Brian Maps
    Mesco (Intermediate)
    Neural Migration
    Degeneracy
    Micro (Local)
    Neurogenesis
    Synaptogenesis / Synaptic Prunning
    Myelination
    14
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
  • 15. Ideas of Brain Simulator
    Analysis of Brain Simulator
    Simulate Brain Models for new Web Intelligence
    15
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
  • 16. Conclusion and Future Work
    Brain Network
    TNGS
    Ideas of Brain Simulator
    Future Work
    Polysynaptic loop structure
    Results of AD related experiments
    Modeling our brain simulator
    Brain-Oriented SLS
    16
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net
  • 17. 17
    ~END~
    THANK YOU
    08:29
    WECO Lab, CSIE Dept., FJU
    http://www.weco.net

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