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CURRICULUM VITAE FOR ACADEMIC PROMOTION

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    CURRICULUM VITAE FOR ACADEMIC PROMOTION CURRICULUM VITAE FOR ACADEMIC PROMOTION Document Transcript

    • Dolores B. Njoku, MD Curriculum Vitae for Academic Promotion The Johns Hopkins University School of Medicine ______________________________ November 21, 2007_______ Dolores B. Njoku, MD Date DEMOGRAPHIC INFORMATION Current Appointments 1997 – Present Assistant Professor, Anesthesiology and Critical Care Medicine and Pediatrics, Johns Hopkins University 1998 – Present Anesthesiology Leader, Pediatric Orthopedic Operating Room Triad, Johns Hopkins Hospital 2002 – Present Lead Investigator, Drug-Induced Autoimmune Liver Diseases, WHO Center for Autoimmune Disease Research, Johns Hopkins University 2002 – Present Junior Editor of the American Board of Anesthesiology/American Society of Anesthesiologists Joint Council on In-Training Examinations 2005 – Present Founder and Director, PEDI-20 (Educational Module for Anesthesiology residents rotating in the Pediatric Anesthesiology operating rooms) 2006 – Present Assistant Professor, Pathology, Johns Hopkins University 2007 – Present Junior Oral Board Examiner of the American Board of Anesthesiology Personal Data Division of Pediatric Anesthesiology and Critical Care Medicine Department of Anesthesiology and Critical Care Medicine Johns Hopkins School of Medicine 600 North Wolfe Street Blalock 906A Baltimore, Maryland 21287 Phone: (410) 955-6412 Fax: (410) 502-5312 Email: dnjoku@jhmi.edu Education and Training 1979 – 1983 University of Dallas
    • Dolores B. Njoku, MD, Page 2 Bachelor of Sciences Major: Biochemistry 1983 – 1987 University of Mississippi Doctor of Medicine 1987 – 1988 Rainbow Babies and Children’s Hospital Case Western Reserve School of Medicine Internship in Pediatrics 1988 – 1990 Rainbow Babies and Children’ Hospital, Cleveland, OH Case Western Reserve School of Medicine Residency in Pediatrics 1992 – 1994 Johns Hopkins Hospital, Baltimore, MD Johns Hopkins School of Medicine Anesthesiology Component of Postdoctoral Fellowship in Pediatric Anesthesiology and Critical Care Medicine 1994 – 1995 Johns Hopkins Hospital, Baltimore, MD Johns Hopkins School of Medicine Postdoctoral Fellowship in Pediatric Anesthesiology 1994 – 1996 Johns Hopkins Hospital, Baltimore, MD Johns Hopkins School of Medicine Postdoctoral Fellowship in Pediatric Critical Care Medicine Professional Experiences 1990 – 1991 Chief Pediatric Resident, Rainbow Babies and Children’s Hospital Case Western Reserve School of Medicine, Cleveland, OH 1991 Pediatrician, Private Practice Kron Medical Company Locum Tenens 1994 – 1995 Assistant Anesthesiologist Johns Hopkins Hospital, Baltimore, MD 1994 – 1998 Special Volunteer, Laboratory of Molecular Immunology Section on Molecular and Cellular Toxicology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 1995 – 1997 Instructor, Anesthesiology and Critical Care Medicine Johns Hopkins University School of Medicine 1997 – Present Assistant Professor, Anesthesiology and Critical Care Medicine
    • Dolores B. Njoku, MD, Page 3 Johns Hopkins University School of Medicine 1998 – 2005 Adjunct Investigator, Laboratory of Molecular Immunology Section on Molecular and Cellular Toxicology, National Heart, Lung and Blood Institute, National Institutes of Health, Bethesda, MD 2000 – Present Assistant Professor, Pediatrics Johns Hopkins University School of Medicine 2002 – Present Lead Investigator in Drug-Induced Autoimmune Liver Diseases, WHO Center for Autoimmune Disease Research, Department of Pathology, Johns Hopkins University School of Medicine 2002 – Present Junior Editor, American Board of Anesthesiology/American Society of Anesthesiologists Joint Council on In-Training Examinations 2006 – Present Assistant Professor, Pathology Johns Hopkins University School of Medicine 2007 Junior Oral Board Examiner, American board of Anesthesiology RESEARCH ACTIVITIES Publications Peer-Reviewed Original Research Articles 1. Njoku D, Kliegman R. Atypical Extrapulmonary presentations of severe respiratory syncytial virus infection requiring intensive care. Clinical Pediatrics 32:155-160, 1993. 2. Njoku DB, Laster, MJ, Gong, DH, Eger, EI, Reed, GF, Martin, JL Biotransformation of halothane, enflurane isoflurane and desflurane to trifluoroacetylated liver proteins: association between protein acylation and hepatic injury. Anesthesia and Analgesia. 84:173-178, 1997. 3. Njoku DB, Pohl LR, Sokoloski EA, Marchick MR, Martin, JL. Immunochemical evidence against the involvement of cysteine conjugate β-lyase in Compound A nephrotoxicity in rats. Anesthesiology 90:458-469, 1999. 4. Njoku DB, Greenberg RS, Bourdi M, Dake B, Martin JL, Pohl LR. Autoantibodies Associated with Inhalational Anesthetic Hepatitis Found in the Sera of a Large Cohort of Pediatric Anesthesiologists. Anesthesia and Analgesia 94:243-9, 2002.
