Respiratory Failure
ByDr.SoliMaN ELKADY   I.C.U ReSiDeNt
IntroductionMost common reason for admission to ICU is toprotect airway and ventilator care to critically                 ...
Primary functions of lung and thorax is to oxygenate         arterial blood and to eliminate                        CO2.
Dysfunction may occur in   oxygenation (intrapulmonary gas              exchange)  or in ventilation (the movement ofgases...
0VERVIEW: RESPIRATORY SYSTEM           ORGANS
Gas Exchange Unit
Respiratory system includes:     CNS (medulla)     Peripheral nervous system (phrenic nerve)     Respiratory muscles     C...
WE SHOULD DIFFRENTIAT BETWEENRESPIRATORY INSUFFICIENCY ANDRESPIRATORY FAILURE
Respiratory insufficiencyThe condition in which the lungs can not take in sufficient oxygen or expel sufficient carbon dio...
Respiratory failureRespiratory failure is a syndrome in which the respiratorysystem fails in one or both of its gas exchan...
In practice : respiratory failure defiend as Pao2 value lessthan 60 mm Hg or PaCO2 value more than50 mm Hg.
classification(1)according to PaCO2■    hypoxemic (Group Ⅰ) respiratory failure      PaO2 of less than 60 mm Hg with a nor...
(2)according to pathogenic mechanism ■   ventilatory disorders 1-obstructive ventilatory disorders asthma, emphysema, chro...
(3)according to primary site ■    central respiratory failure ■    peripheral respiratory failureairway obstruction betwee...
■   peripheral respiratory failure Peripheral airway obstruction may be caused by: specific chemical mediators (such as hi...
clinical
The most important practical classification
HYPOXIC RESPIRATORY FAILURE (TYPE 1)Most common form of respiratory failureLung disease is severe to interfere with pulmon...
Causes of Hypoxic Respiratory failure  1- FiO2 high altitude  2- Ventilation-perfusion (V/Q) mismatch  3- Shunt  4- Diffu...
V/Q mismatchNormal ventilation of alveoli iscomparable to amount ofperfusionNormal V/Q ratio is 0.8 (moreperfusion than ve...
CausesCOPDPneumoniaAsthmaAtelectasisPulmonary embolus
Shunt     An extreme V/Q mismatch((Perfusion without ventilation))Shunting is the most common cause for hypoxaemic respira...
CausesI- Anatomic shuntBlood passes through parts of respiratory system thatreceives no ventilationII- IntracardiacRight t...
Diffusion limitationDistance between alveoli and pulmonary capillary isone- two cells thickWith diffusion abnormalities:th...
Alveolar hypoventilationIs a generalized decrease in ventilation of lungsand resultant buildup of CO2CausesRestrictive lun...
Hypercapnic Respiratory Failure (Type II) This occurs in patients with chronic CO2 retention who worsen and have rising CO...
Causes of Hypercapnic Respiratory failure Respiratory centre (medulla) dysfunction Drug over dose, CVA hypothyroidism Neur...
Common causes    Hypoxemic RF •                        Hypercapnic RF •Chronic bronchitis, emphysema       Chronic bronchi...
Effects of respiratory failure    1- Acid-base disturbances & disorders of electrolyte balance    2- Alteration of the res...
3. Alteration of the cardiovascular system      ■ compensatory    reaction         PaO2<60 mmHg,PaCO2 increase            ...
4. Alteration of the nervous system(1) Hypoxia: the nervous system is very sensible to oxygen lack.   < 40~50 mmHg, seriou...
5. Alteration of the renal function6. Alteration of the digestive system
Respiratory Failure SymptomsWhen compensatory mechanisms fail, respiratory failure occurs            CNS:            Heada...
Pulmonary:CoughChest painsSputum productionStridorDyspnea                    Cardiac:                    Orthopnea        ...
Clinical diagnosisRespiratory compensationTachypnoea RR > 35 Breath /minAccessory musclRetraction intercostal msNasal flar...
Causes of error Pulse oximetry   Poor peripheral perfusion   Dark skin   False nails or nail PAINTING   Bright ambient lig...
