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2014 AEMT Intro to pharmacology cole

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Introduction to essential Pharmacology for Advanced EMT and Paramedic Students. A bit long but a good lecture. Does not goo into individual drugs, that is later. This is JUST the introduction.

Introduction to essential Pharmacology for Advanced EMT and Paramedic Students. A bit long but a good lecture. Does not goo into individual drugs, that is later. This is JUST the introduction.

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  • 1. Introduction to Pharmacology Introduction to Pharmacology By: Robert S. Cole CWI Paramedic Class 2014
  • 2. Learning Objectives  Describe pharmacological as a science and a historical perspective  Differentiate chemical, generic, trade names of drug  List main sources of drug products  Describe how drugs are classified  List authoritative sources for drug information  List legislative acts controlling drug use, abuse in U.S.  Differentiate Schedule I, II, III, IV, V substances; list examples  Discuss standardization of drugs  Discuss paramedic’s s responsibilities and scope of management pertinent to administration of medications
  • 3. Introduction What is a drug? What is pharmacology? Why is it important?
  • 4. Introduction  Drug :  Substance (chemical agents) intended to diagnose, cure, relieve, treat, prevent disease  Affects structure/function of body  Pharmacology : Study of drugs
  • 5. Things that make you go hmmmmm  Based on Greek:  pharmakon: poison in classic Greek; drug in modern Greek";  - logia: "Study of"
  • 6. Introduction  Written records of drug use date back to the ancient Egyptians  Early writings on drugs were observational, and were not based on science  Early pharmacologists focused on natural substances, mainly plant extracts.  The theories of “Humors” were used for almost 2000 years.  It wasn’t until the19th century that Pharmacology developed as a biomedical science that applied the principles of scientific experimentation to therapeutic contexts.
  • 7. Three Early Pharmacists  Hippocrates  Claudius Galen  Pedanius Dioscorides
  • 8. The Renaissance and Phamacology  After Roman Empire fall, most European cultures reverted to folklore, tradition, superstition  By contrast: Muslims, Greeks, Italians/Romans, Jews combined knowledge of math, science, created formularies  Monasteries became some of the earliest learning centers for pharmacy, medicine
  • 9. “Modern” Pharmacology  Pharmaceutical laws enacted late 19th, early 20th century protecting public  Drugs developed improved chronic illness treatment 1950-current, more changes in pharmacology than any other time
  • 10. Introduction  Subspecialties of Pharmacology Pharmacokinetics Pharmacodynamics Pharmacogenetics Pharmacogenomics Pharmacogenosy
  • 11. Pharmacokinetics vs. Pharmacodynamics  Pharmacokinetics describes the movement of the drug throughout the body.  The body’s effect on the drug (e.g. half- life and volume of distribution),  Pharmacodynamics described the effects of the drug on the body, intentional or toxic  Side effects, MOA, desired effects, etc
  • 12. Pharmacokinetics  When describing the pharmacokinetic properties of a chemical, pharmacologists are often interested in LADME:  Liberation - disintegration (for solid oral forms {breaking down into smaller particles}), dispersal and dissolution  Absorption - How is the medication absorbed (through the skin, the intestine, the oral mucosa)?  Distribution - How does it spread through the organism?  Metabolism - Is the medication converted chemically inside the body, and into which substances. Are these active? Could they be toxic?  Excretion - How is the medication eliminated (through the bile, urine, breath, skin)?
  • 13. Pharmacokinetics  This includes  Active transport  Facilitated diffusion  Passive transport
  • 14. Pharmacokinetics  Active Transport  Use of energy (typically ATP) across barrier (i.e. membrane) into target tissue.  Also may involve other ions  Typically this is against a pressure gradient (or else passive transport would work)
  • 15. Pharmacokinetics  Facilitated diffusion (also known as facilitated transport or passive-mediated transport)  Passive transport “with a twist”  Cell walls have specific properties that allow passive transport of certain molecules and not others.  Polarity  Size  Protein assisted : “Channels”
  • 16. Pharmacokinetics  Pharmacokinetics considerations  Molecule size and shape  Solubility in water and lipids  Ability to bind to tissue proteins  Ionization
  • 17. Pharmacodynamics  Drugs may act in four different ways:  Bind to a receptor site  Change the physical properties of the cell  Chemically combine with other chemicals  Alter a normal metabolic pathway
  • 18. Pharmacogenetics and pharmacogenomics Pharmacogenetics and pharmacogenomics Study unique genetic processes linked to DNA coding and genetics
  • 19. Pharmacogenosy  The study of natural drug sources  Plants  Animals  Minerals  What are some common examples of each drug source?
