e-actualització
MANEIG INTEGRAL DEL PACIENT AMB
PATOLOGIA CRÒNICA
Actualització 2013 en risc cardiovascular i
dislipèmies
...
Actualització 2013 en risc cardiovascular i dislipèmies

o Introducción (3)
o Factores de riesgo (8)
o Dieta (2)
o Diabete...
Tendencias en mortalidad por infarto de miocardio. Estudio comparativo
entre España y Estados Unidos: 1990-2006

Orozco et...
Lifetime Risk and Years Lived Free
of Total Cardiovascular Disease

14 años

Wilkins JT et al. JAMA. 2012;308(17):1795-180...
Ideal Cardiovascular Health Is Inversely Associated With Incident Cancer
The Atherosclerosis Risk in Communities Study

3 ...
Factores de riesgo
Long-Term Cardiovascular Risk of Nonsteroidal Anti-Inflammatory Drug Use According
to Time Passed After First-Time Myocard...
Vascular and upper gastrointestinal effects of non-steroidal
anti-inflammatory drugs: meta-analyses of individual
particip...
The Cumulative Effect of Unemployment
on Risks for Acute Myocardial Infarction

Dupre ME. Arch Intern Med. 2012;172(22):17...
The Cumulative Effect of Unemployment
on Risks for Acute Myocardial Infarction

Dupre ME. Arch Intern Med. 2012;172(22):17...
Job strain as a risk factor for coronary heart disease:
a collaborative meta-analysis of individual participant data

Kivi...
Increased risk of coronary heart disease among individuals reporting adverse
impact of stress on their health:
theWhitehal...
Meta-Analysis of Perceived Stress and Its Association With
Incident Coronary Heart Disease

27 %
  LDL 50 mg/dl
  TAS/...
Relation Between Optimism and Lipids in Midlife

Ajustado por demográficos

Ajustado por demog/s.salud

Boehm JK et al. Am...
Residential Proximity to Major Roadway and 10-Year
All-Cause Mortality After Myocardial Infarction

27 %

Rosenbloom JI e...
dieta
Egg consumption and risk of coronary heart disease
and stroke: dose-response meta-analysis of
prospective cohort studies

...
Primary Prevention of Cardiovascular Disease
with a Mediterranean Diet
PREDIMED Study

 30 %

Struch R et al. N Engl J Me...
diabetes
Cardiovascular Effects of Intensive Lifestyle
Intervention in Type 2 Diabetes

The Look AHEAD Research Group*. N Engl J Me...
Association of an Intensive Lifestyle Intervention
With Remission of Type 2 Diabetes

Mayor remisión en :
1. DM tipo 2 de ...
Low HDL Cholesterol and the Risk of Diabetic Nephropathy and
Retinopathy
Results of the ADVANCE study
Third 1 (1.1 mmol/L...
Cardiovascular Event Reduction Versus
New-Onset Diabetes During Atorvastatin Therapy
Effect of Baseline Risk Factors for D...
tratamiento
CHADS2 Score, Statin Therapy, and Risks of Atrial
Fibrillation

19 %

Hung CY et al. The American Journal of Medicine (201...
CHADS2 Score, Statin Therapy, and Risks of Atrial
Fibrillation

31 % , p <.001

Hung CY et al. The American Journal of Med...
PCSK9: proproteína convertasa subtilisina/kexina tipo 9
Low-Density Lipoprotein Cholesterol–Lowering Effects of
AMG 145, a Monoclonal Antibody to Proprotein Convertase
Subtilisin...
Interactive effects of fitness and statin treatment on mortality
risk in veterans with dyslipidaemia: a cohort study

*tod...
Low-Dose Aspirin for Preventing Recurrent
Venous Thromboembolism

26%

Brighton TA et al. N Engl J Med 2012;367:1979-87. D...
Low-Dose Aspirin for Preventing Recurrent
Venous Thromboembolism

34%

Brighton TA et al. N Engl J Med 2012;367:1979-87. D...
Aspirin for Dual Prevention of Venous and Arterial Thrombosis

