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Urinary drugs

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    Urinary drugs Urinary drugs Presentation Transcript

    • URINARY SYSTEM DRUGS Diuretics: maintain balance of water,electrolytes, acids and bases for the body Thiazide diuretics: moa---promote sodium and water excretion in the urine, yields lower sodium in blood and reduces vasoconstriction. works at distal convoluted tubule. indications: hypertension/congestive heart failure adverse reaction------hypokalemia, hypomagmesiumia, hyperuricemia, hyperglycemia, hypercalcemia consider-----take potassium supplements, bananas/oranges example-Hydrochlorothiazide aka (HCTZ)
    • URINARY SYSTEM DRUGS Loop diuretics moa--inhibit reabsorption of sodium and chloride in ascending loop of henle an distal renal tubule, yields urinary excretion of water indications---hypertension, hypercalcemia,pulmunary edema adverse reactions---magnesium, calcium, potasium, depletion Consider-----avoid diueretics at night or may give nocturia examples---furosemide ethacrynic acid bumetanide torsemide
    • URINARY SYSTEM DRUGS Potassium-sparing diuretics moa----do not promote the secretion of potassium into the urine at collecting tubule indications---treatment of hypertension and management of congestive heart failure. adverse reactions---hyperkalemia, arrythemia, gynecomastia in males consider---avoid with ACE inhibitors since it also yields decrease renal excretion of potassium. examples--spironolactone, triamterene,amiloride
    • Combined Diuretics • Diuretics are effective antihypertensive drugs. Each works by affecting a different part of your kidneys. • Side effects---hyperkalemia, maxide yields blue-green urine • Consider---Avoid use with ACE inhibitor • Examples— • Ziac= bisoprolol/HCTZ • Maxide table (also dyazide capsule)= triamterene+HCTZ
    • Alpha blockers for Prostate • BHP-benign prostate hypertrophy • Alpha 1 receptors are located on the postsynaptic membrane of effector organs. Activation of alpha 1 receptors increases vascular smooth muscle contraction, producing increases in blood presure. These receptors also influence activity of genitourinary smooth muscle. • Alpha 1A receptors are located at the external sphincter of the bladder. Blockade of alpha 1A receptors decreases tone in the smooth muscle of the bladder neck and prostate, thus improving urinary flow.
    • Alpha blockers for Prostate • Alpha1 receptors response to epi and norepi to give smooth muscle contraction. • Reactions---headache, dizziness, orthostatic hypotension • • • • • Examples—uroxatral/alfozin Cardura/doxazosin Proscar/finateride Flomax/tamsulosin Hytrin/terazosin
    • Alpha blockers for Prostate • Alpha1 receptors response to epi and norepi to give smooth muscle contraction. • Reactions---headache, dizziness, orthostatic hypotension • • • • • Examples—uroxatral/alfozin Cardura/doxazosin Proscar/finateride Flomax/tamsulosin Hytrin/terazosin