Course = VPAT- 801 Submitted to: Dr. D. V. Joshi Professor and Head, Veterinary Pathology Department, Sardarkrushinagar Dantiwada Agricultural University, Submitted by: Chirag M. Modi Reg. no.- 04-0442-08
Primary union ( healing by 1st intention) -Healing of a clean linear wound /surgical incision with sligth damage of tissues space fills with clotted blood 24 hs:PMN´ mitoses of basal epithelium dehydration at surface scab Primary Intention
Primary union(cont.) A. 1-2 days epithelial cells grow along cut surface B. 3 days macrophages /granulation tissue C. 5 days space filled /granulation tissue D. 2nd wk. accumulation of collagen, fibroblasts E. End of 1st month connective tissue devoid of inflammation, epidermis restored F. Tensile strength increases 70-80% of unwoun ded skin in 3 months
means the healing of a wound where there is a more extensive of tissue that has gradually to be filled in and replaced by new connective tissue. Healing by second intention
The wound is initially cleaned, debrided and observed, typically 4 or 5 days before closure.
The wound is purposely left open
Tertiary Intention (Delayed primary closure)
Within a few weeks, the rapidly dividing epidermis completely lines the original wound site. The fibroblasts generate new connective tissue (scar tissues), which replaces the epidermis destroyed by the wound. Scar tissue persists after the healing of particularly severe wounds .
- CNS gliosis ( may cause hydrocephalia) -PNS neurons can regenerate their axons in ideal conditions, but lack of alignment or inflammation traumatic “neuroma” (Schwann cells+fibroblasts ) -Lungs interstitial pulmonary fibrosis or peribronchial fibrosis bronchectasis -Pleura pleural fibrosis/adhesions(TB ) HEALING IN SPECIFIC TISSUES
-Stomach fibrous stenosis of pylorus (gastric ulcer) -Rectosigmoid fibrous stenosis due to ven. diseases -Liver cirrhosis -Fallopian tubes fibrous occlusion due to P.I.D. -Skin contracture / deformation(burns) HEALING IN SPECIFIC TISSUES(cont)
-Myocardium fibrosis ventricular aneu- rysm -Endocardium valvular fibrosis +deformat. -Pericardium constrictive pericarditis,peri cardial adhesions -Peritoneum adhesions and fibrous bands -Esophagus fibrous stricture(due to burns) HEALING IN SPECIFIC TISSUES(cont)