Graham Hughes - Beta Technology - FP 7 Call Presentation

FP7 2012 Health Call Overview Graham Hughes, FP7UK NCP for Health (Industry)

“ FP7 work programmes will “ continue to secure world excellence in basic research ” through large scale collaborative research efforts
JM Barroso 2009

FP7 - €53 billion spend 2007 - 2013

Cooperation Theme

Cooperation Theme Basics
Top down process, yearly call for proposals based around specific topic areas
Projects performed by consortia of academic/industry/ public sector participants
Matched funding (EU contributes to total cost of project)
Participants sign legal contract with the EU

Three Major Objectives
Improve the health of European citizens
Boost the competitiveness of health related industries
Address global health issues
Also seeking to implement research objectives that help to realise the aims of the Innovation Union (Europe 2020) flagship initiative .
Health Theme Objectives

The Health Theme: Structure Activity 1: Biotechnology, generic tools & technologies for health Activity 2: Translating research for human health Activity 3: Optimising the delivery of health care cross-cutting issues: international cooperation, SMEs, child health, ageing populations, gender -related health issues Activity 4: Support actions & response to policy needs The Innovative Medicines Initiative

Health Theme Funding 2007 - 2013 Year Total Funding Projects Funded 2007 € 641 million 153 2008 € 577 million 172 2009 € 611 million 105 2010 € 621 million 131 2011 € 650 million ~126 2012 € 620 million ? 2013 € 780 million ?

UK Performance (Health Theme) Health Funding totals 2007 -2009 – All Participations

UK FP7 Health Theme in Numbers* Submissions with UK partners = 3264* Successful projects with UK partners = 859 UK coordinated submissions = 383 93 projects coordinated by UK partners *2007 – 2009 data – from GAs and participants database (released on 1 May 2010 - data cut-off date 25 March 2010 52 UK SMEs in active FP7 projects (plus 17 new 2010)

SME Participation EU target of 15% funding to SME partners

Access significant research funding
75% RTD costs and 100% management and training costs
EU contribution between €2 and 12 million
Overhead rate for HEIs and SMEs = 60%
Strengthening Research Capabilities
Increased collaboration between basic and clinical researchers, regulatory bodies and patient groups
Access to new networks and contacts
develop new business contacts from the linkages formed in a consortium
Access to IP and facilities otherwise unavailable
Elevated Profile
Publications, CORDIS
Collaborative Research: Why?

Collaborative Research: Who?
Countries
EU Member States – broadest rights and access
Associated Countries – e.g. Iceland, Norway, Turkey, Israel
International Cooperation Partner Countries (ICPC) – e.g. Russia, Central Asian, Balkan, North African countries
Industrialised high-income countries (e.g Australia, Korea, Japan) – self financing. USA has reciprocal arrangement
Co-operation with “third countries” explicitly encouraged in FP7
Organisations
research groups at universities or research institutes
innovative companies (SMEs and larger)
public or governmental administration (eg NHS trusts)
Charities and other not for profit organisations

Build consortium :
3 legal entities from minimum of 3 EU Member states or Associated Countries
Other partners added per requirements of project/partner mix
Some other special eligibility criteria may apply – read call document carefully
Match project with the topic
Seek advice if not sure
Funding level is indicative of project scope
Pay attention to expected outcome – European scope
Follow rules for submission (EPSS)
Collaborative Research: How?

WP First Draft Open day (Brussels) 09 June 2011 Call published Stage 1 Deadline NCP Roadshow Evaluation results Evaluation PC Meetings Collaborative Research: When?

Framework Programme 7 Support and Further Information Graham Hughes, FP7UK NCP for Health (Industry)

Initial Considerations
Are you ready for participation?
Does it fit your aspirations/business plan
Collaborative projects mean working alongside international partners.
Does this suit you way of working?
Can you pull together or find a consortium?
Funding is highly competitive, prepare to be disappointed
Do you want to lead a project? (Time/resource)
Is the level of funding appropriate?
Can you wait 1 year for the money?

