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Antibiotic therapy and early onset sepsis
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Antibiotic therapy and early onset sepsis

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  • Primeras 24 horas, mayor mortalidad y rara vez meningitis.
  • CDC Primeros 3 dias SN Temprana, posterior Tardia.
  • Paises en vias de desarrollo.
  • Antibioticos de amplio espectro inducen fungemia
  • Descontinuar antibioticos 2-3 dias posterior a cultivos negativos.Proteccion SNC.Beta Lactamasas Resistencias.

Transcript

  • 1. ANTIBIOTIC THERAPY AND EARLY ONSET SEPSIS. Neoreviews 2012;13;e86
  • 2. SEPSIS NEONATAL S R I S + H E M O C U LT I V O O L C R . Muy temprana Temprana. Tardía.
  • 3. RN A TÉRMINO E.U.A. GBS.
  • 4. RN PRETERMINÓ. Primeras 72 horas.
  • 5. LATINOAMÉRICA, ASIA, ÁFRICA. Gram negativos.  Klebsiella 35%. Gram positivos.  S. aureus. 25%.
  • 6. PROFILAXIS INTRAPARTO. AMPICILINA VS S.G.B. I N T R A PA R T O . E. COLI RESISTENTE. S.G.B. RESISTENTE A AMPICILINA. NO SE CREAN RESISITENCIAS.
  • 7. TERAPIA EMPÍRICA VS DEFINITIVA EN S.N. TEMPRANA. AMPICILINA + G E N TA M I C I N A . E. COLI 78% RESISTENCIA AMPICILINA. 4% RESISTENCIA G E N TA M I C I N A .
  • 8. TERAPIA EMPÍRICA. Ampicilina + Cefotaxima. Carbapenem o meropenem.
  • 9. GRACIAS. Carlos Arturo Ayala Palacios. R1 PM.