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William Charles Eckelman, Ph.D. William Charles Eckelman, Ph.D. Document Transcript

  • William Charles Eckelman, Ph.D. WCeckelman@comcast.net EDUCATION: B.S. - Chemistry, St. Louis University, St. Louis, Mo., June, 1963 M.A. - Chemistry, Washington University, St. Louis, Mo., January, 1966 Ph.D. Chemistry, Washington University, St. Louis, Mo., April, 1968 PRESENT APPOINTMENTS • Adjunct Professor, Department of Radiology, University of California at San Diego, San Diego CA Directs the radiochemistry effort at the new PET program involved in incorporating PET literature compounds and compounds developed at UCSD to support clinical protocols in studies of normal and diseased human biochemistry using positron emission tomography. Leader, PET Radiochemistry Group Vice Chair, Scientific Steering Committee PET & Radiochemistry Scientific Evaluation Committee • Chair: Scientific Advisory Board, Molecular Insight Pharmaceuticals, Cambridge MA o Serve as Chief Scientific Advisor to the client’s President and scientific staff on all scientific aspects of the client’s portfolio and strategic plan. Collaborates with the Chief Scientific Officer to set the strategic plan for future areas of research and implements that plan through the federal grant applications. • Consultant for ComputerCraft Corporation, Arlington VA o Senior Investigator in the NIH Roadmap project, which is establishing libraries of chemical molecules that provides imaging probes for molecular and cellular events. Consult on the scientific content of summaries of up to 2000 molecular probes. Coordinate with the curators the general scientific approach including format, relevant references, areas of interest, and regulatory status of molecular probes for in vivo imaging as directed by the NCI in their Molecular Imaging and Contrast Agents Database (MICAD). PREVIOUS APPOINTMENTS: March, 1991 to May 2004. Chief, PET Department, Clinical Center, National Institutes of Health Directed a multi-Institute research program employing short-lived radiolabeled compounds in studies of normal and diseased human physiology using positron emission tomography (PET) and computer systems to measure and display the tissue distribution or metabolism of these agents. Pursued the synthesis of subtype specific ligands through chiral synthesis and the application of both pharmacologic and molecular biology subtype assays for the development of these radiotracers. With these developed appropriate radiopharmaceuticals and pharmacokinetic analysis methods that lead to the development of "one picture" analysis of key biochemical markers. Also pursued the use of PET radionuclides (e.g. I-124, Ga-66 and F-18) for therapy using quantitative imaging and dosimetry as a guide to therapy. NOVEMBER 1987 TO MARCH, 1991 Vice President, Diagnostics R&D, The Squibb Institute for Medical Research Scientific and Administrative Responsibility for 90 employees with a $19MM budget for: • Contrast Media Research • Clinical Assay Development 1
  • • Diagnostic Drug Development • Radiopharmaceutical Research APRIL 1985 TO OCTOBER 1987 Associate Director of The Squibb Institute for Medical Research; Director, Diagnostics R&D Scientific and Administrative Responsibility for: • Contrast Media Research Department • Clinical Assay Development Department • Diagnostic Drug Development Department • Radiopharmaceutical Research Department NOVEMBER 1983 TO MARCH 1985 Chief, Radiopharmaceutical Chemistry Section, Department of Nuclear Medicine, Clinical Center, National Institutes of Health, Bethesda, MD • This position consisted of directing programs in three areas: Radiopharmacy, Cyclotron Operation and Applied Radiochemistry. Specifically, I: • Directed the Radiopharmaceutical Chemistry Section of the Department of Nuclear Medicine. Set specific program goals, allocated resources among the three groups in the Section and monitored their progress toward meeting assigned goals. Planned and conducted research on the synthesis of new radioactive pharmaceuticals. Documented research findings, methodologies and recommendations in reports, papers and articles for publication in scientific journals. Directed the work of recognized experts in the areas of radiopharmacy and radiochemistry. • Maintained an awareness of policy, goals and priorities of the Department and of the Institutes and NIH as a whole as they impinged on the operation of the Radiopharmaceutical Chemistry Section. • Functioned as the major departmental expert on questions related to nuclear radiochemistry. Maintained a continuing awareness of technical advances in instrumentation and analytical techniques which may advance progress of Department programs and implement those which are appropriate. August 1977 – November 1983 Professor of Radiology, George Washington University Medical Center, Washington, D.C. • Chief of Radiopharmaceutical Chemistry Section, George Washington University Medical Center, Washington, D.C. • Chief of Radioassay Section, George Washington University Medical Center, Washington, D.C. • Director, Radiological Science Graduate Program, George Washington University Medical Center, Washington, D.C. • Research Associate at Georgetown University Medical Center • Research Collaborator at Brookhaven National Laboratory • Research Collaborator at Armed Forces Radiobiology Research Institute As Director of the research effort, I was responsible for developing projects, submitting proposals, administering the funded grants, including overseeing the personnel and supply budget, organizing research discussions, literature club and invited seminars and directing the research so that the specific aims were achieved. Over the 10 years in this position, we obtained numerous grants for nearly $3 million for the development of labeled bleomycin, various receptor binding radiotracers, and bifunctional chelates with fatty acids and antibodies. This resulted in over 100 publications and numerous book chapters and review articles. The Section of Radiopharmaceutical Chemistry group 2
  • included 5 Ph.D.s, 2 M.S., 3 B.S., 2 research assistants, 3 graduate students and 1 administrative assistant. • Radiopharmaceutical Chemistry Section Responsibilities: • Resident, technologist, and pre-doctoral Training • Resident, technologist, and pre-doctoral Teaching • Administration • Radiopharmacy o Oversee operation including approval of batch sheet each week. o Develop summer programs for graduate students in Radiopharmacy to incorporate new compounds into routine clinical use. (e.g. In Vitro RBC kit). o Consult on Clinical problems. o Assist in preparation of Clinical SOP manual. July 1974 - July 1977 Associate Professor in Radiology. The George Washington University Medical Center, Washington, D.C. • Chief of the Radiochemistry/Radiopharmacology Section • Chief of the Radioassay Section March 1972 - June 1975 Washington Hospital Center, Washington, D.C. • Chief, Radiopharmacy/Radiochemistry • Department of Nuclear Medicine July 1972 - June 1974 The George Washington University Medical Center, Washington, D.C. • Assistant Professor in Radiology April 1972 - June 1972 Washington Hospital Center, Washington, D.C. • Chemist, Division of Nuclear Medicine October 1969 - March 1972 Brookhaven National Laboratory, Upton, New York • Associate Chemist • Group Leader for development of radiopharmaceuticals. • Scientific Supporting Staff of Medical Research Center in charge of Radiopharmaceuticals. April 1968 - October 1969 Mallinckrodt Nuclear, St. Louis, Missouri • Group leader in research and development. The development of Res-O-Mat T-3 and T-4 insulin radioimmunoassay techniques. Experience in commercial preparation of various Radiopharmaceuticals. September 1963 - April 1968 Washington University, St. Louis, Missouri • Graduate Student; Reactions of radioactive silicon in gas phase. Analysis of products by gas chromatography and proportional counters. Organometallic synthesis of reference compounds. September 1962 - June 1963 St. Louis University, Department of Chemistry, St. Louis, Missouri. • Research Assistant; Long range inductive effects in aliphatic systems in trifluoroacetic acid. SOCIETIES: 3
