5/6/2010 Sarah O'Brien, MD, MSc Curriculum Vitae Current Position ...Document Transcript
Sarah O'Brien, MD, MSc
Current Position: Assistant Professor of Pediatrics,
Division of Hematology/Oncology,
The Ohio State University
Investigator, Center for Innovation in Pediatric Practice,
The Research Institute at Nationwide Children’s Hospital
Work Address: 700 Children’s Drive Suite JW4986
Columbus, OH 43205
Work Phone: 614/722-3066
1992-96 University of Virginia, BA, Interdisciplinary Studies/Echols Scholar
1996-00 University of Pittsburgh, MD, Medicine
2000-03 Children’s Hospital of Pittsburgh, Pediatrics Residency
2003-06 Children’s Hospital of Pittsburgh, Pediatric Hematology/Oncology Fellowship
2004-06 University of Pittsburgh, MSc, Clinical Research
2010 Invited Faculty, American Society of Hematology Clinical Research Training Institute
2009 National Institutes of Health Pediatric Research Loan Repayment Program - Renewal
2007 National Institutes of Health Pediatric Research Loan Repayment Program
2007 Hemophilia and Thrombosis Research Society Career Development Award
2006 American Society of Hematology Fellow Scholar Award
2006 Wallace H. Coulter Foundation Scholar
(awarded to the recipient of an ASH Scholar Award with the highest scored
clinical/translational research application)
2005 American Society of Hematology Clinical Research Training Institute
2004 Hemophilia and Thrombosis Research Society, Clinical Thrombosis Research Award
2003 Mark A. Sperling Resident Research Award, Children’s Hospital of Pittsburgh
2003 Children’s Hospital of Pittsburgh Primary Care Award
2002 Region III Ambulatory Pediatric Association Research Award
2000 Alpha Omega Alpha
2003 American Society of Hematology
2004 American Society of Pediatric Hematology/Oncology
2004 Hemophilia and Thrombosis Research Society
2010 Review Panel, Pilot and Collaborative Translational and Clinical Studies Program, The
Ohio State University CTSA
2009 Peer reviewer: Journal of Pediatrics (3), Pediatric Blood & Cancer (2), Clinical
20008-present Review Panel, Clinical and Translational Research Intramural Funding Program, The
Research Institute at Nationwide Children’s Hospital
2008 Peer reviewer: Pediatric Blood & Cancer (5), Thrombosis Research, Journal of Pediatric
2007 Peer reviewer: Journal of Pediatric Hematology/Oncology (2), Pediatrics, Journal of
2006 Peer reviewer: Journal of Pediatrics
2006 Abstract Reviewer/Oral Session Moderator, American Society of Hematology
2005 Peer reviewer, Pediatrics
2010 O'Brien, SH. Candrilli, SD. In the absence of a central venous line, risk of venous
thromboembolism low in critically injured children, adolescents, and young adults: evidence from
the National Trauma Data Bank. Pediatric Critical Care Medicine. (in press)
2010 O'Brien SH, Fan L, Kelleher KJ. Inpatient use of laxatives during opioid administration in
children with sickle cell disease. Pediatric Blood & Cancer. 2010 Apr;54(4):559-62. Jan.
2009 O’Brien SH, Hankins JS. Decision analysis of treatment strategies in children with severe sickle
cell disease. Journal of Pediatric Hematology & Oncology. 2009 Nov;31(11):873-8. PMID:
2009 O’Brien SH, Smith KJ. Using thrombophilia testing to determine anticoagulation duration in
pediatric thrombosis is not cost-effective. Journal of Pediatrics. 2009 Jul;155(1):100-4. PMID:
2009 O'Brien SH. Secondary data demonstrate safety of splenectomy in spherocytosis. Pediatric
Blood & Cancer. 2009 Jul;52(7):753-4. PMID: 19326407
2009 Cavo M, Wang W, O'Brien SH. Use of low molecular weight heparin for thromboprophylaxis in
a pediatric inpatient population: reasons for use and incidence of bleeding complications.
