1. ÍNDEXMain figures in BiomedicineSpain 2Catalonia 5Biopol’H 8 Biopol’H Scientific and Health Park 9 Biopol’H Business Park area 12 The Bioincubator of Biopol’H 13 Alliances and collaboration agreements 14 Barcelona Bellvitge Biopol ICO campus hospitals cancer knowledge centers HPV clinics development business companies Catalonia biotechnology Spain education Hospitalet de Llobregat HUB innovation spin-off IDIBELL oncology medicine HUBc industry institutions promotion university healthcare production research patients projects health services life Technology transplants network science
2. SpainSpain strongly pledges its commitment to R & D, promoting the knowledge economy and innovation as the drivingforces of wealth production. This country has a growing network of centres and institutions dedicatedto the promotion of research; one of the most outstanding is the Spanish National Research Council (CSIC),which ranges from basic research to knowledge transfer to the productive sector.In 2010, the CSIC invested € 190,835,309.26 in Biology and Biomedicine, by far the largest allocation ofits budget. Nine researchers from spanish research centres were awarded in the announcement of theEuropean Research Council Advanced Grant Life Sciences in 2011. In Spain, we are investing in the develop-ment and consolidation of several biotechnology areas: > Bioinformatics > Generic and Biosimilar Drugs > Advanced Terapies > Oncology > Animal Health Production > Clinical Trials > Nanomedicine > Food Quality and Biosecurity > Personalized Medicine > Biopharming > Anti-aging Medicine > Health TechnologiesThe Spanish biotechnology industry is an emerging industry where the creation of business has in-creased significantly in recent years. In 2009 there were 1,095 companies related to technology activities and 399strictly biotech companies.There is a strong spin-off culture, since every year between ten and twelve new companies are createdfrom Public Institutions. It is estimated that in 2012, directly and indirectly, biotechnology will involve1.6% of Spanish GDP. There are various factors driving this trend: 5th European Clinical Trials power in International with greater Integrated Cooperation Health System scientific profitability production Highly Leading Over 450 Leader country in infraestructure trained Agrobiotechnology pharmaceutical professionals for innovation companies Exponential growth 9th world Great public power in Translational of Science and support for scientific Medicine Technology Parks companies production
3. The scientific production in Life Sciences improved the production of articles of maximum impact significantlythroughout 2011, occupying the 5th position in the EU-15.The number of requested patents kept stable and the volume of R & D agreements between universities andPublic Research Entities (OPI) and companies remains in the same level as in 2007.The complete turnover of the biotechnology business activity was almost €4.500M in 2009, generatingemployment for 12,600 people – including companies of Biotechnology (EB) and the companies of industry,commerce and services of in Biotechnology (EIB) –.In 2010 about 550,000 people received treatment with biopharmaceuticals and biotechnologicaltesting is being introduced into the National Health System for the diagnosis of microbiological, cancer, haemato-logical or genetic diseases.Along with the leading research centres, the Integrated Health System becomes a top-quality system for thedevelopment of translational medicine and the discovery of new drugs and advanced therapies. International cooperation: 143 alliances between Spanish and international companies in 2010, 18% from Europe and 6% from the U.S. Clinical trials with greater profitability: about 3,000 studies are carried out in Spain –it is the 5th country of the EU-27 with more clinical trials. Tthe cost of a clinical trial per patient is 30% lower than in other markets like the U.S. A powerful Spanish pharmaceutical industry: which has over 450 pharmaceutical companies and repre- sents 20.3% of the total private investment in R & D of Spain Strong basic science: as far as scientific production is concerned, Spain ranks as the 9th world power and the 5th European power Integrated Health System: with a comprehensive network of 900 hospitals, public and private. Emerging biotechnology industry: which has great public support for companies Leading infrastructure for innovation: exponential growth of Science and Technology Parks, Research Centres and Institutes of Technology Highly trained professionals: with a surplus of talent to be exploited in competitive and innovative projects
4. Another health sector where Spain stands out is trasplants. In 2011 a total of 81,909 transplants had been made in our country. The National Transplant Organization (ONT) has 179 hospitals approved for donations and 43 hospitals licensed to perform transplants distributed around the 17 autonomous communities. Just to provide some data, 194 heart transplants, 764 liver transplants and 2,063 kidney transplants were performed only in Catalonia in the period between 2008 and 2009. In 2011 the total number of donors in Spain was 1,667 –who were living or asystolic donors. If we break down the total number of transplants performed in Spain by type, the figures are as follows: 51.909 kidney transplants 6.528 heart transplants80intestinetrasplants 1.342 pancreas transplants 2.702 lung transplants 19.399 liver transplants
