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Personalized Medicine and You!
Melanie Swan
Founder
DIYgenomics
+1-650-681-9482
@DIYgenomics
www.DIYgenomics.org
m@melanie...
September 27, 2012
DIYgenomics.org 1
The Realization of Preventive Medicine
Condition Lifecycle
80% Pre-Clinical 20% Clini...
September 27, 2012
DIYgenomics.org 2
Health Social Networks and Collaboration
Source: Extended from Swan, M. Emerging pati...
September 27, 2012
DIYgenomics.org 3
DIYgenomics: Research Model
 Goal: preventive medicine
 Realize preventive medicine...
September 27, 2012
DIYgenomics.org
Big Data: Integrating Health Data Streams
4
Swan, M. Health 2050: The Realization of Pe...
September 27, 2012
DIYgenomics.org 5
Sensor Mania!
Wearable Electronics
Source: Swan, M. Sensor Mania! The Internet of Thi...
September 27, 2012
DIYgenomics.org
DIYgenomics Memory Study
6
Operated on:
September 27, 2012
DIYgenomics.org 7
13 DIYgenomics Studies in Open Enrollment
Source: Swan, M. Sensor Mania! The Internet...
September 27, 2012
DIYgenomics.org
DIYgenomics Studies in Design
 Predictive Risk Profiling
 Immune System and Diseasome...
September 27, 2012
DIYgenomics.org 9
Personalized Preventive Medicine and You!
Individual
2. Peer collaboration and
health...
September 27, 2012
DIYgenomics.org 10
DIYgenomics Press Coverage
"...'accelerating the professionalization' of do-it-
your...
Thank you!
Melanie Swan
Founder
DIYgenomics
+1-650-681-9482
@DIYgenomics
www.DIYgenomics.org
m@melanieswan.comSlides: http...
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Personalized Medicine and You!

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Transcript of "Personalized Medicine and You!"

  1. 1. Personalized Medicine and You! Melanie Swan Founder DIYgenomics +1-650-681-9482 @DIYgenomics www.DIYgenomics.org m@melanieswan.com Health Technology Forum September 27, 2012, San Francisco, CA Slides: http://slideshare.net/LaBlogga
  2. 2. September 27, 2012 DIYgenomics.org 1 The Realization of Preventive Medicine Condition Lifecycle 80% Pre-Clinical 20% Clinical Telemedicine eHealth Initiatives Social Health Media Higher-deductible insurance Consumer Genomics Health Social Networks Health Collaboration Communities Crowdsourced Health Studies Personal Health Records (PHRs) Mobile Health Apps Quantified Self- tracking Devices Biosensors Participatory Medicine Hospital Re-admit Reduction Programs Personalized Molecular Diagnostics Wellness Profiling Disease Risk Prevention Personalized Cancer Treatment Health Coach P4 Medicine (Light) Engagement (Heavy) Home Monitoring Programs Swan, M. Health 2050: The Realization of Personalized Medicine through Crowdsourcing, the Quantified Self, and the Participatory Biocitizen. J Pers Med 2012, 2(3), 93-118.
  3. 3. September 27, 2012 DIYgenomics.org 2 Health Social Networks and Collaboration Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525. Health Collaboration Communities Health Social Networks
  4. 4. September 27, 2012 DIYgenomics.org 3 DIYgenomics: Research Model  Goal: preventive medicine  Realize preventive medicine through predictive risk profiling, determining baseline markers of wellness and variability, and engaging in personalized pre-clinical interventions  Generalized hypothesis  One or more polymorphisms may result in out-of-bounds baseline levels of phenotypic markers which may be ameliorated through personalized intervention Genotype Phenotype Intervention Outcome+ + = Source: Swan, M., Hathaway, K., Hogg, C., McCauley, R., Vollrath, A. Citizen science genomics as a model for crowdsourced preventive medicine research. J Participat Med. 2010, Dec 23; 2:e20. Vitamin B Study: MTHFR SNPs + Vitamin B & Homocysteine Blood Test + Vitamin B = Personalized Outcomes
  5. 5. September 27, 2012 DIYgenomics.org Big Data: Integrating Health Data Streams 4 Swan, M. Health 2050: The Realization of Personalized Medicine through Crowdsourcing, the Quantified Self, and the Participatory Biocitizen. J Pers Med 2012, 2(3), 93-118. Genome SNP mutations Structural variation Epigenetics Microbiome Transcriptome Environmentome Metabolome Diseasome Proteome Personal and Family Health History Prescription History Lab Tests: History and Current Demographic Data Self-reported data: health, exercise, food, mood journals, etc. Biosensor Data Objective Metrics Quantified Self Device Data Mobile App Data Quantified Self Data Streams Traditional Data StreamsNew Data Streams Standardized Instrument Response Legend: Consumer-available