    • Dolores B. Njoku, MD, Page 4 5. Njoku, DB, Shrestha S, Long J, Soloway R, Duray PR, Tsokos M, Abu-Asab MS, Pohl LR, West AB. Subcellular Localization of Trifluoroacetylated Liver Proteins in Association with Hepatitis following Isoflurane. Anesthesiology 96:757-61, 2002. 6. Fairweather D, Frisancho-Kiss S, Gatewood S, Njoku D, Steele R, Barrett M and Rose NR. Mast cells and innate cytokines are associated with susceptibility to autoimmune heart disease following Coxsackievirus B3 infection. Autoimmunity. 37:131-145, 2004 7. Fairweather D, Frisancho-Kiss S, Yusung SA, Barrett MA, Davis SE, Gatewood SJ, Njoku DB and Rose NR. Interferon-γ protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines transforming growth factor-β1, Interleukin-1β and interleukin-4 in the heart. Am J Pathol 165:1883-1894 2004. 8. Njoku DB, Talor MV, Fairweather D, Frisancho-Kiss S, Odumade OA and Rose NR. A Novel Model of Drug Hapten-Induced Hepatitis with Increased Mast Cells in the BALB/c Mouse. Exp Mol Pathol. 78:87-100, 2005. 9. Njoku DB, Mellerson JL, Talor MV, Kerr DR, Faraday NR, Outschoorn I, and Rose NR. Role of CYP2E1 IgG4 subclass antibodies and complement in the pathogenesis of idiosyncratic drug induced hepatitis. Clinical and Vaccine Immunology 13 (2): 258 – 265, 2006. 10. Fairweather D, Frisancho-Kiss S, Njoku DB, Nyland JF. Kaya Z, Yusung SA, Davis SE, Frisancho A, Barrett M and Rose NR. Complement receptor 1 and 2 deficiency increases coxsackievirus B3-induced myocarditis, dilated cardiomyo- pathy and heart failure by increasing macrophages, IL-1beta and immune complex deposition in the heart. J Immunol 176(6): 3516 - 24, 2006. 11. Frisancho-Kiss S, Nyland JF, Davis SE, Barrett MA, Gatewood SJ, Njoku DB, Cihakova D, Silbergeld EK, Rose NR and Fairweather D. Cutting Edge: T Cell Ig Mucin-3 reduces inflammatory heart disease by increasing CTLA-4 during innate immunity. J Immunology, 176(11): 6411 -15, 2006. 12. Anderson JS, Rose NR, Martin JL, Eger EI and Njoku DB. Desflurane hepatitis associated with hapten and autoantigen-specific IgG4 antibodies. Anesthesia and Analgesia, 104 (6): 1452, 2007. 13. Nguyen C, Rose NR and Njoku DB. Trifluoroacetylated IgG4 antibodies in a child with Idiosyncratic acute liver failure following first exposure to halothane. Journal of Pediatric Gastroenterology and Nutrition (in press, 2007 or early 2008).
    • Dolores B. Njoku, MD, Page 5 Editorial, Letters, correspondence 1. Njoku DB, Lenox WC. Use care when injecting rocuronium and thiopental for rapid sequence induction and tracheal intubation. Anesthesiology 83:732, 1995. 2. Njoku DB, Martin, JL, Anesthesia Drug Manual. (Review) Edited by Paul F. White. Philadelphia, W.B. Saunders. In Anesthesiology, January, 1998. 3. Njoku DB, Pohl LR, and Martin JL. Renal Cysteine Conjugate β-lyase and Compound A Nephrotoxicity: Minimal Evidence for an Association. Anesthesiology 90:921, 1999. 4. Njoku DB. Hepatic failure after cardiopulmonary bypass is unlikely to be isoflurane hepatitis – Author reply. Anesthesiology 97:1324, 2002 Book Chapters, Monographs 1. Martin JL, Njoku D. Subclavian Steal Syndrome. In: Essence of Anesthesia Practice, M. Roizen and L. Fleisher, editors. New York: W. B. Saunders Company. 298, 1997. 2. Njoku D. Effects of Halogenated Inhalational Anesthetics on the Liver and Kidney. In: Problems in Anesthesia, M. Yaster, L. Fleisher, and D. Prough, editors. Philadelphia: Lippncott Williams & Wilkins. 10:478-487, 1998. 3. Martin JL, Njoku D. Subclavian Steal Syndrome. In: Essence of Anesthesia Practice, M. Roizen and L. Fleisher, editors. New York: W. B. Saunders Company. 309, 2002. 4. Vax R and Njoku D. Branchial Cleft Cyst. In: Anesthesia for Strategies in Pediatric Anesthesia for the Palm Pilot. Ed.: RS Litman. Pocketmedicine.com, New York, NY, 2002. 5. Kaufman S and Njoku D. Craniotomy for CNS Tumor Excision. In: Anesthesia for Strategies in Pediatric Anesthesia for the Palm Pilot. Ed.: RS Litman. Pocketmedicine.com, New York, NY, 2002. 6. Martin J and Njoku DB Understanding the Metabolism and Toxicity of Modern Fluorinated Anesthetics. In Anesthesiology, R. Miller editor. 5th Edition, 2004. 7. Brady KM, Njoku DB. Latex Allergy. Decision Making in Anesthesiology, 4th edition. Mosby Year Book, in press, 2007. 8. Sharma R, Burek CL, Cihakova D, Njoku DB and Rose NR. Environmental Factors in Autoimmune Endocrinopathies In Autoimmune Endocrinopathies, Weetman, editor in press, 2007.
