Atypical kd with pneumonia

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  • Child was afebrile Showed f/o skin peeling of palms & hands. Inflammatory parameters settled

Transcript

  • 1. Atypical kawasaki disease with unusual combination
  • 2. On admission
    • 3 ½ year old male child, admitted with high grade fever 4 days with loose stools ,vomiting, abdominal pain, erythematous rashes and hepatomegaly with the provisional diagnosis of Dengue illness.
    • CXR on 3 rd day of illness Normal
  • 3. Investigations on admission
    • Neutrophilic leucocytosis, PCV,platelets, SGOT,SGPT-normal
    • CXR-normal
    • CRP-positive(90)
    • Bacterial inf, UTI was suspected.
    • Started on IV.Ceftriaxone.
  • 4. Course of illness…
    • Fever spikes- continued ( peak 102)
    • USG abdomen-minimal pleural fluid left and
    • mild hepatomegaly, kidneys normal.
    • CRP:90  104
    • Leucocytosis
    • ESR-42/80
  • 5. Day 5 of hospitalisation
    • Persistent Abdominal pain
    • Developed Tachypnoea
    • Rpt CXR – Broncho pneumonia predominantly left side
    • Antibiotics escalated to IV Linezolid
  • 6. Repeat Chest X-Ray done Upper abd pain, shoulder pain and tachypnea
  • 7. No improvement after 48 hours of linezolid and 4 days of ceftriaxone
    • What possibilities to consider ?
  • 8. ON 7 th Day Of Illness Bloood, Urine C/S, Widal Negative POSSIBILITY CONSIDERED ACTION TAKEN Empyema CXR repeated – No pleural fluid Atypical pneumonia Clarythromycin added. No response Swine Flu H1N1 screen negative Kawasaki disease Echo screen done- LMCA ectasia.
  • 9. Day 9 of illness
  • 10. Diagnosis ?
    • INCOMPLETE KAWASAKI
  • 11. Management
    • Started IVIG infusion(1 gm/kg/day for 2 days)
    • Aspirin:1oo mg/kg/day
    • Response to treatment within 12 hrs, became afebrile
    • Pneumonia /? II ary to vasculitis
    • Shoulder pain, ECG normal
  • 12. Follow up
    • .
    Showed desquamation after discharge 15 th day of illness
  • 13. Diagnostic criteria for kawasaki disease
    • Fever lasting for at least 5 days
    • Presence of at least 4 of the following 5 signs
    • Bilateral bulbar conjunctival injection
    • Strawberry tongue,mucosal changes,fissured lips
    • Edema/erythema of hands and feet or periungual desquamation
    • Rash ,mainly truncal
    • Cervical lymphadenopathy,usually U/L
  • 14. Atypical KD (Korean J Pediatr 2009)
    • Not meeting diagnostic criteria
    • Lung involvement is uncommon in KD but on autopsy,interstitial pneumonia was recognised in 30-90% of all cases with KD.
    • Ref: Acta PatholJpn.1980(Gen.path of kd on morphological alteration corresponding to clinical manifestations)
  • 15.
    • Respiratory signs is higher in infants less than 6 months of age.
    • Ref: Clinical spectrum of KD in infants <6 months J Pediatr 1986
  • 16. Chest x ray finding in acute phase of KD (Pediatr Radiol 1989)
    • 129 pt with KD studied
    • Abnormal CxR -14.7%
    • Reticulogranular pattern(89.5%), Peribronchial cuffing(21.1%),Pleural effusion(15.8%),Atelectasis(10.5%) and air trapping(5.3%)
    • Pathological basis not clear - lack of HPE.
    • Probably inflammation &/vasculitis/pulm edema-CCF.
  • 17. Report from Archives of Diseases of childhood – October 2003
    • Two cases of atypical Kawasaki disease (KD) manifested as persistent lobar lung consolidation, prolonged fever, and active inflammatory laboratory markers unresponsive to antibiotic treatment are reported. One of the children developed a giant coronary aneurysm.
  • 18. Why this case is presented ?
    • Increasing diagnosis of Atypical Kawasaki disease …
    • Association of Pneumonia
    • KD also should be considered as a DD when ever Pneumonia is not responding to higher antibiotics after ruling out other complications like Empyema?
  • 19.
    • THANK YOU