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FATHER SEAN O'SULLIVAN RESEARCH CENTRE

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  • 1. FATHER SEAN O’SULLIVAN RESEARCH CENTRE Annual Report 2003 - 2004
  • 2. OUR HERITAGE “The wonders of modern medicine have been surpassed only by the tremendous human kindness of such dedicated doctors, nurses, their co-workers and those countless individuals whose prayers and concern have touched my heart”. Father Sean O’Sullivan
  • 3. THIS REPORT “Young Investigators” 1. Our Report Card to You – Use of Foundation Funds – Research Outputs – Financial Indicators 2. Our Young Scientists and how they help patients
  • 4. “Peer Reviewed” This term typically means one of two things; either your research was chosen for publication or your research proposal was chosen for funding and the decision was made by a group of your scientific peers - a panel of independent experts. For a scientist, peer reviewed funding or publication is very prestigious.
  • 5. Kidney & Urinary Researchers Christian Rabbat is investigating the risk of bleeding in haemodialysis patients and how we can minimize it. Note: St. Joseph's Healthcare has 500 patients in dialysis. Joan Krepinsky studies cell signaling and the mechanisms of progression of chronic kidney disease. Catherine Clase looks at factors that lead to cardiovascular disease in dialysis patients, and therapies that will prevent vascular and thrombotic complications. Peter Margetts is investigating fibrosis and angiogenesis in the peritoneum, using molecular biology to determine their role in kidney disease.
  • 6. HOW WE USED FOUNDATION RESOURCES Anne and Neil McArthur Research Award Career Awards + Salaries $ 661,954 Biostatistical & Other Services $ 202,109 Infrastructure $ 127,415 Administration $ 208,523 TOTAL $ 1,200,000 FIRH Support $450,000 DK: Numbers taken from 03/04 Budge projection not actuals DK: Numbers taken from 03/04 Budge projection not actuals
  • 7. LIST OF CURRENT FSORC AWARDEES Career Awards - Dr. M. Levine, CE/Health Services - Dr. B. Sakic, Mental Health/BBI - Dr. M. Smeija, Infection - Dr. D. Willison, CE/Health Services - Dr. R. Labiris, Respiratory/Thoracic Fellowship Awards - Dr. D. Wu, Kidney & Urinary - Dr. T. Sinuff, Clinical Research Studentship Awards - Mr. J. Cosby, CE/Health Services - Mr. D. Ballok, Mental Health/BBI - Mr. D. Johnson, Infection
  • 8. External Research Funding Fiscal Year Ending 1993 – 2004 (Based on Cash Deposits) 3.1 6.3 7.3 7.8 8.8 9.7 10.9 11 12.7 13.3 18.5 19.1 3.3 1.1 7 4.8 1.1 0 5 10 15 20 25 1993 1994 1995 1996 1997 1998 1999 2000 2001 2002 2003 2004 FundinginMillions Capital Operating
  • 9. LIST OF CURRENT CHAIRS  Dr. P. O’Byrne – Moran Campbell Chair in Respiratory Medicine  Dr. M. Sears – AstraZeneca Chair in Respiratory Epidemiology  Dr. J. Miller – Mortgage Intelligence/GMAC Residential Funding of Canada Chair in Thoracic Surgery  Dr. D. Cook – Canada Research Chair, Research Transfer in Intensive Care  Dr. J. Kips – Canada Research Chair  Dr. R. Swinson – Morgan Firestone Chair in Psychiatry  Dr. M. Anvari – J&J Chair in Minimally Invasive Surgery and Surgical Innovation
  • 10. Respirology/Thoracic Researchers Param Nair is a CIHR clinical scientist. His research interests are airway inflammation in asthma and COPD. Martin Kolb is studying the pathogenesis of chronic inflammation and fibrosis in the lung. Renee Labiris, is a Pulmonary Pharmacologist investigating the delivery to the lung of therapeutic aerosols.