    • Dolores B. Njoku, MD, Page 6 9. Njoku D. Branchial Cleft Cyst. In: Anesthesia for Strategies in Pediatric Anesthesia for the Palm Pilot. Second Edition. Ed. RS Litman. Pocketmedicine.com, New York, NY, in press, 2007. 10. Kaufman S and Njoku D. Craniotomy for CNS Tumor Excision. In: Anesthesia for Strategies in Pediatric Anesthesia for the Palm Pilot. Second Edition. Ed.: RS Litman. Pocketmedicine.com, New York, NY, in press, 2007. Published Abstracts with Platform Presentations at National Meetings 1. Njoku DB, Pohl LR, Martin JL. Compound A Toxicity in Wistar Rats: Role of Thiols. Presented at the International Anesthesia Research Society Annual Meeting, San Francisco, CA, March 18, 1997. 2. Njoku DB, Greeenberg RS, Bourdi M, Martin JL, Pohl LR. Autoantibodies Associated with Inhalational Anesthetic Hepatitis Found in the Sera of Anesthesiologists. Presented at the Society of Pediatric Anesthesiology, February 1998. 3. Njoku DB, Pohl LR, Martin JL. Immunochemical evidence against the role of renal cysteine conjugate b-lyase in the nephrotoxicity of Compound A. Presented at the Society of Toxicology 37th Annual Meeting, March, 1998. 4. Njoku DB, Bourdi M, Martin JL, Greenberg RS, and Pohl LR. Autoantibodies Associated with Inhalational Anesthetic Hepatitis Found in the Sera of a Large Cohort of Pediatric Anesthesiologists. Presented at the International Anesthesia Research Society (IARS) Annual Meeting, Los Angeles, CA, March 1999. (Selected as one of the top ten abstracts at the IARS 73rd Clinical and Scientific Congress.) 5.. Njoku DB, Odumade O, Talor M, Fairweather D, Frisancho-Kiss S, Rose NR. Role of Kupffer cells and mast cells in drug-induced hepatitis in mice. AAI Block Symposium, 2004 Experimental Biology meeting abstracts [accessed at http://www.biosis-select.org/faseb/index.html]. The FASEB Journal, 18, Abstract #8226.April, 2004. 6. Fairweather D, Frisancho-Kiss S, Yusung S, Barrett M, Gatewood S, Njoku D and Rose N. IFN-gamma protects against chronic viral myocarditis by reducing mast cell degranulation, fibrosis, and the profibrotic cytokines TGF-beta 1 and IL- 4. AAI Block Symposium, 2004 Experimental Biology meeting abstracts [accessed at http://www.biosis-select.org/faseb/index.html]. The FASEB Journal, 18, Abstract #876.4April, 2004. 7. Frisancho-Kiss S, Njoku DB, Davis S, Barrett MA, Steele RA, Gatewood SL, Rose NR and Fairweather D. Complement Receptor 1 Protects Against Coxsackievirus B3-Induced Myocarditis by Decreasing Interleukin-1β and Crry Levels on Macrophages. Presented at the 12th International Congress of
    • Dolores B. Njoku, MD, Page 7 Immunology and the 4th Annual Conference of FOCIS, Montreal Canada , July 6 2004 8. Bhatnager R, Njoku DB, Miller N, Sponseller PD. Etiological Differences in Blood Loss in Scoliosis Patients Undergoing Posterior Spinal Fusion Surgery. Presented at the American Academy of Pediatrics 2005 National Conference and Exhibition, Washington, D.C., October 9, 2005. 9. Singh D, Gross RM, Monitto C, Heitmiller E and Njoku DB. (2007). Identification of a High Risk Subset of POCA Registrants: Potential Impact on Practice Recommendations for Successful Resuscitation. Selected for Oral Presentation at the Society of Pediatric Anesthesia Winter Meeting, Sante Fe, NM. 10. Njoku DB, Mellerson J, Sharma R, Talor MV, Ligons D, Li Z and Rose NR. (2007) IL-4 promotes experimental drug-induced hepatitis and modulates IP-10. Hepatobiliary Pathobiology II: Liver Injury and Regeneration. 2007 Experimental Biology Meeting. The FASEB Journal, 21, Abstract #7059.April - May, 2007. Other media 1. Njoku DB (1998). “Anesthesiologists May Be Exposed to Too Much Gas”. Interview by National Public Radio. 2. Njoku DB (1998). “Anesthesiologists May be Exposed to Too Much Gas”. Anesthesiology News. 3. “Pediatric Anesthesiologists Risk Halothane-Related Liver Injury” (6/25/1998). Online article written about my research in Science Daily. www.sciencedaily.com/releases/1998/06/980625144459. 4. Summary of “Autoantibodies Associated with Inhalational Anesthetic Hepatitis Found in the Sera of a Large Cohort of Pediatric Anesthesiologists,” (Njoku et al., 2002) in Survey of Anesthesiology 46(5):267-268, October 2002. from their website: “The journal publishes short condensations of the most significant articles on anesthesiology from all over the world. Each condensed article carries a critique by a reviewing editor to provide an expert perspective on the material presented.” 5. Figure from “Biotransformation of halothane, enflurane isoflurane and desflurane to trifluoroacetylated liver proteins: association between protein acylation and hepatic injury,” (Njoku, et al., 1997) in Basics of Anesthesia, 4th edition by Stoelting and Miller. This is one of the most widely used introductory texts in Anesthesiology with world-wide distribution. 6. Figure from “Autoantibodies Associated with Inhalational Anesthetic Hepatitis Found in the Sera of a Large Cohort of Pediatric Anesthesiologists,” (Njoku et al., 2002) in Pharmacology and Physiology in Anesthesiology Practice, 4th edition by