  • 20. Did you know? “Crude Drugs”:  A crude drug is any naturally occurring, unrefined substance derived from organic or inorganic sources such as plant, animal, bacteria, organs or whole organisms intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease in man or other animals.  Crude drugs are unrefined medications in their raw or natural forms.  Prior to the 1950s, every pharmacy student learned about crude drugs in pharmacognosy class.  Pharmacognosy is the study of the proper horticulture, harvesting and uses of the raw medications found in nature.  By the 1980’s, this practice was discontinued in most western pharmacology programs, increasing the reliance of pharmacist on drug companies.  Raising, harvesting and selling crude drugs was how many large pharmaceutical companies started out.  Companies such as Eli Lilly and Company sold crude drugs to pharmacists to save them time and money, but the early pharmacy graduate would know how to raise their own crude drugs if need be.
  • 21. Plant Sources of Drugs  Oldest source of medications  Drugs may consist of using the entire plant, leaves, roots, bulbs, stems, seeds, buds, or blossoms
  • 22. Where do Drugs come from?
  • 23. Animal Sources of Drugs  Body fluids or glands from animals can act as sources for drugs  Hormones  Oils and fats  Enzymes
  • 24. Mineral Sources of Drugs  Metallic and nonmetallic minerals provide various inorganic materials  Occur naturally or are combined to form acids, bases, or salts
  • 25. Orphan Drugs  An orphan drug is a pharmaceutical agent that has been developed specifically to treat a rare medical condition, the condition itself being referred to as an orphan disease.  Development, production, and marketing of an orphan drug is not considered profitable under traditional pharmaceutical business models, and therefore would likely not occur without incentives.  The assignment of orphan status to a disease and to any drugs developed to treat it is a matter of public policy in many countries and the World Health Organization (WHO), and has resulted in medical breakthroughs that may not have otherwise been achieved due to the economics of drug research and development.  In the US and EU it is easier to gain marketing approval for an orphan drug, and there may be other financial incentives such as extended exclusivity periods.
  • 26. Introduction  Laboratory-produced drug sources  New drugs may be a more pure form of a naturally occurring drug or they may be a synthetic form  Or a combination  i.e. Morphine vs. Fentanyl
  • 27. Routes of Administration
  • 28. Routes of Administration  Routes of Administration  Enteral Route  Parenteral Route  Topical Route
  • 29. Routes of Administration  Subroutes of administration  Ingestion  Injection  Absorption  Inhalation
  • 30. Route of Administration  Depends of many factors  Accessibility  Rate of absorption  Deactivation by enzymes or acids  Toxicity to tissues
  • 31. Routes of Administration Enteral Orally (PO) Parenteral (just a few) Intramuscular (IM) Subcutaneous (SC or SQ) Intravenous (IV) Inhalation Sublinqual
  • 32. Local vs. systemic effects  Local effect  Affects specific body part  Systemic effect  Affects entire body
  • 33. Common Routes Oral (PO) Slow Intra-Dermal (ID) Slow Subcutaneous (SQ) Slow Topical /Trans Dermal (TD) Moderate Intramuscular (IM) Moderate Rectal (PR) Rapid Sublingual (SL) Rapid Endotracheal (ET) Rapid Inhalation Rapid Intra-Nasal (IN) Rapid Intraosseous (IO) Immediate Intavenous (IV) Immediate
  • 34. Drug Absorption  Drug’s progress from its pharmaceutical dosage form to a biologically available substance  Several factors affect drug absorption
  • 35. Basic Principles of Pharmacology
  • 36. Factors 1. Solubility 2. Concentration 3. pH 4. Site of absorption 5. Blood supply 6. Bioavailability
  • 37. Bioavailability  Bioavailability (BA) is a subcategory of absorption and is used to describe the fraction of an administered dose of unchanged drug that reaches the systemic circulation  By definition, when a medication is administered intravenously, its bioavailability is 100%.  However, when a medication is administered via other routes (such as orally), its bioavailability generally decreases