  • • American Chemical Society (ACS) • Society of Nuclear Medicine (SNM) • American Association for the Advancement of Sciences (AAAS) • American Association of Pharmaceutical Scientists (AAPS) • Society of Radiopharmaceutical Sciences (SRS) EDITORIAL APPOINTMENTS: • Editor-in-Chief - Nuclear Medicine and Biology, 1985 - present • Editorial Board-Investigative Radiology, 1995-present AWARDS - • Young Investigator's Award, Greater NY Chapter SNM: 1971 • Herrman L. Blumgart Pioneer Lecture Award: 1985 • The Paul C. Aebersold Award for Outstanding Achievement in Basic Science Applied to Nuclear Medicine:1988 (J Nucl Med 29:586-7) • Berson-Yalow Award for Original Contribution to the Field of Clinical Radioimmunoassay: 1990 (J Nucl Med 31:N19A (6)) • 1995 Corporate Committee Achievement Award of the American College of Nuclear Physicians:1995 • The Swedish Society of Medicine medal in recognition of the “Bertil Noslin Lecture”, presented December, 1995. • The Georg deHevesy Nuclear Pioneer Award, Society of Nuclear Medicine, 1997 (J Nucl Med 38, 23N, 1997). • Institute for Clinical PET Distinguished Scientist Award, 2000 • Great Golden Seal of Padua University in recognition of contributions to Radiopharmaceuticals Development, 2002 COMMITTEE APPOINTMENTS: • Radioactive Drug Research Committee at: • George Washington University, 1977 to 1983 • Children's Hospital, 1977 to 1983 • Veterans Administration Hospital, 1977 to 1983 • Prince George's Community Hospital, 1977 to 1983 • Georgetown University, 1977 to 1991 • Member of the Diagnostic Radiology Study Section, NIH, 1982-1986 • Medical Center Faculty Senate Standing Committee on Medical Sciences Graduate Programs, George Washington University, 1977-1983 • Medical School Admissions Committee, George Washington University Medical School, 1977-1983 • Chairman, Radioactive Drug Research Committee, George Washington University Medical Center, 1977-1983 • Medical Center Faculty Senate Standing Committee on Space and Facilities, George Washington University Medical School, 1977-1980 • Member, Associated Universities Advisory Committee - 1987 to 1991 • Member, National Academy of Science, Nuclear and Radiochemistry Committee - 1988 to 1993 • Member, National Academy of Science, Panel for Radiation Research, NIST - 1989-1995 • Member, Institute of Medicine Committee, Availability of Isotopes, 1993-1994 • Chairman, Brookhaven BLIP Users' Committee - 1988 to 1996. 4
  • • Member, International Organizing Committee of the International Symposium on Radiopharmaceutical Chemistry - 1988 - present • Member of the Diagnostic Radiology Study Section, NIH, 1997-2001. • Chair, National Advisory Committee of the BLIP National Isotope Center, 1997-1999 • President, Society of Nuclear Imaging in Drug Development (SNIDD), 1999-2001. • Member, Board of Directors, Institute for Clinical PET, 2000-2003 • President, Society of Radiopharmaceutical Sciences, 2005 to 2007. ACTIVITIES IN THE SOCIETY OF NUCLEAR MEDICINE: SNM Membership 1968 to present Chapter Membership 1969-72 - Greater New York 1972-85 - Mid Eastern 1986-91 - Greater New York 1991- present - Mid Eastern National Activities - • SNM Ad Hoc Committee on Councils 1983-1986 • President-Elect and President, Radiopharmaceutical Science Council:1980-1982 • Board of Directors, Radiopharmaceutical Science Council: 1977-1978 • Continuing Education Course, Annual Meeting, SNM 1982, 1983, 1984, 1985, 1986 • Categorical Seminar, RPSC 1982, 1989 • Scientific Program Committee, Vice Chairman 1979,2001 • Scientific Program Reviewer, 1980, 1983, 1985, 1987, 1988, 1989, 1990,1991 • SNM Scientific Program Chair 1993-1998 • SNM Finance Committee 1984 - 1992 • Society of Nuclear Medicine BOD, 1998-2001. 5
  • PUBLICATIONS ((Original papers, patents (P), extended abstracts from the International Symposium on Radiopharmaceutical Chemistry (A), and book chapters and books (B). --Greater than 375 6
  • 7
  • E. Research Grants GRANT NAME NUMBER start yrs 1. Radioisotope labeling of BLEO CM 43710 74 2 2. Clin. Evaluation of 57Co BLEO CA 18676 75 2 3.Radiolabeled BLEO for Pardee Fnd 75 2 Detection of Breast Cancer 4. Semisynthetic BLEO CA 16188 74 3 5. Technetium Orthophosphate GM 20543 75 3 6. Synthesis of Molecules for HL 16262 75 3 Myocardial Imaging 7. Biological Traces with Gamma CA 18675 75 3 Emitting Isotopes 8. Increased Sensitivity of CA 19383 76 2 Radiopharmaceuticals 9. Synthesis of Molecules for HL 19127 76 2 Myocardial Imaging 10. Biological Tracers with Gamma CA 18675 78 3 Emitting Isotopes 11. Synthesis of Molecules for HL 19127 78 3 Myocardial Imaging 12. Biological Tracers with Gamma CA 18675 81 3 Emitting Isotopes 13. Synthesis of Molecules for HL 19127 81 3 Myocardial Imaging 14. Radiolabeling of Tumor CA 28462 80 3 Antibodies 15. Development of Gamma DOE ER 82 2 Emitting Radiotracers for Imaging 60039 the Brain and Pancreas 16. Radiolabeling of Tumor CA 28462(R) 83 2 Antibodies 17. Radiolabeling of Tumor Am Can Soc 83 2 Antibodies 18. Research Resources: Gamma 1S10 83 1 Camera RR01939 19. Size-Dependent Uptake of 1R41CA11279 03 1 Tc(I)-Labeled RGD Analogs 7-01 20. Workshop on Receptor-Binding 1R13CA10130 03 1 Radiotracers 2003 4-01 21. Workshop on Receptor-Binding DOE 03 1 Radiotracers 2005 22. Workshop on Receptor-Binding DOE 03 1 Radiotracers 2003 23. Workshop on Receptor-Binding DOE 03 1 Radiotracers 2005 8