ASSESSMENT OF PATIENT1-Careful history2-Physical Examination3-InvestigationsI- ABG analysis :PaO2PaCO2pHAlveolar-Arterial ...
where PiO2 = partial pressure of inspired air, R = 0.8i.e, at sea level, breathing air;PAO2 = 20 - PaCO2/0.8 A-a Gradient ...
II-Chest x-rayIII-CBC,IV- sputum/blood cultures,V- Serum electrolytesVI- ECGVII- UrinalysisVIII-V/Q lung scanIX- Pulmonary...
Management of Respiratory Failure PrinciplesHypoxemia may cause death in RFPrimary objective is to reverse and preventhypo...
Management      Correction of hypoxemiaSupplemental O2 therapy essentialTitration based on SaO2, PaO2 levels and PaCO2Goal...
Mobilization of secretionsEncourage pt 4 Effective coughing    Positioning    Semisetting
Hydration and humidification Chest PhysiotherapyChest percussion to loosensecretion   Airway suctioning
Drug TherapyRelief of bronchospasmBronchodilatorsReduction of airway inflammationCorticosteroidsReduction of pulmonary con...
Noninvasive Ventilatory support (IPPV)       BiPAP                   CPAPMild to moderate RFNIPPV INDICATED InAcute exacer...
Benefits                   NIPPV                         ofImproved alveolar ventilationReduced work of breathing  Rest of...
should not be considered for NPPV?                    ContraindicationsCardiac or respiratory arrestNonrespiratory organ f...
Mechanical ventilationIndicationsPaO2< 55 mm Hg or PaCO2 > 60 mm Hgdespite 100% oxygen therapy.Deteriorating respiratory s...
Mechanical Ventilation: Strategies1-SIMV, A/C with PEEPPEEP (positive End-Expiratory pressure)Increase intrathoracic press...
2-High frequency ventilation (HFV)Very small tidal volumes are used(<1ml/kg), very rapid rates and lower meanairway pressu...
5-Prone positioningImprove oxygenation in about 2/3 of alltreated patientsNo improvement on survival, time onventilation, ...
Respiratory failure common in old age due to                ↓ Ventilatory capacity                Alveolar dilation       ...
Thanks for attention
Direct Lung Injury                                      Infectious pneumonia                                      Aspirati...
Respiratory failure
Respiratory failure
Respiratory failure
Respiratory failure
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Respiratory failure

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Dr.SoliMaN ELKADY
I.C.U ReSiDeNt

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Transcript of "Respiratory failure"

  1. 1. Respiratory Failure
  2. 2. ByDr.SoliMaN ELKADY I.C.U ReSiDeNt
  3. 3. IntroductionMost common reason for admission to ICU is toprotect airway and ventilator care to critically ill patients
  4. 4. Primary functions of lung and thorax is to oxygenate arterial blood and to eliminate CO2.
  5. 5. Dysfunction may occur in oxygenation (intrapulmonary gas exchange) or in ventilation (the movement ofgases between the environment and the lungs)
  6. 6. 0VERVIEW: RESPIRATORY SYSTEM ORGANS
  7. 7. Gas Exchange Unit
  8. 8. Respiratory system includes: CNS (medulla) Peripheral nervous system (phrenic nerve) Respiratory muscles Chest wall Lung Upper airway Bronchial tree Alveoli Pulmonary vasculature
  9. 9. WE SHOULD DIFFRENTIAT BETWEENRESPIRATORY INSUFFICIENCY ANDRESPIRATORY FAILURE
  10. 10. Respiratory insufficiencyThe condition in which the lungs can not take in sufficient oxygen or expel sufficient carbon dioxide to meet the needs of the cells of the body..
  11. 11. Respiratory failureRespiratory failure is a syndrome in which the respiratorysystem fails in one or both of its gas exchange functions:oxygenation and carbon dioxide elimination.
  12. 12. In practice : respiratory failure defiend as Pao2 value lessthan 60 mm Hg or PaCO2 value more than50 mm Hg.
  13. 13. classification(1)according to PaCO2■ hypoxemic (Group Ⅰ) respiratory failure PaO2 of less than 60 mm Hg with a normal or low PaCO2. Cause of: Edema, Vascular disease, Chest Wall.■ hypercapnic (Group Ⅱ ) respiratory failure PaO2 low 60 mm Hg and PaCO2 of more than 50 mm Hg. Cause of: Airway obstruction, Neuromuscular disease.