5. CataloniaCatalonia is currently on the 3rd place of the ranking in scientific excellence among the EU, onlybehind the Netherlands and Sweden.The Catalan Bio Region has a bigger concentration in Barcelona’s area, especially around its Metropolitan Area.It has a total number of 1,156 entities, among which there are over 268 enterprises working on redbiotechnology –that is, the Health and Life Sciences Biotechnology.As a whole, the Catalan BioRegion has created jobs for more than 29,000 people –including research staff,associated services, etc. Catalonia houses the 20,5% of all the biotec enterprises established at Spain.However, if Catalonia’s and Spain’s economical impact is compared, this proportion is oversized because with an ap-proximated annual turnover of €15,600 millions, Catalonia contributes with the 29,4% of the state’stotal amount. Also, it is the most dynamical autonomous community, responsible for the creation of the 23%of new biotec in 2010.All this wealth has been created from local initiative and it is deep-seated on Catalan’s social fabric –as it is proved bythe fact that only the 16% of the enterprises from the Catalan BioRegion are multinational’s branches.
6. CataloniaAn autonomous community with a booming biotechnology sector17science parkstechnology and 12universities 10 of them offering studies in Life Sciences13 of them carrying out activities in biotech- and some of the most important internation-nology and biomedicine al business schools (2 of which rank among the 20 best business schools in the world)150researchcenters 900recognized research groups60 of them carrying out research related to 400 of them working on Life Sciences’ relatedLife Sciences research21csic centerslocated in Catalonia 7/1000researchers 7 researchers per 1000 working population215hospitals13 hospitals with noteworthy research activ- 350companies 70 of them are pharmaceutical, 65 biotech-ity out out of 215, 6 of which are among the nological, 123 of innovative medical technol-most productive in Spain in terms of scien- ogies, and the rest provide support servicestific output or are linked to the sector in some way
7. Catalonia has the largest network of hospitals in Spain. It is the autonomous community with morehospitals and healthcare centres. Renowned for its pioneering research in Oncology – especially for theresearch and clinical care that takes place in the Catalan Institute of Oncology, which has three venues in Catalan ter-ritory: L’Hospitalet, Girona and Badalona.The list of TOP-20 Spanish, the ranking of the most prestigious hospitals, is produced every year by the IASIST.The list of the hospitals awarded in the announcement of 2011 includes the following Catalan centres: Small general hospitals Benchmarks of the Nervous System area > Sant Bernabé Regional Hospital. Berga > Health Consortium of Maresme – Hospital of > Campdevànol Regional Hospital of Ripollès Mataró > Sant Jaume Hospital of Olot > St. Pau and St. Tecla Hospital Foundation. Tarragona Medium general hospitals > Comprehensive Health Consortium. Centre Benchmarks of the Respiratory area for Comprehensive Care Dos de Mayo Hospital. > Bellvitge University Hospital. L’Hospitalet de Barcelona Llobregat > Empordà Health Foundation. Figueres > St. Pau and St. Tecla Hospital Foundation. Benchmarks of the Heart area Tarragona > Hospital of Sabadell. Health Corporation Parc Taulí > Mútua Terrassa University Hospital Big general hospitals > Fundación Hospital/Asilo of Granollers Benchmarks of Digestive Surgery > Public Health Consortium of Maresme > Empordà Health Foundation. Figueres > St. Pau Hospital – Puigvert Foundation. Barcelona Hospitals with benchmark Specializations > Hospital of Sabadell. Health Corporation Parc Taulí Benchmarks of Traumatology and Orthopaedics > Mútua Terrassa University Hospital > Hospital of Sabadell. Health Corporation Parc Taulí > Arnau de Vilanova University Hospital. Lleida Benchmarks of Women’s Health Big hospitals of regional and national benchmark > St. Joan de Déu Health Park. Sant Boi de Llobregat > St. Joan de Déu Health Association – Clinic > Campdevànol Regional Hospital of Ripollès Hospital of Barcelona > Health Foundation of Mollet > St. Pau Hospital – Puigvert Foundation. Barcelona > Health Consortium of Anoia. Igualada > Bellvitge University Hospital. L’Hospitalet de >Hospital of Sabadell. Health Corporation Parc Taulí Llobregat Mútua Terrassa University Hospital