Thrombosis Research. 2009 Apr 13. [Epub ahead of print] PMID: 19368960
2009 Candrilli SD, Balkrishnan R, O’Brien SH. Effect of injury severity on the incidence and
resource utilization-related outcomes of deep vein thrombosis among pediatric trauma admissions
in the United States. Pediatric Critical Care Medicine. 2009 Sep;10(5):554-7. PMID: 19451844
2009 Hyatt SA, Wang W, Kerlin BA, O’Brien SH. Applying diagnostic criteria for type 1 von
Willebrand disease to a pediatric population. Pediatric Blood & Cancer. 2009 Jan; 52(1): 102-7.
2008 Standridge SM, O’Brien SH. Idiopathic intracranial hypertension in a pediatric population: a
retrospective analysis of the initial imaging evaluation. Journal of Child Neurology. 2008 Nov;
23(11): 1308-11. PMID: 18984841
2008 O’Brien SH, Haley K, Wang W, McKenna C, Perdue K, Gaines B. Variation in DVT
prophylaxis for adolescent trauma patients: a survey of the Society of Trauma Nurses. Journal of
Trauma Nursing. 2008;15(2):53-57. PMID: 18690134
2008 O’Brien SH. Decision analysis in pediatric hematology. Pediatric Clinics of North America.
2008 Apr;55(2):287-304. PMID: 18690134
2008 O’Brien SH, Kaizar EE, Gold MA, Kelleher KJ. Trends in prescribing patterns of hormonal
contraceptives for adolescents. Contraception.2008 Apr;77(4):264-269. Epub 2008 Mar 4.
2007 O'Brien SH, Lee H, Ritchey AK. Once-daily enoxaparin in pediatric thromboembolism: a dose
finding and pharmacodynamics/pharmacokinetics study. Journal of Thrombosis and
Haemostasis. 2007 Aug 17;5(9):1985-1987. PMID: 17596139
2007 Lampel HP, Patel N, Boyse K, O’Brien SH, Zirwas MJ. Prevalence of hand dermatitis in
inpatient nurses at a United States hospital. Dermatitis. 2007 Sep;18(3):140-2. PMID: 17725920
2007 Lee PL, Lemos B, O’Brien SH, English JC, Zirwas MJ. Cutaneous diphtheroid infection and
review of other cutaneous Gram-positive Bacillus infections. Cutis. 2007 May;79(5):371-7.
2007 O’Brien SH, Ritchey AK, Ragni MV. Combined clotting factor deficiencies: experience at a
single hemophilia treatment center. Haemophilia. 2007 Jan;13(1):26-9. PMID: 17212721
2007 O’Brien SH, Ritchey AK, Smith KJ. A cost-utility analysis of treatment for acute childhood
idiopathic thrombocytopenic purpura (ITP). Pediatric Blood Cancer. 2007 Feb;48(2):173-80.
2004 O’Brien SH, Reis EC. Identification, evaluation, and management of obesity in an academic
primary care center. Pediatrics. 2004 Aug;114(2). e154-9. PMID: 15286251
2010 Reed S, Klima J, Schwarz EB, O’Brien SH. Prescription Contraception Use in Adolescents and
Young Adults with Sickle Cell Disease: Analysis of Michigan Medicaid Claims. Poster
presentation at 23rd annual meeting of the American Society of Pediatric Hematology/Oncology,
April 7-10, 2010, Montréal, Quebec. Canada
2010 Setty B, O’Brien SH, Kerlin BA. Pediatric venous thromboembolism: redefining epidemiology.
Abstract presentation at the National Conference on Blood Disorders in Public Health, Atlanta,
GA, March 9-11, 2010.
2009 Marcus PD, Nire KG, Grooms L, Klima J, O’Brien SH. The power of a standardized bleeding
score in diagnosing pediatric type 1 von Willebrand disease. Abstract presented at the 51st
American Society of Hematology Annual Meeting, New Orleans, LA, December 5-8, 2009.
