Buprenorphine as an alternative treatment for drug addictsPresentation Transcript
BUPRENORPHINE AS ANALTERNATIVE TREATMENTFOR DRUG ADDICTSRISE Program By: Cristina M. Cruz Irizarry
Introduction Since the 70’s methadone has been the treatment used to treat patients that want to get out of opioids. Buprenorphine is a new drug that has been used to treat these patients.
Scheme of the Buprenorphine Treatment Initially compress doses of 0.216 mg of buprenorphine was administrated every six hours and was decreasing the doses gradually by 50% every 48 hours until was totally suppressed. At the same time maintenance for 28 patients was administrated using conidine (0.150 mg Catapresan PL ®). Patients were placed under psychological treatment, therapeutics communities, and group therapy among others support groups.
Beneficial Effects of Buprenorphine Buprenorphine can restore the immune function and cytokine concentration. Buprenorphine normalized the HPA axis when altered when using heroin. Patients using buprenorphine as treatment shows a reduce withdrawal and craving for heroin.
Secondary Effects of Buprenorphine Most of the patients presented nausea/vomiting and dizziness. Other patients presented decreased respiratory rate and drowsiness. Deficiency in salivation. When the dose is doubled the patient can present a close-dependent increase in analgesia.
Buprenorphine Treatment DuringPregnancy and After Delivering Buprenorphine treatment is less harmful for the mother and the child. Women is treated with buprenorphine there is no evidence showing that breastfeeding harm the baby, To prevent withdrawal a modification in dose has to be made during pregnancy.
Comparing Buprenorphine withMethadone 52% of the healthcare providers view methadone treatment negatively, still the preferred one. If compared to buprenorphine that has only 17% negative review. Patients under buprenorphine achieved sustained abstinence that those participants using methadone. Patients using methadone complained about more side effect that those using buprenorphine.
Conclusion One of the motivations is to give a better life style to those patients this aspect must be worked out by the patient and its support group. Buprenorphine offers to science a new tool to treat drug addicts and as the studies presented a safer treatment.
ReferencesPaola Sacerdote, Silvia Franchi, Gilberto Gerra, Vincenzo Leccese, Alberto E. Panerai, Lorenzo Somaini. 2008. 606-613:Buprenorphine and methadone maintenance treatment of heroin addicts preserves immune function. Available from www.sciencedirect.comW. Mei, J. X. Zhang, and Z. Xiao. 2010. 808-815: Acute Effects of Sublingual buprenorphine on brain responses to heroin-related cues in early- abstinence heroin addicts: an uncontrolled trial. Available from Neuroscience 170 (2010).Laurence Simmat-Durand, Claude Lejeune, Laurent Gourarier. 2009. 119-123: Pregnancy under high-dose buprenorphine. Available from European Journal of Obstetrics & Gynecology and Reproductive Biology 142.
ReferencesHayley Pinto, Vivienne Maskrey, Louise Swift, Daphne Rumball, Ajay Wagle, Richard Holland. 2010. The SUMMIT Trial:A field comparison of buprenorphine versus methadone maintenance treatment. Available from Journal of Substance Abuse Treatment. July 2010.Rolley E. Johnson, Paul J. Fudala, and Richard Payne. 2005. 297-326: Buprenorphine: Considerations for Pain Management. Available from Journal of Pain and Symptom Management. Vol. 9 No. 3 March 2005.Judith Martin. 2006. Pregnancy and buprenorphine treatment. Available from PCSS Guidance at http://www.naabt.org/documents/PCSSPregnancy.pdf