Chris Lowe's presentation

NOVEL POINT-OF-CARE BIOMEDICAL SENSORS
FUTURE TRENDS INTECHNOLOGY AT THE INTERFACE OF ICT, MATERIALS SCIENCE AND BIOLOGY
CHRISTOPHER R LOWE
INSTITUTE OF BIOTECHNOLOGY
DEPARTMENT OF CHEMICAL ENGINEERING & BIOTECHNOLOGY

CHANGING DEMOGRAPHICS
GLOBAL ETHICS
HEALTH AND WELFARE ISSUES
CLEAN WATER/
NUTRITIOUS FOOD
DEMOCRATIZATION
1
15
2
14
3
CHANGING RISK PROFILE
PEACE/CONFLICT
4
13
GLOBAL ICT CONNECTIVITY
RICH-POOR GAP
5
12
MULTI-DISCIPLINARY S&T INTEGRATION
ENERGY
6
11
DWINDLING RESOURCES
URBANISATION
10
SUSTAINABLE
DEVELOPMENT
7
ECONOMIC GLOBALISATION
9
8
GLOBAL MEGATRENDS AND INFLUENCES : 2010-2050

LIFESTYLE
WELLBEING
OBESITY
CANCER
PSYCHIATRIC DISORDERS/
NEURODEGENERATIVE
CEREBROVASCULAR DISEASE
DIABETES
FOOD/WATER QUALITY
URBAN AIR QUALITY
OCCUPATIONAL RISKS
TRADITIONAL RISKS
RISK
SIZE
UNDERNUTRITION
INFECTIOUS DISEASES
WATER
SANITATION
HYGEINE
MODERN RISKS
TIME
HUMAN ENVIRONMENTLIFESTYLEHEALTH & WELFARE
CLINICAL DISORDERS
CHEMICAL INTELLIGENCE
THE DEVELOPMENTAL RISK TRANSITION

HEALTHY
SICK
WORRIED WELL
EARLY
SYMPTOMS
DISEASE
FOOD/WATER/AIR QUALITY
LIFESTYLE
STRESS
SLEEP DISORDERS
MIGRAINE
GENETIC PREDISPOSITIONS
PREGNANCY
FERTILITY
DIABETES
CANCER
ISCHAEMIC HEART DISEASE
COPD
NEURODEGENERATIVE/
NEUROPSYCHIATRIC DISORDERS
CEREBROVASCULAR DISEASE
HIV/AIDS
BLOOD ANALYTES
LIVER/KIDNEY DYSFUNCTION
FAECAL OCCULT BLOOD
GLUCOSE
HAEMOGLOBIN A1C
ASTHMA
MENOPAUSE
COAGULATION/PLATELET FUNCTION
INFECTIOUS DISEASES
STI
HOME
PHYSICIAN’S OFFICE
CLINICAL CENTRE
HOME
WORKPLACE
A&E
BEDSIDE
ITU
CENTRAL LABORATORY
DISEASE PROGRESSION

NON-INVASIVE
EXHALED/
CONDENSED
BREATH
TEAR FLUID
SALIVA
NON-INVASIVE
(SPECTROSCOPIC)
CONTACT LENS
INTELLIGENT
CLOTHES/
ACCESSORIES/
JEWELLRY
BREATH ANALYSIS
SKIN E-PATCH
WATCH
INVASIVE
DIGITAL PLASTER
FINGERSTICK
COSMETICS
SMART TATTOO
MINIMALLY
INVASIVE
INDWELLINGCATHETERS
CSF
BLOOD
ISF
BIOPSY
SUBCUTANEOUS
IMPLANTS
SWEAT
SEMEN
URINE
FAECES
PATIENT SENSOR MONITORING FORMATS

ANALYTE
ELECTRICAL
(BIO)RECOGNITION
SYSTEM
OPTICAL
ACOUSTIC
THERMAL
MAGNETIC
INSTRUMENTATION
MICROENGINEERED
TRANSDUCER
BIOSENSOR PRINCIPLES AND TRANSDUCERS

MICROAMPEROMETRIC GLUCOSE SENSOR
ENCODED MICRO-SPR
MICRO-PCR
LOVE WAVE DEVICE
MICROFABRICATED BIOSENSORS

LIQUID SAMPLE
PIEZOELECTRIC QUARTZ DISC
(AT-cut, 0.25mm thick, 12mm dia)
ACOUSTIC WAVE
RF COIL
N
NdFeB MAGNET
AIR GAP
S
ALUMINISED GLASS DISC
RF COIL
MAGNETIC ACOUSTIC RESONATOR SENSOR (MARS)

200
HIGH SENSITIVITY
150
MULTI-FREQUENCY OPERATION (MHz-GHz)
CELLS PROTEINS
SMALL MOLECULES
METABOLITES
100
50
IgG
0
10
30
50
100
200
500
1000
Frequency (MHz)
FREQUENCY TAGGING
(MULTIPLEXING/ARRAYS)
REMOTE MEASUREMENTS
WITH A TOROIDAL
ELECTRIC FLUX
50
1 IgG 1000 µg/ml
40
2 Protein A 250 µg/ml
3 IgG 250 µg/ml
30
4 Protein A 250 µg/ml
Frequencyshift (KHz)
5 IgG 250 µg/ml
20
IMPLANTABLE
10
0
0
100
200
300
400
500
600
Frequency (MHz)
KEY FEATURES OF THE MAGNETIC ACOUSTIC RESONATOR SENSOR (MARS)