2009 Bollinger LM, Rhodes MM, Nire KG, Chisolm DJ, O’Brien SH. Caregivers’ perspectives on
barriers to transcranial Doppler screening in children with sickle cell disease. Abstract presented
at the 51st American Society of Hematology Annual Meeting, New Orleans, LA, December 5-8,
2009 Candrill SD, O’Brien SH, Ware RE, Balkrishnan R. Hydroxyurea adherence and associated
outcomes in Medicaid enrollees with sickle cell disease. Abstract presented at the 51st American
Society of Hematology Annual Meeting, New Orleans, LA, December 5-8, 2009.
2009 Young G, Yee DL, Khanna R, O’Brien S, Nugent DJ. Fondaparinux for the treatment of
thrombosis in children: a prospective, dose-finding, pharmacodynamic and safety study.
Abstract presented at the 51st American Society of Hematology Annual Meeting, New Orleans,
LA, December 5-8, 2009.
2009 Candrilli SD, Balkrishnan R, O'Brien SH. Changes in rates of sickle cell disease-related
inpatient stays and associated resource use among African Americans in the United States
following approval of hydroxyurea. Abstract presented at the ISPOR 12th Annual European
Congress, October26, 2009 at Le Palais des Congrès de Paris in Paris, France.
2008 Powell KK, Wang W, Kelleher KJ, O’Brien SH. Use of SSRIs not associated with increased
bleeding events in children: an analysis of the Michigan Medicaid database from 2000-2003.
Abstract presented at the 50th annual American Society of Hematology Annual Meeting, San
Francisco, CA, December 6-9, 2008.
2008 Gaines BA, O’Brien S, Rodeberg D, McKenna C, Miller M, Sippey M, Dickson J, Ritchey AK.
Management of children at risk for deep venous thrombosis: results of a clinical guideline.
Abstract presented at the 67th Annual Meeting of the American Association for the Surgery of
Trauma, Maui, HI, September 24, 2008.
2008 Fernandez KS, O’Brien SH. Physician knowledge and attitudes regarding contraception and
DVT risk in adolescents. Abstract presented at the 4th Annual Hemophilia and Thrombosis
Research Society Scientific Symposium,Chicago, IL, April 17–19, 2008.
2007 Ritchey AK, Keller FG, O’Brien SH. Hematologic Manifestations of Childhood Illness. In:
Hoffman R, Benz EJ, Shattil SJ, Furie B, Cohen HJ, Silverstein LE, McGlave P (eds):
Hematology. Basic Principles and Practice: 5th Ed. New York, Elsevier, Churchill Livingstone.
2003 O’Brien S, Holtzer K. Hematology/Oncology. In: Kahan S, DeAntonis K. Pediatrics in a Page.
Blackwell Publishing. 2003.
Regional/National Speaking Engagements:
2010 Management and Prevention of Cancer-Related Thrombosis
American Society of Pediatric Hematology/Oncology, 4/10/2010, Montreal, Canada
2007 Anticoagulation in Pediatrics: Thin Evidence on Blood Thinners in Kids
National Hemophilia Foundation Annual Meeting, 11/1/2007, Denver, CO.
Grant Number Title Role in Project Years Source
Percentage Effort Inclusive
1R01HL095110-01 Dose-finding, Co-Investigator 2008-2010 National Heart,
Pharmacokinetic, Safety 2% Lung, Blood
and Efficacy of Bivalirudin PI = Guy Young Institute
R03 HS017344-01 DVT Prevention in Principal 2007–2009 Agency for
Pediatric and Adolescent Investigator Healthcare Research
Trauma Patients: Safety 15% and Quality
R01 FD003091-03 Fondaparinum in Co-Investigator 2008–2009 Food and Drug
children with thrombosis (Site PI) Administration
PI = Guy Young
ASH Fellow Thrombophilia Screening Principal 2006–2008 American Society of
Scholar Award in Children with Venous Investigator Hematology
Thromboembolism: Cost- 35%
Once-Daily Enoxaparin for Principal 2005-2006 General Clinical
the Treatment of Pediatric Investigator Research Center,
Thromboembolic Disease Children’s Hospital