    • Dolores B. Njoku, MD, Page 8 Stoelting and Miller. This is a best-selling and highly-acclaimed text on this subject. Inventions, Patents, Copyrights (pending, awarded) 2005 Murine model of experimental drug-induced hepatitis/2002 (request patent submitted) 2006 PEDI-20 Learning Modules (name and method copyright pending) Extramural Funding (current, pending, previous) Current 07/01/06 – 06/30/08 Mechanisms of Experimental Drug-Induced Hepatitis R21-DK075828 NIH/NIDDK Current Direct Costs: $125,000 Total Direct Costs: $275,000 PI: Dolores B. Njoku (50% effort) Brief Description of the Grant: We are investigating mechanisms of experimental drug- induced hepatitis using an animal model that I formulated with metabolites from halogenated volatile anesthetics. This form of hepatitis resembles the immune-mediated form of hepatitis seen also with other drugs, such as, NSAIDs, antibiotics and seizure medications. We will identify critical epitopes associated with the development of hepatitis in our model and verify immunoreactivity to these epitopes with human sera from persons with immune-mediated hepatitis. We will determine mechanism of epitope spread associated with immune reactions to known autoantigens that we have altered in order to mimic in vivo exposures to halogenated volatile anesthetics. 04/2002 – Present Mechanisms of Autoimmune Hepatitis American Autoimmune Related Diseases Association Current Direct Costs: $5,000 Total Direct Costs: $5,000 PI: Noel R. Rose Co-Investigator: Dolores B. Njoku (10% Effort) Brief Description of the Grant: Investigated autoimmune mechanisms of drug-induced liver diseases using metabolites from halogenated volatile anesthetics. These are on- going translational studies using sera from patients exposed as well as persons who develop immune-mediated hepatitis following exposure to halogenated volatile anesthetics. This line of study resulted in verification of halogenated anesthetic metabolite-specific immunoglobulin subclasses four antibodies, which is strongly associated with allergic disorders, in persons with hepatitis following halogenated volatile anesthetics. These studies helped to verify that immune-mediated hepatitis from drugs can have a strong allergic component. Previous 01/01/2000 – 12/31/2002 Volatile Anesthetics and NALT-Induced Tolerance Foundation for Anesthesia Education and Research Young Investigator Award Total Direct Costs: $140,000
    • Dolores B. Njoku, MD, Page 9 PI: Dolores B. Njoku (60% Effort) Brief Description of the Grant: Investigated the role of nasal-associated lymphoid tissue (NALT) in promoting tolerance to inhaled halogenated volatile anesthetics. Identified sites of halogenated volatile anesthetic metabolism in the nose as well as processing and trafficking of anesthetic metabolites in immune cells. These rudimentary studies were the groundwork for formulating the animal model of experimental drug-induced hepatitis using halogenated volatile anesthetics. 09/01/2004 – 8/31/2006 Role of Membrane Complement Regulatory Proteins in Autoimmune Myocarditis; Minority Investigator Research Supplement to RO1 RO1 HL070729 NIH/NHLBI Total Direct Costs $170,000 PI: Noel R. Rose Recipient: Dolores B. Njoku (75% effort) Brief Description of the Grant: I investigated the role of complement regulation on the development of inflammatory myocarditis following coxsackievirus B3 by identification of inflammatory cells in myocardial tissues following infection as well as identification of key cytokines. Investigated the role of complement activation in the development of inflammatory autoimmune myocarditis from cardiac myosin using male and female complement knock out mice. Through these studies I identified mechanisms that may have a significant role in sex-dependent differences in inflammatory myocarditis. My collaborations resulted in 3 papers in which I was a contributing author. Research Program Building / Leadership 2002 – Present Drug-Induced Autoimmune Liver Diseases in the Johns Hopkins Center for Autoimmune Disease Research Role: Lead Investigator/Principal Investigator 1999 – Present Outcomes in Pediatric Posterior Spinal Fusion and Reconstruction Role: Principal Investigator EDUCATIONAL ACTIVITIES Teaching Classroom Instruction 2000-2005 Johns Hopkins University Tutorial in Pediatric Clinical Research Location: Blalock 906 Brief Description: an undergraduate course primarily for Johns Hopkins University students Interested in Anesthesiology clinical research where they work on an ongoing project which integrated Pediatric Anesthesiology with Pediatric Orthopedic Surgery Role: Course Director and Instructor Clinical Instruction 1994 – 1998 Pediatric Intensive Care Lecture Series Location: CMSC 7 Johns Hopkins Hospital and Blalock 15 Brief Description: I developed an orientation package and year-long
