Wrong confirmation ID

Email
Favorite
Favorited ×
Download
Embed
Private Content
Copy and paste this code into your blog or website Copy Customize Close
We have emailed the verification/download link to "".
Login to your email and click the link to download the file directly.

To request the link at a different email address, update it here. Close
Validation messages. Success message. Fail message.

Check your bulk/spam folders if you can't find our mail.

Loading…

Flash Player 9 (or above) is needed to view presentations.
We have detected that you do not have it on your computer. To install it, go here.

+ Follow

Andrew Herbert's presentation

by James Cotton on Nov 08, 2010

234 views

CEO of Microsoft Research in Cambridge, Andrew Herbert's presentation at the Cambridge Phenomenon Conference

More…

CEO of Microsoft Research in Cambridge, Andrew Herbert's presentation at the Cambridge Phenomenon Conference

Less

2 Embeds 20

http://www.conference.cambridgephenomenon.com	19
http://localhost:8000	1

Statistics

Favorites: 0
Downloads: 1
Comments: 0
Embed Views: 20
Views on SlideShare: 214
Total Views: 234

Clear reference to Luca
Dec. 23, 1947. John Bardeen and Walter Brattain show the first working transistor.Sep. 1958. Jack Kilby builds the first integrated circuit.Dec. 24, 2009. Working transistor made of a single molecule.<10 iterations of Moore’s Law left! The race is on for molecular scale integrated circuits.
By programmed self-assembly
We need a magical material where the pieces are pre-programmed to fit into to each other.At the molecular scale many such materials exist; let’s pick one…
DNA in each human cell:3 billion base pairs2 meters long, 2nm thickfolded into a 6mm ball750 MegaBytesA huge amount for a cellEvery time a cell replicates it has tocopy 2 meters of DNA reliably.To get a feeling for the scale disparity, compute:DNA in human body10 trillion cells133 Astronomical Units long7.5 OctaBytes
SensingReacting to forcesBinding to moleculesActuatingReleasing moleculesProducing forcesConstructingChassisGrowthComputingSignal ProcessingDecision MakingNucleic Acids can do all this and interface to biology
Visual DSD - A Strand Displacement SimulatorMatthew Lakin, Simon Youssef, Andrew Phillips, Microsoft ResearchDesign and simulate a DNA sequence ‘in silico’MSRC has pioneered new tools that allow researchers to write DNA code. They can design the program they wish to run, simulate the effect it will have and debug the design.
Web sites can take DNA specifications and get them synthesized. Vials can arrive on your doorstep by mail order in as little as 24 hours.
Arrives dried, add water, do experiments.DNA Programming in the kitchen sink, no special tools required.
An automaton sequentially reading the string PPAP2B, GSTP1, PIM1, HPS (known cancer indicators) and sequentially cutting the DNA hairpin until a ssDNA drug (Vitravene) is released.Just one of many areas scientists are working on intensively. With molecular programming, a cure for cancer may be reality in the very near future!

Andrew Herbert’s presentation — Presentation Transcript

Molecular programming
Dr Andrew Herbert OBE FREng
Microsoft distinguished engineer & managing Director, Microsoft Research
Smaller andsmaller
Placement and orientation of individual DNA shapes on lithographically patterned surfaces. Nature Nanotechnology 4, 557 - 561 (2009).
H Song et al. Nature 462, 1039-1043 (2009) doi:10.1038/nature08639
Building The Smallest Things
How do we build structures that are by definition smaller than our tools?
Basic answer: We can’t. Structures (and tools) should build themselves!
Molecular assembly
Nature can self-assemble. Can we?
“Dear Furniture Shop, please send me a table that assembles itself.”
ADD WATER
dna
NanoscaleEngineering
Sensing
Computing
Constructing
Actuating
Design & simulation
Compilation & code generation
Just add water & experiment!
The future: Computational Drugs
Simplified (omitting the “no” pathway)
Nature 429, 423-429 An autonomous molecular computer for logical control of gene expression
Yaakov Benenson1,2, Binyamin Gil2, Uri Ben-Dor1, Rivka Adar2 & Ehud Shapiro1,2
1 - Department of Computer Science and Applied Mathematics, Weizmann Institute of Science, Rehovot 76100, Israel
2 - Department of Biological Chemistry, Weizmann Institute of Science, Rehovot 76100, Israel
Acknowledgement: Luca Cardelli, Microsoft Research
//research.microsoft.com

Andrew Herbert's presentation

by James Cotton on Nov 08, 2010

Accessibility

Categories

Tags

Upload Details

Usage Rights

2 Embeds 20

Statistics

Andrew Herbert’s presentation — Presentation Transcript