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  1. 1. FATHER SEAN O’SULLIVAN RESEARCH CENTRE Research at St. Joseph’s Healthcare
  2. 2. FSORC Annual Report 2001-2002 Research at St. Joseph's Healthcare, a leading academic health sciences centre, involves 132 researchers who are members of the Father Sean O’Sullivan Research Centre. These investigators have produced many exciting discoveries in the past year, some of which are featured in this report. Their work contributes to continuing improvements in patient care. Core funding from our partners, McMaster University and the St. Joseph's Healthcare Foundation, supports the research at St. Joseph's Healthcare. The generous support of donors and of the volunteers who participated in studies are important contributions to research. In the past year, researchers have been awarded more than $17 million in research grants and contracts from external agencies and industry. The growth and research excellence has been supported by significant investments from the Ontario Government and Ministry of Health, Canadian Institutes of Health Research, Canada Foundation for Innovation, Ontario Innovation Trust, Ontario Research and Development Challenge Fund, and Canadian Health Infrastructure Partnerships Program. With awards of more than $40 million in research infrastructure funding since 1998, research at St. Joseph’s Healthcare is experiencing tremendous growth. Joint ventures and alliances with industry have played an important role and demonstrate the benefits of collaboration that lead to improvements in health through advances in diagnoses and treatment of disease as well as economic benefits for the community. Major research partnerships in the past year include CTI Inc., G.E. Medical Systems Canada, and GlaxoSmithKline Inc. St. Joseph's Healthcare is proud to share research that has led to many significant advances in patient care. In partnership with St. Joseph's Healthcare Foundation and McMaster University continued growth of research at St. Joseph's Healthcare will be under the leadership of the newly appointed Vice President, Research and Director of Father Sean O’Sullivan Research Centre, Jennifer Sturgess.
  3. 3. FSORC Annual Report 2001-2002 Father Sean O'Sullivan Research Centre External Funding 1993-2002 6.3 7.3 7.8 8.8 9.7 10.9 17.3 3.1 12.3 17.0 0 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 inMillions
  4. 4. FSORC Annual Report 2001-2002 FSORC Total Operating Funds 2001-02 Total Funding: $ 22,219,144 15% 7%3%4% 22% 7% 1% 3% 4% 4% 1% 29% Private Sector Capital Funding (CFI) CIHR Provincial Funding Voluntary Health Associations & Foundations Educational-Related Funding International Agencies Other Agencies & Foundations Other National Agencies Core Funding Peer Reviewed Personnel Awards Private Sector Personnel Awards
  5. 5. FSORC Annual Report 2001-2002 External Funding by Research Program 2001-2002 $ 17,278,928 7,965,177 3,320,374 1,622,242 1,083,092 477,984 736,328 588,691 424,765 417,640 297,562 345,073 - 1,000,000 2,000,000 3,000,000 4,000,000 5,000,000 6,000,000 7,000,000 8,000,000 9,000,000 Respiratory CEM /Health StatusM entalHealth M usculoskeletal Throm bo/CardiacCriticalCare Kidney/UrinaryM icrobiology CM A S and SurgicalO utcom es M aternal/New born O ther Funding
  6. 6. FSORC Annual Report 2001-2002 External Funding by Academic Department St. Joseph's Healthcare Researchers 2001-02 $17,278,928 1,014,327 504,765 417,640 324,462 188,229 1,866,527 12,962,978 - 1,000,000 2,000,000 3,000,000 4,000,000 5,000,000 6,000,000 7,000,000 8,000,000 9,000,000 10,000,000 11,000,000 12,000,000 13,000,000 14,000,000 15,000,000 16,000,000 M edicine CE&B Psychiatry & Behavioural Neurosciences Pathology & M olecular M ed. Surgery Obs & Gynec Diagnostic Imaging Funding