  14. 14. (2)according to pathogenic mechanism ■ ventilatory disorders 1-obstructive ventilatory disorders asthma, emphysema, chronic bronchitis, and bronchiectasis 2-restrictive ventilatory disorders deformity of thorax , fracture of several ribs, tension pneumothorax diffuse interstitial fibrosis ■ gas exchange disorders 1-diffusion disorders 2-ventilation-perfusion mismatching
  15. 15. (3)according to primary site ■ central respiratory failure ■ peripheral respiratory failureairway obstruction between the glottis and the carina ■Obstruction is located in the airway outside the thorax: inspiratory dysnea ■Obstruction is located in the airway inside the thorax: expiratory dysnea expire inspire
  16. 16. ■ peripheral respiratory failure Peripheral airway obstruction may be caused by: specific chemical mediators (such as histamine, leukotrienes, prostaglandins ), other substances released during inflammatory and allergic responses(4)according to duration ■ acute respiratory failure minute to hours ■ chronic respiratory failure several dayes or longer
  17. 17. clinical
  18. 18. The most important practical classification
  19. 19. HYPOXIC RESPIRATORY FAILURE (TYPE 1)Most common form of respiratory failureLung disease is severe to interfere with pulmonary O2exchange, but over all ventilation is maintained
  20. 20. Causes of Hypoxic Respiratory failure 1- FiO2 high altitude 2- Ventilation-perfusion (V/Q) mismatch 3- Shunt 4- Diffusion limitation 5- Alveolar hypoventilation
  21. 21. V/Q mismatchNormal ventilation of alveoli iscomparable to amount ofperfusionNormal V/Q ratio is 0.8 (moreperfusion than ventilation)V/Q Mismatch :Inadequate ventilationPoor perfusion VA Q VA/ Q Top 1.2L/min 0.4L/min 3.0 Middle 1.8L/min 2.0L/min 0.9 Bottom 2.1L/min 3.4L/min 0.6
  22. 22. CausesCOPDPneumoniaAsthmaAtelectasisPulmonary embolus
  23. 23. Shunt An extreme V/Q mismatch((Perfusion without ventilation))Shunting is the most common cause for hypoxaemic respiratory failurein ICU patients.The deoxygenated blood bypasses the ventilated alveoli and mixes withoxygenated blood → hypoxemiaPersistent of hypoxemia despite 100% O2 inhalationHypercapnia occur when shunt is excessive > 60%
  24. 24. CausesI- Anatomic shuntBlood passes through parts of respiratory system thatreceives no ventilationII- IntracardiacRight to left shuntFallot’s tetralogyEisenmenger’s syndrome III- IntraPulmonary A/V malformation Pneumonia Pulmonary edema Atelectasis/collapse Pulmonary Hge Pulmonary contusion
  25. 25. Diffusion limitationDistance between alveoli and pulmonary capillary isone- two cells thickWith diffusion abnormalities:there is an increased distance between alveoli and pulmonary capillary.causesA.R.D.SSever emphysemaRecurrent pulmonary emboliPulmonary fibrosis
  26. 26. Alveolar hypoventilationIs a generalized decrease in ventilation of lungsand resultant buildup of CO2CausesRestrictive lung diseaseCNS diseaseChest wall dysfunctionNeuromuscular disease
  27. 27. Hypercapnic Respiratory Failure (Type II) This occurs in patients with chronic CO2 retention who worsen and have rising CO2 and low pH. Mechanism: respiratory muscle fatigue
  28. 28. Causes of Hypercapnic Respiratory failure Respiratory centre (medulla) dysfunction Drug over dose, CVA hypothyroidism Neuromuscular disease Guillain-Barre, Myasthenia Gravis, polio, spinal injuries Chest wall/Pleural diseases kyphoscoliosis, pneumothorax, massive pleural effusion Upper airways obstruction tumor, foreign body, laryngeal edema Peripheral airway disorder asthma, COPD
