Role of validated and standardized herbal products ; A scientific approach
R OLE OF VALIDATED ANDS TANDARDIZED H ERBALP RODUCTS -A SCIENTIFIC APPROACHDr Capt Tanweer AlamHead( AHP ) International Marketing25th Oct 2011Sun Moon Lake, Nantau, Taiwan
G ROWING I MPORTANCE Out of 252 drugs considered basic and essential by WHO , 11% are exclusively from plant origin and 28% are of synthetic origin but obtained from natural precursors Eighty Five percent (85%) people in developing countries still rely on traditional medicines as first choice for human health care (WHO).
T HE COMPARISON OF SCOPE ! Total world population Poultry : 19 Billion Total world population Cattle : 1.5 billion Human: 6.88 Billion Sheep and goat : 1.6 billion Source: FAOSTAT website
H ERBAL M ARKET: A COMPARISON Total Animal Health Herbal Market Total Global Herbal Market 100 Billion USD 1.5 Billion USD Source: FAOSTAT website & CLFMA REPORT 2009
G ROWING C REDENTIALS : S TANDARDIZATION & B ETTER A NALYTICAL METHODS
G ROWING C REDENTIALS : S TANDARISATION & B ETTER A NALYTICAL METHODS A. paniculata Bacopa monnieri Zingiber officinale
G ROWING C REDENTIALS : AVAILABLE T ECHNICAL B ACK - UPSTotal number of research papers listed on PubMed containing the word "phytoconstituents."
G ROWING C REDENTIALS : A RRAY OF H ERBAL M ONOGRAPHSPublication and availability of authoritativemonographs by various organizations, improvingthe scientific credibility of herbs.
G ROWING C REDENTIALS : A RRAY OF H ERBAL M ONOGRAPHS United States Pharmacopoeia ( USP ) Europe Scientific Cooperative Indian Herbal on Pharmacopoeia Phytotherapy (ESCOP) Confluence of Herbal Pharmacopoeia Chinese Herbal British Herbal PharmacopoeiaPharmacopoeia English Translation of American Herbal German Pharmacopoeia Commissions ( AHP ) E monographs
INDIA 2,50,000 flowering plants world wide India – 8th largest country in natural plants One of the largest flora bio diversity 75% of the medicinal plants grow naturally in India.
Scientific approch of herbal product development
G ENUINENESS Test for Foreign Matter Contaminated(i) Foreign organs: matter coming from the source plant but not defined as the drug.(ii) Foreign elements: matter not coming from the source plant and of either vegetable or mineral origin. (viz,. Free from contamination Moulds, insects and other animal contamination.)
G ENUINENESS HPTLC Finger printPhytochemical profile checked byChromotographic techniques.The samples are chromotographed reference standardsof marker constituents.
E FFICACYQuantification of Markers / Activesusing HPLC High Performance liquid chromatography
E FFICACYEstimation of Forskolinusing HPLC & TLC
E FFICACY LC/MS DETECTION: Powerful Tool for Organic Compound AnalysisIts application is oriented towards the specific detection and potentialentification of phytomarkers in the presence of other phytochemical
S AFETY• Physico-chemical [ Moisture, Ash, Acid insoluble ash,,Silica (Sand)]• Heavy metal residues (Pb, Cd, As, Hg)• Mycotoxin residues• Pesticide residues (organochloro pesticides and organophosphorous pesticides).• Organic volatile impurities (solvent residues-wherever applicable)• Naturally occuring toxins (like pyrrolizidine, alkaloids, beta asarone, cynogenic glycosides etc.)• Microbial Analysis for specific pathogens
CONSISTENCY Batch to batch consistencyS – STANDARD MIXT1- TEST SAMPLE (BATCH NO. AP/07, 24 MONTHS OLD SAMPLE)T2- TEST SAMPLE (BATCH NO. AP/01005, 18 MONTHS OLD SAMPLE)T3- TEST SAMPLE (BATCH NO. AP/02001, 12 MONTHS OLD SAMPLE)T4- TEST SAMPLE (BATCH NO. AP/02006, 6 MONTHS OLD SAMPLE)T5- TEST SAMPLE (BATCH NO. AP/02010, 1 MONTH OLD SAMPLE)
A BRIEF India’s No 1 Herbal Veterinary company for the last 60 years Pioneers in phyto-pharmaceuticals State-of-the-Art R&D with more than 100 qualified scientists
C ORPORATE S OCIAL RESPONSIBILITY Quarterly journal called “Journal of Natural Remedies” dedicated to Medicinal Plant research across the globe. A monthly magazine “Pashudhan”, dedicated to animal healthcare since 35 years and Launched a web portal “vetsjobsindia.com”, developed exclusively for communicating employment opportunities to vets.