  • 38. Bioequivalence  “The absence of a significant difference in the rate and extent to which the active ingredient or active moiety in pharmaceutical equivalents or pharmaceutical alternatives becomes available at the site of drug action when administered at the same molar dose under similar conditions in an appropriately designed study” – The US FDA
  • 39. Biotransformation  Biotransformation has two effects:  It can transform the drug into a more or less active metabolite  It can make the drug more water soluble (or less lipid-soluble) to facilitate elimination
  • 40. Biotransformation  Can activate metabolites to make the drug active (prodrugs)  Many processes occur in the liver  First-pass effect  Body detoxifies and disposes of toxins and excess drug by increasing water solubility
  • 41. First Pass Metabolism  The first-pass effect (AKA first-pass metabolism or presystemic metabolism) is a phenomenon of drug metabolism whereby the concentration of a drug is greatly reduced before it reaches the systemic circulation.  It is the fraction of lost drug during the process of absorption which is generally related to the liver and gut wall. Notable drugs that experience a significant first-pass.  After a drug is swallowed, it is absorbed by the digestive system and enters the hepatic portal system through the portal vein to the liver.  The liver metabolizes many drugs, sometimes to such an extent that only a small amount of active drug emerges from the liver to the rest of the circulatory system.  This first pass through the liver thus greatly reduces the bioavailability of the drug.  Alternative routes administration like suppository , intravenous, intramuscular, inhalational aerosol and sublingual avoid the first-pass effect because they allow drugs to be absorbed directly into the systemic circulation.
  • 42. Distribution  Several factors affect distribution:  Cardiovascular function  Regional blood flow  Drug storage reservoirs  Physiological barriers
  • 43. Physiologic Barriers  Blood Brain Barrier/Placental barrier
  • 44. BLOOD BRAIN BARRIER  The blood- brain barrier is located in endothelial cells of capillaries of the brain.  The blood brain barrier is both a physical barrier and a system of cellular transport mechanisms.  It maintains homeostasis by restricting the entrances of potentially harmful chemicals from the blood, and by allowing the entrance of essential nutrients.
  • 45. BLOOD BRAIN BARRIER  Lipid soluble molecules, (i.e. ethanol , most opioids, and caffeine) are able to penetrate through the barrier relatively easily via the lipid membranes of the cells.  In contrast, water soluble molecules such as sodium and potassium ions are unable to transverse the barrier without the use of specialized carrier- mediated transport mechanisms.
  • 46. BLOOD BRAIN BARRIER  These endothelial cells of capillaries in the brain are different to those found in peripheral tissues in various ways:  Brain endothelial cells are joined by tight junctions of high electrical resistance providing an effective barrier against molecules.  In peripheral endothelial cells there is good transcellular movement of molecules. There is no such movement in brain endothelial cells.  Brain capillaries are in contact with foot processes of astrocytes which essentially separate the capillaries from the neurones.
  • 47. Astrocyte Feet?
  • 48. 3 places w/ no BBB Incomplete until 1-2 yrs Hypothalamus/
  • 49. Therapeutic Index Medication must reach a certain concentration at the target tissue to be effective Therapeutic index Therapeutic threshold
  • 50. Therapeutic Index  Dose calculation  ED50  LD50  TD50
  • 51. Elimination  Can be affected by  Drug half-life  Accumulation  Clearance  Onset, peak, and duration
  • 52. Accumulation  Accumulation: a drug that is not re- administered is eliminated almost completely over time, but a regularly administered remains constant.  When elimination is altered, accumulation increases.  In some cases this results in a drug exceeding its therapeutic window.  Tylonol is a common drug with this problem.  Opioids as well.