  • PUBLICATIONS ((Original papers, patents (P), extended abstracts from the International Symposium on Radiopharmaceutical Chemistry (A), and book chapters and books (B). 1. Gaspar PP, Pate BD, Eckelman WC: Reaction of Recoiling Silicon Atoms with Phosphine and Silane. J. Am. Chem. Soc. 88:3878-3879, 1966. 2. Gaspar PP, Bock SA, Eckelman WC: Reactions of Recoiling Silicon Atoms with Phosphine, Silane and Ethylene. J. Am Chem. Soc. 90:6914-6922, 1968. 3. Eckelman WC: Reaction of Recoil Silicon with Phosphine, Silane, and Ethylene. Ph.D. Thesis, 1968. Diss. Abst. B 29:2348, 1969. 4. Eckelman WC and Richards P: Instant 99m-Tc-DTPA. J. Nucl. Med. 11:761, 1970. 5. Eckelman WC, Richards P: Technetium Labeled Red Blood Cells. J. Nucl. Med. 12:22-24, 1971. 1. Atkins H, Cardinale KG, Eckelman WC, Hauser W, Klopper JF, Richards P: Evaluation Of 99m-Tc-DTPA Prepared By Three Different Methods. Radiology 98:674-677, 1971. 2. Eckelman WC, Richards P, Atkins H, Hauser W, Klopper JF: Visualization of the Human Spleen With 99m-Tc Labeled Red Blood Cells. J. Nucl. Med. 12: 310-311, 1971. 3. Eckelman WC, Meinken G, Richards P: The Chemical State of 99m-Tc in Biomedical Products. J. Nucl. Med. 12:596-600, 1971. 4. Hauser W, Atkins H, Eckelman WC, Richards P: Thyroidal Pertechnetate Uptake in Hashimoto's Disease. Am. J. Roentgenol, Radium Ther and Nucl. Med. 112:720-725, 1971. 5. Eckelman WC, Meinken G, Richards P: 99m-Tc Human Serum Albumin. J. Nucl. Med. 12:707-710, 1971. 6. Eckelman WC and Richards P: Instant 99m-Tc Compounds. Nuklearmedizin 10:245-251, 1971. 7. Eckelman WC, Richards P, Hauser W, Atkins H: Letter to the Editor Concerning 99m- Tc-DTPA Preparation. J. Nucl. Med. 12:699, 1971. 8. Eckelman WC, Richards P, Hauser W, Atkins H: Authors Reply Concerning 99m-Tc Labeled Red Blood Cells. J. Nucl. Med. 12:577-578, 1971. 9. Eckelman WC, Meinken G, Richards P: High Specific Activity 99m-Tc Human Serum Albumin. Radiology 102:185-186, 1972. 9
  • 10. Klopper JF, Hauser W, Atkins HL, Eckelman WC, Richards P: Evaluation of 99m-Tc- DTPA for the Measurement of Glomerular Filtration Rate. J. Nucl. Med. 13:107-110, 1972. 11. Eckelman WC, Richards P: Analytical Pitfalls with 99m-Tc Labeled Compounds. J. Nucl. Med. 13:202-204, 1972. 12. Eckelman WC, Meinken G, Richards P: The Chemical State of 99m-Tc in Biomedical Products. II. The Chelation of Reduced Technetium with DTPA. J. Nucl. Med. 13:577-581, 1972. 13. Klopper JF, Atkins JL, Eckelman WC: Agglutination of Labeled RBC. J. Nucl. Med. 13:397, 1972. 14. Atkins HL, Eckelman WC, Hauser W, Klopper JF, Richards P: Splenic Sequestration of Technetium-99m Labeled Red Blood Cells. J. Nucl. Med. 13:811-814, 1972. 15. Eckelman WC, Richards P: Letter To the Editor: Technetium Labeling of Albumin. J. Nucl. Med. 13:181-182, 1972. 16. Eckelman WC, Meinken G, Richards P: Authors' Reply Concerning the Chemical State of 99m-Tc in Biomedical Products. J. Nucl. Med. 13:341-342, 1972. 17. Eckelman WC, Richards P, Atkins H, Hauser W: Authors' Reply Concerning Alteration Of 99m-Tc Red Blood Cells. J. Nucl. Med. 13:399-400, 1972. 18. Eckelman WC, Meinken G, Richards P, et al: Methods for Tc Localization in Bone. BNL Report, 1972. 19. Atkins Hl, Eckelman WC, Klopper JF, Richards P: Vascular Imaging with 99m-Tc Red Blood Cells. Radiology 106:357-360, 1973. 20. Atkins Hl, Klopper JF, Hauser W, Eckelman WC, Et Al: Authors Reply Concerning GFR Properties Of 99m-Tc DTPA. J. Nucl. Med. 14:249, 1973. 21. Reba RC, Eckelman WC, Albert WN: Tc-99m Labeled Red Blood Cells: A New Radiopharmaceutical For The Determination Of Total Blood Volume And Blood Pool Scanning. Med. Ann. Of D.C. 42:1-3, 1973. 22. Eckelman WC, Reba RC, Albert WN: A Rapid Simple Improved Method For The Preparation Of 99m-Tc Red Blood Cells For The Determination Of Red Cell Volume. Am. J. Roentgenol. Radium Ther. and Nucl. Med. 118:861-864, 1973. 23. Grove RB, Eckelman WC, Reba RC: Distribution of Labeled Bleomycin in Normal and Tumor Bearing Mice. J. Nucl. Med. 14:917-919, 1973. 24. Eckelman WC, Richards P: Technetium Labeling, U.S. Patent No. 3725295, April 3, 1973. 10
  • 25. Steigman J, Eckelman WC, Meinken G, Isaacs HS, Richards P: Chemistry of Technetium Labeling of Radiopharmaceutical By Electrolysis. J. Nucl. Med. 15:75-80, 1974. 26. Eckelman WC, Reba RC, Kubota H, Stevenson JS: 99m-Tc Pyrophosphate for Bone Imaging. J. Nucl. Med. 15:279-283, 1974. 27. Stevenson JS, Eckelman WC, Sobocinski PZ, Reba RC, Barron EL, Levin SG: The Toxicity of Sn-Pyrophosphate - Clinical Manifestations Prior To Acute LD-50. J. Nucl. Med. 15:252-256, 1974. 28. Gaspar PP, Hwang RJ, Eckelman WC: Reaction of Recoiling Silicon Atoms with Phosphine and Butadiene and a New Trap for Silylene. Chem. Comm. 242-243, 1974. 29. Grove RB, Reba RC, Eckelman WC: Clinical Evaluation of Radio-Labeled Bleomycin for Tumor Detection. J. Nucl. Med. 15:386-390, 1974. 30. Book. Eckelman WC, Smith TD, Richards P: Labeling Of Blood Cells with 99m-Tc. In Radiopharmaceuticals. Ed. G. Subramanian, Rhodes BA, Cooper JF, Society of Nuclear Medicine, New York, NY, Pp. 49-54, 1974. 31. Book. Reba RC, Eckelman WC, Poulose KP, Grove RB, Stevenson JS, Rzeszotarski WJ, Primack A: Tumor Specific Radiopharmaceuticals: Radiolabeled Bleomycin. In Radiopharmaceuticals. Ed. G. Subramanian, Rhodes BA, Cooper JF, Society of Nuclear Medicine, pp. 464-473, 1975. 32. Eckelman WC: Technical Considerations in Labeling Of Blood Elements. Semin. Nucl. Med. 5:3-10, 1975. 33. Poulose KP, Watkins AA, Reba RC, Eckelman WC, Goodyear M: Cobalt Labeled Bleomycin - A New Radiopharmaceutical for Tumor Localization. A Comparative Clinical Evaluation with Gallium Citrate. J. Nucl. Med. 16: 839-841, 197, 1975 34. Poulose KP, Reba RC, Eckelman WC, Goodyear M: Extraosseous Localization of 99m- Tc-Sn Pyrophosphate. Brit. J. Radiol. 48:724-726, 1975. 35. Eckelman WC, Karesh SM, Reba RC: New Compounds: Fatty Acid And Long Chain Hydrocarbon Derivatives Containing A Strong Chelating Agent. J. Pharm. Sci. 64:704-706, 1975. 36. Eckelman WC, Rzeszotarski WJ, Siegel B, Kubota H, Chelliah M, Stevenson J, Reba RC: The Chemical And Biological Properties of Isolated Radiolabeled Bleomycin Components. J. Nucl. Med. 16:1033-1037, 1975. 37. Eckelman WC, Kubota H. Siegel B, Komai T, Rzeszotarski WJ, Reba RC: Iodinated Bleomycin: An Unsatisfactory Radiopharmaceutical For Tumor Localization. J. Nucl. Med. 17:385-388, 1976. 11
  • 38. Eckelman WC, Rzeszotarski WJ, Siegel B, Kubota H, Chelliah M: The Chemical and Biological Properties of Isolated Radio-Labeled Bleomycin Components. AFFRI Scientific Report, US Ntls Ad Rep Ad-A021834, 76:70, 1976. 39. Kubota H, Eckelman WC, Poulose KP, Reba RC: Technetium-99m Pyridoxylideneglutamate - A New Radiopharmaceutical for Imaging the Gallbladder. A Comparative Pharmacokinetic Study with I-131 Rose Bengal. J. Nucl. Med. 17:36-39, 1976. 40. Poulose KP, Eckelman WC, Reba, RC, Goodyear M: Clinical Evaluation of 99m-Tc- Pyridoxylideneglutamate for the Different Diagnosis of Jaundice. Clin. Nucl. Med. 1:70-72, 1976. 41. Eckelman WC: Chemical State of Technetium In Vivo. J. Nucl. Med. 17:421-422, 1976. 42. Eckelman WC: Radiochemical Purity of New Radiopharmaceuticals. J. Nucl. Med. 17:865, 1976. 43. Rzeszotarski WJ, Eckelman WC, Reba RC: Chromatography of The Antitumor Antibiotic Bleomycin. Clin. Res. 24:488, 1976. 44. Rzeszotarski WJ, Eckelman WC, Reba RC: Reversed Phase High Pressure Liquid Chromatography of Bleomycin. J. Chromatogr. 124:88-91, 1976. 45. Karesh SM, Eckelman, Reba RC: The Biological Distribution Of Chemical Analogs Of Fatty Acids And Long Chain Hydrocarbons Containing A Strong Chelating Agent. J. Pharm. Sci. 66:225-228, 1977. 46. Book. Eckelman WC, Levenson SM: Chromatographic Purity Of 99m-Tc Compounds. In Quality Control In Nuclear Medicine. Ed. B. Rhodes, C.V. Mosby Co., St.Louis, MO., 1977. 47. Book. Eckelman WC And Levenson SM: Radiopharmaceuticals Labeled With 99m-Tc. In International Journal Applied Radiation And Isotopes. Ed. M. Welch, Pergamon Press, Special Edition 28:67-82, 1977. 48. Eckelman WC, Levenson SM, Johnston GS: Radiochemical Purity Of 99m-Tc Radiopharmaceuticals. Applied Radiology/NM. May/June, 1977, 211-214. 49. Komai T, Eckelman WC, Johnsonbaugh HR, Mazaitis A, Kubota H, Reba RC: Estrogen Derivatives For The External Localization Of Estrogen Dependent Malignancy. J. Nucl. Med. 18:360-366, 1977. 50. Rzeszotarski WJ, Gibson RE, Eckelman WC, Reba RC: Cardioselective Beta-1 Adrenoceptor Antagonists. Clin. Res. 25:251a, 1977. 12
