Published on

A training session for using TOXNET

  • Be the first to comment

  • Be the first to like this

No Downloads
Total Views
On Slideshare
From Embeds
Number of Embeds
Embeds 0
No embeds

No notes for slide
  • Toxnetppt

    1. 1. TOXNET Toxicology and Environmental Health Information on the Internet National Library of Medicine
    2. 2. What is TOXNET ? <ul><li>System of databases </li></ul><ul><li>Information about toxicology, environmental health, hazardous chemicals, and toxic releases </li></ul><ul><li>Developed by the National Library of Medicine (NLM) </li></ul><ul><li> </li></ul>
    3. 4. Types of Files <ul><li>Data </li></ul><ul><li>Literature (bibliographic) </li></ul><ul><li>Chemical Dictionary </li></ul><ul><li>Toxic Release Inventory </li></ul><ul><li>Related: TOXMAP, TOXTown (consumer), PubMed </li></ul>
    4. 5. TOXNET Data Files <ul><li>There are 5 of them </li></ul><ul><li>Click the ? </li></ul><ul><li>for additional information about each database </li></ul>
    5. 6. Data Files <ul><li>HSDB – Hazardous Substances Databank </li></ul><ul><li>CCRIS - Chemical Carcinogenesis Research Information System </li></ul><ul><li>GENTOX – Mutagenicity studies (not updated) </li></ul><ul><li>IRIS – Integrated Risk Information System </li></ul><ul><li>ITER - International Toxicity Estimates for Risk Assessment </li></ul>
    6. 7. Hazardous Substances Data Bank ( HSDB ) <ul><ul><li>Online handbook compiled by NLM </li></ul></ul><ul><ul><li>1 record per chemical </li></ul></ul><ul><ul><li>5,000 + records </li></ul></ul><ul><ul><li>Human and animal toxicity </li></ul></ul><ul><ul><li>Safety and handling </li></ul></ul><ul><ul><li>Human health effects </li></ul></ul><ul><ul><li>Emergency medical treatment guidelines </li></ul></ul>
    7. 8. Chemical Carcinogenesis Research Information System ( CCRIS ) <ul><ul><li>National Cancer Institute (NCI) data </li></ul></ul><ul><ul><li>9,000 + chemical records </li></ul></ul><ul><ul><li>Carcinogenicity studies </li></ul></ul><ul><ul><li>Tumor inhibition studies </li></ul></ul><ul><ul><li>Tumor promotion studies </li></ul></ul><ul><ul><li>Mutagenicity studies </li></ul></ul>
    8. 9. Searching Data Files <ul><li>Search all databases, or </li></ul><ul><li>Select one database, or </li></ul><ul><li>Search “Multi-Database” to search just the data files </li></ul>
    9. 10. Content areas of interest in HSDB <ul><li>Human Health Effects </li></ul><ul><li>Emergency Medical Treatment </li></ul><ul><li>Antidotes </li></ul><ul><li>Physical & chemical properties </li></ul><ul><li>Interactions </li></ul><ul><li>Environmental fate & exposure </li></ul><ul><li>Manufacturers </li></ul><ul><li>Uses: therapeutic, business, etc. </li></ul>
    10. 11. TOXNET’s 2 Literature Files
    11. 12. TOXLINE <ul><li>TOXLINE Core – in PubMed, accessible through TOXNET </li></ul><ul><li>Search in PubMed via TOXLINE subset Limit </li></ul><ul><li>PubMed Features: </li></ul><ul><ul><li>MESH </li></ul></ul><ul><ul><li>Limits </li></ul></ul><ul><ul><li>MyNCBI, </li></ul></ul><ul><ul><li>See Related Articles, LinkOut </li></ul></ul>
    12. 13. TOXLINE <ul><li>TOXLINE Special – in TOXNET only </li></ul><ul><li>Both Core and Special can be searched in TOXNET </li></ul><ul><li>TOXNET Features: </li></ul><ul><ul><li>Search both Core and Special </li></ul></ul><ul><ul><li>Relevancy Ranking </li></ul></ul><ul><ul><li>Link to other TOXNET databases </li></ul></ul>
    13. 14. TRI: Toxics Release Inventory <ul><li>EPA information regarding the release of certain toxic chemicals </li></ul><ul><li>Reporting is mandated by law and does not cover all industries or all businesses </li></ul><ul><li>Release years 1987 – data available in TOXNET. Also available through EPA website </li></ul>
    14. 15. TRI <ul><li>Facility Identification </li></ul><ul><li>Substance Identification </li></ul><ul><li>Environmental release </li></ul><ul><li>Waste treatment (on & off site) </li></ul><ul><li>Source reduction and recycling </li></ul>
    15. 16. Searching TRI Search by chemical name or CAS Specify release amount and type Select a year or years Search by facility name Search by location Search by SIC code
    16. 17. Mapping results <ul><li>This button provides mapping capabilities </li></ul><ul><li>Use it to see where the releases in question were located </li></ul>
    17. 18. ChemIDplus <ul><li>Chemical dictionary/directory file </li></ul><ul><li>Two versions: “Lite” & Advanced </li></ul><ul><li>379,000 + chemical records </li></ul><ul><li>257,000 + structural records </li></ul><ul><ul><li>In the Advanced file only </li></ul></ul><ul><ul><li>Requires JAVA or CHIME software (free) </li></ul></ul><ul><li>Direct link to other resources </li></ul>
    18. 19. ChemIDPlus Versions <ul><li>Lite: </li></ul><ul><ul><ul><li>basic search of the chemical name, registry number </li></ul></ul></ul><ul><ul><ul><li>Results screen allows you to search other databases, and view information: basic, full, names, formulas, classification codes, registry numbers, notes </li></ul></ul></ul>
    19. 20. ChemIDPlus Versions <ul><li>Advanced: </li></ul><ul><ul><li>Advanced searching on chemical name, registry number, molecular formula, classification code, toxicity, chemical property, chemical structure, molecular weight </li></ul></ul><ul><ul><li>Refine search with “similarity” percentages </li></ul></ul><ul><ul><li>View and draw structures with special software such as Marvin, Chime </li></ul></ul><ul><ul><li>Results screen provides all features of Lite plus structure (can be 3D) </li></ul></ul>
    20. 21. Searching ChemIDplus <ul><li>Search by chemical name or CAS Registry Number </li></ul><ul><li>Click on “search” to retrieve results from the “Lite” version </li></ul><ul><li>Use the Advanced button to access the Advanced capabilities </li></ul>
    21. 22. Advanced Searching <ul><li>Search by: </li></ul><ul><ul><li>Substance </li></ul></ul><ul><ul><li>Toxicity ranges </li></ul></ul><ul><ul><li>Physical properties </li></ul></ul><ul><ul><li>Structure </li></ul></ul><ul><ul><li>Molecular weight </li></ul></ul><ul><li>NOTE: Results look the same. Differences are searching and structure </li></ul>
    22. 23. Household Products Database <ul><li>Environmental Consumer Health information </li></ul><ul><li>Search for environmental effects of common household items </li></ul><ul><li>Categories: auto, pesticides, personal care, arts and crafts, home, landscape/yard, home maintenance, pet care </li></ul>
    23. 24. TOXTOWN <ul><li>Environmental consumer health in everyday situations </li></ul>
    24. 25. HaxMap <ul><li>Links jobs and hazardous tasks with occupational diseases and symptoms </li></ul><ul><li>Might NOT want to show this to students as they determine career direction!!  </li></ul>
    1. A particular slide catching your eye?

      Clipping is a handy way to collect important slides you want to go back to later.