La Dra. Martina Amiguet Comins comenta los resultados del estudio publicado en ESC Congress 2022.

1. Martina Amiguet Comins
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MTT - Assessing the effects of ARBs and beta-
blockers in Marfan Syndrome
Presentación del ESC Congress 2022
The Lancet, August 2022
https://doi.org/10.1016/ S0140-6736(22)01534-3
MTT
Meta-analysis on the assessment of the effects of
ARB & beta-blockers in Marfan syndrome

2. Martina Amiguet Comins
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Background Methods Results Conclusions
MTT
Presentación del ESC Congress 2022
The Lancet, August 2022
https://doi.org/10.1016/ S0140-6736(22)01534-3
Gráfico. Tomado de Ramón L. Sandoval

3. Martina Amiguet Comins
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Background Methods Results Conclusions
MTT
Presentación del ESC Congress 2022
The Lancet, August 2022
https://doi.org/10.1016/ S0140-6736(22)01534-3
Elbadawi et al. Cardiol Ther
2019
Li et al. Eur J Prev Cardiol 2020

4. Martina Amiguet Comins
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la imagen del ponente
Background Methods Results Conclusions
MTT
Presentación del ESC Congress 2022
The Lancet, August 2022
https://doi.org/10.1016/ S0140-6736(22)01534-3
Sistematical search at MEDLINE, Embase and CENTRAL (Nov, 2021)
TRIALS comparing ARB vs control / ARB vs b-blocker
Individual patient data with patients with NO prior aortic surgery
PRIMARY ENDPOINT: Annual rate of change of aortic root dimension Z
score, measured at sinuses of Valsalva, adjusted to body surface
ARB vs control TRIALS ARB vs b-blockers TRIALS

5. Martina Amiguet Comins
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la imagen del ponente
Background Methods Results Conclusions
MTT
Presentación del ESC Congress 2022
The Lancet, August 2022
https://doi.org/10.1016/ S0140-6736(22)01534-3

6. Martina Amiguet Comins
Espacio reservado para
la imagen del ponente
Background Methods Results Conclusions
MTT
Presentación del ESC Congress 2022
The Lancet, August 2022
https://doi.org/10.1016/ S0140-6736(22)01534-3
Annual rate of change of aortic root dimension Z score
Both treatments seem to have similar
magnitude, using indirect analysis

7. Martina Amiguet Comins
Espacio reservado para
la imagen del ponente
Background Methods Results Conclusions
MTT
Presentación del ESC Congress 2022
The Lancet, August 2022
https://doi.org/10.1016/ S0140-6736(22)01534-3
Previous treatment with b-blockers did not modify the observed results for ARB

8. Martina Amiguet Comins
Espacio reservado para
la imagen del ponente
Background Methods Results Conclusions
MTT
Presentación del ESC Congress 2022
The Lancet, August 2022
https://doi.org/10.1016/ S0140-6736(22)01534-3
• ARBs reduce the rate of aortic growth in Marfan syndrome in this meta-analysis.
• B-blockers appear effective in indirect analyses
• There is no evidence of any interaction in the effects of ARB with any effects of b-blockers, so
dual combinations appear to be an option.
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