WarkentinTE. N Engl J Med 2012;367:2039-2041
Statin treatment and the risk of recurrent
pulmonary embolism

Biere-Rafi S et al. European Heart Journal (2013) 34, 1800–...
Risc cardiovascular i dislipèmies
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Risc cardiovascular i dislipèmies

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Risc cardiovascular i dislipèmies

  1. 1. e-actualització MANEIG INTEGRAL DEL PACIENT AMB PATOLOGIA CRÒNICA Actualització 2013 en risc cardiovascular i dislipèmies Dr. Cèsar Asenjo ABS Martí Julià- Cornellà 1 Grup de Lípids CAMFiC 9 octubre 2013 Matí: 14.00 hores Tarda: 20:30 hores Ja us podeu inscriure a la nostra pagina web www.camfic.cat Sol·licitada acreditació al Consell Català de la Formació Continuada de les Professions Sanitàries Organitza: Col·labora:
  2. 2. Actualització 2013 en risc cardiovascular i dislipèmies o Introducción (3) o Factores de riesgo (8) o Dieta (2) o Diabetes (4) o Tratamiento (6)
  3. 3. Tendencias en mortalidad por infarto de miocardio. Estudio comparativo entre España y Estados Unidos: 1990-2006 Orozco et al. Rev Esp Cardiol. 2012;65(12):1079–1085
  4. 4. Lifetime Risk and Years Lived Free of Total Cardiovascular Disease 14 años Wilkins JT et al. JAMA. 2012;308(17):1795-1801
  5. 5. Ideal Cardiovascular Health Is Inversely Associated With Incident Cancer The Atherosclerosis Risk in Communities Study 3 ------- 25 % riesgo menor 6-7 ---- > 50 % riesgo menor Rasmussen-Torvik LJ. Circulation. 2013;127:1270-1275.
  6. 6. Factores de riesgo
  7. 7. Long-Term Cardiovascular Risk of Nonsteroidal Anti-Inflammatory Drug Use According to Time Passed After First-Time Myocardial Infarction A Nationwide Cohort Study Schjerning Olsen AM et al. Circulation. 2012;126:1955-1963.
  8. 8. Vascular and upper gastrointestinal effects of non-steroidal anti-inflammatory drugs: meta-analyses of individual participant data from randomised trials Coxib and traditional NSAID Trialists’ (CNT) Collaboration*. Lancet 2013; 382: 769–79
  9. 9. The Cumulative Effect of Unemployment on Risks for Acute Myocardial Infarction Dupre ME. Arch Intern Med. 2012;172(22):1731-1737.
  10. 10. The Cumulative Effect of Unemployment on Risks for Acute Myocardial Infarction Dupre ME. Arch Intern Med. 2012;172(22):1731-1737.
  11. 11. Job strain as a risk factor for coronary heart disease: a collaborative meta-analysis of individual participant data Kivimäki M et al. Lancet 2012; 380: 1491–97
  12. 12. Increased risk of coronary heart disease among individuals reporting adverse impact of stress on their health: theWhitehall II prospective cohort study Riesgo 1,49 mayor (p0.004) European Heart Journal June 26,2013. doi:10.1093/eurheartj/eht216
  13. 13. Meta-Analysis of Perceived Stress and Its Association With Incident Coronary Heart Disease 27 %   LDL 50 mg/dl   TAS/TAD 2,7/1,4 mmHg  Fumar 5 cig/día Richardson S et al. Am J Cardiol 2012;110:1711–1716
  14. 14. Relation Between Optimism and Lipids in Midlife Ajustado por demográficos Ajustado por demog/s.salud Boehm JK et al. Am J Cardiol 2013http://dx.doi.org/10.1016/j.amjcard.2013.01.292
  15. 15. Residential Proximity to Major Roadway and 10-Year All-Cause Mortality After Myocardial Infarction 27 % Rosenbloom JI et al. Circulation. 2012;125:2197-2203
