Two pounds is a fairly good sized meatloaf, and it will require considerable time, no matter your method. I cover it with aluminum foil (like Reynold's Wrap non-stick) for about an hour and ten minutes, with the oven set at 375 degrees F. Uncover it and continue cooking for about 20 minutes more. Some people may cook it at 400 degrees for a shorter time; others don't cover it. But my method gives me good success, and covering it prevents a hardened or burnt "crust" on the outside of the meatloaf and keeps the meatloaf moist.
Remember, to answer the question, how long do I cook a two pound meatloaf, you have to know two things: the oven temperature and whether you will cover the meatloaf. Start with my method of covering with aluminum foil for about 1 hour and ten minutes, and the cook for about 20 minutes more, uncovered. Once you have the hang of cooking a meatloaf, you can try adjusting the temperature to speed up the baking time.
How Long do I Cook a Two Pound Meatloaf ? The Answer as seen on TV shows < click here > to GO