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Beyond the Condom
Male Contraception
Future of male contraception
scenarios:
male pill
male injection
vas deferens block
vas deferens cut
calcium blockers
interference with sperm formation
interference with maturation of sperm
interference with energy use of sperm (tail)
inter...
Sperm production
1) hypothalamus ---> Gnrh
Gnrh--> pituitary
pituitary--> LH and FSH
LH --> stimulates testicles to make t...
Can we disrupt sperm?
1) block gnrh ( at Hypothalamus)
2) block LH/FSH
3) interfere with sperm production in teste
interfe...
A problem

If pituitary gland is involved
then
no FSH ( no sperm)
no LH ( no testosterone) Oh! Oh!!!!!!!!!
let’s try heat
blocking hormones ( gnrh, or lh/fsh) means side
effects ...............no Testosterone
other issues
self injection
self medication (pills)
lag time till return to fertility
Can we change ( ruin) sperm entry to the egg?
we can alter the chemistry of the head (acrosome)
we can change tail function
we can:
bind a chemical to the sperm head( blocks egg entry)
disrupt sperm surface protection( sperm death)
block calcium ...
vas deferens blockade
 similar to vasectomy
2 overall routes
 1) sperm alteration
2) hormonal alteration
up till now
condoms
abstinence
withdrawal
vasectomy
take your trouble in hand
contraception
safe?
long lasting
reversible
no side effects
prevents STIs
cheap
10s of millions of sperm mature in
           epididymis
   cycle is 75 days--> a long process
   contraception in testes ...
stem cells ( spermatogonia) --> divide into
primary spermatocytes = 46 chromosomes ( mitosis)
division to 23 chromosomes (...
Embryo
Sex
review
alter vas deferens patency
alter hormones ( FSH) or Gnrh ( depoprovera )
calcium channel blockers alter lipids in sperm
ej...
Male contraception
Male contraception
Male contraception
Male contraception
Male contraception
Male contraception
Male contraception
Male contraception
Male contraception
Male contraception
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Male contraception

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  • Transcript of "Male contraception"

    1. 1. Beyond the Condom Male Contraception
    2. 2. Future of male contraception scenarios: male pill male injection vas deferens block vas deferens cut calcium blockers
    3. 3. interference with sperm formation interference with maturation of sperm interference with energy use of sperm (tail) interference with ejaculation
    4. 4. Sperm production 1) hypothalamus ---> Gnrh Gnrh--> pituitary pituitary--> LH and FSH LH --> stimulates testicles to make testosterone FSH makes sperm if T helps it along.
    5. 5. Can we disrupt sperm? 1) block gnrh ( at Hypothalamus) 2) block LH/FSH 3) interfere with sperm production in teste interfere with maturation of sperm vasectomy or block (plug)
    6. 6. A problem If pituitary gland is involved then no FSH ( no sperm) no LH ( no testosterone) Oh! Oh!!!!!!!!!
    7. 7. let’s try heat
    8. 8. blocking hormones ( gnrh, or lh/fsh) means side effects ...............no Testosterone
    9. 9. other issues self injection self medication (pills) lag time till return to fertility
    10. 10. Can we change ( ruin) sperm entry to the egg?
    11. 11. we can alter the chemistry of the head (acrosome) we can change tail function
    12. 12. we can: bind a chemical to the sperm head( blocks egg entry) disrupt sperm surface protection( sperm death) block calcium ions crossing plasma membrane( entry) cholesterol interference on plasma membrane(entry)
    13. 13. vas deferens blockade similar to vasectomy
    14. 14. 2 overall routes 1) sperm alteration 2) hormonal alteration
    15. 15. up till now condoms abstinence withdrawal vasectomy take your trouble in hand
    16. 16. contraception safe? long lasting reversible no side effects prevents STIs cheap
    17. 17. 10s of millions of sperm mature in epididymis cycle is 75 days--> a long process contraception in testes takes 2 1/2 months there are always some extra sperm maturing in the seminiferous tubules
    18. 18. stem cells ( spermatogonia) --> divide into primary spermatocytes = 46 chromosomes ( mitosis) division to 23 chromosomes ( 2 of them) ( meiosis) these secondary spermatocytes become spermatids then spermatazoa 23 chromosome sperm meets 23 chromosome egg
    19. 19. Embryo
    20. 20. Sex
    21. 21. review
    22. 22. alter vas deferens patency alter hormones ( FSH) or Gnrh ( depoprovera ) calcium channel blockers alter lipids in sperm ejaculation blockers ( separate orgasm from ejaculation) render a sperm protein inactive --> sterility (GBAZ protein) shut down energy use in tail mitochondria protein( SFEC protein)sperm flagellar energy
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