Key Tips
Competition is fierce – must be well over the threshold to succeed
Remember the European aspect
Read the call carefully – seek 2 nd and 3 rd opinions on topic fit
Write simply and clearly – don’t assume expert knowledge
Make time to do a good job – avoid last minute submissions
Seek help early on

Support and Further Information

Informing and Awareness Raising
Call documents and supporting information
Website and printed newsletters, e-bulletins
Promotional activities – info days, seminars,
Signposting – other themes + funding schemes
Advising and Training
Helpline – e-mail and telephone enquiries
Partner search
Direct support
Feedback and Signposting
Problems or difficulties during implementation or participation
Direct contact with EU Scientific Officers
Identifying and communicating other areas of support and funding
NCP Support All advice is impartial, confidential and free

Support and Further Information
Website https://ktn.innovateuk.org/web/fp7uk
E mail [email_address]
Phone 01302 322633
Mobile 07775 584028
Alternative
[email_address]
+44 (0)20 7395 2205

Framework Programme 7 2012 Call Information Graham Hughes, FP7UK NCP for Health (Industry)

2012 Call – Context
Innovation Union
research and innovation are key drivers of competitiveness, jobs, sustainable growth and social progress.
More topics targeting knowledge generation to deliver innovative products, processes and services.
Challenge led programme focusing on specific issues
More emphasis on exploitation issues such as dissemination, IP protection and knowledge generation.

2012 Call – Innovation Driven
Challenge driven – fewer areas open, multiple projects in each area. (36 topics total)
Primary focus is European Innovation Partnership initiative on active and healthy ageing
Aim to mobilise critical mass of resources and implement coherent set of actions
Interlinked topics to bring in wide range of inputs
Balance upstream research and activities closer to market to achieve short and medium-term outcomes
focus on medical technologies
address the socio-economic challenge of innovation

2012 Call – Closed Areas
1.1 High Throughput Research
1.3 Suitability, Safety and Efficacy of Therapies*
2.2.1 Brain and Brain Related Diseases
2.3.1 Anti Microbial Drug Resistance
2.3.3 Potentially New and Re-emerging Epidemics
2.3.4 Neglected Infectious Diseases*
2.4.1 Cancer
2.4.2 Cardiovascular Disease
3.1 Translating the Results of Clinical Research Outcome
3.3 Health Promotion and Prevention
4.2 Responding to EU Policy Needs

2012 Call Overview
SME Focus – many SME targeted topics and new SME Call
Active and Healthy Ageing – 9 coordinated topics
Medical Technologies – feature highly (related to SME focus)
Other areas of focus:
Rare Diseases
Clinical Trials
Personalised and Regenerative Medicine (inc transplantation)
Systems Biology and -omics
HIV/AIDS, Malaria and TB
Healthcare delivery
Coordination and Support Activities

2012 Call – SME Focused
Two stage submission/evaluation
Several funded proposals per topic
Technology/Methods based topics
Open topic descriptions
Small – medium sized projects
€ 3m or €6m EC contribution
2 – 5 year duration
SME targeted topics
10 Minimum 30% of EC contribution to SMEs
6 Minimum 15% of EC contribution to SMEs
> 30% >15%

Health Theme Funding 2007 - 2013 Year Total Funding Projects Funded SME Targeted 2 Stage 2007 € 641 million 153 0% 0 2008 € 577 million 172 0% 0 2009 € 611 million 105 0% 0 2010 € 621 million 131 0% 19% 2011 € 650 million ~126 20% 75% 2012 € 620 million ? 53% 100% 2013 € 780 million ? ~ 50% 100%

2012 Call – Pilot SME Innovation Call
3 topics only:
1,4-2: Medical Technology for transplantation and bioartificial organs
2.3.0-1: Diagnostics for infectious diseases in humans
2.4.5-1: Technological approaches to combating sensory impairments
SMEs have leading role in the project
>50% EU funding goes to SME partners
# participants limited (3 – 5)
All partners from EU MS or ACs
Limits on project duration
Accelerated evaluation and grant negotiation timeline
> 50%