  • 11. Publications in Past 5 Years Summarized by Program Peer reviewed articles Non-Peer reviewed articles Book Chapters Reports Abstracts CE/Health Serv. 275 19 28 80 326 Clinical Res. 443 30 69 399 Infection 143 10 38 16 245 Kidney/Urinary 154 8 5 3 134 Mental Hlth/BBI 265 21 114 4 535 Resp/Thoracic 416 42 57 11 457 TOTALS 1696 130 311 114 2096
  • 12. Clinical Researchers Mark Crowther, MD, is an Associate Professor in the Department of Medicine. His research interest is focused on management of patients with antiphospholipid antibodies, including patients with recurrent pregnancy loss, and on studies designed to optimize oral anticoagulant therapy.
  • 13. Current “Snapshot” Students and Trainees Summarized by Program Residents (involved in research) Clinical research fellows MSc students Under- graduate students CE/Health Serv. 9 4 Clinical Res. 6 3 3 3 Infection 9 1 3 1 Kidney/Urinary 10 1 7 5 Mental Hlth/BBI 2 1 9 8 Resp/Thoracic 2 5 6 4 TOTALS 29 11 37 2525 33 10 3 7 2 4 2 9 9 3 2 2 5 Post-doctoral fellows PhD students
  • 14. Mental Health/BBI Researchers Michael Noseworthy is an imaging scientist (MRI), his research interests focus on microcirculation and in MR spectroscopy. Geoffrey Hall’s main research focus is the application of neuro- imaging (PET and MRI) to mental health disorders such as depression, autism and social phobia. Jane Foster’s main area of research interest is psycho-neuroimmunology. Her laboratory uses genetic, pharmacological, biochemical, neuroanatomical, and molecular biological approaches to investigate psychiatric disorders such as depression.
  • 15. CHALLENGES FOR SCIENTISTS  Shift from “curiosity” to “contractualized research”  More “strings” attached to funding  Less flexibility in use of funds  More legislative requirements (e.g. ethics and privacy)  Scientists spend more of their time getting the fund for their salaries and research – less time for research  Shift from academic to business model  Expectation of economic benefit for Canada
  • 16. Why is the Foundation so Critical to Research at SJHH  Peer Review (supports science) Usually a foundation or government funded agency. Use panels of scientists to carefully select projects to be funded based on scientific merit.  Government (supports government policy goals) Provide research funding to projects that support government policies.  Industry (supports profits) Provide funding to support research that will: - lead to new commercial discoveries/technologies - support government approval of products
  • 17. Where Our Funding Comes From Total Funding $ 20,261,388 2003 – 2004 (Based on Cash Deposits) Government 25% Industry 26% Agencies (Peer Reviewed) 26% Other External Agencies (Non peer-reviewed) 16% Foundation 7%
  • 18. WHY FOUNDATION? As the only truly “flexible” SJHH source of funding aligned with our Mission for our community you: - Create a synergy with McMaster University - Support research enterprise and unleash the research capacity of our clinicians and scientists - Leverage $20 million plus capital for research - Create career building blocks for Canadian talent - Attract research talent to our community - Create superb programs and high quality jobs
  • 19. CE/Health Services Researchers Lisa Dolovich, BScPhm, PharmD, MSc. Associate Professor in the Department of Family Medicine. Lisa’s research includes interventions that can improve prescribing and patient medication-taking behaviour.
  • 20. 0 5 10 15 20 25 2000 2001 2002 2003 2004 FundinginMillions Capital Other Industry Government Personnel Award Peer Reviewed External Funding 2000-2004 By Source
  • 21. PATH and Infection Researchers Chengsheng Zhang, MD, He is interested in SARS and HIV and currently studying the interaction of viruses and host cells. Photo not available Ron Goeree, His primary interests are methods of economic appraisal and modeling the long-term costs and benefits of health care interventions / technologies.
  • 22. 0 2 4 6 8 10 12 14 16 18 20 CE/PATH ClinicalResearch Infection Kidney & Urinary M entalHealth/BBI Nursing Respiratory/Thoracic Surgery Program FundinginMillions Peer Reviewed Other Industry Government Total Grants & Contracts 2000-2004 By Research Groups
  • 23. Our Young Investigators FSORC CE/Health Services Clinical Research Respiratory Thoracic Kidney & Urinary Infection Mental Health/BBI Dr. Zhang