  • 51. Eckelman WC: The Chemistry Of Technetium. J. Labelled Cpd. Radiopharm. 13:155, 1977 (Abst). 52. Rzeszotarski WJ, Eckelman WC, Reba RC: Application Of Mannich Reaction To Introduction Of Chelating Groups Into A Biologically Active Molecule. J. Labelled Cpd. Radiopharm. 13:171, 1977 (Abst). 53. Komai T, Eckelman WC, Johnsonbaugh R, Mazaitis A, Jiang VW, Reba RC: Estrogen Derivatives For External Localization Of Estrogen Dependent Malignancy. J. Labelled Cpd. Radiopharm. 13:279-280, 1977 (Abst). 54. Komai T, Eckelman WC, Rzeszotarski WJ, Reba RC: Preparation And Evaluation Of Beta Adrenergic Derivatives. J. Labelled Cpd. Radiopharm. 13:217-218, 1977 (Abst) 55. Rzeszotarski WJ, Paik C, Eckelman WC, Reba RC: The Synthesis Of Chelating Agents For The Preparation Of Drug Derivatives. J. Labelled Cpd. Radiopharm. 13:172, 1977 (Abst). 56. Jiang VW, Gibson RE, Rzeszotarski WJ, Eckelman WC, Reba RC, Vieras F, Alderson PO: Radioiodinated Derivatives Of Beta Adrenoceptor Blockers For Myocardial Imaging. J. Nucl. Med. 19:918-924, 1978. 57. Eckelman WC, Reba RC: The Classification Of Radiotracers. J. Nucl. Med. 19:1179-1181, 1978. 58. Bradley WP, Alderson PO, Eckelman WC, Hamilton RG, Weiss JF: Decreased Tumor Uptake Of Gallium-67 In Animals After Whole Body Irradiation. J. Nucl. Med. 19:204-209, 1978. 59. Book Eckelman WC, Levenson SM: Radiopharmaceutical Chemistry Of Technetium And Iodine. In Textbook Of Nuclear Medicine: Basic Science. Ed. A. DeRoche And J. Harbert. Lea Febinger Co., pp. 192-233, 1979. 60. Paik CH, Eckelman WC, Reba RC: Reactivity Of Some Amino Acids In The Azo Coupling Reaction I. Dependence Of Their Reactivity On pH. Bioorg. Chem. 8(1):25-34, 1979. 61. Book Eckelman WC, Gibson RE, Rzeszotarski WJ, Vieras F, Mazaitis JK, Francis B, Reba RC: The Design Of Receptor Binding Radiotracers. In Principles Of Radiopharmacology. Ed. L. Colombetti, CRC Press, Boca Raton, Fl 1:251-274, 1979. 62. Book.Gibson RE, Eckelman WC, Rzeszotarski WJ, et al: Radiotracer Localization By Receptor-Ligand Interactions. In Principles Of Radiopharmacology. Vol. II. Ed. L. Colombetti, CRC Press, 1979, Pp. 17-40. 63. Eckelman WC, Reba RC, Gibson RE, Rzeszotarski WJ, Vieras F, Mazaitis JK, Francis B: Receptor Binding Radiotracers: A Class Of Potential Radiopharmaceuticals. J. Nucl. Med. 20:350-357, 1979. 13
  • 64. Gibson RE, Komai T, Rzeszotarski WJ, Reba RC, Eckelman WC: Evaluation Of Beta Adrenoceptor Antagonist Affinity And Cardioselectivity By Radioligand-Receptor Assay. J. Pharmacol. Exp. Ther. 209:153-161, 1979. 65. Rzeszotarski WJ, Gibson RE, Eckelman WC, Reba RC: Cardioselectivity Of Beta- Adrenoceptor Blocking Agents. 1. 1-(4-Hydroxyphenethylamino)-3-Aryloxypropan-2- ols. J. Med. Chem. 22:735-737, 1979. 66. Gibson RE, Eckelman WC, Vieras F, Reba RC: The Distribution Of The Muscarinic Acetylcholine Receptor Antagonist 3-H Quinclidinyl Benzilate And 3-H Quinuclidinyl Benzilate Methiodide In Rat, Guinea Pig, And Rabbit. J. Nucl. Med. 20:865-870, 1979. 67. Rzeszotarski WJ, Eckelman WC, Gibson RE, Jiang VW, Reba RC, Vieras F, Alderson PO: Beta Adrenergic Blocking Agents For Myocardial Imaging. J. Labelled Cpd. Radiopharm. 16:72-74, 1979 (Abst). 68. Yokoyama A, Horiuchi K, Hata N, Saji A, Tanaka H, Eckelman WC: Technetium In 99m-Tc Radiopharmaceuticals I. Tetravalent Mononuclear Technetium Penicillamine Complex. J. Labelled Cpd. Radiopharm. 16:80-81, 1979 (Abst). 69. Eckelman WC: Preparation Of Receptor Binding Radiotracers. Trans. Am. Nucl. Soc. 33:226-228, 1979. 70. Eckelman WC, Gibson RE, Vieras F, Rzeszotarski WJ, Francis B, Reba RC: In Vivo Receptor Binding Of Iodinated Beta Adrenoceptor Blockers. J. Nucl. Med. 21:436-442, 1980. 71. Mazaitis JK, Gibson RE, Komai T, Eckelman WC, Francis B, Reba RC: Radioiodinated Estrogen Derivatives. J. Nucl. Med. 21:142-146, 1980. 72. Book Eckelman WC, Levenson SM, Welch MJ, Krohn K: Radiopharmacology. In Nuclear Medicine Review Syllabus. Ed. P. Kirchner, Society Of Nuclear Medicine, 1980. 73. Paik C, Herman D, Eckelman WC, Reba RC: Synthesis, Plasma Clearance And In Vitro Stability Of Proteins Containing Conjugated Indium-111 Chelate. J. Radioanal. Chem. 57:553-564, 1980. 74. Paik C, Eckelman WC, Vieras F, Reba RC: Exchange Labeling Of Proteins: 99m-Tc Labeled Transferrin. J. Radioanal. Chem. 60:281-289, 1980. 75. Selikson M, Gibson RE, Eckelman WC, Reba RC: Calculation Of Binding Isotherms When Ligand And Receptor Are In Different Volumes Of Distribution. Anal. Biochem. 108:64-71, 1980. 14
  • 76. Eckelman WC, Paik CH, Reba RC: Radiolabeling Of Antibodies. In Workshop On Radioimmunodetection Of Cancer. Lexington Ky., July 19-21, 1979. Cancer Res. 40:3036-3042, 1980. 77. Mazaitis JK, Francis B, Eckelman WC, Gibson RE, Reba RC: No-Carrier-Added Bromination Of Estrogens With Chloramine T And Na77Br. J. Labelled Cpd. Radiopharm. 18:1033-1038, 1981. 78. Book Eckelman WC And Reba RC: Labeled Estrogens And Analogues. In Radiopharmaceuticals: Structure-Activity Relationships. Ed. Richard P. Spencer, Grune And Stratton, pp.449-458, 1981. 79. Eckelman WC and Reba RC: One Of Three Thousand. J. Nucl. Med. 22:190-191, 1981. 80. Rzeszotarski WJ, Eckelman WC, Gibson RE, Simms DA, Reba RC: (R,S)-3- Quinuclidinyl-4-Iodobenzilate (4IQNB). The Triazene Approach. J. Labelled Cpd. Radiopharm. 18:94-95, 1981 (Abst). 81. Eckelman WC, Gibson RE, Rzeszotarski WJ, et al.: Radiolabeled Adrenegic And Muscarinic Blockers For In Vivo Studies. J. Labelled Cpd. Radiopharm. 18:96-98, 1981 (Abst). 82. Eckelman WC, Herrara NE, Hauser W: Radiopharmaceutical Quality Assurance Pilot Study. J. Nucl. Med. 22:94, 1981. 83. Paik CH, Eckelman WC, Lei KS, Friend KE, Reba RC: Bifunctional Chelates For Tumor Imaging J. Nucl. Med. 22:32, 1981. (Abst). 84. Book: Eckelman WC: The Development Of Muscarinic Cholinergic Receptor-Binding Radiotracers. In Applications Of Nuclear And Radiochemistry. Ed. N. Marcos And R. Lambrecht, Pergamon Press, Elmsford N.Y., Pp.287-297, 1982. 85. McElroy NL, Sauerbrunn BJL, Eckelman WC: The Feasibility Of Recycling Glass Liquid Scintillation Vials. Health Physics 42:236-238, 1982. 86. Book: Eckelman WC, and Reba RC: Future Applications of Nuclear Medicine. In Nuclear Medicine In Clinical Practice. Ed L. Greenfield And M. Uszler. Verlag Chemie Int'l. Deerfield Beach, Fl, 1982. 87. Book: Eckelman WC: Radiolabeled Adrenergic And Muscarinic Blockers For In Vivo Studies. In Receptor Binding Radiotracers. Ed. W. C. Eckelman, CRC Press, Inc., 1:69-91, 1982. 88. Book: Eckelman WC (Editor): Receptor Binding Radiotracers. Vol I And Vol. II CRC Press, Inc. Boca Raton, Fl, 1982. 15