2012 Call – Research Priorities #1 Ageing
Must meet Europe 2020 objectives of active and healthy ageing:
Healthy, active and independent lives until old age
Ensure the sustainability and efficiency of social and healthcare systems
Create a European/Global market for innovative products and services related to healthy and active ageing
11 Topics in call are linked to EIP initiative
Cross thematic initiative: ICT,KBBE + SSH
EIP

2012 Call – Research Priorities #2 Medical Technologies
Supporting the “innovation” strategy and closer to market approach
Large overlap with “SME friendly” topics
9 topics through the work programme
Tech

2012 Call – Research Priorities #3 Clinical Trials
Continue the initiative started in the 2011 call for investigator driven clinical trials
Improve quality of clinical trials data in Europe
Strengthen CTs in Europe in areas with unmet medical needs
Funding for Stage II,III or IV clinical trials as RTD activities (i.e. 75% EC contribution). Flexibility w.r.t. duration and participation.
Involvement of patient groups encouraged
Outsourcing possible
Subcontracted third party
Reimbursement on cost basis
Clin

1.2: Detection, Diagnosis and Monitoring EIP > 30%
Support R&D and/or proof of principle of technologies for application in the area of personalised medicines
Tailored medical interventions
More effective
Fewer undesirable side effects
Technologies should be of use for research, screening, diagnostics and/or guidance on therapeutic interventions
1.2.1 Development of technologies with a view to patient group stratification for personalised medicine applications 6,000,000 >1

1.4: Innovative Therapeutic Approaches and Interventions >15% >15% EIP > 50% > 30% Tech Tech * 1.4-3 requires cooperation with Australia Clin Transplantation topics have not featured highly in FP7 to date 1.4-1 Innovative approaches to solid organ transplantation 6,000,000 >1 1.4-2 Medical technology for the transplantation sector and bioartificial organs 6,000,000 >1 1.4-3* Innovative strategies for translation of stem cell based therapies in regenerative medicine 6,000,000 1 1.4-4 Targeted nucleic acid delivery as an innovative therapeutic or prophylactic approach 6,000,000 >1

2.1.1: Large Scale Data Gathering >15% EIP > 30% > 30%
Objective is to use high-throughput technologies to generate data for elucidating the function of genes and gene products.
Topics focus on the clinical use of –omics approaches and analysis of their outcomes.
2.1.1.1-A Support for international rare disease research 2,000,000 1 2.1.1.1-B Clinical utility of -omics for better diagnosis of rare diseases 12,000,000 2 2.1.1.1-C Databases, biobanks and clinical bio-informatics' hub for rare diseases 12,000,000 1 2.1.1-2 Validation of -omics based biomarkers for diseases affecting the elderly 12,000,000 >1 2.1.1-3 Statistical methods for collection and analysis of -omics data 6,000,000 >1

2.1.2: Systems Biology
medical needs should drive systems biology research
using systems medicine to improve understanding of disease mechanisms, prognosis and diagnosis of common diseases
Coordinate European research activities for systems biology applications to medicine
> 30% 2.1.2-1 Systems medicine: SME-driven research applying systems biology approaches to address clinical needs 3,000,000 >1 2.1.2-2 Systems medicine: Applying systems biology approaches for understanding common human diseases and their co-morbidities 12,000,000 >1 2.1.2-3 Preparing for the future research and innovation activities in systems medicine 3,000,000 1

2.2.2: Human Development and Ageing >15% EIP EIP Clin > 30%
Focus on use and application of –omics knowledge and tools to gain a clear understanding of the fundamental mechanisms of human ageing
Clinical trials should compare outcomes of various treatment regimens
2.2.2-1 Integrative systems biology and comparative genomics for studying human ageing and most common age-related conditions 6,000,000 >1 2.2.2-2 Investigator-driven clinical trials for optimisation of treatment for elderly patients with multiple diseases 6,000,000 >1

2.3.0: Cross Cutting > 50% Tech
SMEs should take a leading role in 2.3.0-1
Project should be < 3 years
€ 6,000,000 ceiling is max only
ERA-NET should deepen and extend the coordination of European research in infectious diseases and be complementary to other European activities in this area.
2.3.0-1 Diagnostics for infectious diseases in humans 6,000,000 >1 2.3.0-2 ERA-NET on Infectious Diseases 2,000,000 1