8. Biopol’HBiopol’H is a hub of innovation constituted by a number of companies, organizations, and public healthcareand research institutions performing closely related activities to share knowledge.These companies and organizations give a high added value to the scientific and financial district, whichgoes along Gran Via in Hospitalet, from the Bellvitge University Hospital to the Institute of Legal Medicine. Part of thisdistrict are pharmaceutical adn medical devices companies such as Ferrer, Chiesi and Werfen; service companies,training companies (Study Centre Joan XXIII) and engineering companies of high technology competitive value(PROMAUT, Gutmar).Some of the most important research and health centres in Catalonia are also present, like the Catalan Institute ofOncology, the Bellvitge University Hospital and the Bellvitge Biomedical Research Institute, the Institutefor Bioengineering of Catalonia and the Health & Life Sciences Campus (University of Barcelona) as thecentre of training and knowledge production. The hub employs 4380 people. Employees of the Biopol’H institutions Chirurgical Medical Welfare support Logistics support ResearchersIn short, Biopol’H is a cluster of companies andorganizations performing closely related activities in orderto carry out a joint action in search of a collective efficiency.
9. HOSPITALS The Health University of Barcelona Campus (HUBc) has Hospital Duran i Reynals been recognized as a Campus of International Excellence Hospital Universitari de Bellvitge (CEI). It comprises 6 hospitals and 4 schools, offers more Hospital Moisès Broggi than 30 degrees and performs 500 clinical trials Hospital General de L’Hospitalet RESEARCH CENTERS ENTERPRISES 80 research groups distributed among three re- 11 companies of health sector, services, training search centers and medical technologyBiopol’H Scientific and Health ParkCatalan Institute of Oncology (ICO)Located in the Duran i Reynals Hospital, the Catalan Institute of Oncology (ICO) is the hospital centre in Spain withthe highest quality research by its impact factor, normalized by its publications as an institution devoted to health(SCIMAGO SIR World Report 2011). 70% of their articles are published in the most influential scientificjournals. As a hospital, it is the 10th best in Spain according to the Ranking Web of World. There are 10 linearaccelerators in the premises, the highest amount of Spain.One of the remarkable projects is the research on Human Papilloma Virus (HPV), developed by DrXavier Bosch’s team. This research has taken the organization to lead the creation of an international platform on thevaccine for HPV – which is responsible for cervical cancer. The aim of the International Information Centre onHPV and prevention of cervical cancer – formed by the ICO and the Bill and Melinda Gates Foundation – is to advicethe WHO on preventive vaccination against HPV, which can avoid the 70 % of cancer cases.In particular, it is also worth mentioning the collaboration of the ICO with the WHO in the QUALY programmefor the promotion of quality in palliative care; the patient care in Functional Units that comprise differ-ent professionals to jointly evaluate every case that comes to the ICO – to make the decision together aboutwhat would be the most appropriate diagnosis and treatment for the patient –, and the advanced radiotherapyand brachytherapy devices of the institute.
10. Bellvitge University Hospital (HUB)The HUB has been given the TOP-20 Hospitals Awards prize for the fourth time, being the winner inthe field of Hospital Management. It is a tertiary benchmark centre for Stroke, resistant bone and joint infections inCatalonia and was the first Spanish hospital to perform a partial breast reconstruction via endoscopy,the fourth hospital to do so in the world. The Hospital is a high complexity centre of reference for over 2 millioninhabitants.The HUB pledged its commitment to the Davinci system in interventions of the services of Urology, Gynaecologyand General and Digestive Surgery, with some pioneering operations of the whole state.The Functional Unit of Septic Surgery of the Orthopaedic Surgery and Trauma Service of the Bellvitge UniversityHospital was appointed last February by the Interregional Council of the National Health System as one of thebenchmark centres of the state in the treatment of resistant bone and joint infections.Bellvitge Biomedical Research Institute (IDIBELL)The Bellvitge Biomedical Research Institute (IDIBELL) is a research centre in cellular medicine, where the basic re-search of high level is at the service of relevant clinical questions and the economic development. Since March2009 it is one of the five Spanish research centres that have been accredited as Health ResearchInstitute by the Carlos III Health Institute.Because of its index of excellence (27.3), the IDIBELL is at position 115 out of the 500 institutions witha best valuation of the world in all disciplines. The impact of its publications puts it among the top 10research centres in Spain (SCIMAGO SIR World Report 2011). The IDIBELL works to do research in collaborationwith the Bellvitge University Hospital, the University of Barcelona and the Catalan Institute of Oncology.One of the researchers, Dr Manel Esteller, has received several awards and recognitions for his scientific career.These include the World Health Summit and Pfizer Award for Innovation in Biomedical Research in 2010 and theNational Award in Genetics in 2011. One project of his was selected in 2009 to receive an Advanced Grant from theEU and is member of Faculty1000.
