4. Mutation
Superoxide dismutase (SOD1:21q22.1) is the most
common mutation
SOD1 mutation is only seen in 20% of familial ALS
Juvenile onset - may be autosomal dominant
(SETX:9q34.13) or autosomal recessive (ALS2:2q33
or ALS5:15q15.1−21.1)
Adult onset – autosomal dominant (SOD1:21q22.1 or
ALS3:18q21)
7. References
1. Amyotrophic lateral sclerosis. Retrieved October 2, 2014 from Wikipedia:
http://en.wikipedia.org/wiki/Amyotrophic_lateral_sclerosis
2. Rohkamm, R. (2004). Color atlas of neurology. Germany: Georg Thieme Verlag
3. Solar Radiation and Climate Experiment. (2007). [Graph illustration the SORCE
Spectral Plot May 8, 2008]. Solar Spectral Data Access from the SIM, SOLSTICE, and
XPS Instruments. Retrieved from http://lasp.colorado.edu/cgi-bin/ion-
p?page=input_data_for_ spectra.ion
4. Solar Radiation and Climate Experiment. (2007). [Graph illustration the SORCE
Spectral Plot May 8, 2008]. Solar Spectral Data Access from the SIM, SOLSTICE, and
XPS Instruments. Retrieved from http://lasp.colorado.edu/cgi-bin/ion-
p?page=input_data_for_ spectra.ion
5. Images:
http://webuny.alsa.org/images/content/pagebuilder/2013_walk_to_defeat_als319528.jp
g; http://www.firstcovers.com/index.php/als+awareness.html?site=image&id=3779;
http://www.alsrg.org/National%20Red%20logo%20w%20BK%20tag.jpg;
http://www.alstshirts.com/images/z_als_butterfly_3_w3pr.jpg;
http://www.kickals.org/sitebuildercontent/sitebuilderpictures/webassets/KickALS.jpg;
https://www.als.ca/splash/logo.png?x=bust; http://www.wallpaperlo.com/wp-
content/uploads/2014/08/IceBucketChallenge.jpg;
http://www.discoversmithsfalls.ca/wp-content/uploads/2014/09/als-walk-for-life.png
Editor's Notes
AFFECTS LATERAL CORTICOSPINAL TRACT AND MOTOR NEURONS OF THE ANTEROR GREY COLUMN
www.alsa.org/donate