  • 53. Half Life  Technically a biological half life or elimination half-life  In a medical context, half-life may also describe the time it takes for the blood plasma concentration of a substance to halve ("plasma half-life") its steady-state.  The relationship between the biological and plasma half-lives of a substance can be complex, due to factors including accumulation in tissues, active metabolites, and receptor interactions.
  • 54. Question  Is the Half Life of a drug is 6 hours, how long does it take to eliminate 98% the drug from the body?
  • 55. KEY POINT  IT TAKES SIX HALF LIVES TO REACH 98% ELIMINATION  So it would take 36 hours for the hypothetical drug to be (mostly) eliminated
  • 56. Basics  Drugs are eliminated in either their original form or as metabolites  Drug excretion is the movement of a drug or its metabolites from the tissues back into circulation and from secretion into organs of excretion
  • 57. Drug Forms
  • 58. Drug Forms  Usually consist of a powder dissolved in a liquid Solute: drug Solvent: liquid in which it is dissolved, typicaly water  Primary difference between one preparation and another is the solvent  What is a solution?
  • 59. Drug Forms  Liquids  Solids  Suppositories  Inhalants  Sprays  Creams/lotions  Patches  Lozenges
  • 60. Liquid Drugs  Solutions: preparations that contain a drug dissolved in a solvent, usually water.  Tinctures: drugs chemically extracted from alcohol.  Suspensions: drugs that do not remain dissolved in a solution.  Spirits: drugs that contain volatile chemicals dissolved in alcohol. • Solutions: preparations that contain a drug dissolved in a solvent, usually water. • Tinctures: drugs chemically extracted from alcohol. • Suspensions: drugs that do not remain dissolved in a solution. • Spirits: drugs that contain volatile chemicals dissolved in alcohol.
  • 61. Liquid Drugs  Emulsions: an oily substance is mixed with a solvent into which it doesn’t dissolve.  Elixirs: a drug in an alcohol solvent.  Syrups: drugs suspended in sugar and water to improve the taste.
  • 62. Packaging  Packaging and preparations  Vials  Ampules  Self-contained systems or syringes  Nebules
  • 63. Solid Drugs  Administered orally or rectally  Pills: shaped into a form  Powders: dry, particulate form of drug  Capsules: gelatin container filled with powder  Tablets: compressed powder covered with sugar coating  Suppositories: carried in a solid base that melts at body temperature • Administered rectally or vaginally • Produce local and systemic effects
  • 64. Inhalants Both powdered or liquid forms of a drug given via the respiratory route and absorbed by the capillaries in the lungs. Nebulizers Metered-dose aerosols Turbo inhalers Vaporizers
  • 65. Take a Break….
  • 66. Receptors
  • 67. Receptors  Mechanism of Action: how a drug works Drug action Drug effect
  • 68. Receptors  Drug receptors: proteins present on cell membrane to which a drug must bind in order to elicit a desired response
  • 69. Receptors  Receptors are classified based on effects  Agonist  AKA “ –Memetic”  Antagonist  Competitive antagonist  Noncompetitive antagonist  AKA “ -lytic”  A drug attached to a receptor site displays affinity
  • 70. Receptors
  • 71. Receptors  Efficacy: the power of a drug to produce a therapeutic effect  Agonists have affinity and efficacy  Antagonists have affinity but not efficacy  Drug potency: relative amount of drug required to produce the desired response
  • 72. Receptors  How do drugs bind to receptor sites?  Ionic bonds: chemical bonds in which ions are transferred from one molecule to another so that one end is positive and the other negative  Hydrogen bonds: bonds that share a hydrogen ion between molecules  Hydrophobic bonds nonpolar bonds created between molecules  Van der Waals forces: transient, weak electrical attraction of one atom for another that allows a molecule to change shape  Covalent bonds: chemical bond between two atoms achieved by sharing pairs of electrons
  • 73. Receptors  Receptor sites  Several drugs may bind to the same receptor site, thus creating different responses by the cells  Two main functions  Ligand binding  Message propagation
  • 74. Neurotransmitters
  • 75. Neurotransmitters  The nervous system is the body’s control system, regulating all bodily function via electrical impulses  What are the two main parts of the central nervous system that drugs can affect?