  • 89. Book: Eckelman WC: Receptor Specific Radiopharmaceuticals. In Emission Computed Tomography. Ed. P.J. Ell And B.L. Holman, Oxford University Press, Oxford, England, 1982. 90. Francis B, Eckelman WC, Grissom M, et al.: The Use Of Tritium Labeled Compounds To Develop Gamma-Emitting, Receptor Binding Radiotracers. Int. J. Nucl. Med. Biol. 9:173-179, 1982. 91. Rzeszotarski WJ, Gibson RE, Eckelman WC, Simms DA, Jagoda EM, Ferreira NL, Reba RC: Analogues Of R, S-3-Quinuclidinyl Benzilates. J. Med. Chem. 25:1103-1106, 1982. 92. Pieslor P, Gibson RE, Eckelman WC, Oates K, Cook B, Reba RC: Three Radioligands Compared For Determining Cytoplasmic Estrogen Receptor Content Of Human Breast Carcinomas. Clin. Chem. 28:532-537, 1982. 93. Paik CH, Murphy PR, Eckelman WC, Volkert WA, Reba RC: The Conjugation Of Metal Chelates To Antibodies. J. Nucl. Med. 23:37, 1982 (Abst). 94. Eckelman WC, Volkert WA: In Vivo Chemistry Of 99m-Tc Chelates. In Technetium-99m Generators, Chemistry, And Preparation Of Radiopharmaceuticals. Ed. W.C. Eckelman And B.M. Coursey. Int. J. Appl. Radiat. Isot., Pergamon Press, Pp. 945-951, 1982. 95. Gibson RE, Eckelman WC, Francis B, et al.: 77-Br-17-Alpha-Bromoethynyl Estradiol: In Vivo And In Vitro Characterization Of An Estrogen Receptor Radiotracer. J. Nucl. Med. Biol. 9:245-250, 1982. 96. Eckelman WC And Coursey BM (Editors): Technetium-99m Generators. Chemistry And Preparation Of Radiopharmaceuticals. Int. J. Appl. Radiat. Isot. 33:793-952, 1982. 97. Eckelman WC, Grissom M, Conklin JJ, Rzeszotarski WJ, Gibson RE, Francis BR, Eng R, Reba RC: In Vivo Displacement By Muscarinic Acetylcholine Receptor (M-AChR) Binding Ligands. J. Labelled Cpd. Radiopharm. 19:1289-1291, 1982 (Abst). 98. Francis BE, Rzeszotarski WJ, Eckelman WC, Reba RC: Nucleophilic Iodination Of 3- Quinuclidinyl Benzilate (QNB). J. Labelled Cpd. Radiopharm. 19:1499-1500, 1982 (Abst). 99. Rzeszotarski WJ, Potenzone R Jr., Eckelman WC, Gibson RE, Reba RC: Application Of NIH-EPA Cis Chemlab Programs For Design Of Radiopharmaceuticals. J. Labelled Cpd. Radiopharm. 19:1514-1515, 1982 (Abst). 100.Adams HR, Paik CH, Eckelman WC, Reba RC: Electrophilic Iodination Of Aromatic Rings. J. Labelled Cpd. Radiopharm. 19:1476-1478, 1982 (Abst). 16
  • 101.Paik CH, Ebbert ME, Sassman CR, Reba RC, Eckelman WC: pH Effect On DTPA Conjugation To Antibodies Via Cyclic DTPA Anhydride. Hybridoma 2:126, 1983 (Abst) 102.Rzeszotarski WJ, Gibson RE, Simms D, Vaughn JN, Jagoda EM, Eckelman WC: Cardioselectivity Of Beta-Adrenoceptor Blocking Agents. 2. The Role Of The Amino Group Substituent. J. Med. Chem. 26:644-648, 1983. 103.Book: Eckelman WC and Levenson SM: Radiopharmaceutical Chemistry. In Textbook Of Nuclear Medicine: Basic Sciences. Ed. A. DeRoche And J. Harbert. 2nd Ed. Lea Febinger Co., 1983. 104.Paik CH, Sassman CR, Murphy PR, Ebbert MA, Reba RC And Eckelman WC: One Step Method For DTPA Conjugation To Antibodies. J. Nucl. Med. 24:31, 1983. 105.Book: Eckelman WC: 99m-Tc Red Blood Cells. In Scintigraphy For Evaluation Of Vascular Disease. Ed. E. Siegel, CRC Press, Inc., 1983. 106.Book: Lambrecht R and Eckelman WC (Editors): Animal Models in Radiotracer Design. Springer Verlag, N.Y., 1983. 107.Gibson RE, Rzeszotarski WJ, Eckelman WC, et al.: Differences In Affinities Of Muscarinic Acetylcholine Receptors Antagonists For Brain And Heart Receptors. Biochem. Pharmacol. 32:1851-1856, 1983. 108.Book: Rzeszotarski WJ, Potenzone R Jr., Eckelman WC, et al.: Applications of NIH/EPA Cis Chemlab Programs For the Design of Radiopharmaceuticals. In Computer Applications In Chemistry. (Eds) S.R. Heller And R. Potenzone Jr., Elsevier, P.341, 1983. 109.Paik CH, Murphy PR, Eckelman WC, Volkert WA, Reba RC: Optimization Of The DTPA Mixed Anhydride Reaction With Antibodies At Low Concentration. J. Nucl. Med. 24:932-936, 1983. 110.Paik CH, Ebbert MA, Murphy PR, Sassman CR, Reba RC, Eckelman WC: Factors Influencing DTPA Conjugation To Antibodies Via Cyclic DTPA Anhydride. J. Nucl. Med. 24:1158-1163, 1983. 111.Eckelman WC, Grissom M, Conklin J, Rzeszotarski WJ, Gibson RE, Francis BE, Jagoda EM, Eng R, Reba RC: In Vivo Competition Studies With Analogues Of Quinuclidinyl Benzilate. J. Pharm. Sci. 73:529-533, 1984. 112.Gibson RE, Weckstein DJ, Jagoda EM, Rzeszotarski WJ, Reba RC, Eckelman WC: The Characteristics Of I-125 QNB And H-3 QNB In Vivo And In Vitro. J. Nucl. Med. 25:214-222, 1984. 113.Eckelman WC, Gibson RE: Receptor-Binding of F-18 Haloperidol And Spiroperidol. Letter J. Nucl. Med. 25:532-533, 1984. 17
  • 114.Rzeszotarski WJ, Eckelman WC, Francis BE, Simms DA, Gibson RE, Jagoda EM, Grissom MP, Eng RR, Conklin JJ, Reba RC: Synthesis And Evaluation Of Radioiodinated Derivatives Of 1-Azabicycolo-(2.2.2.)Oct-3-Yl Alpha-Hydroxy-Alpha- (4-Iodophenyl)Phenylacetate As Potential Radiopharmaceuticals. J. Med. Chem. 27:156-159, 1984. 115.Nakatsuka I, Ferreira N, Eckelman WC, Francis BE, Rzeszotarski WJ, Gibson RE, Reba RC: The Synthesis And Evaluation Of (17a, 20e)-21-[125i]Iodo-19- Norpregne-1.3,5(10),20-Tetraene-3,17-Diol And (17a 20e)-21-[125i]Iodo-11b- Methoxy-19-Norpregna-1,3,5(10), 20-Tetraene-3,17-Diol (17a-Iodovinyl Estradiol Derivatives) As High Specific Activity Potential Radiopharmaceuticals. J. Med. Chem. 27:1287-1291, 1984. 116.Gibson RE, Coenen HH, Jagoda EM, Reba RC, Eckelman WC: In Vivo And In Vitro Characteristics Of The N-Methyl Derivative Of (I-125) 3-Quinuclidinyl 4-Iodobenzilate. Int. J. Nucl. Med. Biol. 11:167-169, 1984. 117.Gibson RE, Rzeszotarski WJ, Jagoda EM, Francis BE, Reba RC, Eckelman WC: (I-125) 3-Quinuclidinyl 4-Iodobenzilate: A High Affinity High Specific Activity Radioligand For The M1 And M2-Acetylcholine Receptors. Life Sciences. 34:2287-2296, 1984. 118.Eckelman WC, Reba RC, Rzeszotarski WJ, Gibson RE, Hill T, Holman BL, Budinger T, Conklin JJ, Eng R, Grissom MP: External Imaging Of Cerebral Muscarinic Acetylcholine Receptors. Science. 223:291-293, 1984. 119.Eckelman WC, Adams HR, Paik CH: Electrophilic Iodination Of Aromatic Rings. Int. J. Nucl. Med. Biol 11:163-166, 1984. 120.Jagoda EM, Gibson RE, Goodgold H, Ferreira N. Francis BE, Rzeszotarski WJ, Reba RC, Eckelman WC: I-125 17alpha-Iodovinyl 11beta-Methoxyestradiol: In Vivo And In Vitro Properties Of A High Affinity Estrogen-Receptor Radiopharmaceutical. J. Nucl. Med. 25:472-477, 1984. 121.Powe J, Pak KY, Paik CH, Steplewski Z, Ebbert MA, Herlyn D, Alavi A. Eckelman WC, Reba RC and Koprowski H: Labeling Monoclonal Antibodies and F(Ab')2 Fragments With 111In Indium Using Cyclic DTPA Anhydride and Their In Vivo Behavior in Mice Bearing Human Tumor Xenografts. Cancer Drug Delivery. 1:125-135, 1984. 122.Eckelman WC, Alter WA III, Grissom MP, Vieras F, Phillips J, Eng R, Gibson RE And Reba RC: Comparison Of Myocardial Uptake And Distribution Of Thallium-201 And Two Prototype Receptor-Binding Radiopharmaceuticals In The Normal And Ischemic Canine Heart. Int. J. Nucl. Med. Biol. 11:287-290, 1984. 123.Pert CB, Danks Ja, Channing MA, Eckelman WC, Larson SM, Bennett JM, Burke Jr. TR, Rice KC: [18F]-3-Acetyl-Cyclofoxy: A Useful Probe For The Visualization Of Opiate Receptors In Living Animals. FEBS Letter. 177:281-286, 1984. 18