  16. 16. dieta
  17. 17. Egg consumption and risk of coronary heart disease and stroke: dose-response meta-analysis of prospective cohort studies Rong Y et al. BMJ 2013;346:e8539 doi: 10.1136/bmj.e8539
  18. 18. Primary Prevention of Cardiovascular Disease with a Mediterranean Diet PREDIMED Study  30 % Struch R et al. N Engl J Med 2013.DOI: 10.1056/NEJMoa1200303
  19. 19. diabetes
  20. 20. Cardiovascular Effects of Intensive Lifestyle Intervention in Type 2 Diabetes The Look AHEAD Research Group*. N Engl J Med 2013;369:145-54. DOI: 10.1056/NEJMoa1212914
  21. 21. Association of an Intensive Lifestyle Intervention With Remission of Type 2 Diabetes Mayor remisión en : 1. DM tipo 2 de corta duración 2. Niveles de HbA1c bajos 3. No han requerido insulina Gregg EW. JAMA. 2012;308(23):2489-2496
  22. 22. Low HDL Cholesterol and the Risk of Diabetic Nephropathy and Retinopathy Results of the ADVANCE study Third 1 (1.1 mmol/L) Third 2 (1.1–1.34 mmol/L) Third 3 (1.34 mmol/L) T1 vs T3 p T2 vs T3 p Total eventos microvasculares 1,17 (1,06-1,28) 0,001 1,11 (1,02-1,20) 0,02 Total eventos renales 1,19 (1,08-1,32) 0,0005 1,13 (1,04-1,24) 0,006 Nuevos casos de microalbuminuria 1,14 (1.03-1,27) 0,01 1,10 (1,01-1,21) 0,04 Total eventos retina 1,01 (0,82-1,25) 0,9 0,98 (0,82-1,18) 0,9 Morton J et al. Diabetes Care 35:2201–2206, 2012
  23. 23. Cardiovascular Event Reduction Versus New-Onset Diabetes During Atorvastatin Therapy Effect of Baseline Risk Factors for Diabetes 4 factores independientes predictores de nuevos casos de DM: • glucemia > 100 mg/dl • TGs > 150 mg/dl • IMC > 30 kg/m2 • historia de HTA Waters DD et al. J Am Coll Cardiol 2013;61:148–52
  24. 24. tratamiento
  25. 25. CHADS2 Score, Statin Therapy, and Risks of Atrial Fibrillation 19 % Hung CY et al. The American Journal of Medicine (2013) 126, 133-140
  26. 26. CHADS2 Score, Statin Therapy, and Risks of Atrial Fibrillation 31 % , p <.001 Hung CY et al. The American Journal of Medicine (2013) 126, 133-140
  27. 27. PCSK9: proproteína convertasa subtilisina/kexina tipo 9
  28. 28. Low-Density Lipoprotein Cholesterol–Lowering Effects of AMG 145, a Monoclonal Antibody to Proprotein Convertase Subtilisin/Kexin Type 9 Serine Protease (PCSK9) in Patients With Heterozygous Familial Hypercholesterolemia Aal F et al. Circulation. 2012;126:2408-2417.
  29. 29. Interactive effects of fitness and statin treatment on mortality risk in veterans with dyslipidaemia: a cohort study *todas con diferencias significativas en relación con el grupo de referencia Kokkinos PF et al. Lancet 2013; 381: 394–99
  30. 30. Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism 26% Brighton TA et al. N Engl J Med 2012;367:1979-87. DOI: 10.1056/NEJMoa1210384
  31. 31. Low-Dose Aspirin for Preventing Recurrent Venous Thromboembolism 34% Brighton TA et al. N Engl J Med 2012;367:1979-87. DOI: 10.1056/NEJMoa1210384
  32. 32. Aspirin for Dual Prevention of Venous and Arterial Thrombosis WarkentinTE. N Engl J Med 2012;367:2039-2041
  33. 33. Statin treatment and the risk of recurrent pulmonary embolism Biere-Rafi S et al. European Heart Journal (2013) 34, 1800–1806.

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