  • 76. Neurotransmitters  Two divisions:  Central Nervous System (CNS)  Peripheral Nervous System (PNS)
  • 77. Neurotransmitters
  • 78. Neurotransmitters Organ Sympathetic stimulation Parasympathetic stimulation Heart Increased rate, force Decreased rate, force Lungs Bronchodilation Bronchoconstriction Kidneys Decreased output None Systemic blood vessels Constricted – a dilated – b None Liver Glucose release Glycogen synthesis Blood glucose Increased None Pupils Dilated Constricted Basal metabolism Increased up to 100% None Skeletal muscle Increased strength None
  • 79. Neurotransmitters  Nerves of the autonomic nervous system exit the CNS and enter autonomic ganglia
  • 80. Neurotransmitters  No connection exists between two nerve cells or a nerve cell and its target organ; instead there is a space called a synapse  Neurotransmitters are specialized chemicals that conduct impulses between nerve cells or between a nerve cell and an organ
  • 81. Neurotransmitters  Neurotransmitters of ANS:  Acetylcholine (Ach)  Norepinephrine (NE)  Synapses:  Cholinergic synapses: use acetylcholine  Adrenergic synapses: use norepinephrine
  • 82. Neurotransmitters  What is the action of an adrenergic drugs?  What is the action of a cholinergic drug?
  • 83. Neurotransmitters  Cholinergic receptors  Acetylcholine Interacts with receptors, physiologic response  Sympathetic receptors (Adrenergic receptors)  When sympathetic division stimulated, adrenal medulla stimulated, releases epinephrine into circulatory system  Sympatho-mimetic  Sympatho-lytics
  • 84. Neurotransmitters  Sympathetic Nervous System  Arises from the thoracic and lumbar regions of the spinal cord  Results in direct stimulation of adrenal medulla and release of norepinephrine (noradrenaline) and epinephrine (adrenaline)
  • 85. Neurotransmitters  Sympathetic Nervous System  Stimulation ultimately results in release of norepinephrine from postganglionic nerves  Sympathetic stimulation also results in release of epinephrine and norepinephrine from the adrenal medulla  What is/are the chemical mediators of the SNS?
  • 86. Neurotransmitters  Types of sympathetic receptors  What is the action of adrenergic receptors?  Alpha1 (a1)  Alpha2 (a2)  Beta1 (b1)  Beta2 (b2)  Of dopaminergic receptors?
  • 87. Neurotransmitters alpha1 (a1) Peripheral vasoconstriction, increased contractile force, decreased rate alpha2 (a2) Peripheral vasoconstriction beta1 (b1) Increased heart rate, contractile force and automaticity beta2 (b2) Peripheral vasodilation, bronchodilation, uterine smooth muscle relaxation dopaminergic Renal vasodilation and mesenteric vasodilation Receptor Actions
  • 88. Neurotransmitters  Sympathomimetics: medications that stimulate the sympathetic nervous system  Sympatholytics: medications that inhibit the sympathetic nervous system
  • 89. Neurotransmitters  The Parasympathetic Nervous System  Arises from the brain stem and sacral segments of the spinal cord  Synapse in parasympathetic ganglia  What is/are the chemical mediators of the PNS?
