Evaluation of CXCR4 and CD31 expression in 39 patients with non-small cell lung cancer
Relation between CXCR4 and CD31 expression
( Microvascular Density)
To confirm CD31 and CXCR4 expression as a potential high risk for metastasis and poor prognosis.
MATERIAL and METHODS 39 paraffin specimens from completely resected primary non-small cell lung cancer (pT1-4 pN0-2), texted by CXCR4 and CD31 immunohistochemistry. Blood samples obtained in theatre from pulmonary veins after lobectomy or pneumonectomy were examined for occult tumour cells by immunocytochemical staining of cytospins using the pancytokeratin antibody A45-B/B3 that binds to the cytokeratins 8, 18 and 19.
HIGH AND LOW MVD Low expression CD31 High expression CD31
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