Toxnetppt

TOXNET Toxicology and Environmental Health Information on the Internet National Library of Medicine

What is TOXNET ?
System of databases
Information about toxicology, environmental health, hazardous chemicals, and toxic releases
Developed by the National Library of Medicine (NLM)
http://toxnet.nlm.nih.gov/

Types of Files
Data
Literature (bibliographic)
Chemical Dictionary
Toxic Release Inventory
Related: TOXMAP, TOXTown (consumer), PubMed

TOXNET Data Files
There are 5 of them
Click the ?
for additional information about each database

Data Files
HSDB – Hazardous Substances Databank
CCRIS - Chemical Carcinogenesis Research Information System
GENTOX – Mutagenicity studies (not updated)
IRIS – Integrated Risk Information System
ITER - International Toxicity Estimates for Risk Assessment

Hazardous Substances Data Bank ( HSDB )
Online handbook compiled by NLM
1 record per chemical
5,000 + records
Human and animal toxicity
Safety and handling
Human health effects
Emergency medical treatment guidelines

Chemical Carcinogenesis Research Information System ( CCRIS )
National Cancer Institute (NCI) data
9,000 + chemical records
Carcinogenicity studies
Tumor inhibition studies
Tumor promotion studies
Mutagenicity studies

Searching Data Files
Search all databases, or
Select one database, or
Search “Multi-Database” to search just the data files

Content areas of interest in HSDB
Human Health Effects
Emergency Medical Treatment
Antidotes
Physical & chemical properties
Interactions
Environmental fate & exposure
Manufacturers
Uses: therapeutic, business, etc.

TOXNET’s 2 Literature Files

TOXLINE
TOXLINE Core – in PubMed, accessible through TOXNET
Search in PubMed via TOXLINE subset Limit
PubMed Features:
MESH
Limits
MyNCBI,
See Related Articles, LinkOut

TOXLINE
TOXLINE Special – in TOXNET only
Both Core and Special can be searched in TOXNET
TOXNET Features:
Search both Core and Special
Relevancy Ranking
Link to other TOXNET databases

TRI: Toxics Release Inventory
EPA information regarding the release of certain toxic chemicals
Reporting is mandated by law and does not cover all industries or all businesses
Release years 1987 – data available in TOXNET. Also available through EPA website

TRI
Facility Identification
Substance Identification
Environmental release
Waste treatment (on & off site)
Source reduction and recycling

Searching TRI Search by chemical name or CAS Specify release amount and type Select a year or years Search by facility name Search by location Search by SIC code

Mapping results
This button provides mapping capabilities
Use it to see where the releases in question were located

ChemIDplus
Chemical dictionary/directory file
Two versions: “Lite” & Advanced
379,000 + chemical records
257,000 + structural records
In the Advanced file only
Requires JAVA or CHIME software (free)
Direct link to other resources

ChemIDPlus Versions
Lite:
basic search of the chemical name, registry number
Results screen allows you to search other databases, and view information: basic, full, names, formulas, classification codes, registry numbers, notes

ChemIDPlus Versions
Advanced:
Advanced searching on chemical name, registry number, molecular formula, classification code, toxicity, chemical property, chemical structure, molecular weight
Refine search with “similarity” percentages
View and draw structures with special software such as Marvin, Chime
Results screen provides all features of Lite plus structure (can be 3D)

Searching ChemIDplus
Search by chemical name or CAS Registry Number
Click on “search” to retrieve results from the “Lite” version
Use the Advanced button to access the Advanced capabilities

Advanced Searching
Search by:
Substance
Toxicity ranges
Physical properties
Structure
Molecular weight
NOTE: Results look the same. Differences are searching and structure

Household Products Database
Environmental Consumer Health information
Search for environmental effects of common household items
Categories: auto, pesticides, personal care, arts and crafts, home, landscape/yard, home maintenance, pet care

TOXTOWN
Environmental consumer health in everyday situations

HaxMap
Links jobs and hazardous tasks with occupational diseases and symptoms
Might NOT want to show this to students as they determine career direction!! 

Toxnetppt

by Beth Transue on Jun 25, 2007

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Toxnetppt — Presentation Transcript