Clc Bio Basic Company Presentation

CLC bio Bioinformatics Solutions

Presentation of CLC bio

HQ in Denmark. Offices in USA, Brazil & India, and resellers in 10+ countries

Focus on bioinformatics solutions: Software, Hardware, and Consulting services

A large number of world class bioinformatics scientists work for CLC bio

More than 47,000 software users since the first release in July 2005

CLC bio – global reach CLC bio – global reach

Software objectives

• To make user-friendly state-of-the-art bioinformatics software

• To integrate all analyses in one program

• To make software that works on:

• To involve users as much as possible

– CLC bio offers free user-support to all programs

– CLC bio is very open to user suggestions

– There are at least 2 program upgrades a year

CLC bio’s software solutions

CLC Free Workbench : A number of basic bioinformatics analyses, all integrated in the same software package.

CLC DNA Workbench : A large number of advanced DNA sequence analyses.

CLC RNA Workbench: Provides easy access to a range of complex algorithms and options, for RNA secondary structure prediction and editing.

CLC Protein Workbench : A large number of advanced protein sequence analyses.

CLC Combined Workbench : All the above gathered in one single, fully integrated software package.

CLC Free Workbench

Bioinformatics feature examples :

Multiple alignment

Phylogenetic trees

Restriction site finding

GenBank search

Viewing of all results from our commercial programs

CLC DNA Workbench

Assembly of DNA sequencing data ( Assembly)

Advanced primer design

Cloning

Automatic SNP annotation

Complexity region analyses

Dot plot based analyses

CLC RNA Workbench

Structure prediction

2D structure editor

Linear structure editor

RNA alignment

Pattern discovery

BLAST analysis

CLC Protein Workbench

Secondary structure predictions

BLAST searches (NCBI or Local)

Signal peptide prediction

3D molecule viewer

Transmembrane helix prediction

Hydrophobicity analyses

CLC Combined Workbench

All the functionalities of Free, DNA, RNA and Protein in one program!

System requirements

… for all workbenches from CLC bio:

Mac OS X 10.3 or later (including Intel-based Macs)

Windows 2000, Windows XP, or Windows Vista

Linux: Redhat or SuSE

256 MB RAM required

512 MB RAM recommended

1024 x 768 display recommended

Additional requirements for CLC Protein Workbench and CLC Combined Workbench

3D viewing requires an OpenGL 3D graphics driver

CLC Software Developer Kit

Software Developer Kit: This API enables the user to make his/her own modules for the CLC Workbench.

www.clccube.com

Hardware accelerated bioinformatics

Acceleration through innovative use of FPGA technology

Smith-Waterman more than 100 times faster than a fast desktop computer

Hardware accelerated bioinformatics

Portable: Plug-and-play connection through a USB 2.0 port

Upcoming: Faster Smith-Waterman searches, ClustalW, and other alignments

Cube Interfaces

Blast interface

Like NCBI Blast (including extension)

Add a command line parameter and the hardware Smith- Waterman is used

Easy integration with existing infrastructure

Graphical interface

Easy to use for all people

Better overview and workflow for Workbench users

CLC Bioinformatics Cell

Acceleration through innovative use of SIMD technology

Smith-Waterman more than 100 times faster than a fast desktop computer - speed depends on CPU-power

Current algorithms: Smith-Waterman and ClustalW

Upcoming: - Even faster - Significantly more algorithms - Able to run in clusters

Some of CLC bio’s customers

NASA Exobiology Branch, USA

National Institutes of Health (NIH), USA

Pasteur Institute, France

Royal Perth Hospital, Australia

National Hospital of Denmark

Solvay Pharmaceuticals, Germany

“ The wide variety of other tools in CLC's software are extremely useful - BLAST searches from within the program, in silico restriction digests, alignments, phylogenetic trees, among a lot of other features.” Dr. Stefan J. Green, NASA, Exobiology branch.