Chris Lowe's presentation

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Chris Lowe's presentation at the Cambridge Phenomenon Conference

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Chris Lowe's presentation

  1. 1. NOVEL POINT-OF-CARE BIOMEDICAL SENSORS FUTURE TRENDS INTECHNOLOGY AT THE INTERFACE OF ICT, MATERIALS SCIENCE AND BIOLOGY INSTITUTE OF BIOTECHNOLOGY DEPARTMENT OF CHEMICAL ENGINEERING & BIOTECHNOLOGY CHRISTOPHER R LOWE
  2. 2. GLOBAL MEGATRENDS AND INFLUENCES : 2010-2050 CLEAN WATER/ NUTRITIOUS FOOD DWINDLING RESOURCES HEALTH AND WELFARE ISSUES RICH-POOR GAP GLOBAL ICT CONNECTIVITY DEMOCRATIZATION CHANGING RISK PROFILE URBANISATION MULTI-DISCIPLINARY S&T INTEGRATION GLOBAL ETHICS 1 2 3 6 5 4 8 7 10 9 12 11 13 14 15 CHANGING DEMOGRAPHICS ENERGY SUSTAINABLE DEVELOPMENT ECONOMIC GLOBALISATION PEACE/CONFLICT
  3. 3. THE DEVELOPMENTAL RISK TRANSITION CHEMICAL INTELLIGENCE TRADITIONAL RISKS MODERN RISKS LIFESTYLE WELLBEING OBESITY CANCER PSYCHIATRIC DISORDERS/ NEURODEGENERATIVE CEREBROVASCULAR DISEASE DIABETES FOOD/WATER QUALITY URBAN AIR QUALITY OCCUPATIONAL RISKS RISK SIZE TIME HUMAN ENVIRONMENT LIFESTYLE HEALTH & WELFARE CLINICAL DISORDERS UNDERNUTRITION INFECTIOUS DISEASES WATER SANITATION HYGEINE
  4. 4. FOOD/WATER/AIR QUALITY LIFESTYLE STRESS SLEEP DISORDERS MIGRAINE GENETIC PREDISPOSITIONS PREGNANCY FERTILITY DIABETES CANCER ISCHAEMIC HEART DISEASE COPD NEURODEGENERATIVE/ NEUROPSYCHIATRIC DISORDERS CEREBROVASCULAR DISEASE HIV/AIDS BLOOD ANALYTES LIVER/KIDNEY DYSFUNCTION FAECAL OCCULT BLOOD GLUCOSE HAEMOGLOBIN A1C ASTHMA MENOPAUSE COAGULATION/PLATELET FUNCTION INFECTIOUS DISEASES STI HEALTHY WORRIED WELL SICK EARLY SYMPTOMS DISEASE HOME PHYSICIAN’S OFFICE CLINICAL CENTRE HOME WORKPLACE A&E BEDSIDE ITU CENTRAL LABORATORY DISEASE PROGRESSION
  5. 5. PATIENT SENSOR MONITORING FORMATS NON-INVASIVE INVASIVE MINIMALLY INVASIVE CONTACT LENS WATCH FINGERSTICK INTELLIGENT CLOTHES/ ACCESSORIES/ JEWELLRY NON-INVASIVE (SPECTROSCOPIC) INDWELLING CATHETERS SUBCUTANEOUS IMPLANTS BREATH ANALYSIS SMART TATTOO SKIN E-PATCH DIGITAL PLASTER COSMETICS TEAR FLUID SALIVA SWEAT SEMEN URINE FAECES EXHALED/ CONDENSED BREATH CSF BLOOD ISF BIOPSY
  6. 6. BIOSENSOR PRINCIPLES AND TRANSDUCERS ANALYTE (BIO)RECOGNITION SYSTEM TRANSDUCER ELECTRICAL OPTICAL ACOUSTIC MAGNETIC THERMAL MICROENGINEERED INSTRUMENTATION
  7. 7. MICROFABRICATED BIOSENSORS MICROAMPEROMETRIC GLUCOSE SENSOR ENCODED MICRO-SPR LOVE WAVE DEVICE MICRO-PCR
  8. 8. MAGNETIC ACOUSTIC RESONATOR SENSOR (MARS) RF COIL NdFeB MAGNET LIQUID SAMPLE N S AIR GAP ACOUSTIC WAVE RF COIL PIEZOELECTRIC QUARTZ DISC (AT-cut, 0.25mm thick, 12mm dia) ALUMINISED GLASS DISC
  9. 9. KEY FEATURES OF THE MAGNETIC ACOUSTIC RESONATOR SENSOR (MARS) 1 IgG 1000 µg/ml 2 Protein A 250 µg/ml 3 IgG 250 µg/ml 4 Protein A 250 µg/ml 5 IgG 250 µg/ml 0 10 20 30 40 50 0 100 200 300 400 500 600 Frequency (MHz) Frequencyshift(KHz) HIGH SENSITIVITY FREQUENCY TAGGING (MULTIPLEXING/ARRAYS) REMOTE MEASUREMENTS WITH A TOROIDAL ELECTRIC FLUX IMPLANTABLE MULTI-FREQUENCY OPERATION (MHz-GHz) CELLS PROTEINS SMALL MOLECULES METABOLITES Frequency (MHz) 10 30 50 100 200 500 1000 0 50 100 150 200 IgG