11. Health & Life Sciences Campus of Bellvitge ofthe University of Barcelona (UB)The University of Barcelona ranks as the number one in the ranking of higher education cen-tres in Spain (SCIMAGO SIR World Report 2011). If we focus on the teaching of Life Sciences and Medicine, ithas the 68th position of the World University Rankings, with the honour of being the only Spanishuniversity that appears among the top 100 of this ranking. It was the 30th world leader in scientificproduction in the decade 1999-2009, according to the data of the ISI Web. The Health Sciences Campus ofBellvitge in the Biopol’H area offers degrees in Basic Medical Sciences, Nursing, Medicine, Dentistry and Podiatry.In October 2010, the project Health University of Barcelona Campus (HUBc) achieved the recognition ofCampus of International Excellence (CEI) given by the Ministry of Education and the Ministry of Scienceand Innovation. Therefore, the UB became the first and only general university of the country with two campuses ofinternational excellence. The environment of the HUBC is a space that joins the potential of two cities (Barcelonaand L’Hospitalet de Llobregat) from three main areas: the Health Sciences Campus of Bellvitge and Biopolof L’Hospitalet de Llobregat (Biopol’H), August Pi i Sunyer Campus (Clinical Hospital), together with the St.Joan de Déu Hospital and, finally, Zona Franca.Comprehensive Health Consortium (CSI)The Comprehensive Health Consortium is integrated by three hospitals –Hospital Dos de Maig, Hospital MoisèsBroggi and Hospital General de L’Hospitalet- and a network of primary attention health centres.The Minister of Health, Social Policy and Equality has awarded the Holistic Health Consortium the national prizein Innovation for the comprehensive improvement in quality care. The award recognizes CSI’s project ofestablishing the new management system Lean healthcare, which aims to improve and increase public safety,service quality and the satisfaction of the staff, and reduce costs too. In addition, three other projects which in-volve CSI have been selected out of the 100 Best ideas of Diario Médico.Institute for Bioengineering of Catalonia (IBEC)The Institute has currently 15 research groups and 250 researchers and staff members coming fromtwenty different countries. Furthermore, 17 projects are funded by the European Union, six of whichare funded by the Seventh Framework Programme (FP7). Today, its headquarters is located in the Barcelona SciencePark but it will be moved into the Biopol’H area very soon.The IBEC groups and their activities are organized into six research programmes: • Cellular Biotechnology • Cellular Biomechanics and Biophysics • Nanobiotechnology • Biomaterials, implants and tissue engineering • Medical signals and instrumentation • Robotics and biomedical imaging
12. Biopol’H Business ParkLocated in the arterial road of Gran Via in L’Hospitalet, the Biopol’H area has a Business Park that is being consoli-dated day by day. Biopol’H gathers companies of health sector, services, training and medical technology:With over 50 companies, the pharmaceutical division is Pharmaceutical group with 100% family capital, 3,500 em-present in Europe, Latin America, Central America and ployers, over EUR 1,000 million sales and 24 internationalAsia. It is also present in food industry and chemical mar- branches. This conglomerate has its origens in an italianket. In 2012 its R&D building will begin to be built in the pharmacy, founded in 1935 by Giacomo Chiesi. Chiesi SpainBiopol’H area, right next to the Duran i Reynals Hospital. has 250 employers and develops an outstanding work of R&D as well, mainly in clinical trials of phase III.This company’s packaging solutions ensure the cold chain It has designed and manufactured drill holders and other com-of thermo-sensitive products, guaranteeing customers the plementary tools since 1957. Committed to innovation, one ofdistribution of its products in perfect conditions -respect- its innovative products is a programme of stainless drill hold-ing the product’s lifetime, regardless of environmental ers for surgical instruments, being the only manufacturer in theconditions or transport conditions. world to have the ISO 13485 certification for the medical sector.Specialized in the comissioned manufacture of medical- Provides social, healthcare and mental health services bothhospital products with CE certification and a rigorous and in hospitalization and day hospital. It collaborates with thesystematic application of the EN 13485 