  29. 29. Common causes Hypoxemic RF • Hypercapnic RF •Chronic bronchitis, emphysema Chronic bronchitis,emphysemaPneumonia, pulmonary edema Severe asthma, drug overdosePulmonary fibrosis Poisonings, Myasthenia gravisAsthma, pneumothorax Polyneuropathy, PoliomyelitisPulmonary embolism, Primary ms disordersPulmonary hypertension 1ry alveolar hypoventilationBronchiectasis, ARDS Obesity hypoventilation synd.Fat embolism, KS, Obesity Pulmonary edema, ARDSCyanotic congenital heart disease Myxedema, head and cervicalGranulomatous lung disease cord injury
  30. 30. Effects of respiratory failure 1- Acid-base disturbances & disorders of electrolyte balance 2- Alteration of the respiratory system peripheral chemoreceptor■ PaO2↓ <60mmHg respiratory center(+) respiratory movement↑ <30mmHg respiratory center (-) respiratory movement ↓■ PaCO2↑ central chemoreceptor <80mmHg respiratory center (+) respiratory movement↑ >80mmHg respiratory center (-) respiratory movement ↓
  31. 31. 3. Alteration of the cardiovascular system ■ compensatory reaction PaO2<60 mmHg,PaCO2 increase cardiovascular center(+) increase in cardiac output : increase in stroke volume and heart rate redistribution of blood flow ■ injurious changes PaO2< 40 mmHg,PaCO2> 80 mmHg cardiovascular center(-) rate slow, decreased blood pressure cardiac output decrease pulmonary hypertension
  32. 32. 4. Alteration of the nervous system(1) Hypoxia: the nervous system is very sensible to oxygen lack. < 40~50 mmHg, serious but reversible deterioration in cerebral function ( orientation, arithmetic tasks, memory) occurs, and restlessness and confusion are common. < 30 mmHg, loss of consciousness results. < 20 mmHg, irreversible damage of neural cells.(2) Hypercapnia: CO2 nacosis.condition of confusion, tremors, convulsions, and possible coma thatmay occur if blood levels of carbon dioxide increase to 80mm Hg or higher
  33. 33. 5. Alteration of the renal function6. Alteration of the digestive system
  34. 34. Respiratory Failure SymptomsWhen compensatory mechanisms fail, respiratory failure occurs CNS: Headache Visual Disturbances Anxiety Confusion Memory Loss Weakness Decreased Functional Performance
  35. 35. Pulmonary:CoughChest painsSputum productionStridorDyspnea Cardiac: Orthopnea Chest pain Other: Fever, Abdominal pain, Anemia, Bleeding
  36. 36. Clinical diagnosisRespiratory compensationTachypnoea RR > 35 Breath /minAccessory musclRetraction intercostal msNasal flaringSympathetic stimulation HR BP Tissue hypoxiasweating Altered mental stateHaemoglobin desaturation HR and BP (late)Low spo2Cyanosis (late)
  37. 37. Causes of error Pulse oximetry Poor peripheral perfusion Dark skin False nails or nail PAINTING Bright ambient light Poorly adherent probe Excessive motion Carboxyhaemoglobin or methaemoglobin
  38. 38. ASSESSMENT OF PATIENT1-Careful history2-Physical Examination3-InvestigationsI- ABG analysis :PaO2PaCO2pHAlveolar-Arterial PO2 Gradient P(A-a)02 = (PiO2 - PaCO2) – PaO2 R
  39. 39. where PiO2 = partial pressure of inspired air, R = 0.8i.e, at sea level, breathing air;PAO2 = 20 - PaCO2/0.8 A-a Gradient = 20 - PaCO2/0.8 -PaO2Normal P(A-a)O2 gradient: 5-10 mm of HgA sensitive indicator of disturbance of gas exchange.Useful in differentiating extrapulmonary and pulmonary causes ofresp. failure.