  • 90. Neurotransmitters  Stimulation of the parasympathetic nervous system results in:  Pupillary constriction  Secretion by digestive glands  Increased smooth muscle activity along GI tract  Bronchoconstriction  Reduction in heart rate and contractile force
  • 91. Neurotransmitters  Parasympatholytics: medications that block the actions of the parasympathetic nervous system  Parasympathomimetics: medications that stimulate the parasympathetic nervous system
  • 92. Homeostasis and Balance
  • 93. Homeostasis and Balance  Our bodies require constant regulation in order to maintain balance and control
  • 94. Legal Concerns and Drugs
  • 95. Legal Concerns  Legal regulations, standards, and legislation  International controls  United Nations World Health Organization provides technical assistance and encourages new research for drug use  US Controls  The FDA and the DEA share responsibility and enforcement
  • 96. The FDA  In the United States, the Food and Drug Administration (FDA) is responsible for creating guidelines for the approval and use of drugs. The FDA requires that all approved drugs fulfill two requirements:  The drug must be found to be effective against the disease for which it is seeking approval.  The drug must meet safety criteria by being subject to extensive animal and controlled human testing.  Gaining FDA approval usually takes several years to attain. Testing done on animals must be extensive and must include several species to help in the evaluation of both the effectiveness and toxicity of the drug. The dosage of any drug approved for use is intended to fall within a range in which the drug produces a therapeutic effect or desired outcome.  The safety and effectiveness of prescription drugs in the U.S. is regulated by the federal Prescription Drug Marketing Act of 1987.
  • 97. Legal Concerns  Legal regulations, standards, and legislation Controls in the U.S.  Testing (animals studies and clinical patient trials)  Legislative control
  • 98. Legal Concerns  Legal regulations, standards, and legislation  “Truth in labeling”  Why might “truth in labeling” be important?
  • 99. Legal Concerns  Legal regulations, standards, and legislation  Narcotics  Harrison Narcotic Act, 1914  Comprehensive Drug Abuse Prevention and Control Act, 1970
  • 100. Schedule of Controlled Drugs Category Examples Schedule I No recognized medical use; high abuse potential Opiates (heroin), hallucinogens (LSD), depressants (methaqualone) Schedule II Written prescriptions required; no telephone renewals Opiates (codeine, morphine, meperidine), stimulants (amphetamines), depressants Schedule III Prescriptions rewritten after six months or five refills Opiates (codeine <1.8 g/dl), stimulants, depressants, anabolic steroids Schedule IV Prescriptions rewritten after six months or five refills Opiates (propoxyphene), stimulants, depressants (chloral hydrate) Schedule V Any non- narcotic medication, OTC Small amounts of opiates when uses as antitussives or antidiarrheals
  • 101. Legal Concerns  Legal regulations, standards, and legislation  Controlled Substances Act, 1970
  • 102. KEY NOTEs  The US scheduling system and the WHO scheduling system is very similar, but still slightly different.  The scheduling does not include distilled spirits, wine, malt beverages, or tobacco 
  • 103. Split Schedule Drugs  gamma-Hydroxybutyric acid (GHB), which has been used as a general anaesthetic and for the treatment of narcolepsy and alcohol withdrawal and controlled action but a limited safe dosage range.  It was placed in Schedule I in March 2000 after widespread recreational use led to increased emergency room visits, hospitalizations, and deaths.  Uniquely, this drug is also listed in Schedule III for limited uses, under the trademark Xyrem;
  • 104. Legal Concerns  Legal regulations, standards, and legislation  Canadian drug legislation  Under direct control of Department of National Health and Welfare  Food and Drug Act, 1941  Canadian Food and Drugs Act, 1953
  • 105. Legal Concerns  Legal regulations, standards, and legislation  Canadian Narcotic Control Act and Regulations  Canadian Narcotic Control Act, 1965  Restricts sale, possession, and use of narcotics  Restricts narcotic distribution to authorized personnel
  • 106. Drug Names and References
  • 107. Need to Know  Legal regulations, standards, and legislation  Drug Standards  United States Pharmacopeia (USP) is official standard to maintain uniformity
  • 108. Drug Names and References  Drug Classification Prescription (Rx) Over-the-counter (OTC)  Herbal Dietary Suppliments
