Growth hormone
Upcoming SlideShare
Loading in...5
×
 

Growth hormone

on

  • 563 views

 

Statistics

Views

Total Views
563
Views on SlideShare
555
Embed Views
8

Actions

Likes
0
Downloads
23
Comments
0

2 Embeds 8

http://study.myllps.com 7
http://a0.twimg.com 1

Accessibility

Upload Details

Uploaded via as Microsoft PowerPoint

Usage Rights

© All Rights Reserved

Report content

Flagged as inappropriate Flag as inappropriate
Flag as inappropriate

Select your reason for flagging this presentation as inappropriate.

Cancel
  • Full Name Full Name Comment goes here.
    Are you sure you want to
    Your message goes here
    Processing…
Post Comment
Edit your comment

    Growth hormone Growth hormone Presentation Transcript

    • Growth Hormone Dr. Sadaf Mumtaz 17/02/11
    • Growth hormone promotes growth of many body tissues
    • Metabolic actions of GH unrelated to growth
      • Increased mobilization of FA from adipose tissues
      • Decreased rate of glucose utlization
    • Growth-promoting actions of GH on soft tissues and skeleton
      • Soft tissues
        • Hyperplasia
          • Cell division
          • apoptosis
        • Hypertrophy
          • Promoting synthesis of proteins
            • Enhancement of AA transport through the cell membrane
            • Enhancement of RNA translation
            • Increased nuclear transcription
            • Dec catabolism of proteins and AA
    • Effect of growth hormone on FA utilization
      • FA------acetyl coenzyme A-----citric acid cycle
      • Ketoacidosis
    • GH decreases carbohydrate utilization
      • Dec glucose uptake in skeletal muscles and fat
        • Insulin resistance
        • Inhibits gluconeogenesis
      • Increased glucose production by the liver
      • Increased insulin secretion
        • Compensatory increase --- arginine and glucose
        • Protein anabolic effect
      • Diabetogenic effects
    • Bone
      • Thickness
        • Osteoblastic activity
      • Length
        • Hyperplasia and hypertrophy of chondrocytes
        • Osteoblastic and osteoclastic activity
    • Somatomedins
      • IGF-1
      • African pygmies
      • Levi Lorain Dwarfs
      • Half life of Somatomedin C is more as compared to GH
    • Typical variations in growth hormone secretion 5 to 20yrs 6ng/ml 20 to 40yrs 3ng/ml 40 to 70yrs 1.6ng/ml
    • Effect of extreme protein deficiency on plasma concentration of growth hormone in the disease Kwashiokor The name is derived from the Ga language of coastal Ghana , translated "the sickness the baby gets when the new baby comes
    •  
    • Abnormalities
      • Panhypopituitarism
        • Hypothyroidism
        • Dec Glucocorticoids
        • Suppresses Gonadotrophic hormones
      • Dwarfism
        • Can they reproduce?
        • African pygmy or Levi-Lorain
        • Hereditary inability to form somatomedin C
        • Rx
    • Gigantism
      • Acidophillic tumors
      • Before adolescence
      • Hyperglycemia
        • Diabetes develops
      • Tumor overgrows leads to death in early adulthood
    • Acromegaly
    • Age and growth hormone
    • Thanks