Sjogren’s syndrome

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Sjogren’s syndrome

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Sjogren’s syndrome

  1. 1. SJOGREN’S SYNDROME
  2. 2. Chronic, slowly progressive autoimmune disease char by lymphocytic infiltrationof exocrine glands Char by immunologically mediated destruction of the exocrine glands – lacrimal and salivary glands Mainly affects middle aged woman, may occur in all ages
  3. 3. CLINICAL FEATURES Keratoconjunctivitis sicca Xerostomia Clues: Difficulty eating buiscuit Absence of pooling of saliva when tongue is lifted
  4. 4. PE: Dry, erythematous , sticky oral mucosa Atrophy of the filiform papillae in the dorsum of the tongue Saliva from the major gland is not expressible or cloudy Enlargement of parotid or other salivary glands
  5. 5. TYPES Primary Sjogren’s Syndrome – disease presents alone - 0.5 – 1% prevalence Secondary Sjogren’s Syndrome – inassociation with another autoimmune disease - commonly: SLE; RA - 30% of pts with autoimmune rheumatic disease
  6. 6. OTHER CLINICAL FEATURES Arthritis Raynaud’s Phenomenon RenalTubular Defects: > Diabetes Insipidus > Renal Tubular Acidosis Pulmonary Acidosis Vasculitis Hodgkin’s B Cell Lymphoma
  7. 7. c/o easy fatiguability Low-grade fever Myalgias Arthralgias Dry cough – attributed to small airway disease
  8. 8. LABS: Serum Autoantibodies: ANA (80% of patients) Anti-rho (60 – 90%) Rheumatoid Factor Labial Gland Biopsy: lymphocyte infiltration and destruction of acinar tissue SchirmerTest (+): wetting of filter <10mm in 5 minutes
  9. 9. DX TEST Sialometry Sialography schintigraphy
  10. 10. TREATMENT Symptomatic: Artificial tears Saliva Replacements Solutions http://crisbertcualteros.page.tl

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