Faculty Profile

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Faculty Profile

  1. 1. _________________________________________________________________________________________ _ Faculty Profile Name: Michael J. Apostolakos Unit/Division: Pulmonary / CCM Phone: (585) 275 -2050 Email: michael_apostolakos@urmc.rochester.edu URMC Box #: 692 Research interests: ● ARDS ● Sepsis ● Pneumonia _________________________________________________________________________________________ _ Faculty Profile Name: Mark W. Frampton MD Unit/Division: Pulmonary/Critical Care Phone: (585) 275-4861 Email: mark_frampton@urmc.rochester.edu URMC Box #: 692 Research interests: Each day the average person breathes about 15,000 liters, or approximately 35 pounds, of air. Gaseous and particulate contaminants in that air gain access to the body with each breath, and may have both short and long-term effects on human health. Our ongoing studies examine the effects of particle exposure on lung function, airway inflammation, and cardiovascular function. Utilizing both environmental chamber and mouthpiece exposure systems, subjects are exposed to environmentally relevant concentrations of pollutants, with or without exercise. Respiratory and systemic effects are determined using measures of lung function, recovery of inflammatory cells from the airways using sputum induction, examination for markers of inflammation in exhaled air, characterization of blood leukocyte responses using 3-color flow cytometry, and detailed cardiovascular monitoring. Ultrafine particles (UFP, <100 nm diameter) may be particularly important with regard to cardiovascular effects because of their potential for evading clearance mechanisms and entering the lung interstitium and vascular space. We have demonstrated in healthy nonsmokers that inhalation of low concentrations of UFP causes changes in pulmonary diffusing capacity and leukocyte expression of adhesion molecules that are consistent with altered endothelial function. Smokers and the elderly may be more susceptible to vascular effects of particle exposure because of impaired endothelial function and increased risk for atherosclerosis. Our studies explore the hypothesis that inhalation of ultrafine particles alters endothelial function in healthy and susceptible people. Endothelial dysfunction is critically linked to the pathogenesis of atherosclerotic vascular disease. Data from these human clinical studies of exposure to air pollutants help to elucidate the mechanisms responsible for pollutant health effects, and assist in establishing rational air quality standards.
  2. 2. ________________________________________________________________________________ Faculty Profile Name: Joe Modrak, MD Unit/Division: Pulmonary Phone: (585) 341-7575 Email: joseph_modrak@urmc.rochester.edu URMC Box #: 692 Research interests: Obstructive sleep apnea syndrome in both adults and children. I am currently performing a study looking at tonsil size and risk for obstructive sleep apnea syndrome in 6-10 y.o. children. The field of sleep medicine is in its infancy, and so the clinical research options are endless. I would be very happy to help mentor a resident on any research in the field of sleep medicine that they are interested in. ________________________________________________________________________________ Faculty Profile Name: Anthony P. Pietropaoli, M.D. Unit/Division: Pulmonary / Critical Care Medicine Unit Phone: (585) 275-4861 Email: Anthony_Pietropaoli@urmc.rochester.edu URMC Box #: 692 Research interests: 1. Translational studies exploring mechanisms to explain the apparent gender differences in sepsis incidence, severity and outcome. 2. Studies defining predictors of physical, functional, and psychological outcomes of critically ill patients. 3. Laboratory studies evaluating the interaction of nitric oxide (NO) gas with various components of whole blood. The goal of these studies is to help explain the “hemoglobin-nitric oxide paradox”: how can nitric oxide operate as endothelium-derived relaxing factor (EDRF) when previous studies have demonstrated that it is scavenged (and thus inactivated) almost instantaneously in the presence of hemoglobin? 4. Studies applying a novel technique of measuring airway NO dynamics to research subjects at risk for airway inflammation. This measurement technique allows separate but simultaneous
  3. 3. measurement of NO production by the alveolar and conducting airways of the lung. By localizing production of this inflammatory marker to specific lung regions, this technique provides insight into the primary lung regions affected by environmental stressors and! or human disease states. ________________________________________________________________________________________ Faculty Profile Name: Patricia J. Sime, MD. FRCP Unit/Division: Pulmonary and Critical Care Phone: (585) 275-4861 Email: patricia_sime@urmc.rochester.edu URMC Box #: 692 Research interests: My research group investigates two main areas of pulmonary medicine: pulmonary fibrosis and pulmonary inflammation. We are focused on these important diseases because there are few, if any, effective therapies for devastating conditions such as idiopathic pulmonary fibrosis, ARDS or smoking related lung diseases. We have a translational program focused on understanding the pathogenetic mechanisms by which fibrotic and inflammatory diseases develop. By understanding some of the mechanisms involved in inciting these diseases, we have developed novel and exciting new treatment strategies aimed at targeting key mediators and pathways that are up-regulated during lung injury and repair. Our studies range from studies of patients with lung fibrosis to animal models of disease and in vitro culture systems. My research laboratory is housed in the new Medical Research Building (MRB-X), and I have a Specialized Interstitial Disease clinic in the Medical Center. I am delighted to welcome residents and fellows to our team to undertake projects and will do my utmost to ensure the experience is educational, productive and of course fun! ________________________________________________________________________________ Faculty Profile Name: R. James White, MD, PhD Unit/Division: Pulmonary and Critical Care Phone: (585) 275-7237 Email: jim_white@urmc.rochester.edu URMC Box #: 692 Research interests: My focus is to understand the pathophysiology of pulmonary hypertension (PAH) and to apply the best science in the care of patients. My lab uses a rat model of severe PAH (pneumonectomy and
  4. 4. monocrotaline) and we have great fun while we measure the animal’s exercise tolerance using a treadmill prior to studying their hemodynamics invasively at the time of sacrafice. I am currently treating ~ 50 patients for PAH with 15 patients on a prostacyclin agent. ________________________________________________________________________________

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