  • 109. Drug Names and References  Drug Names  Official: generally same as generic name  meperidine hydrochloride, USP  Chemical: anatomic and molecular structure  Ethyl 1-methyl-4-phenylisonipecotate hydrochloride  Generic: abbreviated version of chemical name  meperidine hydrochloride  Trade: name based on chemical name or problem used to treat  Demerol hydrochloride  What is another term for a drug’s trade name?  Brand Name
  • 110. Drug Approval by the FDA  A process must be approved by the FDA  Studies take place in four phases  Preclinical testing, research, and development  Clinical research and development  NDA Review  Postmarketing surveillance
  • 111. Typical Trials (FDA)  Pre-Clinical  Animal and lab studies  Phase 0  Optional, Studying basic pharmokenetics/dynamics in humans  Phase 1  Studied in healthy volunteers  Phase 2  To determine efficacy on patients , small groups limits study of safety  Phase 3  Final studies prior to FDA approval and marketing  Studied in real patients vs. control group  Primarily for safety  Phase 4  Long Term studies on real patients
  • 112. Drug Names and References  Bringing a drug to market is a process that takes several years and must be approved by the U.S. Food and Drug Administration (FDA)
  • 113. Drug Names and References  Studies take place in four phases  Preclinical testing, research and development  Clinical research and development  NDA Review  Postmarketing surveillance
  • 114. Drug Names and References  New Drug Development  Phase I  Testing to determine the drug’s pharmacokinetics, toxicity, and safe dosing in humans  Phase II  Determination of the therapeutic drug level and observation for toxicity and side effects  Phase III  Refinement of the usual therapeutic dose and collection of relevant data on side effects  Phase IV  Post marketing analysis during conditional approval  Drug’s manufacturer is required to monitor its performance  Expedited Drug Approval
  • 115. Unlabeled uses of drugs  Unlabeled uses of drugs  AKA “Off Label”  FDA recognizes that a drug’s labeling does not always contain the most current information on usage
  • 116. Classifying of Medications for Therapies
  • 117. Classifying Medications  Classified with other similar medications with the same effects  Anatomical/Body system/disease used to treat  cardiac, respiratory, GI  Anti-arrhythmic, Anti-emetic  Chemical group  benzodiazepines, xanthine derivatives, nitrates, opioids, TCA’s, SSRI’s  Receptor binding site  parasympathetic blocker, adrenergic, dopaminergic
  • 118. AHA Classes of Recommendations for Drug Therapies  Class I Benefit >>> Risk Procedure/treatment or diagnostic test/assessment should be performed/administered Table 15-7
  • 119. Classes of Recommendations • Most previous classes retained with better clarifications and descriptions. •“Class Indeterminate” recommendations, which were used in 2005, are not included in the 2010 AHA Guidelines for CPR and ECC. The elimination of the term “Class Indeterminate” is consistent with the ACCF–AHA Classes of Recommendation. •When the AHA writing groups felt that the evidence was insufficient to offer a recommendation either for or against the use of a drug or intervention, no recommendation was given.
  • 120. Levels of Evidence
  • 121. KEY POINT: “ A recommendation with Level of Evidence B or C does not imply that the recommendation is weak. Many important clinical questions addressed in the guidelines do not lend themselves to clinical trials. Even though randomized trials are not available, there may be a very clear clinical consensus that a particular test or therapy is useful or effective.” -2010 AHA ECC Guidelines Circulation 2010;122;S657-S664
  • 122. Patient Medication Rights
  • 123. Patient Medication Rights  What are the six “rights” of patient medication administration that ensure safe, proper, and effective administration?
  • 124. Patient Medication Rights 1. Right patient 2. Right medication 3. Right dose 4. Right route 5. Right time 6. Right documentation
  • 125. Street Smart Medic Tip  Be Very Careful with multiple patients, Mutiple providers, and Multiple Drugs  The complexity of ANY situation increases the chance of a critical error in medication administration.  In otherwords:  KEEP YOUR SH*T TIGHT! Street Smart Medic Tip • Be Very Careful with multiple patients, Multiple providers, and Multiple Drugs • The complexity of ANY situation increases the chance of a critical error in medication administration. • In other words: – KEEP YOUR SH*T TIGHT!