  7. 7. FSORC Annual Report 2001-2002 Father Sean O’Sullivan Research Centre Expenditures 2001-02 Total $1,200,000 26% 27% 18% 13% 4% 1% 1% 1% 8% 1% Career Aw ards Research Grants Allocation Salaries & Wages Research Administration Studentships New Investigator Grants Health Economics Biostatistical Services (excluding Salaries) Finance Administration Public Relations
  8. 8. Career Awards Dr. Gerard Cox 1995-2003 Dr. Frederick Hargreave 1996-2004 Firestone Institute for Respiratory Health Centre for Evaluation of Medicines Dr. Bernie O’Brien 2001- Dr. Mitchell Levine 2001-2006 Dr. Rolf Sebaldt 1997-2005 Brain Body Institute Dr. Boris Sakic 2001-2004*
  9. 9. Career Awards Dr. Damu Tang 2000 – 2003/6 Kidney & Urinary Disease Obstetrics & Gynecology Critical Care Dr. Rory McDonagh 2001-2004* Dr. J. McMullin 2002- 2005
  10. 10. Career Awards – Dr. Gerard Cox • Inflammation of the lung • How steroids work • Non-invasive ways to detect disease - Asthma - Early Detection of cancer “Lung Alert” • Novel surgical approaches for treatment of asthma Chair: Ontario Thoracic Society Advisor: MOHLTC – Asthma Chair: Canada Asthma Consensus Guidelines
  11. 11. Career Award – Dr. Frederick Hargreave  Understanding and treating asthma and lung disease  Objective measures of airway inflammation  Predictive tests for diagnosis and treatment of asthma, based on sputum analysis that have been adopted internationally Honorary Awards: • Canadian, American and International Allergy, Asthma and Immunology Associations • Queen Elizabeth Golden Jubilee Medal
  12. 12. Career Awards – Dr. Rolf Sebaldt  Studies of the “Care Gap” – between real world of clinical care and current standards of evidence-based medicine  Primary Care Practice to improve health and reduce the need for hospitalization - Osteoporosis “Guelph-Edmonton Project” and “Candoo” - Osteoarthritis “Candoo” - Bone Health  Electronic medical record system for emergency psychiatric care at St. Joseph’s Healthcare.
  13. 13. Career Award – Dr. Bernie O’Brien  Cost effectiveness of new drugs, devices and technologies  Economic evaluation and priority setting in health care e.g. heart disease  Patient preferences in colorectal cancer screening methods  Health Technology evaluation: - PET imaging for lung, breast, head & neck cancers - Repair of aortic aneurysm -Use of drug-eluting stents Health Technology Assessment for MOHLTC $3 million over 3 yrs
  14. 14. Career Awards – Dr. Boris Sakic  Investigation of immune and inflammatory mediators in mental disorders  Identification of toxic antibodies in the cerebrospinal fluid of patients with autoimmune disease and with mental disorders  Investigations of toxic effects of antibodies on neurones in the brain  Diagnosis and treatment of neuropsychiatric lupus erythematosus  Research will improve understanding of several common mental disorders including schizophrenia, epilepsy, autism and alzheimer’s disease
  15. 15. Career Awards – Dr. Damu Tang  Basic scientific research in kidney disease and prostate cancer  With Dr. Ingram, has had a major impact on research in Nephrology  Studies of programmed cell death or “apoptosis” and the regulatory mechanisms that are involved. Key area of science since disruption contributes to several diseases such as kidney disease, diabetes, and alzheimer’s disease  Targeted studies on the “signals” to suppress tumour growth in prostate cancer  Investigate of pTEN – a tumour suppressor – and how its normal function is compromised in patients with prostate cancer Grants and awards from CIHR, Kidney Foundation of Canada, Prostate Cancer Research Foundation, National Cancer Institute of Canada
  16. 16. Career Award – Dr. Rory McDonagh  Risk management, particularly in obstetrical care  Awareness of legal principles among clinicians so that they can apply knowledge to improve quality of care and clinical decision making  Clinical practice guidelines: a systematic review of Canadian legal cases involving guidelines. – Are they rigorous? – Are they applied? – Are they used by legal system as medical standard of care? – Will they supplant the role of “medical expert” in legal proceedings?
