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Academic Centers Research Node of PECARN

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  • 1. Academic Centers ResearchAcademic Centers Research Node of PECARNNode of PECARN ((“ACORN”“ACORN”)) Supported by Project #U03 MC00001-01 from the MaternalSupported by Project #U03 MC00001-01 from the Maternal and Child Health Bureau, Health Resources and Servicesand Child Health Bureau, Health Resources and Services Administration, Department of Health and Human ServicesAdministration, Department of Health and Human Services
  • 2. Who We AreWho We Are University of California, Davis Medical Center,University of California, Davis Medical Center, University of California, Davis School of MedicineUniversity of California, Davis School of Medicine Children’s Hospital of Wisconsin,Children’s Hospital of Wisconsin, Medical College of WisconsinMedical College of Wisconsin Children’s Hospital of Philadelphia,Children’s Hospital of Philadelphia, University of Pennsylvania School of MedicineUniversity of Pennsylvania School of Medicine St. Louis Children’s Hospital,St. Louis Children’s Hospital, Washington University School of MedicineWashington University School of Medicine Primary Children’s Medical Center,Primary Children’s Medical Center, University of Utah School of MedicineUniversity of Utah School of Medicine Children’s Hospital Medical Center,Children’s Hospital Medical Center, University of Cincinnati School of MedicineUniversity of Cincinnati School of Medicine
  • 3. University of California, Davis Medical CenterUniversity of California, Davis Medical Center University of California, DavisUniversity of California, Davis Nathan Kuppermann, MD, MPHNathan Kuppermann, MD, MPH Chair, Department of Emergency Medicine,Chair, Department of Emergency Medicine, Professor of Emergency Medicine/PediatricsProfessor of Emergency Medicine/Pediatrics Emily Kim, MPHEmily Kim, MPH ACORN Node AdministratorACORN Node Administrator James Holmes Jr., MD, MPHJames Holmes Jr., MD, MPH Trauma ConsultantTrauma Consultant Associate Professor of Emergency Medicine/PediatricsAssociate Professor of Emergency Medicine/Pediatrics
  • 4. Children’s Hospital of Wisconsin,Children’s Hospital of Wisconsin, Medical College of WisconsinMedical College of Wisconsin Marc Gorelick, MD, MSCEMarc Gorelick, MD, MSCE Medical Director, Emergency Department,Medical Director, Emergency Department, Professor of Pediatrics and Emergency MedicineProfessor of Pediatrics and Emergency Medicine
  • 5. Children’s Hospital of Philadelphia,Children’s Hospital of Philadelphia, University of PennsylvaniaUniversity of Pennsylvania Elizabeth Alpern, MD, MSCEElizabeth Alpern, MD, MSCE Assistant Professor of PediatricsAssistant Professor of Pediatrics Kathy Shaw, MD, MSCEKathy Shaw, MD, MSCE Division Chief, Pediatric Emergency Medicine,Division Chief, Pediatric Emergency Medicine, Professor of PediatricsProfessor of Pediatrics Evaline Alessandrini, MD, MSCEEvaline Alessandrini, MD, MSCE Associate Professor of PediatricsAssociate Professor of Pediatrics
  • 6. St. Louis Children’s Hospital,St. Louis Children’s Hospital, Washington University in St. Louis School of MedicineWashington University in St. Louis School of Medicine David Jaffe, MDDavid Jaffe, MD Medical Director of Emergency Services,Medical Director of Emergency Services, Professor of PediatricsProfessor of Pediatrics Walton Schalick, MD, PhDWalton Schalick, MD, PhD Ethics ConsultantEthics Consultant Assistant Professor of Bioethics, Medical History, PediatricAssistant Professor of Bioethics, Medical History, Pediatric Orthopedics & RehabilitationOrthopedics & Rehabilitation University of Wisconsin-MadisonUniversity of Wisconsin-Madison
  • 7. Primary Children’s Medical Center, University of UtahPrimary Children’s Medical Center, University of Utah Douglas Nelson, MDDouglas Nelson, MD Professor of PediatricsProfessor of Pediatrics Associate Chief, Emergency Pediatric MedicineAssociate Chief, Emergency Pediatric Medicine
  • 8. Cincinnati Children’s HospitalCincinnati Children’s Hospital Medical Center, University ofMedical Center, University of Cincinnati College of MedicineCincinnati College of Medicine Richard Ruddy, MDRichard Ruddy, MD Director, Division of Emergency Medicine,Director, Division of Emergency Medicine, Professor of Clinical PediatricsProfessor of Clinical Pediatrics