  • 124.Rice KC, Pert CH, Burke, Jr. TR, Larson SM, Eckelman WC, Channing MA: Synthesis And Utilization Of 17-Methyl And 17-Cyclopropyl-Methyl-3, 14-Dihydroxy-4,5 Epoxy 6 -Fluoromorphinans. Patent Application No. 06/675,276, 1984. 125.Eckelman WC, Reba RC, Rzeszotarski WJ, Gibson RE: Gamma-Emitting Receptor- Binding 3-Quinuclidinyl Glycolates; Methods Of Preparation Thereof And Imaging And Assay Methods Utilizing Same. U.S. Patent No. 4,431,627, Feb. 14, 1984. 126.Rice KC, Pert CB, Burke,Jr. TR, Larson SM, Eckelman WC, Channing MA: Synthesis and Utilization of 17-Methyl and 17-Cyclopropyl-Methyl-3,14-Dihydroxy-4, 5 Alpha- Epoxy-6 Beta Fluoromorphinans (Foxy and Cyclofoxy) As 18F-Labeled Opioid Ligands for Positron Emission Tomography (PETT). Us Patent Application, Filed 11/27/84. 127.Gibson RE, Eckelman WC, Reba RC, Jagoda EM, Grissom M, Conklin J, Eng R: Receptor Selective Localization In Pancreas. Int. J. Nucl. Med. Biol. 12:29-32, 1985. 128.Eckelman WC, Eng R, Rzeszotarski WJ, Gibson RE, Francis B And Reba RC: The Use Of 3-Quinuclidinyl 4-Iodobenzilate As A Receptor Binding Radiotracer. J. Nucl. Med. 26:637-642, 1985. 129.Zeeberg BR, Carson R, Bacharach S, Green MV, Eckelman WC And Larson SM: Theoretical Analysis Of Optimal Conditions In Equilibrium Imaging Of In Vivo Receptors - Institute Of Electrical & Electronic Engineers. Trans. Nucl. Sci. 32:1496-1502, 1985. 130.Holman BL, Gibson RE, Hill TC, Eckelman WC, Albert M, Reba RC: Muscarinic Acetylcholine Receptors In Alzheimer's Disease. In Vivo Imaging With I-123 IQNB And Emission Tomography. JAMA. 254:3063-3066, 1985. 131.Channing MA, Eckelman WC, Bennett JM, Burke Jr. TR, Rice KC: Radiosynthesis Of 18 F-3-Acetylcyclofoxy: A High Affinity Opiate Antagonist. Int. J. Appl. Radiat. Isot. 36:429-434, 1985. 132.Paik CH, Phan L, Hong JJ, Sahami MW, Heald SC, Reba RC, Steigman J And Eckelman WC: The Labeling Of High Affinity Sites Of Antibodies With 99mtc. Int. J. Nucl. Med. Biol. 12:3-8, 1985. 133.Eckelman WC: The Design Of Cholinergic Tracers In Discussions In Neuro Sciences. Vol II, (No. 2) 60-71. Ed., Feindel W, Frackowiak RSJ, Gadian D, Magistretti PL And Zalutsky MR. Foundation For The Study Of The Nervous System. Netherlands, 1985. 134.Book: Eckelman WC: Potentials Of Receptor Binding Radiotracers. In New Brain Imaging Techniques In Cerebrovascular Diseases. Vol. 2:113-124, Ed. J. Cahn And N.A. Lassen. John Libbey Euro Text. Paris, 1985. 19
  • 135.Paik CH, Hong JJ, Ebbert MA, Heald SC, Reba RC And Eckelman WC: Relative Reactivities Of DTPA, Immuno Reactive Antibody DTPA And Nonimmunoreactive Antibody DTPA-Conjugates Toward 111in. J. Nucl. Med. 26:482-487, 1985. 136.Eckelman WC: Clinical Potential Of Receptor Based Radiopharmaceuticals. In Advances In Radiopharmaceuticals. Ed. A.R. Fritzberg, CRC Press, Inc. Boca Raton, Fl., 2:89-114, 1986. 137.Eckelman WC: Receptor Binding Radiotracers, Takeda Science Foundation Symposium On Bioscience, October 1984. In Biomedical Imaging Ed. By O. Hayaishi And K. Torizuka. Academic Press, Inc. Tokyo 1986, 357-374. 138.McManaway ME, Jagoda EM, Eckelman WC, Larson SM, Francis BE, Gibson RE, Reba RC And Lippman ME: Binding Characteristics And Biological Activity Of Studies With 125I 17a -Iodovinyl 11b -Methoxyestradiol, An Estrogen Receptor-Binding Radiopharmaceutical, In Human Breast Cancer Cells (MCF-7). Cancer Research 46:2386-2389, 1986. 139.Book: Eckelman WC And Paik CH: Comparison 99mTc And 111-In Labeling Of DTPA Conjugated Antibodies In Radionuclide-Labeled Monoclonal Antibodies - Techniques And Applications. Editors S.C. Srivastava And L.F. Mausner. Nucl. Med. Biol. 13:335-344, 1986. 140.Book: Paik CH, Eckelman WC, Reba RC: Transchelation of 99mtc at Low Affinity Sites To High Affinity Sites. In Radionuclide-Labeled Monoclonal Antibodies - Techniques And Applications. Editors S.C. Srivastava And L.F. Mausner. Nucl. Med. Biol. 13:359-362, 1986. 141.Eckelman WC: Receptors Labeled With Gamma-Emitting Radiotracers. Nucl. Med. Biol. 13:135-139, 1986. 142.Kiesewetter DO, Finn Rd, Eckelman WC: Radiochemical Synthesis Of [18F]- Fluoroethylspiperone. J. Labelled Cpd. And Radiopharm. 23:1040-1041, 1986 (Abst). 143.Tweedle MF, Eckelman WC, Wedeking PW: Pharmacokinetics And Metabolism Of 153-Gadolinium Chelates. J. Labelled Cpd. And Radiopharm. 23:1347-1348, 1986 (Abst). 144.Kiesewetter DO, Eckelman WC, Cohen RM, Finn Rd, Larson SM: Syntheses And D2 Receptor Affinities Of Derivatives Of Spiperone Containing Aliphatic Halogens. Int. J. Rad. Appl. Instrum. 37:1181-1188, 1986 145.Rzeszotarski WJ, Gibson RE, Eckelman WC, Reba RC: 3-Quinuclidinol Esters, Useful As Antagonists Of Muscarinic Acetylcholine Receptors. U.S. Patent No. 4,644,003, Feb. 17, 1987. 146.McManaway ME, Jagoda EM, Eckelman WC, Gibson RE, Kasid A, Lippman MM: 125I 17-Alpha-Iodovinyl 11 Beta-Methoxyestradiol. Interaction In Vivo With Estrogen 20
  • Receptors In Hormones-Independent MCF-7 Human Breast Cancer Transfected With The V-Ras Oncogene. Canc. Res. 47:2945-2949, 1987. 147.Book: Paik CH, Eckelman WC, Reba RC: Important Chemical Variables For Labeling Antibodies With Indium-111 And Technetium-99m. In Radiolabeled Monoclonal Antibodies For Imaging And Therapy. S. C. Srivastava, Editor, Plenum Publishing Corp., New York, Pp. 253-260, 1988. 148.Book: Eckelman WC, Tweedle MF, Welch MJ: NMR Enhancement with Gd Labeled Antibodies. In Radiolabeled Monoclonal Antibodies For Imaging And Therapy. S. C. Srivastava, Editor, Plenum Publishing Corp., New York, Pp. 571-580, 1988. 149.Book: Tweedle MF, Brittain HG, Eckelman WC, Gaughan GT, Hagan JJ, Wedeking PW, Runge VM: Principles Of Contrast Enhancement With Paramagnetic Metal Complexes. In Magnetic Resonance (MR) Imaging 2nd Edition, Edited By C. Leon Partain, WB Saunders, 1988. 150.Book: Eckelman WC: Radiopharmaceuticals (Chapter 13) In Diagnostic Nuclear Medicine (2nd Edition) Ed. A. Gottschalk, P.B. Hoffer, H.J. Berger and E.J. Potchen. Williams And Wilkens, N.Y., pp. 150-163, 1988. 151.Book: Eckelman WC: Receptor Site Imaging (Chapter 54) In Diagnostic Nuclear Medicine (2nd Ed.) Ed. By A. Gottschalk, P.B. Hoffer, H.J. Berger And E.J. Potchen. Williams and Wilkins, N.Y., pp.830-836, 1988. 152.Book: Eckelman WC And Paik CH: Labeling Antibodies with Metals Using Bifunctional Chelates. In Antibodies In Radiodiagnosis And Therapy. Editor M. Zalutsky, CRC Press, Boca Raton, Fl., Pp. 103-128, 1988. 153.Eckelman, WC: Radiopharmaceuticals For Tomographic Imaging Of The Brain. Am. J. Physiol. Imaging 3:66, 1988. 154.Book: Narra RK, Kuczynski BL, Feld T, Nunn AD, Eckelman WC: A Comparison Of The Pharmacokinetics Of A New Technetium-99-Labeled Myocardial Imaging Agent, SQ 32,014 With SQ 30,217. Nuklearmedizin-New Trends And Possibilities. In Nuclear Medicine, Ed. HAE Schmidt, L Csernay, FK Schattauer Verlag, Suppl. (Stuttgart) [Nmbsag] 1988, 24, 731-4 (Eng). 155.Tweedle MF, Eaton SM, Eckelman WC, Gaughan GT, Hagan JJ, Wedeking PW, Yost FJ: Comparative Chemical Structure And Pharmacokinetics Of MRI Contrast Agents. Invest. Radiol. September 1988, 23 (Suppl 1), No. 9, S236-S239. 156.Narra RK, Kuczynski BL, Silva D, Nunn AD, Eckelman WC: SQ 32,097: A Potential Tc-99m Labeled Brain Imaging Agent. J. Labelled Cpd. And Radiopharm.26:60-61, 1988 (Abst). 21
