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Multiple Myeloma

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Multiple Myeloma Multiple Myeloma Presentation Transcript

  • Multiple Myeloma Presented by: Mike Lynch
  • Outline of Presentation
    • Multiple myeloma
    • Statistics
    • Causes
    • Symptoms
    • Prognosis
    • Treatment options
  • Multiple Myeloma (myeloma or plasma cell myeloma)
    • Hematological cancer
    • Plasma cells
      • White blood cells
      • Immune system
      • Bone marrow
  • How Plasma Cells Work
    • Develop from stem cells in bone marrow
    • Stem cells develop into B cells (B lymphocytes)
    • Antigens enter body then B cells develop into plasma cells
    • Produce antibodies
  • Normal Cell (5%)
  • Myeloma Cells (10%)
  • What Causes Myeloma Cells To Grow?
    • Adhesion molecules
    • Stromal cells
    • Interactions:
      • Cytokins (chemical messengers)
      • Growth factors that promote angiogenesis
      • Inactivated immune system
  • Statistics
    • Second most prevalent blood cancer
    • Approximately 1% of all cancers and 2% of all cancer deaths.
    • 45,000 currently have multiple myeloma
    • 14,600 new cases of myeloma each year.
    • Responsible for more than 10,000 deaths in the United States annually.
    • 5 year survival rate
    http://www.multiplemyeloma.org/about_myeloma/2.03.asp
  • Causes
    • Is not known for sure
    • Decline in the immune system
    • Biological factors
    • Certain occupations
    • Exposure to certain chemicals
    • Exposure to radiation
    • Virus
  • Symptoms
    • Abnormal proteins
      • Blood and urine
      • Polyclonal to Monoclonal proteins
    • High level of calcium in blood
      • Excessive thirst and urination
      • Sleepiness
      • Constipation
      • Nausea
      • Loss of appetite
      • Mental confusion
  • Symptoms Continued
    • Anemia
    • Fatigue
    • Bone pain
      • Back
      • Ribs
    • Unexplained bone fractures
    • Repeated infections
      • Pneumonia
      • Bladder and kidney infection
      • Urinary tract infection
    • Weight loss
    • Weakness and numbness in limbs
  • Screening and Diagnosis
    • Blood and urine tests
    • X-rays
    • Magnetic Resonance Imaging (MRI)
    • Computerized Tomography (CT)
    • Bone marrow examination
  • Staging
    • Stage 1
      • Low amount of myeloma
    • Stage 2
      • Medium amount of myeloma
    • Stage 3
      • High amount of myeloma
    • A
      • Normal kidney function
    • B
      • Abnormal kidney function
  • Treatment Options
    • Chemotherapy
    • Stem cell transplantation
    • Radiation therapy
    • Bortezomib (Velcade)
    • Thalidamide
  • Thank you for your time
    • Any Questions
    • ?