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The search of the origin of DNA and alternative functions

The search of the origin of DNA and alternative functions






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    The search of the origin of DNA and alternative functions The search of the origin of DNA and alternative functions Presentation Transcript

    • Catalina Bermúdez González Third semester Molecular biologyBolivarian Pontifical University
    • • DNA be template for the synthesis ofTranscriptio RNA by the enzyme RNA polymerase n • RNA serves as an intermediary to carry the genetic information from the nucleus to the cytoplasmTranslation • Serves as template for the synthesis of proteins DNA RNA Double chain Single chain Desoxirribose Ribose sugar sugar Uracil Timine
    •  Science Daily (Jan. 9, 2012)
    •  The Scientifics are searching alternatives genetic molecules for know how the first life began TNA is a nucleic acid similar to DNA and RNA but has a threose (tetrose sugar) so is more simple than de ribose or desoxiribose sugar, so could assemble more easily in a probiotic world
    •  A single strand of TNA can bind with DNA and RNA using polymerase enzymes TNA nucleotides could attach by complementary base pairing to a random sequence of DNA, forming a hybrid DNA-TNA strand
    •  TNA can fold into complex shapes that can bind to a desired target with high affinity so the scientifics hope to produce a TNA as a high-specificity binding receptor for the human protein thrombin
    • Beside for be a newknowledge with a greatapplication in medicine andhigh technologist especiallyin gene therapy, ifit continues to deepen thestudy could be a new theoryabout the origin of life .
    •  By Sabrina Richards (January 19, 2012)
    •  Use DNA’s simplicity to build nanostructures of DNA that mimic polymerases or another enzymes for do biological process
    •  DNA nanostructures is used to enzymatic reactions Meta-DNA structures was build using pieces of DNA Meta-bases are three strands of double- stranded DNA. The ends of strand complement the other two
    •  Meta-DNA act like enzymes and providing an opening for other single-stranded bit of meta-DNA to bind. New meta-bases could start binding allowing for possible enzymatic reactions. The meta-DNA should eliminate unnecessary unpredictability of RNA and proteins but to become useful, have to interact proteins and the preform reactions more slowly
    • This development wouldfacilitate gene therapyand become more efficientin terms ofreduction process should bedone, but I think it is a studythat is still notvery viable becausethe target DNA requirethe interaction withproteins andreactions develop moreslowly
    •  These developments increasingly specialized can be used extensively in medicine, especially in gene therapy.
    •  The TNA can be adopted to mark places of micro clots doing to bring human protein Throm bin receptor be useful for surgery As the TNA a precursor molecule of primitive life forms could be created vectors carrying DNA strands or drugs directly to cellular receptors
    •  With regard to self- replication of DNA if a string can start processes that normally require many other factors, would be more efficient therapy. The most important thing is to give the patient the greatest possible comfort and quality of life because after all the objetive of science is always to serve the people
    •  MARTINEZ SANCHEZ , Lina María. Biología molecular. 6. ed. Medellín: UPB. Facultad de medicina, 2012. 70 p. Simpler Times: Did an Earlier Genetic Molecule Predate DNA and RNA?. Science daily [seriada en línea]. Enero 9, 2012. Disponible en: URL: http://www.sciencedaily.com/releases/2012/01/12 0109103029.htm. Consultado Enero, 2012. RICHARDS, Sabrina. Can DNA Self-replicate?.The Scientist: Magazine of the life sciences [Seriada en línea] Enero 19, 2012. Disponible en: URL:http://the-scientist.com/2012/01/19/can- dna-self-replicate/. Consultado Enero, 2012