RBC Disorders - case studies


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Cases on RBC disorders specially designed for UG medical students. To know the correct answers to theses cases contact the author <csbrprasad>

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RBC Disorders - case studies

  1. 1. CASE STUDIES in RBC Disorders Dr.CSBR.Prasad, M.D., v1-CSBRP-Nov-2012
  2. 2. Case-1• 8month old infant with 2week history of swollen hands and feet v1-CSBRP-Nov-2012
  3. 3. Case-1v1-CSBRP-Nov-2012
  4. 4. Case-1 Peripheral blood smear v1-CSBRP-Nov-2012
  5. 5. Case-11. What are the x-ray findings?2. How do you describe the hand?3. What is the abnormality in the peripheral smear?4. How do you confirm your diagnosis?5. How do you prevent future recurrent complications of this disease? v1-CSBRP-Nov-2012
  6. 6. Case-2• 29yo male. Incidental finding in routine hemogram. What is your interpretation? v1-CSBRP-Nov-2012
  7. 7. Case-2v1-CSBRP-Nov-2012
  8. 8. Case-2• How do you confirm your suspicion? v1-CSBRP-Nov-2012
  9. 9. Case-3• 60yo male with weakness and pallor.• Hemogram and PBS are given for your interpretation. v1-CSBRP-Nov-2012
  10. 10. Case-3v1-CSBRP-Nov-2012
  11. 11. Case-3 PBS v1-CSBRP-Nov-2012
  12. 12. Case-31. What are the significant abnormal values in hemogram report?2. What are your PBS findings?3. What is your diagnosis?4. What do you do next? v1-CSBRP-Nov-2012
  13. 13. Case-4• 60yo female with chronic severe joint pains and deformity was found to have HGB=8gm/dl, MCV=68fl, serum iron=100µg/dl• Peripheral smear and BM are given for your interpretation v1-CSBRP-Nov-2012
  14. 14. Case-4v1-CSBRP-Nov-2012
  15. 15. Case-4 PBS v1-CSBRP-Nov-2012
  16. 16. Case-4 BM, Perl’s stain v1-CSBRP-Nov-2012
  17. 17. Case-41. How do you describe the appearance of the hand ?2. Describe the peripheral blood smear3. What is being demonstrated in the Bone marrow smear? Is it normal or altered?4. What is your diagnosis?5. What is the basic pathology in this disease?6. What should be the main stay of treatment? v1-CSBRP-Nov-2012
  18. 18. Case-5• 40yo female with weakness and very mild jaundice and recent onset foot drop• Hemogram and PBS and BM images are given for your interpretation v1-CSBRP-Nov-2012
  19. 19. Case-5 Hemogram v1-CSBRP-Nov-2012
  20. 20. Case-5 PBS v1-CSBRP-Nov-2012
  21. 21. Case-5 BM v1-CSBRP-Nov-2012
  22. 22. Case-5 BM v1-CSBRP-Nov-2012
  23. 23. Case-5 BM v1-CSBRP-Nov-2012
  24. 24. Case-5 BM v1-CSBRP-Nov-2012
  25. 25. Case-51. What are the striking abnormalities in hemogram values?2. What are your findings in PBS, BM smears?3. Why this patient has foot drop?4. How do you assess the response to treatment in these cases?5. How do you explain jaundice in this patient? v1-CSBRP-Nov-2012
  26. 26. Case-6• 35yo female with chronic anemia and whitish skin lesions and indigestion• Gastric biopsy was done v1-CSBRP-Nov-2012
  27. 27. Case-6 Skin lesions v1-CSBRP-Nov-2012
  28. 28. Case-6 Section from stomach v1-CSBRP-Nov-2012
  29. 29. Case-6 PBSv1-CSBRP-Nov-2012
  30. 30. Case-61. Enumerate the histological findings in stomach biopsy2. What are the PBS findings?3. What is your diagnosis?4. What is the importance of finding shown in the clinical photograph of the patient? v1-CSBRP-Nov-2012
  31. 31. Case-7• 40yo male patient complains of passing red colored urine after consuming beans shown in the image. v1-CSBRP-Nov-2012
  32. 32. Case-7v1-CSBRP-Nov-2012
  33. 33. Case-7B - Patient’s urine sampleA - Normal urine forcomparison v1-CSBRP-Nov-2012
  34. 34. Case-7 PBS v1-CSBRP-Nov-2012
  35. 35. Case-7 Reticulocyte preparation v1-CSBRP-Nov-2012
