Kaplan–Meier Estimates of the Probability of Survival in the Group Assigned to Receive an Implantable Defibrillator and the Group Assigned to Receive Conventional Medical Therapy. Moss AJ et al. N Engl J Med 2002;346:877-883.
1232 PATIENTS RANDOMISED 3:2 TO ICD OR CONVENTIONAL MED.TREATMENT
AVERAGE FOLLOW UP20 MONTHS RANGE 6 DAYS TO 53 MONTHS
Supported by a research grant from Guidant, St. Paul, Minn., to the University of Rochester School of Medicine and Dentistry. Drs. Cannom, Daubert, and Higgins have given lectures sponsored by Guidant. PATIENTS DID NOT PAY FOR THE ICD DEVICE WAS PAID FOR BY GUIDANT
Defibrillator therapy was associated with a 49% reduction in risk of death among patients with >1 risk factor whereas no ICD benefit was identified in patients with 0 risk factors and very high risk patients JACC 2008
OPEN LABEL COMAPARISION OF ICD VS NO THERAPY-IDENTICAL CLINICAL VARIABLES
ICD- 342 PATIENTS
NO THERAPY 342 PATIENTS
6-40 DAYS POST MI
DEPRESSED HEART RATE VARIAB.OR ELEVATED AVG.24HOUR HEART RATE ON HOLTER
Kaplan–Meier Estimates of the Cumulative Risk of Death from Any Cause. Hohnloser SH et al. N Engl J Med 2004;351:2481-2488.
Mortality Rates. Hohnloser SH et al. N Engl J Med 2004;351:2481-2488.
Infrequent physician use of implantable cardioverter-defibrillators risks patient safety-New York state residents undergoing ICD implantation Stephen Lyman , Art Sedrakyan , Huong Do , Renee Razzano , Alvin I ushlin 2 Heart 2011;97:1655-1660