  • 9. Where We Are LocatedWhere We Are Located
  • 10. ACORN Organizational StructureACORN Organizational Structure
  • 11. Key Features of the ACORN NodeKey Features of the ACORN Node • Comprised of Three HEDA CoresComprised of Three HEDA Cores AdministrativeAdministrative Ethics/ Human SubjectsEthics/ Human Subjects Epidemiological/BiostatisticsEpidemiological/Biostatistics
  • 12. Key Features of the ACORN NodeKey Features of the ACORN Node • HEDA CoresHEDA Cores AdministrativeAdministrative • Overall nodal organizational responsibilityOverall nodal organizational responsibility • Oversee generation of nodal research priority listOversee generation of nodal research priority list • Oversee the conduct of nodal researchOversee the conduct of nodal research • Oversee intranodal, internodal communicationsOversee intranodal, internodal communications • Build partnerships with the MCHB/EMSCBuild partnerships with the MCHB/EMSC
  • 13. Key Features of the ACORN NodeKey Features of the ACORN Node • HEDA CoresHEDA Cores Ethics / Human SubjectsEthics / Human Subjects • Insure the protection of human subjectsInsure the protection of human subjects • Review ethical content of all nodal research by committeeReview ethical content of all nodal research by committee • Advise nodal investigators regarding all ethical issues pertainingAdvise nodal investigators regarding all ethical issues pertaining to nodal research prior to submission to PECARNto nodal research prior to submission to PECARN • Review IRB issues at nodal HEDAs and help coordinateReview IRB issues at nodal HEDAs and help coordinate activities which require cooperation between IRBsactivities which require cooperation between IRBs
  • 14. Key Features of the ACORN NodeKey Features of the ACORN Node • HEDA CoresHEDA Cores Epidemiology / BiostatisticsEpidemiology / Biostatistics • Review nodal research proposals and provide specific feedback toReview nodal research proposals and provide specific feedback to investigators on issues of study design, sources of bias andinvestigators on issues of study design, sources of bias and confounding, sample size and power, logistics and feasibilityconfounding, sample size and power, logistics and feasibility • Assist in the development of surveys and other data collectionAssist in the development of surveys and other data collection instrumentsinstruments • Assist with statistical analysis of completed nodal research,Assist with statistical analysis of completed nodal research, including multivariable statistical models and techniques forincluding multivariable statistical models and techniques for validationvalidation • Assist with preparation of research presentations and manuscriptsAssist with preparation of research presentations and manuscripts
  • 15. ACORN Proposal Generation & ReviewACORN Proposal Generation & Review ProcessProcess
  • 16. ACORN ResearchACORN Research Approved Projects:Approved Projects: • Randomized Trial of Oral Dexamethasone in AcuteRandomized Trial of Oral Dexamethasone in Acute BronchiolitisBronchiolitis • PECARN Core Data Project (with CARN)PECARN Core Data Project (with CARN) • Head Injury ProjectHead Injury Project • Cervical Spine Injury ProjectCervical Spine Injury Project • Intra-abdominal Injury ProjectIntra-abdominal Injury Project • Patient Safety Project (with CARN)Patient Safety Project (with CARN) • Quality Measures ProjectQuality Measures Project
  • 17. Concluding StatementConcluding Statement The ACORN Node of PECARN is committed toThe ACORN Node of PECARN is committed to applying our strengths and expertise to the studyapplying our strengths and expertise to the study of the prevention and treatment of acutely illof the prevention and treatment of acutely ill and injured children.and injured children. We will forge strong collaborations with all otherWe will forge strong collaborations with all other Nodes of PECARN and the MCHB/EMSC.Nodes of PECARN and the MCHB/EMSC. We are confident that the strong commitment ofWe are confident that the strong commitment of all the Nodes of PECARN will insure theall the Nodes of PECARN will insure the success of this novel and exciting network.success of this novel and exciting network.