Tissue Growth and Repair
Body Defenses at Tissue Level <ul><li>Physical Barriers </li></ul><ul><ul><li>Skin </li></ul></ul><ul><ul><li>Mucous membr...
Tissue Injury <ul><li>Stimulates inflammatory and immune response </li></ul><ul><li>Healing process begins </li></ul>
Tissue Injury <ul><li>Specific  </li></ul><ul><li>Attack against invaders (bacteria, toxins, viruses) </li></ul><ul><li>No...
Tissue Repair <ul><li>Regeneration </li></ul><ul><li>Fibrosis </li></ul>
Tissue Repair <ul><li>Repair by dense connective tissue </li></ul><ul><li>Formation scar tissue </li></ul><ul><li>Replacem...
Regeneration or Fibrosis? <ul><li>Depends on </li></ul><ul><ul><li>Type of tissue damaged </li></ul></ul><ul><ul><li>Sever...
After Tissue Injury <ul><li>Capillaries become permeable </li></ul><ul><li>Granulation tissue forms </li></ul><ul><li>Surf...
Permeable Capillaries <ul><li>Allows clotting proteins to reach injured area </li></ul><ul><li>Clot stops blood loss </li>...
Granulation Tissue Formation <ul><li>Delicate pink connective tissue </li></ul><ul><li>Fibroblasts </li></ul><ul><li>Colla...
Surface Epithelium Regeneration <ul><li>Across granulation tissue </li></ul><ul><li>Beneath scab </li></ul><ul><li>Cover u...
Regeneration Time <ul><li>Epithelial tissues </li></ul><ul><ul><li>Skin </li></ul></ul><ul><ul><li>Mucous membranes </li><...
Homeostatic Imbalance <ul><li>Scar tissue </li></ul><ul><ul><li>Strong </li></ul></ul><ul><ul><li>Lacks flexibility of nor...
Tissue Growth <ul><li>Tissues made of cells </li></ul><ul><li>Cells undergo mitosis </li></ul><ul><li>Routine division </l...
Aging <ul><li>Due to  </li></ul><ul><ul><li>Chemical insults </li></ul></ul><ul><ul><ul><li>Drugs </li></ul></ul></ul><ul>...
Aging and Tissue Changes <ul><li>Epithelia </li></ul><ul><ul><li>Become thinner </li></ul></ul><ul><ul><li>More easily dam...
Aging and Tissue Changes <ul><li>Connective Tissue </li></ul><ul><ul><li>Bones become porous and weaken </li></ul></ul><ul...
Other Tissue Changes <ul><li>Neoplasm </li></ul><ul><ul><li>Uncontrolled cell division </li></ul></ul><ul><ul><li>Benign o...
Upcoming SlideShare
Loading in …5
×

Tissue growth and repair

3,555 views

Published on

0 Comments
0 Likes
Statistics
Notes
  • Be the first to comment

  • Be the first to like this

No Downloads
Views
Total views
3,555
On SlideShare
0
From Embeds
0
Number of Embeds
36
Actions
Shares
0
Downloads
44
Comments
0
Likes
0
Embeds 0
No embeds

