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A training session for using TOXNET

A training session for using TOXNET

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Toxnetppt Toxnetppt Presentation Transcript

  • TOXNET Toxicology and Environmental Health Information on the Internet National Library of Medicine
  • What is TOXNET ?
    • System of databases
    • Information about toxicology, environmental health, hazardous chemicals, and toxic releases
    • Developed by the National Library of Medicine (NLM)
    • http://toxnet.nlm.nih.gov/
  •  
  • Types of Files
    • Data
    • Literature (bibliographic)
    • Chemical Dictionary
    • Toxic Release Inventory
    • Related: TOXMAP, TOXTown (consumer), PubMed
  • TOXNET Data Files
    • There are 5 of them
    • Click the ?
    • for additional information about each database
  • Data Files
    • HSDB – Hazardous Substances Databank
    • CCRIS - Chemical Carcinogenesis Research Information System
    • GENTOX – Mutagenicity studies (not updated)
    • IRIS – Integrated Risk Information System
    • ITER - International Toxicity Estimates for Risk Assessment
  • Hazardous Substances Data Bank ( HSDB )
      • Online handbook compiled by NLM
      • 1 record per chemical
      • 5,000 + records
      • Human and animal toxicity
      • Safety and handling
      • Human health effects
      • Emergency medical treatment guidelines
  • Chemical Carcinogenesis Research Information System ( CCRIS )
      • National Cancer Institute (NCI) data
      • 9,000 + chemical records
      • Carcinogenicity studies
      • Tumor inhibition studies
      • Tumor promotion studies
      • Mutagenicity studies
  • Searching Data Files
    • Search all databases, or
    • Select one database, or
    • Search “Multi-Database” to search just the data files
  • Content areas of interest in HSDB
    • Human Health Effects
    • Emergency Medical Treatment
    • Antidotes
    • Physical & chemical properties
    • Interactions
    • Environmental fate & exposure
    • Manufacturers
    • Uses: therapeutic, business, etc.
  • TOXNET’s 2 Literature Files
  • TOXLINE
    • TOXLINE Core – in PubMed, accessible through TOXNET
    • Search in PubMed via TOXLINE subset Limit
    • PubMed Features:
      • MESH
      • Limits
      • MyNCBI,
      • See Related Articles, LinkOut
  • TOXLINE
    • TOXLINE Special – in TOXNET only
    • Both Core and Special can be searched in TOXNET
    • TOXNET Features:
      • Search both Core and Special
      • Relevancy Ranking
      • Link to other TOXNET databases
  • TRI: Toxics Release Inventory
    • EPA information regarding the release of certain toxic chemicals
    • Reporting is mandated by law and does not cover all industries or all businesses
    • Release years 1987 – data available in TOXNET. Also available through EPA website
  • TRI
    • Facility Identification
    • Substance Identification
    • Environmental release
    • Waste treatment (on & off site)
    • Source reduction and recycling
  • Searching TRI Search by chemical name or CAS Specify release amount and type Select a year or years Search by facility name Search by location Search by SIC code
  • Mapping results
    • This button provides mapping capabilities
    • Use it to see where the releases in question were located
  • ChemIDplus
    • Chemical dictionary/directory file
    • Two versions: “Lite” & Advanced
    • 379,000 + chemical records
    • 257,000 + structural records
      • In the Advanced file only
      • Requires JAVA or CHIME software (free)
    • Direct link to other resources
  • ChemIDPlus Versions
    • Lite:
        • basic search of the chemical name, registry number
        • Results screen allows you to search other databases, and view information: basic, full, names, formulas, classification codes, registry numbers, notes
  • ChemIDPlus Versions
    • Advanced:
      • Advanced searching on chemical name, registry number, molecular formula, classification code, toxicity, chemical property, chemical structure, molecular weight
      • Refine search with “similarity” percentages
      • View and draw structures with special software such as Marvin, Chime
      • Results screen provides all features of Lite plus structure (can be 3D)
  • Searching ChemIDplus
    • Search by chemical name or CAS Registry Number
    • Click on “search” to retrieve results from the “Lite” version
    • Use the Advanced button to access the Advanced capabilities
  • Advanced Searching
    • Search by:
      • Substance
      • Toxicity ranges
      • Physical properties
      • Structure
      • Molecular weight
    • NOTE: Results look the same. Differences are searching and structure
  • Household Products Database
    • Environmental Consumer Health information
    • Search for environmental effects of common household items
    • Categories: auto, pesticides, personal care, arts and crafts, home, landscape/yard, home maintenance, pet care
  • TOXTOWN
    • Environmental consumer health in everyday situations
  • HaxMap
    • Links jobs and hazardous tasks with occupational diseases and symptoms
    • Might NOT want to show this to students as they determine career direction!! 