Parathyroid hormone
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Parathyroid hormone

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Parathyroid hormone Parathyroid hormone Presentation Transcript

  • Parathyroid hormone Dr. Sadaf Mumtaz 03/03/11
  •  
  • What is the role of Kidneys?
    • Preventing reprecipation of Calcium freed from bones
    • Enhance activation of Vit D
    What is the role of intestine? View slide
  • Mechanism of action
    • hPTH/PTHrP receptor
    • PTH-2
    • CPTH
    • Pseudohypoparathyroidism
    Adenylyl cyclase PLC View slide
  • Negative feed back loops
    • Calcitonin plays a role in skeletal integrity in pregnancy or breast feeding
    • Gastrointestinal hormones
  •  
  • Causes of hypophosphatemia
    • Respiratory alkalosis
    • Alcohol abuse
    • Malabsorption
    • Phosphaturia
      • Primary renal dysfunction
      • Diuretics
      • Hyperparathyroidism
  •  
  • Pathophysiology
    • Hypoparathyroidism
      • Osteocytes
      • Osteoclasts
      • Rx
    • Primary Hyperparathyroidism
      • Osteoclasts
      • Osteoblast----alkaline phosphatase
      • Effects of hypercalcemia
      • Parathyroid poisoning and metastatic calcification
      • Kidney stones
  • Secondary hyperparathyroidism
    • Difference
    • Vit D deficiency
    • Chronic renal disease
    • Tapping the facial nerve at the angle of jaw in a patient with moderate hyposecretion of a particular hormone elicits a characteristic grimace on that side of the face. Which endocrine abnormality could give rise to this so called ‘Chvostek sign’ ?
  • Thanks