The document provides an overview of genomics and genome-wide association studies. It discusses how genetics looks at single genes while genomics analyzes multiple genes. Genome-wide association studies use single nucleotide polymorphisms to identify genetic variations associated with diseases by comparing cases to controls. While associations are found, they only confer small increases in relative risk rather than proving causation. Direct-to-consumer genetic testing is now widely available but results require careful medical interpretation.

1. Genomics 101 Murugu Manickam, MD discloses no significant financial interests or other relationships with commercial interests. Presentation will not include discussion of commercial products or services and will not include unapproved or off-label usage of a commercial product or device. The following planning committee members have no significant financial interests or relationships with commercial interests to disclose, their educational unit does not have a financial interest or affiliation with an organization that may receive direct benefit from the subject of the proposed CME activity, and they will not be personally compensated for their role in the planning or execution of this proposed CME activity by an organization other than The Ohio State University: Amy Ehrlich, MA and Henry Zheng, PhD, MBA Murugu Manickam, MD Clinical Assistant Professor Division of Human Genetics

36. Do you feel comfortable talking to a patient if they bring in a report like this to you…