  6. 6. September 27, 2012 DIYgenomics.org 5 Sensor Mania! Wearable Electronics Source: Swan, M. Sensor Mania! The Internet of Things, Objective Metrics, and the Quantified Self 2.0. J Sens Actuator Netw 2012, submitted. The Brain: 24/7 Consumer EEG, Eye-tracking, Emotion Mapping, Augmented Reality Glasses Smartwatch (Pebble) and Smartring (ElectricFoxy) Electronic tattoos (mc10), $1 blood API (Sano Intelligence), and Electronic T-shirt (Carre) Dried blood spot testing (ZRT Lab) Continuous Monitors (Medtronic) Image credit: Cisco
  7. 7. September 27, 2012 DIYgenomics.org DIYgenomics Memory Study 6 Operated on:
  8. 8. September 27, 2012 DIYgenomics.org 7 13 DIYgenomics Studies in Open Enrollment Source: Swan, M. Sensor Mania! The Internet of Things, Objective Metrics, and the Quantified Self 2.0. J Sens Actuator Netw 2012, submitted.  Sleep, Genomics, and Caffeine  20 sleep SNPs + 3 standardized sleep instruments + myZeo + caffeine intervention  Empathy  OXTR SNP + IRI (Interpersonal Reactivity Index) + Personal Virtual Coach  Microbiome  Human gut disease risk SNPs + Microbiome Sequencing + Questionnaire + Probiotic  Diabesity prevention  Diabetes & obesity risk SNPs + Hemoglobin & other blood tests + Glucometer tracking Genotype Phenotype Intervention Outcome+ + = Full List: http://ww.DIYgenomics.org
  9. 9. September 27, 2012 DIYgenomics.org DIYgenomics Studies in Design  Predictive Risk Profiling  Immune System and Diseasome  Environmentome (Body Burden and Capacity)  Cancer Risk and Drug Response  Mental Performance Optimization  Creativity  Learning  Flow State  Diabesity Prevention  Do you have a Sweet Tooth? Genomics and Dietary Preference 8 Genotype Phenotype Intervention Outcome+ + = Image credit: http://sciencemag.org Source: DIYgenomics
  10. 10. September 27, 2012 DIYgenomics.org 9 Personalized Preventive Medicine and You! Individual 2. Peer collaboration and health advisors Health social networks, crowdsourced studies, health advisors, wellness coaches, preventive care plans, boutique physicians, genetics coaches, aestheticians, medical tourism 3. Public health system Deep expertise of traditional health system for disease and trauma treatment 1. Continuous health information climate Automated digital health monitoring, self-tracking devices, and mobile apps providing personalized recommendations Source: Extended from Swan, M. Emerging patient-driven health care models: an examination of health social networks, consumer personalized medicine and quantified self-tracking. Int. J. Environ. Res. Public Health 2009, 2, 492-525.
  11. 11. September 27, 2012 DIYgenomics.org 10 DIYgenomics Press Coverage "...'accelerating the professionalization' of do-it- yourself studies" - March 2012 "Ordinary people are taking control of their health data" - December 2011 "A group called DIYgenomics has banded together to analyse their genomes, and even conduct and participate in small clinical trials" - October 2010 "...early adopters are showing how empowering and beneficial to science personal genetic information can be" - September 2010 "...they wanted to build a model trial that could be easily replicated by citizen scientists anywhere" - March 2011
  12. 12. Thank you! Melanie Swan Founder DIYgenomics +1-650-681-9482 @DIYgenomics www.DIYgenomics.org m@melanieswan.comSlides: http://slideshare.net/LaBloggaCreative Commons 3.0 license Collaborators: Lorenzo Albanello Janet Chang Cindy Chen John Furber Hong Guo Kristina Hathaway Laura Klemme Priya Kshirsagar Lucymarie Mantese Raymond McCauley Personal genome apps Crowd-sourced clinical trials Marat Nepomnyashy Ted Odet Roland Parnaso Thomas Pickard William Reinhardt Greg Smith Aaron Vollrath Lawrence S. Wong International collaborations: JST and Rikengenesis Takashi Kido Minae Kawashima Jin Yamanaka University Hospitals of Geneva Louis Nahum Armin Schnider
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