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    Seminar summaries Seminar summaries Document Transcript

    • Summary 1. Jessica Torres- Incorporation of Unnatural Amino Acids into Proteins & Biomedical ReserchWith the discovery of protein labeling, the study of the cell, and the development of some diseases have beenbetter understood. Proteins are involved in 60% of the cellular dry mass; they have the important role ofsignaling, transporting, maintaining, and defending. Scientists like Ms. Jessica Torres have been trying to findan ideal method for making protein labeling, “rapid and quantitative” (Lang, 2012). Proteins are composed ofpolypeptides which are formed with amino acid chains. There are only 20 amino acids, but in order tomanipulate the system, to produce this new efficient way to label proteins, the creation of unnatural amino acidswas imperative. After inserting the unnatural amino acid in the chain and being recognized by an orthogonalsynthetase it is then transferred to tRNA. Eventually it will be treated like a normal amino acid, forming alabeled protein. Technology applied to mammalian cells, which are discovered by researches like this, help tosolve diseases mysteries at the medical campus; Huntington’s disease is one of them that can be beneficed.Summary 3.Yadilette Rivera- Against all Odds: Protein Crystallography and Graduate School“Against all Odds” Ms. Rivera decided to study three proteins at the same time: GALNS, GLB, and SGSH,having as motivation the lysosomal disorder patients. Rivera-Colon (2012) explains that a lysosomal storagedisease outcome from the deficiencies of the lysosomal enzymes which results in the accumulation ofundergraded substrates in tissues. GALNS, the lysosomal protein that “removes sulfate groups from a terminalin mucopolysaccharides” (Rivera-Colon et al. 2012), was the focus of this particular study. In order to make thisenzyme more stable to treat the disorder, the study of its structure by crystallography is necessary. By purifyingthe protein, having it as a molecule, as a unit cell, and then using the technique of sitting drop or hanging drop,crystals will form. After picking the right crystals, with the help of technology, obtaining a diffraction patternand an electron density the structure of the protein will revealed. Studies like this facilitate the development ofnew ways for therapy and to predict the behavior of the protein and the future development of the disease.Summary 4. Speaker: Orielyz Flores- Nanotechnology: Providing Tools For the Improved Diagnosis andTreatment of CancerThis year, the National Cancer Institute in the United States reported; 28,170 deaths caused by prostate cancer.Willing to reduce the death toll and provide more efficient treatments, Mrs. Ortiz joined Dr. Perez’s laboratory,whose principal aim is to develop tools using nanotechnology. The creation of these systems will make thetargeting, diagnosis, and treatment of a tumor, more successful than now if these researches keep developing. Inthis particular research, instead of using nanoparticles to create a coagulation cascade, they are constructingpolymeric nanoparticles to handle prostate cancer. The principal problem with this disease is that the drugs usedto treat it are not stable enough and don’t have an efficient delivery system, causing damages to the healthycells. These polymeric nanoparticles provide a retention effect that will carry the drug, deliver it to the specificSEMINAR SUMMARIESSCIENTIFIC LITERATURE
    • tissue, and discard it from the body. Hopefully, in a couple of years, this technique will become an excellenttreatment that will change the perspective of being diagnosed with cancer.Summary 1. Jessica Torres- Incorporation of Unnatural Amino Acids into Proteins & Biomedical ReserchWith the discovery of protein labeling, the study of the cell, and the development of some diseases have beenbetter understood. Proteins are involved in 60% of the cellular dry mass; they have the important role ofsignaling, transporting, maintaining, and defending. Scientists like Ms. Jessica Torres have been trying to findan ideal method for making protein labeling, “rapid and quantitative” (Lang, 2012). Proteins are composed ofpolypeptides which are formed with amino acid chains. There are only 20 amino acids, but in order tomanipulate the system, to produce this new efficient way to label proteins, the creation of unnatural amino acidswas imperative. After inserting the unnatural amino acid in the chain and being recognized by an orthogonalsynthetase it is then transferred to tRNA. Eventually it will be treated like a normal amino acid, forming alabeled protein. Technology applied to mammalian cells, which are discovered by researches like this, help tosolve diseases mysteries at the medical campus; Huntington’s disease is one of them that can be beneficed.