No notes for slide

Tissue growth and repair

  1. 1. Tissue Growth and Repair
  2. 2. Body Defenses at Tissue Level <ul><li>Physical Barriers </li></ul><ul><ul><li>Skin </li></ul></ul><ul><ul><li>Mucous membranes </li></ul></ul><ul><li>Cilia </li></ul><ul><li>Stomach acid </li></ul>
  3. 3. Tissue Injury <ul><li>Stimulates inflammatory and immune response </li></ul><ul><li>Healing process begins </li></ul>
  4. 4. Tissue Injury <ul><li>Specific </li></ul><ul><li>Attack against invaders (bacteria, toxins, viruses) </li></ul><ul><li>Nonspecific body response </li></ul><ul><li>Prevent further injury </li></ul>Inflammation Immune Response
  5. 5. Tissue Repair <ul><li>Regeneration </li></ul><ul><li>Fibrosis </li></ul>
  6. 6. Tissue Repair <ul><li>Repair by dense connective tissue </li></ul><ul><li>Formation scar tissue </li></ul><ul><li>Replacement of destroyed tissue </li></ul><ul><li>Same kind of cells </li></ul>Regeneration Fibrosis
  7. 7. Regeneration or Fibrosis? <ul><li>Depends on </li></ul><ul><ul><li>Type of tissue damaged </li></ul></ul><ul><ul><li>Severity of injury </li></ul></ul><ul><li>Clean cuts heal faster than ragged tears </li></ul>
  8. 8. After Tissue Injury <ul><li>Capillaries become permeable </li></ul><ul><li>Granulation tissue forms </li></ul><ul><li>Surface epithelium regenerates </li></ul>
  9. 9. Permeable Capillaries <ul><li>Allows clotting proteins to reach injured area </li></ul><ul><li>Clot stops blood loss </li></ul><ul><li>Walls off injured area </li></ul><ul><li>Prevents bacteria from spreading to other tissues </li></ul><ul><li>Clot exposed to air forms scab </li></ul>
  10. 10. Granulation Tissue Formation <ul><li>Delicate pink connective tissue </li></ul><ul><li>Fibroblasts </li></ul><ul><li>Collagen </li></ul><ul><li>New capillaries </li></ul><ul><ul><li>Fragile and bleed freely </li></ul></ul><ul><li>Phagocytes (Macrophages) </li></ul><ul><ul><li>Dispose of clot, fibroblasts, and foreign material </li></ul></ul>
  11. 11. Surface Epithelium Regeneration <ul><li>Across granulation tissue </li></ul><ul><li>Beneath scab </li></ul><ul><li>Cover underlying fibrous tissue (scar tissue) </li></ul><ul><ul><li>Scar invisible or visible </li></ul></ul>
  12. 12. Regeneration Time <ul><li>Epithelial tissues </li></ul><ul><ul><li>Skin </li></ul></ul><ul><ul><li>Mucous membranes </li></ul></ul><ul><li>Fibrous connective tissues </li></ul><ul><ul><li>Bone </li></ul></ul><ul><li>Skeletal muscle </li></ul>Fairly Successful Poor Replaced by Scar Tissue <ul><li>Cardiac muscle </li></ul><ul><li>Nervous tissue </li></ul>
  13. 13. Homeostatic Imbalance <ul><li>Scar tissue </li></ul><ul><ul><li>Strong </li></ul></ul><ul><ul><li>Lacks flexibility of normal tissues </li></ul></ul><ul><ul><li>Cannot perform normal function of tissue it replaces </li></ul></ul><ul><ul><li>Hinders organ function </li></ul></ul>
  14. 14. Tissue Growth <ul><li>Tissues made of cells </li></ul><ul><li>Cells undergo mitosis </li></ul><ul><li>Routine division </li></ul><ul><ul><li>Skin cells </li></ul></ul><ul><ul><li>Intestinal cells </li></ul></ul><ul><li>Stop dividing but still have ability </li></ul><ul><ul><li>Liver cells </li></ul></ul><ul><li>Lose ability to divide </li></ul><ul><ul><li>Heart muscle cells </li></ul></ul><ul><ul><li>Nervous tissue </li></ul></ul>
  15. 15. Aging <ul><li>Due to </li></ul><ul><ul><li>Chemical insults </li></ul></ul><ul><ul><ul><li>Drugs </li></ul></ul></ul><ul><ul><ul><li>CO </li></ul></ul></ul><ul><ul><li>Physical factors </li></ul></ul><ul><ul><ul><li>Radiation </li></ul></ul></ul><ul><ul><li>Aging “clock” </li></ul></ul><ul><ul><ul><li>Built into genes </li></ul></ul></ul>
  16. 16. Aging and Tissue Changes <ul><li>Epithelia </li></ul><ul><ul><li>Become thinner </li></ul></ul><ul><ul><li>More easily damaged </li></ul></ul><ul><ul><li>Skin looses elasticity and sags </li></ul></ul><ul><ul><li>Exocrine glands less active </li></ul></ul><ul><ul><li>Endocrine glands less hormones </li></ul></ul>
  17. 17. Aging and Tissue Changes <ul><li>Connective Tissue </li></ul><ul><ul><li>Bones become porous and weaken </li></ul></ul><ul><ul><li>Tissue repair slows </li></ul></ul><ul><li>Muscle Tissue </li></ul><ul><ul><li>Atrophy </li></ul></ul><ul><li>Nervous Tissue </li></ul><ul><ul><li>Atrophy </li></ul></ul>
  18. 18. Other Tissue Changes <ul><li>Neoplasm </li></ul><ul><ul><li>Uncontrolled cell division </li></ul></ul><ul><ul><li>Benign or malignant </li></ul></ul><ul><li>Hyperplasia </li></ul><ul><ul><li>Increase in cell numbers </li></ul></ul><ul><ul><li>Enlargement of tissue </li></ul></ul><ul><ul><li>Due to irritant or stimulant </li></ul></ul><ul><li>Atrophy </li></ul><ul><ul><li>Decrease in size </li></ul></ul><ul><ul><li>Loss normal stimulation </li></ul></ul>

×