TOXNET Toxicology and Environmental Health Information on the Internet National Library of Medicine

What is TOXNET ? System of databases Information about toxicology, environmental health, hazardous chemicals, and toxic releases Developed by the National Library of Medicine (NLM) http://toxnet.nlm.nih.gov/

System of databases

Information about toxicology, environmental health, hazardous chemicals, and toxic releases

Developed by the National Library of Medicine (NLM)

http://toxnet.nlm.nih.gov/

Types of Files Data Literature (bibliographic) Chemical Dictionary Toxic Release Inventory Related: TOXMAP, TOXTown (consumer), PubMed

Data

Literature (bibliographic)

Chemical Dictionary

Toxic Release Inventory

Related: TOXMAP, TOXTown (consumer), PubMed

TOXNET Data Files There are 5 of them Click the ? for additional information about each database

There are 5 of them

Click the ?

for additional information about each database

Data Files HSDB – Hazardous Substances Databank CCRIS - Chemical Carcinogenesis Research Information System GENTOX – Mutagenicity studies (not updated) IRIS – Integrated Risk Information System ITER - International Toxicity Estimates for Risk Assessment

HSDB – Hazardous Substances Databank

CCRIS - Chemical Carcinogenesis Research Information System

GENTOX – Mutagenicity studies (not updated)

IRIS – Integrated Risk Information System

ITER - International Toxicity Estimates for Risk Assessment

Hazardous Substances Data Bank ( HSDB ) Online handbook compiled by NLM 1 record per chemical 5,000 + records Human and animal toxicity Safety and handling Human health effects Emergency medical treatment guidelines

Online handbook compiled by NLM

1 record per chemical

5,000 + records

Human and animal toxicity

Safety and handling

Human health effects

Emergency medical treatment guidelines

Chemical Carcinogenesis Research Information System ( CCRIS ) National Cancer Institute (NCI) data 9,000 + chemical records Carcinogenicity studies Tumor inhibition studies Tumor promotion studies Mutagenicity studies

National Cancer Institute (NCI) data

9,000 + chemical records

Carcinogenicity studies

Tumor inhibition studies

Tumor promotion studies

Mutagenicity studies

Searching Data Files Search all databases, or Select one database, or Search “Multi-Database” to search just the data files

Search all databases, or

Select one database, or

Search “Multi-Database” to search just the data files

Content areas of interest in HSDB Human Health Effects Emergency Medical Treatment Antidotes Physical & chemical properties Interactions Environmental fate & exposure Manufacturers Uses: therapeutic, business, etc.

Human Health Effects

Emergency Medical Treatment

Antidotes

Physical & chemical properties

Interactions

Environmental fate & exposure

Manufacturers

Uses: therapeutic, business, etc.

TOXNET’s 2 Literature Files

TOXLINE TOXLINE Core – in PubMed, accessible through TOXNET Search in PubMed via TOXLINE subset Limit PubMed Features: MESH Limits MyNCBI, See Related Articles, LinkOut

TOXLINE Core – in PubMed, accessible through TOXNET

Search in PubMed via TOXLINE subset Limit

PubMed Features:

MESH

Limits

MyNCBI,

See Related Articles, LinkOut

TOXLINE TOXLINE Special – in TOXNET only Both Core and Special can be searched in TOXNET TOXNET Features: Search both Core and Special Relevancy Ranking Link to other TOXNET databases

TOXLINE Special – in TOXNET only

Both Core and Special can be searched in TOXNET

TOXNET Features:

Search both Core and Special

Relevancy Ranking

Link to other TOXNET databases

TRI: Toxics Release Inventory EPA information regarding the release of certain toxic chemicals Reporting is mandated by law and does not cover all industries or all businesses Release years 1987 – data available in TOXNET. Also available through EPA website

EPA information regarding the release of certain toxic chemicals

Reporting is mandated by law and does not cover all industries or all businesses

Release years 1987 – data available in TOXNET. Also available through EPA website

TRI Facility Identification Substance Identification Environmental release Waste treatment (on & off site) Source reduction and recycling

Facility Identification

Substance Identification

Environmental release

Waste treatment (on & off site)

Source reduction and recycling

Searching TRI Search by chemical name or CAS Specify release amount and type Select a year or years Search by facility name Search by location Search by SIC code

Mapping results This button provides mapping capabilities Use it to see where the releases in question were located

This button provides mapping capabilities

Use it to see where the releases in question were located

ChemIDplus Chemical dictionary/directory file Two versions: “Lite” & Advanced 379,000 + chemical records 257,000 + structural records In the Advanced file only Requires JAVA or CHIME software (free) Direct link to other resources

Chemical dictionary/directory file

Two versions: “Lite” & Advanced

379,000 + chemical records

257,000 + structural records

In the Advanced file only

Requires JAVA or CHIME software (free)

Direct link to other resources

ChemIDPlus Versions Lite: basic search of the chemical name, registry number Results screen allows you to search other databases, and view information: basic, full, names, formulas, classification codes, registry numbers, notes

Lite:

basic search of the chemical name, registry number

Results screen allows you to search other databases, and view information: basic, full, names, formulas, classification codes, registry numbers, notes

ChemIDPlus Versions Advanced: Advanced searching on chemical name, registry number, molecular formula, classification code, toxicity, chemical property, chemical structure, molecular weight Refine search with “similarity” percentages View and draw structures with special software such as Marvin, Chime Results screen provides all features of Lite plus structure (can be 3D)

Advanced:

Advanced searching on chemical name, registry number, molecular formula, classification code, toxicity, chemical property, chemical structure, molecular weight

Refine search with “similarity” percentages

View and draw structures with special software such as Marvin, Chime

Results screen provides all features of Lite plus structure (can be 3D)

Searching ChemIDplus Search by chemical name or CAS Registry Number Click on “search” to retrieve results from the “Lite” version Use the Advanced button to access the Advanced capabilities

Search by chemical name or CAS Registry Number

Click on “search” to retrieve results from the “Lite” version

Use the Advanced button to access the Advanced capabilities

Advanced Searching Search by: Substance Toxicity ranges Physical properties Structure Molecular weight NOTE: Results look the same. Differences are searching and structure

Search by:

Substance

Toxicity ranges

Physical properties

Structure

Molecular weight

NOTE: Results look the same. Differences are searching and structure

Household Products Database Environmental Consumer Health information Search for environmental effects of common household items Categories: auto, pesticides, personal care, arts and crafts, home, landscape/yard, home maintenance, pet care

Environmental Consumer Health information

Search for environmental effects of common household items

Categories: auto, pesticides, personal care, arts and crafts, home, landscape/yard, home maintenance, pet care

TOXTOWN Environmental consumer health in everyday situations

Environmental consumer health in everyday situations

HaxMap Links jobs and hazardous tasks with occupational diseases and symptoms Might NOT want to show this to students as they determine career direction!! 

Links jobs and hazardous tasks with occupational diseases and symptoms

Might NOT want to show this to students as they determine career direction!! 