  • 157.Narra RK, Eckelman WC, Kuczynski BL, Silva D, Feld T, Nunn AD: Pharmacokinetics Of 99Tc-Myocardial Perfusion Agents In Different Species. J. Labelled Cpd. And Radiopharm. 26:418-420, 1988 (Abst). 158.Eckelman WC: General Imaging And SPECT. Proceedings Of The DOE Workshop On The Role Of A High-Current Accelerator In The Future Of Nuclear Medicine. LA11579-C, UC-408:9-13, May 1989. 159.Book: Eckelman WC: Receptor-Specific Radiopharmaceuticals. In Pharmaceuticals In Medical Imaging. (Ed. Swanson DP, Chilton HM, And Thrall JH) Macmillan Publishing Co., N.Y., 1989. 160.Eckelman WC: The Use Of In Vitro Models To Predict The Distribution Of Receptor Binding Radiotracers In Vivo. Nucl. Med. Biol. L6:233-245, 1989. 161.Eckelman WC, Paik CH, And Steigman J: Three Approaches To Radiolabeling Antibodies. Nucl. Med. Biol. 16:171-176, 1989. 162.Eckelman WC: Diagnostic Isotopes: Prospects For Improved Agents. Invest. Radiol. Current Concepts 24:252-254, 1989. 163.Narra RK, Nunn AD, Kuczynski BL, Feld T, Wedeking P, Eckelman WC. A Neutral Tc-99m Complex For Myocardial Imaging. J. Nucl. Med. 30:1830-1837, 1989. 164.Paik CH, Reba RC, And Eckelman WC: Method Of Radiolabeling Antibodies. U.S. Patent Application No. 606,731, Filed 5/3/84, Serial No. 606,731. 165.Gibson RE, Schneidau TA, Cohen VI, Sood V, Ruch J, Melograna J, Eckelman WC, Reba RC: In Vitro And In Vivo Characteristics Of [Iodine-125] 3-(R)-Quinuclidinyl (S)-4-Iodobenzilate. J. Nucl. Med. 30:1079-1087, 1989. 166.Book: Eckelman WC: A Review of Preclinical and Clinical Studies of 3-Quinuclidinyl 4-Iodobenzilate (4-IQNB). In Iomazenil And Other Brain Receptor Tracers For SPECT. November 10-11, 1989, Bottstein, Switzerland 167.Dirocco RJ, Silva D, Narra RK, Hirth W, Nunn AD, Eckelman WC: The Single Pass Cerebral Extraction Of Putative CBF Imaging Agents In The Rat. J. Cereb. Blood Flow Metab. 9, Sup 1: S399, 1989. 168.Eckelman WC. The Development Of Pure Antibodies (RCP-Ab). Second Conference On Radioimmunodetection And Radioimmunotherapy Of Cancer. Cancer Research : 780s-782s, 1990. 169.Sawada Y, Hiraga S, Francis B, Patlak C, Pettigrew K, Ito K, Owens E, Gibson R, Reba RC, Eckelman WC, Larson S, Blasberg R: Kinetic Analysis Of 3-Quinuclidinyl 4-[125I] Iodobenzilate Transport And Specific Binding To Muscarinic Acetylcholine Receptor In Rat Brain In Vivo. J. Cereb. Blood Flow Metabol., 10: 781-807, 1990. 22
  • 170.Wedeking P, Eaton S, Nair S, Tweedle MF, Eckelman WC: Pharmacokinetic Analysis Of Blood Distribution Of Intravenously Administered 99mTc DTPA And 153Gd/Gd(DTPA)2 In Rats. Mag. Reson. Imaging. 8:567-575, 1990 171.Narra RK, Nunn AD, Kuczynski BL, Dirocco RJ, Feld T, Silva DA, Eckelman WC: A Neutral Lipophilic Tc-99m Complex For Regional Cerebral Blood Flow Imaging. J. Nucl. Med. 31:1370-1377, 1990 172.Nunn A, Linder K, Jurisson S, Eckelman WC: Boronic Acid Adducts Of Rhenium Dioxime And Technetium-99m Dioxime Complexes Containing A Biochemically Active Group. Us Patent Application, 1990. 173.Jurisson S, Linder KE,Hirth W, Feld T, Nowotnik DP, Nunn AD, Eckelman WC: Ligand Exchange Reactions Of Tc And Re Dioxime Complexes, MX(Dioxime)3Br, Involving The Seventh Coordination Site. In Technetium And Rhenium In Chemistry And Nuclear Medicine 3. Edited By M. Nicolini, G. Bandoli, U. Mazzi. Cortina Int., Verona, Italy, pp. 189-194, 1990. 174.Linder KE,Jurisson S, Francesconi L, Nowotnik DP, Eckelman WC, Nunn AD: Template Synthesis Of Technetium And Rhenium Dioxime Complexes: The Mechanism Of Formation Of TcX(Dioxime)3Br From Pertechnetate. In Technetium And Rhenium In Chemistry And Nuclear Medicine 3. Edited By M. Nicolini, G. Bandoli, U. Mazzi. Cortina Int., Verona, Italy, pp. 195-200, 1990. 175.Nowotnik DP, Hirth W, Jurisson S, Linder KE, Narra RK, Nunn AD, Eckelman WC: Studies Of The In Vivo Chemistry Of BATOs. In Technetium And Rhenium In Chemistry And Nuclear Medicine 3. Edited By M. Nicolini, G. Bandoli, U. Mazzi. Cortina Int., Verona, Italy, pp. 393-398, 1990. 176.Eckelman WC: The Development Of 99mTc Radiopharmaceuticals For Perfusion And Biochemistry. In Technetium And Rhenium In Chemistry And Nuclear Medicine 3. Edited By M. Nicolini, G. Bandoli And U. Mazzi. Cortina Int., Verona, Italy. pp. 571-580, 1990. 177.Tu J, Brennan J, Stouffer B, And Eckelman WC: A Radioimmunoassay SQ 27,519: The Active Phosphinic Acid-Carboxylic Diacid Of The Prodrug Fosinopril In Human Serum. Therapeutic Drug Monitoring 12:404-410, 1990. 178.Book: Eckelman WC: Radiopharmaceuticals And Brain Pathology Studied With PET And SPECT. Chapter 4: The Testing Of Putative Receptor Binding Radiotracers In Vivo. Edited By Mirko Diksic And Richard C. Reba. CRC Press, Inc. 1990. P. 41-68. 179.P. Linder K, Eckelman WC, Jurisson S, Nowotnik D, Nunn AD: Boronic Acid Adducts Of Rhemium Dioxime And Technetium-99m Dioxime Complexes Containing A Biochemically Active Group. US Patent 1990. 23
  • 180.Rosenspire K, Hirth W, Jurisson S, Nowotnik DP, Eckelman WC And Nunn AD: Direct Chromatographic Analysis Of Metabolites Of Lipophilic Tracers In Whole Blood By ISRP Chromatography. J Labelled Cpd Radiopharm 30: 284-287, 1991 (Abst) 181.Linder KE,Wen MD, Ramalingam K, Nowotnik DP, Nunn AD, Eckelman WC, And Sharkey RM: Isothiocyanato BATOs: New Tc Reagents For Protein Labeling. J Labelled Cpd Radiopharm 30: 200-202, 1991 (Abst) 182.Eckelman WC And Steigman J: Direct Labeling With 99mTc. Nucl. Med. Biol. 18:3-8, 1991. 183.Eckelman WC: The Status Of Radiopharmaceutical Research: Editorial. Nucl. Med. Biol. 18 (7): iii-vi, 1991. 184.Hwang Dr, Eckelman WC, Mathias CJ, Petrillo Jr. EW, Lloyd J, Welch MJ: Positron Labeled Angiotensin-Converting Enzyme (ACE) Inhibitor: [18F] Fluorocaptopril Probing The ACE Activity In Vivo By Positron Emission. Tomography J. Nucl. Med. 32:1730-1737, 1991. 185.Book: Eckelman WC: Future Development of Radiopharmaceuticals in: Progress In Radiopharmacy (Ed. PA Schubiger, G. Westera), Kluwer Academic Publishers, Dordrecht, The Netherlands; 1991; 1-8. 186.P. Nunn AD, Jurisson S, Linder KE, Eckelman WC. Boronic Acid Adducts Of Rhenium Dioxime And Technetium Dioxime Complexes Containing A Biochemically Active Group. European Patent No. 91300414.9, March 21, 1991. 187.Linder KE,Wen MD, Nowotnik DP, Malley MF, Gougoutas JZ, Nunn AD, Eckelman WC: Technetium Labeling Of Monoclonal Antibodies With Functionalized BATOs: 1. TcCl(DMG)3Pitc (Pitc = Phenylisothiocyanate). Bioconjug Chem 2:160-170,1991 188.Linder KE,Wen MD, Nowotnik DP, Ramalingam K, Sharkey RM, Yost F, Narra RK, Nunn AD, Eckelman WC. Technetium-Labeling Of Monclonal Antibodies With Functionalized BATOs. 2. TcCl(DMG)3Cpitc (Cpitc = Carboxyphenylisothiocyanate) Labeling Of B72.3 And NP-4 Whole Antibodies And NP-4 F(Ab')2. Bioconjugate Chemistry 2:407-414,1991 189.P. Nunn AD, Jurisson S, Linder KE, Eckelman WC. Boronic Acid Adducts Of Rhenium Dioxime And Technetium-99m Dioxime Complexes Containing A Biochemically Active Group European Patent EP 441,491, 1991. 190.Rosenspire KC, Hirth W, Jurisson S, Nowotnik DP, Eckelman WC, Nunn AD. Direct Analysis Of Whole ISRP Chromatography: An Examination Of The Binding And Metabolism Of Technetium Dioxime Complexes. J. Chromat. 574:119-126,1992 191.Book: Eckelman WC: The Development Of Single-Photon Emitting, Receptor-Binding Radiotracers. In The Chemistry And Pharmacology Of Radiopharmaceuticals. Ed. A. Nunn, Marcel Dekker Inc., 1992 24
