Interesting medical news presentation

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Here I show to you very interesting research news and medical utility. We can see the future of the epigenetics and molecular medicine. …

Here I show to you very interesting research news and medical utility. We can see the future of the epigenetics and molecular medicine.

Universidad Pontificia Bolivariana
Medicina School

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  • 1. EPIGENETICS ALTERS GENESIN RHEUMATOID ARTHRITIS //ANXIETY LINKED TOSHORTENED TELOMERES,ACCELERATED AGING
  • 2. INTRO Telomeres are located at the end of eukaryotic chromosomes Epigenetics not affect de DNA sequence but vary its expresion Short telomeres are a marker of cellular aging Cytosine methylation Process used in epigenetic
  • 3. EPIGENETICS ALTERSGENES IN RHEUMATOID ARTHRITIS  Rheumatoid arthritis is an autoimmune disease in which joints, usually including those of the hands and feet, are symmetrically inflamed  The immune system attacks the tissue that lines and cushions joints
  • 4. EPIGENETICS ALTERSGENES IN RHEUMATOID ARTHRITIS  DNA methylation is the addition of a methyl group at the 5 position of cytosine pyrimidine ring  This modification can be inherited through cell division  DNA methylation also plays a crucial role in the development of almost all cancers  The Cytosine methylation decrease gene expression
  • 5. EPIGENETICS ALTERSGENES IN RHEUMATOID ARTHRITIS  The researchers had evaluated the autoimmune process in fibroblast-like synoviocytes (FLS) isolated from the site of the disease in RA  FLS interact with the immune cells in RA  They looked and compared the methylation patterns with patients with non inflammatory joint disease
  • 6. EPIGENETICS ALTERS GENES IN RHEUMATOID ARTHRITIS They found hypomethylation of individual genes was associated with increase gene expression and occurred in multiple pathways critical to inflammatory responses They concluded: : Differentially methylated genes can alter FLS gene expression and contribute to the pathogenesis of RA
  • 7. PERSONAL PERSPECTIVE  This inflammatory disease affect million of people in the world. Many investigations are searching therapies to RA. Epigenetics can be the way to find a cure
  • 8. ANXIETY LINKED TOSHORTENED TELOMERES, ACCELERATED AGING  The cellular aging is correlated with the shortening of telomeres and the free radicals too  Cell DNA doubles before the division is not able to copy all of the telomere sequence and as a result, the telomere becomes shorter at each replication, the loss of about 50 to 200 nucleotides in each cycle of cell division
  • 9. ANXIETY LINKED TOSHORTENED TELOMERES, ACCELERATED AGING A cause of aging are the shortened telomeres. They shorten with each cell replication that makes and in a determinate moment they are very short and this is the aging When the telomeres are too short, or damaged, it activates an emergency system specific for the irretrievable breakdown of DNA, the cycle stops and the cell enters the phase of aging
  • 10. ANXIETY LINKED TO SHORTENED TELOMERES, ACCELERATED AGING Researches had obtained blood samples from 5243 women Using the samples the researchers analyzed telomere lengths Having a high phobic anxiety level was associated with significantly shorter telomere lengths
  • 11. ANXIETY LINKED TO SHORTENED TELOMERES, ACCELERATED AGING Olivia Okereke MD said: “… This study is notable for showing a connection between a common form of psychological stress -- phobic anxiety -- and a plausible mechanism for premature aging. However, this type of study design cannot prove cause-and-effect or which problem came first -- the anxiety or shorter telomeres.“ The results are a prove for correlation between external factors how stress and anxiety with the length of telomeres
  • 12. PERSONAL PERSPECTIVE Well as the anxiety is related to aging, should be also many other disorders that affect people and medicine can come in and play a role in this, trying to make a patients emotional valuation when reaching consultation and try to help them overcome their emotional distress and related diseases so avoid these factors
  • 13. MEDICAL UTILITY With all the epigenetic investigations we can think in a cancer future cure because the DNA methylation play an important role in the development of this disease
  • 14. MEDICAL UTILITY The doctors must to do a correct promotion and prevention of diseases caused for cellular aging and a correct emotional valoration to the patient to avoid stress and states that can accelerate the aging
  • 15. MEDICAL UTILITY The epigenetic investigations are opening the doors to new treatments for different pathologies. With the researches some day we will can treat a lot of diseases with manipulation of genome
  • 16. MEDICAL UTILITY With all this investigations in the future we will can find specific target sites for drugs interactions and find a cure or an new effective therapy
  • 17. BILBIOGRAFIAS ANXIETY LINKED TO SHORTENED TELOMERES, ACCELERATED AGING, ScienceDaily, (July 11,2012), Available on web: http://www.sciencedaily.com/releases/2012/07/120711210102.htm EPIGENETICS ALTERS GENES IN RHEUMATOID ARTHRITIS, ScienceDaily, (July 3, 2012), Available on web: http://www.sciencedaily.com/releases/2012/07/120703172549.htm http://www.epigenetica.org/?page_id=150 MARTINEZ SÁNCHEZ, Lina María. Biología molecular. 7. ed. Medellín: UPB. Fac. de Medicina, 2012. 300 p. BERLOW, Robert. BEERS H, Mark. The merk manual of medical information. USA. 1997.1509p.
  • 18. Thanks!!....