    • Dolores B. Njoku, MD, Page 10 lecture series for fellows in Pediatric Critical Care Role: Course director and Instructor 1997 – 2001 Uptake and Distribution of Inhaled anesthetics Location: Blalock 15 Brief Description: Lecture given yearly to residents in Anesthesiology Role: Lecturer 2000 – 2005 Review of Malignant Hype4rthermia Location: Doctor’s Dining Room Brief Description: Lecture given yearly to first-year residents in Anesthesiology Role: Lecturer 2000 – 2003 Mock Oral Board Exams Location: Blalock 9 Brief Description: Mock Oral Anesthesiology Board Exam to familiarize residents in Anesthesiology with the format of the exam and delineate what is expected of them in this exam Role: Mock Oral Board Examiner 07/2003 Uptake and Distribution of Inhaled Anesthetics Small Group Session Location: Blalock 15 Brief Description: Intensive, interactive session in small group format with first-year Anesthesiology residents Role: Small Group Leader 2003 – Present Airway Location: Blalock 15 Brief Description: A 45 minute hands-on introduction to airway management to 3rd and 4th-year medical students during their Anesthesiology clerkship. Role: Lecturer 2004 Outcomes in Pediatric Spinal Fusion Location: Pediatric Orthopedic Surgery Department Brief Description: Discussed findings from the Pediatric Spine Database with Pediatric Orthopedic residents and attendings Role: Lecturer 2005 – Present Pediatric Anesthesiology Educational Series (PEDI-20) Location: General Operating Room 10 (twice a week) Brief Description: I developed a series of semi-formal lectures on key topics for residents rotating in Pediatric Anesthesiology Role: Founder and Course Director 2006 – Present Anesthesiology Morning Report
    • Dolores B. Njoku, MD, Page 11 Location: Blalock 14 Brief Description: An informal discussion and review of management of operating room cases that the call team encountered overnight followed by a discussion of the article of the week. Role: Attending Moderator CME Instruction 1999 – 2002 Shock and Fluid Resuscitation. Location: Tilghman Auditorium Presented in conjunction with the Advanced Pediatric Life Support course instruction. Role: Lecturer Slide Sets 1. Chen, E and Njoku DB. (2005). Blood Conservation Techniques. Slide set for Anesthesiology resident E-learning files. 2. Njoku DB. (2006). Pharmacogenetics. Slide set for Anesthesiology resident E- learning files. Mentoring I have been a member of the clinical faculty in Pediatric Anesthesiology at Johns Hopkins University since 1995. I have also been an adjunct basic science investigator at the National Institutes of Health from 1998 - 2005 as well as the lead investigator in drug-induced autoimmune-mediated liver diseases in the Johns Hopkins University Center for Autoimmune Disease Research since 2002. In my clinical duties I directly supervise training residents with various levels of experience as well as fellows in Pediatric Anesthesiology. Pediatric Anesthesiology is part of one of the busiest surgical services in the general operating rooms. Pediatric Anesthesiology services a vast clinical load which includes Pediatric Audiology, Cardiology, Gastroenterology, General Surgery, Hematology-Oncology, Interventional Radiology, Neurosurgery, Orthopedics, Otolaryngology, Plastic Surgery, Pulmonology and Urology. The Anesthesiology Program and Pediatric Anesthesiology Fellowship has a long history of ACGME accreditation. In my basic science duties I supervise pre- as well as post-doctoral students and fellows. Postdoctoral Fellows (Mentored publication below name) 1999 – 2002 Zenobia Casey, MD, Anesthesiologist, Assistant Professor, Johns Hopkins University, Baltimore, MD 1999 – 2002 Emily White, MD, Anesthesiologist, Private Practice, Maryland 2001 – 2002 Sandra Kaufman, MD, Pediatric Anesthesiologist, Private Pediatric Hospital, Miami, FL Kaufman S and Njoku D. Craniotomy for CNS Tumor Excision. In: Anesthesia for Strategies in Pediatric Anesthesia for the Palm Pilot. Ed.: RS Litman. Pocketmedicine.com, New York, NY, 2002.
