The search of the origin of DNA and alternative functions
Catalina Bermúdez González Third semester Molecular biologyBolivarian Pontifical University
• DNA be template for the synthesis ofTranscriptio RNA by the enzyme RNA polymerase n • RNA serves as an intermediary to carry the genetic information from the nucleus to the cytoplasmTranslation • Serves as template for the synthesis of proteins DNA RNA Double chain Single chain Desoxirribose Ribose sugar sugar Uracil Timine
The Scientifics are searching alternatives genetic molecules for know how the first life began TNA is a nucleic acid similar to DNA and RNA but has a threose (tetrose sugar) so is more simple than de ribose or desoxiribose sugar, so could assemble more easily in a probiotic world
A single strand of TNA can bind with DNA and RNA using polymerase enzymes TNA nucleotides could attach by complementary base pairing to a random sequence of DNA, forming a hybrid DNA-TNA strand
TNA can fold into complex shapes that can bind to a desired target with high affinity so the scientifics hope to produce a TNA as a high-specificity binding receptor for the human protein thrombin
Beside for be a newknowledge with a greatapplication in medicine andhigh technologist especiallyin gene therapy, ifit continues to deepen thestudy could be a new theoryabout the origin of life .
Use DNA’s simplicity to build nanostructures of DNA that mimic polymerases or another enzymes for do biological process
DNA nanostructures is used to enzymatic reactions Meta-DNA structures was build using pieces of DNA Meta-bases are three strands of double- stranded DNA. The ends of strand complement the other two
Meta-DNA act like enzymes and providing an opening for other single-stranded bit of meta-DNA to bind. New meta-bases could start binding allowing for possible enzymatic reactions. The meta-DNA should eliminate unnecessary unpredictability of RNA and proteins but to become useful, have to interact proteins and the preform reactions more slowly
This development wouldfacilitate gene therapyand become more efficientin terms ofreduction process should bedone, but I think it is a studythat is still notvery viable becausethe target DNA requirethe interaction withproteins andreactions develop moreslowly
These developments increasingly specialized can be used extensively in medicine, especially in gene therapy.
The TNA can be adopted to mark places of micro clots doing to bring human protein Throm bin receptor be useful for surgery As the TNA a precursor molecule of primitive life forms could be created vectors carrying DNA strands or drugs directly to cellular receptors
With regard to self- replication of DNA if a string can start processes that normally require many other factors, would be more efficient therapy. The most important thing is to give the patient the greatest possible comfort and quality of life because after all the objetive of science is always to serve the people
MARTINEZ SANCHEZ , Lina María. Biología molecular. 6. ed. Medellín: UPB. Facultad de medicina, 2012. 70 p. Simpler Times: Did an Earlier Genetic Molecule Predate DNA and RNA?. Science daily [seriada en línea]. Enero 9, 2012. Disponible en: URL: http://www.sciencedaily.com/releases/2012/01/12 0109103029.htm. Consultado Enero, 2012. RICHARDS, Sabrina. Can DNA Self-replicate?.The Scientist: Magazine of the life sciences [Seriada en línea] Enero 19, 2012. Disponible en: URL:http://the-scientist.com/2012/01/19/can- dna-self-replicate/. Consultado Enero, 2012
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