Hemophilia

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Hemophilia

  1. 1. Hemophilia A Inherited blood disease where your blood doesn’t clot normally.
  2. 2. Cause <ul><li>Lack of clotting factors </li></ul><ul><li>Hemophilia A (most common type) </li></ul><ul><ul><li>Lack of clotting factor VIII </li></ul></ul><ul><li>Passed on with X chromosome </li></ul>1
  3. 3. Symptoms <ul><li>Spontaneous bleeding </li></ul><ul><ul><li>Large or deep bruises </li></ul></ul><ul><ul><li>Joint pain and swelling - internal bleeding </li></ul></ul><ul><ul><li>Random bleeding or bruising </li></ul></ul><ul><ul><li>Blood in urine </li></ul></ul><ul><ul><li>Nosebleeds </li></ul></ul><ul><ul><li>Tightness in joints </li></ul></ul>2
  4. 4. Symptoms <ul><li>Emergency Signs </li></ul><ul><ul><li>Sudden pain, swelling, and warmth of joints and muscles </li></ul></ul><ul><ul><li>Long and painful headaches </li></ul></ul><ul><ul><li>Constant vomiting </li></ul></ul><ul><ul><li>Fatigue </li></ul></ul><ul><ul><li>Neck Pain </li></ul></ul><ul><ul><li>Double Vision </li></ul></ul>3
  5. 5. Characteristics <ul><li>Continuous bleeding after: </li></ul><ul><ul><li>Injury </li></ul></ul><ul><ul><li>Surgery </li></ul></ul><ul><ul><li>Tooth extraction </li></ul></ul>4
  6. 6. Characteristics <ul><li>More serious complications- </li></ul><ul><ul><li>Bleeding into: </li></ul></ul><ul><ul><ul><li>Joints </li></ul></ul></ul><ul><ul><ul><li>Muscles </li></ul></ul></ul><ul><ul><ul><li>Brain </li></ul></ul></ul><ul><ul><ul><li>Other internal organs </li></ul></ul></ul>5
  7. 7. Characteristics <ul><li>Lifelong Disease </li></ul>
  8. 8. Who Is Affected? <ul><li>Women may be carriers </li></ul><ul><ul><li>Passed down to children </li></ul></ul><ul><ul><ul><li>Males have 50% chance of getting disease </li></ul></ul></ul><ul><ul><ul><li>Females have 50% chance of carrying disease </li></ul></ul></ul><ul><li>Hemophilia is mostly in men </li></ul><ul><ul><li>Men only have one X-chromosome </li></ul></ul><ul><li>All age groups </li></ul><ul><ul><li>Mostly children </li></ul></ul>6
  9. 9. How It Normally Works Blood vessels are cut or damaged Clotting factor recruits collagen http://www.3dchem.com/molecules.asp?ID=195 8 7 Blood reacts to clotting factors Platelets form plug at the injury site Bleeding stops!! 11 10 9 How Disease Affects Homeostasis No clotting factor to recruit collagen No clotting factor for blood to react to Platelets don’t form a plug Bleeding Does Not Stop! 12
  10. 10. Diagnosis <ul><li>Family history of hemophilia </li></ul><ul><ul><li>Fetus testing </li></ul></ul><ul><li>Blood testing from a child or adult </li></ul><ul><li>Diagnostic Testing </li></ul><ul><li>Carrier Testing </li></ul>13
  11. 11. Treatment <ul><li>Replacement of the missing clotting factor </li></ul><ul><li>Desmopressin </li></ul><ul><ul><li>Injected into vein </li></ul></ul><ul><ul><li>Can be given as nasal medication </li></ul></ul><ul><ul><ul><li>Helps body release factor VIII </li></ul></ul></ul>14
  12. 12. Prevention <ul><li>Can’t be prevented </li></ul><ul><ul><li>Genetic disorder </li></ul></ul><ul><li>Genetic Counseling </li></ul><ul><ul><li>Figures out the chance of your child getting hemophilia </li></ul></ul><ul><li>Regular exercise </li></ul><ul><ul><li>Prevents bleeding </li></ul></ul>15
  13. 13. Bibliography - Contents <ul><li>http://www.nhlbi.nih.gov/health/dci/Diseases/hemophilia/hemophilia_what.html </li></ul><ul><li>http://www.mayoclinic.com/health/hemophilia/DS00218/DSECTION=causes </li></ul><ul><li>http://ghr.nlm.nih.gov/condition/hemophilia </li></ul><ul><li>http://www.mayoclinic.com/health/hemophilia/DS00218/DSECTION=symptoms </li></ul><ul><li>http://www.inheritedhealth.com/condition/Hemophilia/179#symptomsandcharacteristics </li></ul><ul><li>http://www.ncbi.nlm.nih.gov/pubmedhealth/PMH0001565/ </li></ul><ul><li>http://www.mayoclinic.com/health/hemophilia/DS00218/DSECTION=treatments-and-drugs </li></ul><ul><li>http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/C/Clotting.html </li></ul>
  14. 14. Bibliography - Pictures <ul><li>1- http://biomed.brown.edu/Courses/BI108/2006-108websites/group01Heparin-coatedOxygenators/pages/Heparin_pharmacokinetics.htm </li></ul><ul><li>2 - http://en.nkfu.com/what-is-hemophilia-signs-and-treatment/ </li></ul><ul><li>3 - http://www.tmj.ro/article.php?art=58506380129851 </li></ul><ul><li>4 - http://www.unm.edu/~mpachman/Blood/displaz.htm </li></ul><ul><li>5 - http://www.psd202.org/PEHS/departments/science/tmurphy/sixth_hour_web/Hemophilia/symptons_and_characteristics.html </li></ul><ul><li>6 - http://presscoverage.us/soapbox/the-redefinition-of-perfect/ </li></ul><ul><li>7 - http://www.health911.com/cuts-&-wounds </li></ul><ul><li>8 - http://www.3dchem.com/molecules.asp?ID=195 </li></ul><ul><li>9 - http://www.healthjockey.com/2008/02/11/vacuming-blood-clots-proves-to-be-effective-heart-attack-treatment/ </li></ul><ul><li>10 - http://sciencephoto.com/images/download_lo_res.html?id=802600116 </li></ul><ul><li>11 - http://www.fotosearch.com/illustration/blood-drop.html </li></ul><ul><li>12 - http://www.flickr.com/photos/csessums/4966652884/ </li></ul><ul><li>13 - http://www.thereforyou.com/about-hemophilia/overview/who-gets-hemophilia.html </li></ul><ul><li>14 - http://products.hospira.com/search/productDetails?listNumber=DESMOPRESSIN_ACETATE&page=Drugs&sort=ndc&order=asc </li></ul><ul><li>15 - http://www.thereforyou.com/about-hemophilia/gist-of-genetics/genetics-counseling.html </li></ul>

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