    • Dolores B. Njoku, MD, Page 12 Kaufman S and Njoku D. Craniotomy for CNS Tumor Excision. In: Anesthesia for Strategies in Pediatric Anesthesia for the Palm Pilot. Second Edition. Ed.: RS Litman. Pocketmedicine.com, New York, NY, in press, 2007. 2001 – 2002 Richard Vax, MD, Pediatric Anesthesiologist, Private Practice, Texas Vax R and Njoku D. Branchial Cleft Cyst. In: Anesthesia for Strategies in Pediatric Anesthesia for the Palm Pilot. Ed.: RS Litman. Pocketmedicine.com, New York, NY, 2002. 2003 – 2005 Kevin Brady, MD, Military Commander, Anesthesiologist, Private Practice, California Brady KM, Njoku DB. Latex Allergy. Decision Making in Anesthesiology, 4th edition. Mosby Year Book, (2007). 2004 – 2005 Sharon Luo, MD, Pediatric Anesthesiologist, Dupont Medical Center, Delaware Luo S, Sponsellor PD, Njoku DB. (2005). Male patients with cerebral palsy bleed more during posterior Spinal fusion and reconstruction. Presented at the Society of Pediatric Anesthesia Winter meeting. 2004 – 2005 Richard Marn, MD, Pediatric Anesthesiologist, Mount Sinai Medical Center, New York Marn RY, Sponseller PD, Njoku DB. (2005). Preoperative valproate and tegretol therapy does not increase blood loss during spinal reconstruction and fusion surgery. Presented at the Society of Pediatric Anesthesia Winter Meeting. 2005 – 2006 Marco Corridore, MD, Pediatric Anesthesiologist, Assistant Professor, Johns Hopkins University, Baltimore, MD Corridore M, Sponseller PD, Njoku DB. (2006). Neurological Outcomes Following Spine Fusion. Presented at the Society of Pediatric Anesthesia Winter Meeting, Sanibel Island, FL. 2005 – 2006 Mario Zelaya, MD, Pediatric Anesthesiology Fellow, Johns Hopkins University, Baltimore, MD 2005 – 2007 Christine Nguyen, MD, Pediatric Gastroenterology Fellow, Lucille Packard Children’s Hospital, University of California-San Diego, San Diego, CA. Nguyen C, Rose NR and Njoku DB.TFA IgG4 antibodies in a child with Idiosyncratic acute liver failure following first exposure to halothane. Journal of Pediatric Gastroenterology. (in press, 2007).
    • Dolores B. Njoku, MD, Page 13 2006 – 2007 Robert M. Gross, MD, Pediatric Anesthesiology Fellow, Johns Hopkins University, Baltimore, MD Singh D, Gross RM, Monitto C, Heitmiller E and Njoku DB. (2007). Identification of a High Risk Subset of POCA Registrants: Potential Impact on Practice Recommendations for Successful Resuscitation. Selected for Oral Presentation at the Society of Pediatric Anesthesia Winter Meeting, Sante Fe, NM. 2006 – 2007 Devika Singh, MD, Pediatric Anesthesiology Fellow, Johns Hopkins University, Baltimore, MD Singh D, Gross RM, Monitto C, Heitmiller E and Njoku DB. (2007). Identification of a High Risk Subset of POCA Registrants: Potential Impact on Practice Recommendations for Successful Resuscitation. Selected for Oral Presentation at the Society of Pediatric Anesthesia Winter Meeting, Sante Fe, NM. 2006 – Present Zhaoxia Li, MD PhD, Senior Research Fellow, Anesthesiology and Critical Care Medicine, Johns Hopkins University, Baltimore, MD Predoctoral Students (Mentored publication below name) 1997 – 2000 Michael R. Marchick, Medical Student, University of Pittsburgh Njoku DB, Pohl LR, Sokoloski EA, Marchick MR, Martin, JL. Immunochemical evidence against the involvement of cysteine conjugate β-lyase in Compound A nephrotoxicity in rats. Anesthesiology 90:458- 469, 1999 Njoku DB, Marchick MR, Graf ML, Pohl LR. (2000). High Levels of Soluble Fas Ligand (sFasL) in the Serum of Clinical Anesthesiologists: A Possible Role in Tolerance to Anesthetic Hepatitis-Associated Antigens. Anesthesia and Analgesia 90(2):S370, Suppl. 2000 – 2001 Lisa M. Jones, Medical Student, Duke University 2001 Susan Mozzicato, Undergraduate, Johns Hopkins University 2001 - Present Leo Tsay, Medical Student, University of Maryland, Anesthesiology resident, University of Maryland starting 2009 2001 - Present Murija Gathinji, Medical Student, Johns Hopkins University, 2004 – 2005 Jenelle Mellerson, Masters in Epidemiology, Emory University Njoku DB, Mellerson JL, Talor MV, Kerr DR, Faraday NR, Outschoorn I, and Rose NR. Role of CYP2E1 IgG4 subclass antibodies and complement in the pathogenesis of idiosyncratic drug induced hepatitis. Clinical and Vaccine Immunology 13 (2): 258 – 265, 2006. Njoku DB, Mellerson JL, Rose NR. (2005). Immune-mediated drug-induced, idiosyncratic hepatitis in mice requires IL-4 as well as IL-
