DNA Roulette: Understanding genetics and genetic testing through gaming


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DNA Roulette was developed by Michigan State University professor Carrie Heeter and Stanford geneticist Barry Starr to help players understand what Direct to Consumer (DTC) testing does and does not tell you about your health. This presentation at Games for Health 2012 in Boston introduces the game.

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  • The basic premise is simple. A game that surrounded by well-concieved pre-game experiences, carefully planned game context, and following up post-game activities will be a much more impactful learning experience than simply playing the game. Over to you, Joe.
  • DNA Roulette: Understanding genetics and genetic testing through gaming

    1. 1. DNA Roulette:Understanding Genetics & Genetic Testing through Gaming by Professor Carrie Heeter
    2. 2. Dr. Barry Starr• Geneticist, Stanford• Director of Stanford at the Tech If only I were in Boston…
    3. 3. Michigan State University launches fullyonline graduate certificate in serious games web: seriousgames.msu.edu contact: Carrie Heeter heeter@msu.edu LIKE us on Facebook: facebook.com/GamesAndMeaningfulPlay Games for Health Conference 2012
    4. 4. Meaningful Play conference • meaningfulplay.msu.edu • July 16 submission deadline for games, talks, & papers • Keynotes so far: – Kurt Squire (U Wisconsin) – Phaedra Boinodiris (IBM) – Donald Brinkman (Microsoft) – Ann DeMarle (Emergent Media Center, Breakaway) – John Ferrara (Fitter Critters, Playful Design) Games for Health Conference 2012
    5. 5. W h a t I’ m P la y in g SuperbetterInnovationGames’BudgetBalancing Games for Health Conference 2012
    6. 6. • Who has had your genome tested?
    7. 7. • If you could buy a kit at Walgreens for $150 to have your genome tested, would you?• Why or why not?
    8. 8. Oops, sorry.• Pathway Genomics had announced that its saliva swab would be on Walgreens shelves, offering millions of Americans the chance peek into their genetic code for signs of inheritable diseases like Alzheimers.• The FDA blocked it, saying the kit has not been proven effective.• Today, to use Pathways, “ a physician will need to register and order the report for you.” Games for Health Conference 2012
    9. 9. Direct to Consumer Testing (DTC)• Is a big deal because – Science and technology are advancing rapidly – DTC testing is currently legal and available – It’s controversial – Legislative decisions may eliminate DTC
    10. 10. What’s your opinion?• Individuals should be free to find out information about their own genes to whatever extent they wish, in accord with what they judge to be their own best interests, uncoerced by law or public policy. AGREE! DISAGREE! Genetic testing should only be available when ordered by a doctor.
    11. 11. An informed citizenry• Citizens, policy makers, and health care professionals need to understand what DTC testing does and does not tell us, to make good decisions.
    12. 12. One piece of a larger strategy During game > Pre- Post-game game Game Game
    13. 13. DNA Roulette• 2 teams, 3 rounds each, high score at the end wins $1.• 3 collective exploratory rounds to help you plan your strategies.• Let’s see what you learn.
    14. 14. Game Demo and Competition• note: DNA Roulette will be published to the Understanding Genetics web site run by the San Jose Tech Museum of Innovation and Stanford University in August, 2012. To play, go to:• http://genetics.thetech.org/online-exhibits
    15. 15. Now that you’ve played, what have you learned? Q u i c k Q u i z• Having your DNA tested tells you exactly what diseases you will develop. – True – False• Most diseases and traits are caused by: – A single genetic variant – Multiple variants
    16. 16. Genes are Destiny• MISCONCEPTION: “Genes determine everything form your sex, and hair color, to what diseases you many have and how high you will grow.”• CORRECT CONCEPTION: Genes are not necessarily deterministic. More frequently, environmental influences coupled with genotype determine phenotype.
    17. 17. One Gene, One Trait•  MISCONCEPTION: One gene is always responsible for one trait or one gene with one mutation always causes one disease.• CORRECT CONCEPTION: Instead, multiple factors contribute to phenotype. Multiple genes often work together, with the environment, to determine ultimate phenotype. Essay Contest Reveals Misconceptions of High School Students in Genetics Content Kenna R. Mills Shaw, Katie Van Horne, Hubert Zhang, Joann Boughman Genetics. 2008 March; 178(3): 1157–1168. doi: 10.1534/genetics.107.084194 PMCID: PMC2278104 Games for Health Conference 2012
    18. 18. Data the game is based on…• These next slides will show the kinds of data available on DTC genetics testing sites. The screen shots are from 23andMe.com• DNA Roulette pulls data from an XML file, making it easy to add new traits and disease conditions without changing the game engine.
    19. 19. 118 Diseases
    20. 20. (I made a version that plays MY genes)
    21. 21. 44 Carrier Status
    22. 22. 19 Drug Responses
    23. 23. 55 Traits
    24. 24. Muscle Performance SNP (single nucleotide polymorphism)
    25. 25. Scary (and rare): Not so scary (and common): single marker, large genetic 11+ markers, moderateimpact, no treatment or cure genetic impact, treatable Alzheimer’s Type 2 Diabetes Games for Health Conference 2012
    26. 26. Games for Health Games for Health Conference 2012
    27. 27. Thank you!Professor Carrie Heeter heeter@msu.edu seriousgames.msu.edu Games for Health Conference 2012