  • 126. Additional stuff you HAVE to know
  • 127. What Paramedics Need to Know About Drugs  Comprehensive drug list based on protocol  Be familiar with AHA Guidelines for treating cardiac patients  Know local protocol and drugs used in your region
  • 128. Some thoughts on protocols
  • 129. Pediatric Dosages  Know the pediatric doses, adult doses, and all approved routes for administration
  • 130. Street Smart Medic:  Before giving any drug, several actions must performed:  Oxygen and monitor should be started as appropriate  Establish IV access with appropriate fluids started
  • 131. Need to Know  Components of a drug profile  Names  Classification  Mechanism of action  Indications  Pharmacokinetics
  • 132. What Paramedics Need to Know About Drugs  Components of a drug profile  Side effects/adverse reactions  Contraindications  Dosage  How supplied  Special considerations
  • 133. Need to Know  Special considerations in drug therapy  Pediatric patients  Geriatric patients  Pregnant and lactating patients
  • 134. Need to Know  Use care administering medications  Follow the medication order
  • 135. What Paramedics Need to Know About Drugs  Preparation involves selecting the appropriate sized needle and syringe  No compensation for dead space is necessary when drawing up medications
  • 136. What Paramedics Need to Know About Drugs  Use different needles when reconstituting medication to be drawn up  Use caution when mixing drugs in one syringe  ALWAYS use sterile technique
  • 137. Need to Know  Medical control  As a paramedic, you operate under the licensure of a medical director who is responsible for all of your actions  The medical director determines which drugs you will administer and the routes by which they are given
  • 138. Need to Know  Reduce the potential for contamination  Identify allergies prior to contacting hospital  Obtain vital signs  Obtain and confirm/repeat order  Write the order and the time
  • 139. Need to Know  Select the proper medication  Inspect the medication  Confirm the order and medication  Six rights of administration  Record drug, dose, volume, route, and time, and obtain vital signs and effects
  • 140. What Paramedics Need to Know About Drugs  Storage and handling considerations  USP28-NF23, PF30 (6), p. 2118  “Storage of Drugs in Emergency Medical Services (EMS) Vehicles”  Narcotics and controlled substances should be secured according to local protocols
  • 141. Need to Know  Important pharmacological terminology  What is antagonism?  What is cumulative action?  What is potentiation?  What is synergism?
  • 142. Need to Know  Important pharmacological terminology  Contraindications  Hypersensitivity  Idiosyncrasy  Side effects  Untoward effects
  • 143. Need to Know  Important pharmacological terminology  Bolus  Indication  Therapeutic action  Tolerance
  • 144. Need to Know  Important pharmacological terminology  Depressant  Habituation  Refractory  Stimulant
  • 145. Administration Procedures
  • 146. Preparation  Before starting each shift, make sure all medications are  Stocked in the proper amount  Not expired  In good condition  Stored properly
  • 147. Preparation  Make sure you have adequate supplies to administer them  Including syringes, needles, or needleless systems
  • 148. Narcotic Drugs  Follow local, state, and federal regulations when it comes to usage and storage
  • 149. Administration Procedures  Premedication procedures  Obtain a complete SAMPLE history  Obtain a full set of vital signs  Complete a detailed exam  Contact medical control for authorization
  • 150. Consider the whole patient…  Complete a thorough assessment  Look for medication bottles and herbal preparations  Determine if the patient has been compliant with his or her medication  Consider the medications the patient already has on board before you give any more….
  • 151. Get Good Data  Get a FULL set of RELIABLE vitals before you administer a medication  Be Prepared for adverse reactions  Know your situation…
  • 152. Administration Procedures  Prior to administration  Make sure you have all necessary equipment
  • 153. Medical Asepsis During Medication Administration  Medical asepsis is keeping the environment free of pathogens  Several ways to keep the environment clean include:  Sterilization  Medically clean  Disinfectants  Antiseptics
  • 154. Disposal of Contaminated Material  Use sharps container to dispose of anything capable of piercing the skin  Dispose of all contaminated material in the proper biohazard container
  • 155. Administration Procedures  Post-medication procedures  Document  Obtain a full set of vital signs  Complete a detailed exam  Ongoing assessment
  • 156. Summary
  • 157. Summary  In order to deliver exceptional patient care, the paramedic must have a basic understanding of the responsibilities and scope of management prior to administration of any drug
  • 158. The END

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