5. fullante   sickle cell anemia
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5. fullante sickle cell anemia

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  • Anemia is a condition in which a person’s blood has a lower than normal number of red blood cells, or the red blood cells don’t have enough hemoglobin. Hemoglobin is an iron-rich protein that gives blood its red color and carries oxygen from the lungs to the rest of the body. Normal red blood cells last about 120 days in the bloodstream and then die. Their main role is to carry oxygen, but they also remove carbon dioxide (a waste product) from cells and carry it to the lungs to be exhaled. In sickle cell anemia, a lower-than-normalnumber of red blood cells occurs because sickle cells don’t last very long. Sickle cells die faster than normal red blood cells, usually after only about 10 to 20 days. The bone marrow can’t make new red blood cells fast enough to replace the dying ones. The result is anemia.
  • Common sites: bones, lungs, abdomen, and joints. Lack of blood flow can cause pain and organ damage.
  • A.B. due to a decreased number of red blood cellsC. Inflammation of the tongue
  • SCD-Because infection is the most common precipitating event in a sickle cell crisis, any potential sources of oral infection (pericoronitis, symptomatic impacted teeth, nonrestorable teeth, and so forth) must be removed-EXTRACTION-since the patient may have osteopenia, osteoporosis, and a thin mandibular border, increasing the risk of mandibular jaw fractures
  • MendelianSickle cell anemia is an autosomal recessive genetic disorder caused by a defect in the HBB gene, which codes for hemoglobin. The presence of two defective genes (SS) is needed for sickle cell anemia. If each parent carries one sickle hemoglobin gene (S) and one normal gene (A), each child has a 25% chance of inheriting two defective genes and having sickle cell anemia; a 25% chance of inheriting two normal genes and not having the disease; and a 50% chance of being an unaffected carrier like the parents.

5. fullante   sickle cell anemia 5. fullante sickle cell anemia Presentation Transcript

  • SICKLE CELL ANEMIA FULLANTE, Kasey Anne E. DMD 2D
  • A. DefinitionA genetic blooddisorder caused by thepresence of anabnormal form ofhemoglobin. Thesehemoglobin moleculestend to aggregate afterunloading oxygenforming long, rod-likestrictures that forcethe red cells to assumea sickle shape.
  • Signs & Symptoms Fatigue (tiredness) pale skin nail beds Jaundice shortness of breath Sudden episode of pain throughout the body.
  • Oral Manifestation An increased risk for periodontitis, or gum disease Abnormally pale tissue in mouth Glossitis
  • GLOSSITISPALE GUMS PERIODONTITIS
  • Oral Care SCD patients must undergo a thorough oral and dental examination, using appropriate radiographs. Proper hygiene. Strict dental appointments. Extractions should be done atraumatically
  • Classification of Sickle CellAnemia as a disease: •Mendelian- autosomal recessive genetic disease •Cytogenetics- The HBB gene is found in region 15.5 on the short (p) arm of human chromosome 11.