2.3.2: HIV/AIDS Malaria and TB
Co-infection and co-morbidity of HIV and other common infectious diseases poorly understood
Prevention topic is looking for small, rapid projects
1 – 3 years, €1 – 6 million funding
Low cost interventions looking for solutions that can be implemented within the project period
>15% 2.3.2-1 Co-infection and co-morbidity in HIV/AIDS, malaria, tuberculosis and/or hepatitis 6,000,000 >1 2.3.2-2 Co-morbidity between infectious and non-communicable diseases 6,000,000 >1 2.3.2-3 Prevention and treatment for HIV/AIDS, malaria and tuberculosis 6,000,000 >1 2.3.2-4 Low-cost interventions for disease control in resource poor settings 3,000,000 >1

2.4.3: Diabetes and Obesity Clin > 30% Tech 2.4.3-1 Innovative approach to manage diabetes 6,000,000 >1 2.4.3-2 Investigator-driven clinical trials for type 1 diabetes research 6,000,000 >1

2.4.4: Rare Diseases Clin Clin > 30% 2.4.4-1 Preclinical and/or clinical development of substances with a clear potential as orphan drugs 6,000,000 >1 2.4.4-2 Observational trials in rare diseases 3,000,000 >1 2.4.4-3 Best practice and knowledge sharing in the clinical management of rare diseases 2,000,000 1

2.4.5: Other Chronic Diseases EIP > 50% >15% EIP Tech Tech 2.4.5-1 Technological approaches to to combating sensory impairments 6,000,000 >1 2.4.5-2 Biomarkers and diagnostics for chronic inflammatory diseases of the joints 6,000,000 >1

2012 Call – Healthcare Delivery
Addressing the need for systematic mapping of variations in health care practice and standardisation of health technology assessment
Various areas of healthcare covered
EU has strong political stance on healthcare equality
EIP EIP Tech 3.2-1 Improving the organisation of health service delivery 3,000,000 >1 3.2-2 New methodologies for health technology assessment 3,000,000 >1 3.2-2 Social Innovation platform for ageing research 6,000,000 1 3.4-1 Health systems/services research in low and middle income countries 6,000,000 >1

2012 Call – Coordination and Support Actions
Various actions to complement research activities, develop infrastructure and determine future activities
4.1-1 Network to encourage technology transfer in FP-funded health research (especially in academic and governmental organisations) 2,000,000 1 4.1-2 Training actions linked to intellectual property rights management and technology transfer 2,000,000 1 4.1-3 Support for Presidency events: Organisation of supporting actions and events related to the Presidency of the European Union 100,000 >1 4.1-4 Communicating the benefits of European research to the general public 1,000,000 >1 4.1-5 Preparing for the future for health research and innovation 500,000 >1

09 June 2011: Open Info Day, Brussels
10 June 2011: Brokerage Event, Brussels
20 July 2011: Call Opens – EPSS available
27 Sept 2011: likely Stage 1 deadline (INNOVATION 2)
04 Oct 2011: likely Stage 1 deadline (INNOVATION 1)
Dec 2011: Stage 1 notification
Feb 2012: Stage 2 deadline
Key Dates

Other Health Related EU Funding Sources 2011 Nanosciences, Materials and Production NMP NMP.2012.1.2-2: Development and phase-I clinical trials of novel therapeutic nanotechnology-enabled systems for the diagnosis and treatment of atherosclerosis NMP.2012.2.2-1: Biomaterials for improved performance of medical implants Likely timeframe similar to Health call

Other Health Related EU Funding Sources 2011
ICT call
Virtual Physiological Human
E-health and data management
KBBE call
Research For the Benefit of SMEs
Call opens July 2011
Ambient Assisted Living
ICT based solutions for Advancement of Older Persons’ Mobility
Call opened 31 March 2011, deadline 30 June 2011

Graham Hughes - Beta Technology - FP 7 Call Presentation

by CK Group on May 23, 2011

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