SUBCUTANEOUSLY IMPLANTED
e-PATCH
CONTACT LENS
MRAS QUARTZ DISC
30
GASES
pH/IONS
METABOLITES
PROTEINS
20
10
0
-10
-20
-30
20.1
20.12
20.14
20.16
20.18
20.2
f (MHz)
100
50
0
-50
-100
Amplitude (mV)
-150
-200
TOROIDAL ANTENNA
(TRANSCEIVER)
-250
6.57
6.59
6.61
6.63
6.65
6.67
6.69
6.71
6.73
Frequency (MHz)
REMOTE ACOUSTIC MEASUREMENTS WITH A TOROIDAL ELECTRIC FLUX

PHYSICAL PARAMETERS (°C, hʋ, P)
GASES (O2, CO2, CO, NO, NH3, H2S, alka(e,y)nes)
VOCs (Alcohols, ketones, aldehydes)
IONS (Na+, K+, Ca2+, Cu2+, Cd2+, Pb2+)
METABOLITES (Glucose, urea)
DRUGS (Penicillin)
ANTIGENS/ANTIBODIES
OLIGONUCLEOTIDES
WHOLE CELLS
PLANAR
OPTICAL ELEMENTS
BEADS
PARTICLES
FLAKES
OTHER GEOMETRIES
FIBRE OPTICS
HOLOGRAPHIC(BIO)SENSORS

HOH
C
2
O
O
O
-
WHOLE BLOOD
B
HO
INDWELLING CATHETER
HO
HO
SUBCUTANEOUS NEAR-IR
CONTACT LENS
mol% 3-APB
180
SKIN PATCH/TATTOO
25
160
140
120
15
100
max(nm)
80
12
60
10
40
8
20
5
0
2
4
6
8
10
-20
[GLUCOSE] (mM)
DIABETIC MONITORING WITH GLUCOSE HOLOGRAMS

TOXICITY
TEAR [GLUCOSE]<BLOOD [GLUCOSE]
pH VARIABILITY (5.8-7.8)
TIME LAG (~MIN)
SELECTIVITY (LACTATE/FRUCTOSE)
OPTICAL PHYSICS
COMFORT/COSMETIC APPEARANCE
INSTRUMENTATION
160
740
140
720
Wavelength [nm]
Blood-Glucose [mg%]
120
700
100
80
680
0
12
16
19
23
26
Time [minutes]
CONTACT LENS HOLOGRAPHIC GLUCOSE SENSOR

H2
ETHANE
n-PENTANE
BUTANE
NO
CO
NH3
ETHANOL
ACETONE
THIOLS
DIABETIC KETOACIDOSIS
RENAL FAILURE
LIVER DYSFUNCTION
ALCOHOL INTOXICATION
CANCER
CYSTIC FIBROSIS
ASTHMA
GIT DISORDERS (H pylori)
HALITOSIS
STRESS
700
680
660
640
620
Wavelength (nm)
600
580
560
540
520
0
20
40
60
80
100
120
140
160
Time (s)
HUMAN BREATH ANALYSIS

640
6.5
6.3
620
6.1
600
5.9
580
max (nm)
5.7
700
pH
5.5
560
600
max (nm)
5.3
540
500
5.1
520
400
4.9
4
5
6
7
pH
500
4.7
0
2000
4000
6000
8000
10000
12000
14000
Time (s)
7.3
10
7.2
7.1
1
7
OD 600 nm
6.9
pH
6.8
0.1
6.7
6.6
6.5
0.01
6.4
0
1
2
3
4
5
6
7
8
9
10
Time (h)
WHOLE CELLS

BIOCHEMISTRY
CHEMISTRY/
MATERIALS
SCIENCE
BIOLOGY
BIOINFORMATICS
BIOENGINEERING
BIOTECHNOLOGY
BIOSENSORS
CHEMICAL
INFORMATICS
CHEMICAL
ENGINEERING
INFORMATION/
COMMUNICATIONS
TECHNOLOGY
ENGINEERING
INFORMATION
ENGINEERING
CONVERGENCE OF S&T

PHYSICIAN’S
OFFICE
WATCH
PATIENT
CELL
PHONE
EMERGENCY ROOM
BEDSIDE
PDA
DATA STORE/
SERVER
USB
OPERATING
THEATRE
ITU
ePATCH
TATTOO
LENS
BREATH
CLOTHES
CATHETER
COSMETICS
TRANSCUTANEOUSSUBCUTANEOUS
SPECTROSCOPIC
LAPTOP
FIRST
RESPONDER
BEDSIDE
MONITOR
SERVICES/INTERNET
WEARABLE AND MOBILE SENSOR SYSTEMS

Chris Lowe's presentation

by James Cotton on Nov 12, 2010

Accessibility

Categories

Tags

Upload Details

Usage Rights

1 Embed 18

Statistics

Chris Lowe’s presentation — Presentation Transcript