  10. 10. REMOTE ACOUSTIC MEASUREMENTS WITH A TOROIDAL ELECTRIC FLUX TOROIDAL ANTENNA (TRANSCEIVER) SUBCUTANEOUSLY IMPLANTED e-PATCH CONTACT LENS MRAS QUARTZ DISC -30 -20 -10 0 10 20 30 20.1 20.12 20.14 20.16 20.18 20.2 f (MHz) -250 -200 -150 -100 -50 0 50 100 6.57 6.59 6.61 6.63 6.65 6.67 6.69 6.71 6.73 Frequency MHz AmplitudemV pH pH pH pH pH pH pH pH pH pH pH 100 50 0 -50 -100 -150 -200 -250 Amplitude(mV) 6.57 6.59 6.61 6.63 6.65 6.67 6.69 6.71 6.73 Frequency (MHz) GASES pH/IONS METABOLITES PROTEINS
  11. 11. HOLOGRAPHIC (BIO)SENSORS PHYSICAL PARAMETERS (°C, hʋ, P) GASES (O2, CO2, CO, NO, NH3, H2S, alka(e,y)nes) VOCs (Alcohols, ketones, aldehydes) IONS (Na+, K+, Ca2+, Cu2+, Cd2+, Pb2+) METABOLITES (Glucose, urea) DRUGS (Penicillin) ANTIGENS/ANTIBODIES OLIGONUCLEOTIDES WHOLE CELLS PLANAR OPTICAL ELEMENTS BEADS PARTICLES FLAKES OTHER GEOMETRIES FIBRE OPTICS
  12. 12. DIABETIC MONITORING WITH GLUCOSE HOLOGRAMS -20 0 20 40 60 80 100 120 140 160 180 2 4 6 8 10 [GLUCOSE] (mM) 25 15 12 10 8 5 mol% 3-APB max(nm) O HO HOH 2C O HO O B HO - WHOLE BLOOD INDWELLING CATHETER SUBCUTANEOUS NEAR-IR CONTACT LENS SKIN PATCH/TATTOO
  13. 13. CONTACT LENS HOLOGRAPHIC GLUCOSE SENSOR TOXICITY TEAR [GLUCOSE]<BLOOD [GLUCOSE] pH VARIABILITY (5.8-7.8) TIME LAG (~MIN) SELECTIVITY (LACTATE/FRUCTOSE) OPTICAL PHYSICS COMFORT/COSMETIC APPEARANCE INSTRUMENTATION 80 100 120 140 160 0 12 16 19 23 26 Time [minutes] Blood-Glucose[mg%] 680 700 720 740 Wavelength [nm]
  14. 14. HUMAN BREATH ANALYSIS DIABETIC KETOACIDOSIS RENAL FAILURE LIVER DYSFUNCTION ALCOHOL INTOXICATION CANCER CYSTIC FIBROSIS ASTHMA GIT DISORDERS (H pylori) HALITOSIS STRESS 520 540 560 580 600 620 640 660 680 700 0 20 40 60 80 100 120 140 160 Time (s) Wavelength(nm) H2 ETHANE n-PENTANE BUTANE NO CO NH3 ETHANOL ACETONE THIOLS
  15. 15. Time (h) 0.01 0.1 1 10 0 1 2 3 4 5 6 7 8 9 10 OD600nm 6.4 6.5 6.6 6.7 6.8 6.9 7 7.1 7.2 7.3 pH 500 520 540 560 580 600 620 640 0 2000 4000 6000 8000 10000 12000 14000 4.7 4.9 5.1 5.3 5.5 5.7 5.9 6.1 6.3 6.5 Time (s) pH max(nm) 400 500 600 700 4 5 6 7 pH max(nm) WHOLE CELLS
  16. 16. BIOENGINEERING BIOCHEMISTRY CHEMICAL INFORMATICS BIOINFORMATICS CHEMICAL ENGINEERING INFORMATION ENGINEERING CHEMISTRY/ MATERIALS SCIENCE BIOLOGY INFORMATION/ COMMUNICATIONS TECHNOLOGY ENGINEERING BIOTECHNOLOGY BIOSENSORS CONVERGENCE OF S&T
  17. 17. CELL PHONE PDA LAPTOP BEDSIDE MONITOR PHYSICIAN’S OFFICE EMERGENCY ROOM BEDSIDE OPERATING THEATRE ITU FIRST RESPONDER PATIENT DATA STORE/ SERVER SERVICES/INTERNET WEARABLE AND MOBILE SENSOR SYSTEMS WATCH USB ePATCH TATTOO LENS BREATH CLOTHES CATHETER COSMETICS TRANSCUTANEOUS SUBCUTANEOUS SPECTROSCOPIC

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