Parathyroid hormone Dr. Sadaf Mumtaz 03/03/11
 
What is the role of Kidneys? <ul><li>Preventing reprecipation of Calcium freed from bones </li></ul><ul><li>Enhance activa...
Mechanism of action <ul><li>hPTH/PTHrP receptor </li></ul><ul><li>PTH-2 </li></ul><ul><li>CPTH </li></ul><ul><li>Pseudohyp...
Negative feed back loops <ul><li>Calcitonin plays a role in skeletal integrity in pregnancy or breast feeding </li></ul><u...
 
Causes of hypophosphatemia <ul><li>Respiratory alkalosis </li></ul><ul><li>Alcohol abuse </li></ul><ul><li>Malabsorption <...
 
Pathophysiology <ul><li>Hypoparathyroidism </li></ul><ul><ul><li>Osteocytes </li></ul></ul><ul><ul><li>Osteoclasts </li></...
Secondary hyperparathyroidism <ul><li>Difference </li></ul><ul><li>Vit D deficiency </li></ul><ul><li>Chronic renal diseas...
<ul><li>Tapping the facial nerve at the angle of jaw in a patient with moderate hyposecretion of a particular hormone elic...
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Parathyroid hormone

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Parathyroid hormone

  1. 1. Parathyroid hormone Dr. Sadaf Mumtaz 03/03/11
  2. 3. What is the role of Kidneys? <ul><li>Preventing reprecipation of Calcium freed from bones </li></ul><ul><li>Enhance activation of Vit D </li></ul>What is the role of intestine?
  3. 4. Mechanism of action <ul><li>hPTH/PTHrP receptor </li></ul><ul><li>PTH-2 </li></ul><ul><li>CPTH </li></ul><ul><li>Pseudohypoparathyroidism </li></ul>Adenylyl cyclase PLC
  4. 5. Negative feed back loops <ul><li>Calcitonin plays a role in skeletal integrity in pregnancy or breast feeding </li></ul><ul><li>Gastrointestinal hormones </li></ul>
  5. 7. Causes of hypophosphatemia <ul><li>Respiratory alkalosis </li></ul><ul><li>Alcohol abuse </li></ul><ul><li>Malabsorption </li></ul><ul><li>Phosphaturia </li></ul><ul><ul><li>Primary renal dysfunction </li></ul></ul><ul><ul><li>Diuretics </li></ul></ul><ul><ul><li>Hyperparathyroidism </li></ul></ul>
  6. 9. Pathophysiology <ul><li>Hypoparathyroidism </li></ul><ul><ul><li>Osteocytes </li></ul></ul><ul><ul><li>Osteoclasts </li></ul></ul><ul><ul><li>Rx </li></ul></ul><ul><li>Primary Hyperparathyroidism </li></ul><ul><ul><li>Osteoclasts </li></ul></ul><ul><ul><li>Osteoblast----alkaline phosphatase </li></ul></ul><ul><ul><li>Effects of hypercalcemia </li></ul></ul><ul><ul><li>Parathyroid poisoning and metastatic calcification </li></ul></ul><ul><ul><li>Kidney stones </li></ul></ul>
  7. 10. Secondary hyperparathyroidism <ul><li>Difference </li></ul><ul><li>Vit D deficiency </li></ul><ul><li>Chronic renal disease </li></ul>
  8. 11. <ul><li>Tapping the facial nerve at the angle of jaw in a patient with moderate hyposecretion of a particular hormone elicits a characteristic grimace on that side of the face. Which endocrine abnormality could give rise to this so called ‘Chvostek sign’ ? </li></ul>
  9. 12. Thanks
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