  36. 36. Case-71. Describe the abnormality in urine sample2. What are your findings in retic prep?3. Describe the typical cells shown in the peripheral blood4. How do you confirm the diagnosis?5. Which famous mathematician suffered from this disease? v1-CSBRP-Nov-2012
  37. 37. Case-8 Urine samples from a patient What is your diagnosis? v1-CSBRP-Nov-2012
  38. 38. Case-9• 18yo boy with h/o jaundice since birth• Operated for Gall stones recently• Sectioned gall bladder and PBS images are given for your interpretation v1-CSBRP-Nov-2012
  39. 39. Case-9v1-CSBRP-Nov-2012
  40. 40. Case-9 PBS v1-CSBRP-Nov-2012
  41. 41. Case-91. What are your findings in the gall bladder?2. What are your findings in the peripheral smear?3. What is your diagnosis?4. What test will help in establishing the diagnosis?5. What one may find in the abdominal examination?6. Name some other causes for PBS findings7. What are the other causes for gall bladder findings8. Can you name some causes for “jaundice since birth”9. After what period “neonatal jaundice” becomes worrysome? v1-CSBRP-Nov-2012
  42. 42. Case-10 Patient’s spun blood sample and micro-HCT tubes (Arrows). What are the causes for such a finding?v1-CSBRP-Nov-2012
  43. 43. Case-11• Child with chronic microcytic hypochromic anemia• Blood and BM images are given v1-CSBRP-Nov-2012
  44. 44. Case-11 PBS & BM v1-CSBRP-Nov-2012
  45. 45. Case-11 v1-CSBRP-Nov-2012
  46. 46. Case-111. What is your diagnosis?2. What are the differentials for microcytic hypochromic anemia? v1-CSBRP-Nov-2012
  47. 47. Case-12• A child with hemolytic anemia• After a brief illness his anemia worsened• Clinical image, BM pictures are given for your interpretation v1-CSBRP-Nov-2012
  48. 48. v1-CSBRP-Nov-2012
  49. 49. Case-12 BM v1-CSBRP-Nov-2012
  50. 50. Case-12 BM aspirate v1-CSBRP-Nov-2012
  51. 51. Case-12 BM biopsy v1-CSBRP-Nov-2012
  52. 52. Case-12• What are the BM findings?• How do you treat these cases? v1-CSBRP-Nov-2012
  53. 53. Case-13• 40 yo female with muscle weakness and anterior mediastinal tumor• Chest CT and BM images are given for interpretation v1-CSBRP-Nov-2012
  54. 54. Case-13 Chest CT v1-CSBRP-Nov-2012
  55. 55. Case-13 BM v1-CSBRP-Nov-2012
  56. 56. Case-13 BM v1-CSBRP-Nov-2012
  57. 57. Case-131. What are the CT findings?2. Name some DDs for anterior mediastinal mass3. What are the BM findings?4. What is your diagnosis?5. How do explain muscle weakness in this patient?6. What are the other causes for this type of BM changes? v1-CSBRP-Nov-2012
  58. 58. Case-14 15yo female with chronic anemia v1-CSBRP-Nov-2012
  59. 59. Case-14 PBS v1-CSBRP-Nov-2012
  60. 60. Case-141. What is the descriptive term used for the facial appearances in this case?2. Describe the changes in skull X-ray?3. What are the findings in peripheral blood smear?4. What is your diagnosis?5. How do you confirm the diagnosis? v1-CSBRP-Nov-2012
  61. 61. Case-15 50yo male with a HGB=11gm/dl. PBS given for your interpretation. v1-CSBRP-Nov-2012
  62. 62. Case-16 How do you prove it’s hereditary? v1-CSBRP-Nov-2012
  63. 63. Case-17 Paleopathology case Skull from Italian excavation site v1-CSBRP-Nov-2012
  64. 64. Case-17 Clue: Bottom image v1-CSBRP-Nov-2012
  65. 65. Case-17 Paleopathology case1. Describe the abnormality seen in the skull2. What are the causes for such changes3. How do you interpret the findings in the bottom image4. What is your probable diagnosis? v1-CSBRP-Nov-2012
  66. 66. ENDv1-CSBRP-Nov-2012
  67. 67. Please make an attempt to get the right answersFor answers contact:Dr.CSBR.Prasad, M.D.,Associate Professor,Deptt. of Pathology,Sri Devaraj Urs Medical College,Kolar-563101,Karnataka<CSBRPRASAD@rediffmail.com> v1-CSBRP-Nov-2012