    • Dolores B. Njoku, MD, Page 14 4-dependent, MIP-2. Hepatology, Suppl. 1, 42 (4): pp. 567A-8A. 2004 – 2005 Oludare Odumade, Medical Student, University of Minnesota Njoku DB, Talor MV, Fairweather D, Frisancho-Kiss S, Odumade OA and Rose NR. A Novel Model of Drug Hapten-Induced Hepatitis with Increased Mast Cells in the BALB/c Mouse. Exp Mol Pathol. 78:87- 100, 2005. 2004 – 2005 Kevin Little, Medical Student, Johns Hopkins University, Presently an Orthopedic Surgery Resident at University of Colorado. 2005 – 2006 Onyi Onuoha, Medical Student, Johns Hopkins University, Presently an Anesthesiology Redsident at University of Pennsylvania. Thesis committees 2005 – PresentDavinna Ligons, Johns Hopkins University, “The Role of EAM1 susceptibility locus in autoimmune myocarditis.” Editorial Activities 2002 Archives of Disease in Childhood 2005 – Present Hepatology 2007 – Present Science of the Total Environment Educational Program Building / Leadership 2005 – Present PEDI-20 (Educational Module for Anesthesiology residents rotating in the Pediatric Anesthesiology operating rooms.) Role: Founder and Director 2005 – Present Pediatric Anesthesiology and Critical Care Mentoring Project (Part of PEDI-20 where Pediatric Anesthesiology and combined Pediatric Anesthesiology and Pediatric Critical Care Fellows give assigned Partnered with a Faculty Mentor where we stress ACGME core competencies, Presentation Style and Mentor Interaction. (1 -3 sessions per lecture) Role: Director 2006 – Present Clinical Anesthesia-2/Clinical Anesthesia-3 Pediatric Anesthesiology Lectures Role: Curriculum Organization and Lecture Assignment CLINICAL ACTIVITIES I currently provide Pediatric Anesthesia to children with complex diseases for various surgeries, other painful procedures and radiological studies. In conjunction with some of my call duties I also provide comprehensive pain management to children following surgical procedures.
    • Dolores B. Njoku, MD, Page 15 Certification Medical Licensure 2005 - Present State of Maryland Board of Physicians License #D0046311 Boards/Specialty Certification 1987 FLEX 1991, 1998 Pediatrics 1995, 2005 Anesthesiology 2000 Pediatric Critical Care Clinical (Service) Responsibilities 1997 – Present Attending Anesthesiologist in Pediatric Anesthesiology. I supervise residents, coordinating operating room and remote cases, phone consultation with other services and parents. Time Commitment: 1.25 – 2 days/ week; Call 3 – 4 days/month 1997 – Present Pediatric Pain Service Attending. I round on all in-house pediatric pain service patients, accept new consults and give advice on pediatric pain management to other clinical services. Time commitment: 1 weekend day/month Clinical Program Building / Leadership 2002 – Present Pediatric Orthopedic Triad Pediatric Orthopedic Surgery represents the highest volume of pediatric operating room scheduled cases. The majority of these cases have severe underlying illnesses making them not only surgically challenging, but also challenging pediatric Anesthesiology cases. In collaboration with Dr. Paul Sponseller and Nurse Courtney Campbell, we have implemented guidelines for pre-operative evaluation of pediatric spinal fusion patients reduced spine infection rate, identified high risk patients and decreased the incidence of intraoperative arrest on children with severe spine curvatures, developed our first Pediatric Orthopedic Spine Database, which has resulted in presentations at national meetings in Pediatrics, Orthopedics and Anesthesiology. Role: Anesthesiology Leader Time Commitment: 1 – 3 hours/week ORGANIZATIONAL ACTIVITIES Institutional Administrative Appointments 1998 – Present Interviewer for Anesthesiology Resident Selection 2000 – 2002 Pediatric Operation Room Operations Committee Professional Societies 1989 – Present American Academy of Pediatrics
    • Dolores B. Njoku, MD, Page 16 1993 – Present American Society of Anesthesiology 1996 – Present International Anesthesia Research Society 1996 – Present Johns Hopkins Medical and Surgical Association 2000 – Present Fellow of the American Academy of Pediatrics Committees: Section on Critical Care Section on Anesthesiology 2001 – 2002 Pediatric critical Care Exam Question Writer 2002 – Present American Board of Anesthesiology/American Society of Anesthesiology Joint Council on In-Training Examinations Role: Junior Editor 2003 – Present Society of Education in Anesthesia Committee on Residency Curriculum 2007 – Present Society of Education in Anesthesia Committee on Faculty Development 2007 – 2008 Adjunct Member of the ASA Committee on Surgical Anesthesia RECOGNITION Awards 1979 O’Hara Summer Science Chemistry Institute Description: Science Institute for academically exceptional in- coming college freshmen Sponsor: University of Dallas 1979 – 1983 Partial Scholarship from the Catholic Diocese of Natchez-Jackson Description: academic scholarship for college Sponsor: University of Dallas Honor Roll and Dean’s List Sponsor: University of Dallas 1998 Young Investigator Award Description: award for the best scientific presentation Sponsor: Society of Pediatric Anesthesia 1999 73rd Clinical and Scientific Congress, Best of the Meeting of Scientific Abstracts Description: award for the best abstract of the meeting
