Antidepressants

851 views
570 views

Published on

Published in: Health & Medicine
0 Comments
1 Like
Statistics
Notes
  • Be the first to comment

No Downloads
Views
Total views
851
On SlideShare
0
From Embeds
0
Number of Embeds
20
Actions
Shares
0
Downloads
15
Comments
0
Likes
1
Embeds 0
No embeds

No notes for slide

Antidepressants

  1. 1. AFFECTIVE DISORDERS Anxiety----uneasiness from apprehension and worry about possible events. Try psychotherpay first. Anti-anxiety agents: xanax/aplrazolam valium/diazepam avitan/lorazepam equanil/meprobamate Adverse reactions: drug dependance, sedation, depression, possible birth defect, muscle relaxation
  2. 2. Anti-anxiety agents:  Benzodiazepines  Mechanism of Action • Benzodiazepines bind to benzodiazepine receptors in the CNS and act as agonists. • They enhance the action of the inhibitory neurotransmitter gamma-aminobutyric acid (GABA). • Reduce anxiety and panic. • Cause sedation. • Skeletal muscle relaxation Uses •The short-term treatment of anxiety, panic attacks, insomnia, and •alcohol withdrawal. •Some benzodiazepines are used to treat seizure disorders.
  3. 3. Anti-anxiety agents:  Barbiturates       These drugs are the original sedative-hypnotics. They have been associated with a high rate of abuse and complete respiratory and cardiovascular depression. They are lethal in an overdose. Benzodiazepines have pretty much replaced barbiturates in treating anxiety, insomnia and panic because of their more acceptable safety profile. Barbiturates are used to treat seizure disorders and to induce general anesthesia. like benzodiazepine but also help block glutamate, the principal excitatory CNS neurotransmitter.
  4. 4. Depression  feelings of pessimism, worry, sadness, reduced eating and sleeping, concentration.  Types of antidepressants---- SSRI  Tricyclic  MAOI
  5. 5. Anti-depressant---SSRI     SSRI--selective seratonin reuptake inhibitor moa---blocks reuptake of seratonin(brain neurotransmitter. reduced seratonin may affect mood. indications---major depression,obsessivecompulsion adverse effect---takes 2-3weeks to work, insomia, nervousness, diarrhea, weight loss, reduced libido
  6. 6. SSRI antidepressants  celexa  cymbalta  prozac  paxil  zoloft  effexor
  7. 7. Tricyclic antidepressant (TCA) 10 11 9 8 1 B C 5 N moa--block reuptake of seratonin or norepinephrine(hormone and neurotransmitter most responsible for alertness ) indications--depression, bedwetting children adverse reactions---cardiotoxic in high dose, drowsiness, several weeks to work 7 2 A 3 6 N R2 R1
  8. 8. Tricyclic antidepressant (TCA)  Examples  amytriptyline  doxepin  imipramine  desipramine
  9. 9. MAOI antidepressant      monoamine oxidase inhibitor catecholamines are monoamine---mostly epinephrine (adrenaline), norepinephrine (noradrenaline) and dopamine MAOIs act by inhibiting the activity of monoamine oxidase, thus preventing the breakdown of monoamine neurotransmitters and thereby increasing their availability. indications--atypical depression adverse effect---hypertension, avoid certain wines,yeast,cheese. avoid ephedrine,levopoda
  10. 10. MAOI examples  phenelzine---Nardil  tranylcypromine---Parnate  selegiline-----Eldepryl
  11. 11. Bipolar disorder  swings between mania and depression  lithium moa unknown….has sodium properties to generate action potentials, also enhance seratonin.watch salt diet.  use carbamezepine more severe cases but interferes with many many drugs  adverse reactions--bloating, abnomral fetus, increased weight, acne
  12. 12. Psychosis  not living in reality,hallucinations, bizarre behavior  dose varies drug to drug  moa--affects neurotransmitters  adverse reactions---sedation, bone marrow suppression, pseudoparkinson’s  allow 6-12 weeks for improvement
  13. 13. Anti-psychotics  haldol  abilify  compazine  risperdal  geodon  prolixin

×