  17. 17. Career Awards – Dr. Joe McMullin  Control of glucose in critically ill patients “LOGIC”  Clinical Practice in Intensive Care such as thromboprophylasix
  18. 18. Nursing Awards  Canadian Institute of Health Research – St. Joseph’s Healthcare – McMaster University  Career Awards – National stature  Support Nursing Research – Janet Landeen – Psychiatry – Jenny Ploeg – Community Care
  19. 19. Nursing Awards  Co-Director of Community Care Research Centre  Factors contributing to homelessness of seniors and interventions to stabilize housing and health care  Guidelines and Nursing “Best Practices” in community care  Early interventions to minimize progression of schizophrenia  Approaches to minimize side- effects of anti-psychotic drugs  Spirituality group therapy for severe mental illness  Psychiatric/mental health education and certification program for nurses Jenny Ploeg 2002-2006 Janet Landeen 2002-2006
  20. 20. Research Training FSORC Awards Graduate students: MSc and PhD Postdoctoral Fellowships: MD and PhD
  21. 21. Studentships MSc Degree Program Kalpana Nair CEM 2000-2002 Nicole Brazier CEM 2001-2002 Lizhi He Nephrology 2001-2002 Kiran Pohar CEM 2001-2002 David Southam FIRH 2001-2003 Dustin Johnson Microbiology 2001-2003 Jarrold Cosby CEM 2002-2004 Sumeet Singh CEM 2002-2003 David Ballok BBI 2002-2003
  22. 22. Studentships In the Centre for Evaluation of Medicines …  Treatment of type 2 diabetes – benefits and risks  How do we improve the quality of life for patients with chronic disease? Kalpana Nair Sumeet Singh Nicole Brazier  Use of herbal and natural supplements in Canada  What are the potential adverse reactions and interactions with conventional drugs?  Interactions among herbal remedies and conventional medications  A compendium of herbal information for physicians and of potential dangers of using herbal and conventional medication
  23. 23. Studentships In Kidney and Urinary Disease…  Basic scientific work in prostate cancer  Why does the tumor suppressor (pTEN) no longer function in prostrate cancer? Lizhi He
  24. 24. Studentships In Microbiology …  Investigation of Chlamydia pneumoniae invades, and persists in the lung, causing pneumonia and other complications  Understanding the way Chlamydia attacks the host cells, can we find new ways to treat infection? Dustin Johnson
  25. 25. Studentships In Respiratory Health …  Fundamental scientific research on the nature and trafficking of cells to sites of inflammation in the lung, after exposure to allergens  Understanding of the inflammatory process in respiratory disease, can we prevent or better treat asthma? David Southam
  26. 26. Research Fellowships – Mental Health  Clinical research on depression in new mothers  Intervention to reduce sleep deprivation after delivery to reduce the prevalence of post-partum depression  Focus on women at risk – with a history or psychiatric illness – and then extend to all obstetrical patients. Lori Ross PhD 2002 – 2004 (with Dr. M. Steiner)
  27. 27. Research Fellowships – Respiratory Health  Clinical research in asthma and allergy  Investigations of smoking and aspiration from gastro- oesophageal reflux  Nasal challenge test for nasal inflammation to evaluate new treatment  Clinical trials of drugs to seasonal allergic rhinitis and asthma Andrew Wilson, MD 2002 – 2003
  28. 28. Research Programs Peter Margetts Deb Cook
  29. 29. Research Administration “The unsung heroes!” SJH and SJHF support staff, Finance, Redevelopment, Public Relations
  30. 30. “RESEARCH IS OUR FUTURE” FSORC Recommendations for 2003  Focus awards on trainees and young investigators  Increase number of fellowships  Incentives for trainees to compete for external funds  Dedicate career awards to young investigators  Encourage multidisciplinary research and collaboration
  31. 31. Research Program – Critical Care  Intensive Care medicine  Clinical studies in ICU to improve treatment for seriously ill patients particularly those with post- operative complications and organ failure  Studies include: - Blood clots - End of life issues -Mechanical ventilation Dr. Deborah Cook
  32. 32. Research Program – Surgical Outcomes Research Centre (SOURCE)  Joint venture of St. Joseph’s Healthcare Foundation and McMaster University  Evidence-based surgery workshops  Application of research knowledge and advances in technology: - To interpret and apply evidence to surgery, building on good scientific evidence - To improve clinical and surgical practice Dr. Ved Tandan