    • Dolores B. Njoku, MD, Page 17 Sponsor: International Anesthesia Research Society 2002 Junior Editor, American Board of Anesthesiology/American Society of Anesthesiologists Joint Council on In-Training Examinations Description: Formulation of exam questions for certification exam Sponsor: American Board of Anesthesiology 2007 Junior Oral Board Examiner Description: apprentice oral board examiner Sponsor: American Board of Anesthesiology Mentored Awards 2007 American Academy of Pediatrics Resident Research Competition 3rd Place Recipients: Drs. Devika Singh and Robert Gross Invited Talks, Panels 1998 Anesthesiology Research Conference and Grand Rounds, University of Pennsylvania “Mechanisms of toxicity of the sevoflurane degradation product Compound A” (02/25 – 26/1998). 1998 Anesthesiology Grand Rounds, Howard University, “Presence of autoantibodies associated with anesthetic hepatitis in pediatric anesthesiologists”, (09/21/1998). 1998 Visiting Professor, Plovdiv Hospital, Plovdiv, Bulgaria. Sponsored by Surgical Aid to Children of the World and the Souris Foundation. “Feasibility of establish- ing an updated, regional pediatric intensive care unit in Plovdiv Hospital”. Evaluated the feasibility of establishing an updated, regional pediatric intensive care unit in Plovdiv Hospital. Met with government health officials and physicians to assess needs and resources available (11/09 – 20/1998). 1999 Anesthesiology Grand Rounds, Children’s National Medical Center, “Presence of autoantibodies associated with anesthetic hepatitis in Pediatric anesthesiologists” (05/27/1999). 2000 Anesthesiology Grand Rounds, Children’s Hospital of Michigan, “Presence of autoantibodies associated with anesthetic hepatitis in pediatric anesthesiologists” (01/12/2000). 2000 Anesthesiology Grand Rounds, University of Maryland, “Volatile anesthetics and the immune system”, (10/05/2000). 2000 Invited Speaker, 3rd Annual Respiratory Care Conference, Johns Hopkins University Bayview Campus, “Volatile Anesthetics and Asthma in the ICU”, (11/04/2000).
    • Dolores B. Njoku, MD, Page 18 2001 Visiting Professor and Anesthesiology Grand Rounds, SUNY Health Sciences Center, “Volatile Anesthetics and the Immune System”, (01/21 – 22/2001). 2001 Anesthesiology Grand Rounds, National Institutes of Health Department of Anesthesiology, “Volatile anesthetics and the immune system: what every anesthesiologist should know”, (11/09/2001). 2001 Anesthesiology Grand Rounds, George Washington Department of Anesthesiology “Volatile Anesthetics and the Immune System: What Every Anesthesiologist Should Know”, (12/05/2001). 2003 Invited Speaker, Medical and Surgical Association biennial Meeting, Johns Hopkins University, “The pathogenesis of inflammation in organ-specific autoimmune diseases”, (05/02/2003). 2005 Invited Speaker, Refresher Course, Society of Pediatric Anesthesiology Winter Meeting, “Blood Conservation Techniques”, (02/2005). 2005 Invited Speaker, Seventh Annual Autoimmunity Day, Johns Hopkins University, “A novel model of drug hapten, immune-mediated, hepatitis with autoimmune features, (06/10/2005). 2007 Invited Panel Speaker, “Pre-operative Screening for the Obese Adolescent”. Johns Hopkins University Department of Pediatrics (03/01/2007) 2007 Invited Speaker, Medical and Surgical Association biennial Meeting, Johns Hopkins University, “Role of Gender, Cytokines and Cells in Drug-Induced Immune-Mediated Hepatitis”, (07/01/2007). 2007 Invited Speaker, Children’s National Medical Center, “Role of Gender in Autoimmunity”, (09/20/2007) 2007 Panel Moderator, American Society of Anesthesiologists Annual Meeting. “My patient developed acute liver failure after anesthesia! Who done it and what do I do?” San Francisco, CA (10/17/2007) OTHER PROFESSIONAL ACCOMPLISHMENTS Community Activities 1. Noonan’s Society Family Support Group 10/21-22/2000 Columbia, MD “Anesthetic Implications of Noonan’s Syndrome”. Discussed topic with families and clinicians and researchers who interact with Noonan’s patients. 2. Noonan’s Society General Session 7/2002 Towson, MD “Anesthetic Implications of Noonan’s Syndrome”. discussed topic with families and clinicians and researchers who interact with Noonan’s patients.
    • Dolores B. Njoku, MD, Page 19 3. 2nd International CFC Family network Conference 7/2003 Bethesda, MD “Anesthetic implications of Cardio-Facio-Cutaneous Syndrome” discussed topic with families and clinicians and researchers who interact with CFC patients. 4. Noonan’s Society General Session 7/18/2004 Towson, MD “Anesthetic Implications of Noonan’s Syndrome”. discussed topic with families and clinicians and researchers who interact with Noonan’s patients. 5. Noonans’s Society General Session 08/18/2007 Towson, MD “Anesthetic Implications of Noonan’s Syndrome” Held workshop and discussed topic with families of children with Noonan’s syndrome.