quality system Autonomous University of Barcelona, Ramon LLull Universityand the DIR 93/42-DIR98/79. It has a clean room 100,000, (Blanquerna Foundation) and the Red Cross in an educa-which guarantees the rigorous perfomance of the rules of tional level. The Centre of Duran i Reynals Hospital has anenvironment, health and safety. allocation of 450 beds and 20 places in a Day Hospital for Neurological Diseases.Five-star hotel, opened in 2006. It offers 280 rooms, a con- Four-star hotel, designed by the Japanese architect Toyo Ito,vention centre, auditorium, spa and multipurpose rooms. it has been awarded as the Best sky-scraper of the world. It offers 320 rooms.Four-star hotel, it has 160 rooms and it is mainly thought Four-star hotel, it has 116 rooms and many function roomsfor business sector. It offers different meeting rooms and of over 500m², specially aimed for Meetings, Incentives,other gathering places. Conventions and Exhibitions (MICE).
13. The Bioincubator of Biopol’HThe Biopol’H Bioincubator I offers spin-off, companies and technical or consulting offices, legally constituted as a com-pany, some office space with voice and data services, meeting room, lecture hall and soon TV and videoconferencingroom as well, in addition to basic cleaning, maintenance and security services. It currently has 4 companies: VCN Biosciences Zyrnat Biotherapeutics The spin-off arisen from the Virotherapy group of the Catalan Focused on research innovation and development of Institute of Oncology is dedicated to the development of on- biopharmaceutical products colytic adenovirus designed to fight tumour cells. Adbroncus CESPU Aimed at developing new solutions, methods of diagnosis and Private enterprise committed to research and ad- treatment of lung conditions. The company seeks to resolve vanced training in science and health technologies. medical needs not yet covered in the respiratory market as well as in the bronchoscopy practice.Besides these companies, the Bioincubator has two university groups with future spin-off projection: FISIOLOGIA DE L’EXERCICI CAMBRA HIPOBÀRICA Hypobaric Chamber Barcino The Hypobaria and Biomedical Physiology Service offers specif- It is a project of the Centre for Thermal Spray at the ic programmes to patients with breast cancer, spinal cord injury University of Barcelona, which does research on new or chronic fatigue for the recovery of their physical and psychic prosthesis coatings by using cold thermal spraying. This conditions. These may include treatments of intermittent ex- is the only group in Spain that has this “know-how”. posure to hypobaric hypoxia and hypoxia tolerance tests.
14. Alliances and collaboration agreementsBiopol’H is member of the Network of Science and Technology Parks of Catalonia (XPCAT), the Associationof Science and Technology Parks of Spain (APTE) and the International Association of Science Parks (IASP).Moreover, it takes part in a series of entities working to promote the economic and scientific development in theterritory:CataloniaBioAssociation of companies which, directly or indirectly, de- Barcelona Chamber of Commercevelop their activities in connection with biotechnology in An institution that aims to ensure the promotion of the eco-Catalonia, such as companies operating in other sectors but nomic and business activity and the sustainable develop-have identified potential and synergies in this field (legal ment of the territory.consultancies, agencies, IT services and so on).FENIN Spanish Federation of Healthcare Technology Cedars-Sinai Health SystemFounded in 1977, it includes Spanish companies in the sector A non-profit, independent healthcare organization and bio-to coordinate and defend their interests and represent them medical research institution. With more than 2,000 physi-before the regional, national and European authorities. cians in every clinical specialty, 10,000 employees, 2,000 volunteers and 15,000 fundraising support group members.AEBALL Business Association of L’Hospitalet and BaixLlobregatIt is the business organization for the representation, man- ASBTEC Biotechnologist Association of Cataloniaagement, defence, coordination and promotion of the pro- A non-profit entity composed by professonals, students andfessional interests of the companies doing general economic people related to Biotechnology, to coordinate all theseactivities of various sectors: industrial, commercial and ser- agents and set up an organized collective.vices. It comprises over 3,000 companies with more than48,000 jobs.