  40. 40. II-Chest x-rayIII-CBC,IV- sputum/blood cultures,V- Serum electrolytesVI- ECGVII- UrinalysisVIII-V/Q lung scanIX- Pulmonary artery catheter (severe cases)
  41. 41. Management of Respiratory Failure PrinciplesHypoxemia may cause death in RFPrimary objective is to reverse and preventhypoxemiaSecondary objective is to control PaCO2 andrespiratory acidosisTreatment of underlying diseasePatient’s CNS and CVS must be monitoredand treated
  42. 42. Management Correction of hypoxemiaSupplemental O2 therapy essentialTitration based on SaO2, PaO2 levels and PaCO2Goal is to prevent tissue hypoxiaTissue hypoxia occurs (normal Hb & C.O.)- venous PaO2 < 20 mmHg or SaO2 < 40%- arterial PaO2 < 38 mmHg or SaO2 < 70%Increase arterial PaO2 > 60 mmHg(SaO2 > 90%) or venous SaO2 > 60% Correction of hypercapniaControl the underlying causeControlled O2 supply1 -3 lit/min, titrate according O2 saturationO2 supply to keep the O2 saturation >90% but<93 to avoid inducing hypercapnia
  43. 43. Mobilization of secretionsEncourage pt 4 Effective coughing Positioning Semisetting
  44. 44. Hydration and humidification Chest PhysiotherapyChest percussion to loosensecretion Airway suctioning
  45. 45. Drug TherapyRelief of bronchospasmBronchodilatorsReduction of airway inflammationCorticosteroidsReduction of pulmonary congestionIV diureticsTreatment of pulmonary infectionsIV antibiotics Nutritional TherapyMaintain protein and energy storesEnteral or parenteral nutrition Supplements
  46. 46. Noninvasive Ventilatory support (IPPV) BiPAP CPAPMild to moderate RFNIPPV INDICATED InAcute exacerbation of COPD WITHRespiratory acidosis pH 7.25 Or lessCardiogenic pulmonary edemaAsthmaType II R.F secondary to chest wall deformityor neuro muscular diseasesWeaning off mechanical ventilation
  47. 47. Benefits NIPPV ofImproved alveolar ventilationReduced work of breathing Rest of the respiratory musculature Increased intrathoracic pressure decreases preload and afterload
  48. 48. should not be considered for NPPV? ContraindicationsCardiac or respiratory arrestNonrespiratory organ failureHemodynamic instabilitySevere encephalopathySevere UGI bleedFacial or neurosurgery, traumaUpper airway obstructionInability to cooperate or protect airwayHigh risk for aspiration
  49. 49. Mechanical ventilationIndicationsPaO2< 55 mm Hg or PaCO2 > 60 mm Hgdespite 100% oxygen therapy.Deteriorating respiratory status despiteoxygen and Nebulization therapyAnxious, with deteriorating mental status.Respiratory fatigue: for relief of metabolicstress of the work of breathing
  50. 50. Mechanical Ventilation: Strategies1-SIMV, A/C with PEEPPEEP (positive End-Expiratory pressure)Increase intrathoracic pressureKeeps the alveoli openDecrease shuntingImprove gas exchange
  51. 51. 2-High frequency ventilation (HFV)Very small tidal volumes are used(<1ml/kg), very rapid rates and lower meanairway pressures are used3-Lung RecruitmentTo open the collapsed alveoliA sustained inflation of the lungs to higherairway pressure and volumes 4-Permissive HypercapniaAllows the PaCO2 to rise into the 60-70 mm ofHg range, as long as the patient is adequatelyoxygenated (SaO2> 92%), and able to toleratethe acidosis.This strategy is used to limit the amount ofbarotrauma and volutrauma to the patient
  52. 52. 5-Prone positioningImprove oxygenation in about 2/3 of alltreated patientsNo improvement on survival, time onventilation, or time in ICUMight be useful to treat refractoryhypoxemiaRoutine use is not recommended
  53. 53. Respiratory failure common in old age due to ↓ Ventilatory capacity Alveolar dilation Larger air spaces Loss of surface area Diminished elastic recoil Decreased respiratory muscle strength ↓ Chest wall compliance
  54. 54. Thanks for attention
  55. 55. Direct Lung Injury Infectious pneumonia Aspiration, chemical pneumonitisAcute Respiratory Distress Syndrome Pulmonary contusion, penetrating lung injury Fat emboli Near-drowning Inhalation injury Reperfusion pulmonary edema s/p lung transplant Indirect Lung Injury Sepsis Severe trauma with shock/hypoperfusion Burns Massive blood transfusion Drug overdose: ASA, cocaine, opioids, phenothiazines, TCAs. Cardiopulmonary bypass Acute pancreatitis

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