  • 192.Book: Steigman J And Eckelman WC: 99m-Tc Chemistry As Applied To Medicine; Nuclear Science Series, National Research Council, National Academy Press, Washington, D.C. 1992. 193.Eckelman, WC. The Use Of Radioligands For Physiologic Studies, Diagnosis, And Drug Development. Proceedings Of The 4th International Symposium On The Synthesis And Applications Of Isotopes And Isotopically Labelled Compounds. Elsevier Scientific Publishers, 1992 194.Book: Gibson RE, Burns HD, Eckelman WC. The Potential Uses Of Radiopharmaceuticals In The Pharmaceutical Industry. In Nuclear Imaging In Drug Discovery, Development And Approval (Ed. HD Burns, RE Gibson, RF Dannals And PKS Siegl). Birkhauser Boston, Inc. Boston Ma. 1992, P. 321-332 195.Book: Eckelman WC And Gibson RE. The Design Of Site Directed Radiopharmaceuticals For Use In Drug Discovery. In Nuclear Imaging In Drug Discovery, Development And Approval (Ed. HD Burns, RE Gibson, RF Dannals And PKS Siegl). Birkhauser Boston, Inc. Boston Ma. 1992, P 113-134 196.Eckelman WC. Recent Advances In Radiopharmaceuticals. J. Nucl Med. Tech. 20:135-138, 1992 197.Di Rocco RJ, Silva DA, Kuczynski B, Narra RK, Jurisson S, Nunn AD, Eckelman WC: The Single-Pass Cerebral Extraction And Capillary Permeability-Surface Area Product Of Several Putative Agents For Imaging Cerebral Blood Flow. J. Nucl. Med. 34:641-648,1993. 198.Stadalnik RC, Kudo M, Eckelman WC, Vera D: In Vivo Functional Imaging Using Receptor-Binding Radiopharmaceuticals: 99mTc-Galactosyl-Neoglycoalbumin (TcNGA). (Progress In Clinical Radiology) Investigative Radiology 28:64-70, 1993 199.Eckelman WC: Designing A Molecular Probe For Muscarinic Acetylcholine Receptor Imaging. Proceedings of DOE Conference On New Initiatives In Molecular Nuclear Medicine. Dept. Of Energy, Germantown, MD, 1993 200.Kumar K, Sukuimaran K, Chang CA, Tweedle MF And Eckelman WC: True Tracer Radiolabeling Of Gadolinium Complex Of 10(2-Hydroxypropyl)-1,4,7,10- Tetraazacyclododecane-1,4,7 Triacetic Acid (HP-DO3A). J Labelled Cpd Radiopharm. 33:473-482,1993 (Abst). 201.Schmall B, Simpson Nr, Eckelman WC: Specific Activity Of 11C-CO2 Determined By Reaction With Trityllithium Yielding 11C-Triphenylacetic Acid. J Labelled Cpd Radiopharm 32:176-177, 1993 (Abst) 25
  • 202.Adams HR, Channing MA, Eckelman WC: Some Things To Consider When Preparing 6-[18F]FDOPA By Radiofluorodemercuration. J Labelled Cpd Radiopharm 32:279-281, 1993 (Abst) 203.Channing MA, Freed LM, Wakabayashi S, Carson RE, Simpson N, Dunn BB, Eckelman WC, Rapoport SI: 1-[11C]Labeled Polyhomoallylic Fatty Acids: Phospholipid Metabolic Tracers For The Brain. J Labelled Cpd Radiopharm 32:539-540, 1993 (Abst) 204.Linder KE, Chan Y-W, Cyr JE, Nowotnik DP, Eckelman WC Nunn AD: Synthesis, Characterization, And In Vitro Evaluation Of Nitroimidazole-BATO Complexes: New Technetium Compounds Designed For Imaging Hypoxic Tissue. Bioconjugate Chemistry 4:326-333,1993. 205.Eaton, SM, Wedeking P, Tweedle MF, Eckelman WC: A Multi-Organ, Axially Distributed Model Of Capillary Permeability For A Magnetic Resonance Imaging Contrast Agent. J Pharm Sci 82(5):531-6, 1993 206.Eckelman WC: The Application Of Receptor Theory To Receptor-Binding And Enzyme-Binding Oncologic Radiopharmaceuticals. Nucl Med Biol 21, 759-770,1994 207.Hiramatsu Y, Eckelman WC And Baum BJ. Interaction Of Iodinated Quinuclidinyl Benzilate Enantiomers With M3 Muscarinic Receptors. Life Sci. 54, 1777-1783,1994. 208.Kawai K, Channing, Kiesewetter DO, Eckelman WC: Synthesis And Halodemercuration Of Polymer-Bound 6-Thiolatomercury And 6-Mercuric Sulfonate DOPA Precursors. J Labelled Cpd Radiopharm 35: 217-219,1994 (Abst) 209.Channing MA, Dunn BB, Kiesewetter DO, Plascjak P And Eckelman WC: The Quality Of [13N] Ammonia Produced By Using Ethanol As A Scavenger. J Labelled Cpd Radiopharm 35: 334-336,1994 (Abst) 210.Kiesewetter DO, Silverton JV, Eckelman WC: Stereoselective Synthesis Of [R,R]IQNB And Fluoroalkyl Analogs Of QNB. J Labelled Cpd Radiopharm 35:419-421,1994 (Abst) 211.Lang L And Eckelman WC: One Step Synthesis Of Fluorine-18 Labeled [18F]-N- Succinimidyl 4-(Fluoromethyl)Benzoate For Protein Labeling. Appl Radiat Isot 45:1155-1163,1994 212.Book: Eckelman WC. Ch 13. Radiochemistry And Radiopharmacy. In Year Book Of Nuclear Medicine (Ed PB Hoffer), Mosby, Baltimore MD, 323-338, 1994. 213.Adelstein SJ, Budinger TF Coleman RE, Danford D, Eckelman WC, Nolan, Jr. JA, Riedinger Ll, Ruth TJ, Schroeder L, Welch MJ, Yates SW. Isotopes For Medicine And The Life Sciences. A Report Of The Committee On Biomedical Isotopes. Institute Of Medicine, National Academy Of Sciences, Washington, D.C., December, 1994. 26
  • 214.Book Adams HR, Channing MA, Divel JE, Dunn BB, Kiesewetter DO, Plascjak P, Regdos SL, Simpson NR, Eckelman WC. Trend Analysis Of Quality Control Data. In Chemists’ Views Of Imaging Centers (Ed. A. Emran) Plenum Press, NY 1995. P. 175-188. 215.Hiramatsu Y, Carrasquillo JA, Eckelman WC, Miletich RS, Valdez IH, Kurrasch RHM, Macynski AA, Paik CH, Neumann RD And Baum BJ: Kinetic Analysis Of Muscarinic Receptors In Human Brain And Salivary Gland In Vivo. Am J Physiol 268: R1491- R1499, 1995 216.Kiesewetter DO, Lee JT, Lang L, Park SG, Paik CH, Eckelman WC: Preparation Of 18F-Labeled Muscarinic Agonist With M2 Selectivity. J Med Chem 38: 5-8,1995 217.Book: Eckelman WC and Gibson RE. The Path From In Vitro Autography To Ex Vivo Autoradiography To "In Vivo Autoradiography" By External Imaging. In In Vitro/In Vivo Autoradiography & Correlative Imaging, (Ed By W. Stumpf And H. Soloman), Academic Press, NY, 529-559, 1995 218.Eckelman WC. Designing A Molecular Probe For Muscarinic Acetylcholine Receptor Imaging. J Nucl Med. 36: 5s-7s,1995 219.K. Kawai, M.A. Channing, D.O. Kiesewetter And W.C. Eckelman. Synthesis Of Polymer-Bound 6-Thiolatomercury And 6-Mercuric Sulfonate DOPA Precursors And Their Halodemercuration Reactivity. Nucl Med Biol 22: 37-43, 1995 220.Kiesewetter DO, Lee JT, Park SG, Paik CH, Eckelman WC: Syntheses And Biological Properties Of Chiral Fluoroalkyl Quinuclidinyl Benzilates. J Med Chem. 38:1711-1719, 1995 221.Eckelman WC. Radiolabeling With 99mTc To Study High Capacity And Low Capacity Biochemical Systems. Eur J Nucl Med. 22:249-263,1995 222.Book: Eckelman WC . Ch 10 Radiopharmaceuticals. In Diagnostic Nuclear Medicine, 3rd Edition, (Ed. MP Sandler, RE Coleman, FJ Th Wackers, JA Patton, A Gottschalk, P Hoffer) Williams & Wilkins, Baltimore MD, 1995 223.Book: Eckelman WC. Ch 54 Receptor Site Imaging. In Diagnostic Nuclear Medicine, 3rd Edition, (Ed. MP Sandler, RE Coleman, FJ Th Wackers, JA Patton, A Gottschalk, P Hoffer) Williams & Wilkins, Baltimore MD, 1995 224.Lee JT, Paik CH, Kiesewetter DO, Park SG, Eckelman WC. Evaluation Of Stereoisomers Of 4-Fluoroalkyl Analogs Of 3-Quinuclidinyl Benzilate: In Vivo Competition Study For Muscarinic Receptor Subtypes, M1, M2 And M3. Nucl Med Biol 22:773-382, 1995 225.Jurisson SS, Pirro J, Dirocco RJ, Rosenspire KC, Jagoda EM, Nanjappan P, Eckelman WC, Nowotnik DP, Nunn AD. Boronic Acid Adducts Of Technetium Dioxime (BATO) 27
  • Complexes Derived From Quinculidinyl Benzilate (QNB) Boronic Acid Stereoisomers: Synthesis And Studies Of Their Binding To The Muscarinic Acetylcholine Receptor. Nucl Med Biol 22:269-282 1995. 226.CW Choi, L Lang, JT Lee, KO Webber, Tm Yoo, HK Chang, N Le, E Jagoda, CH Paik, I Pastan, Eckelman WC, Carrasquillo JA. Biodistribution Of [18F]- And [125I]- Labeled Anti-Tac Disulfide Stabilized Fv Fragments In Nude Mice With Il-2a Receptor Positive Tumor Xenografts. Cancer Research 55:5323-5329, 1995. 227.Baum S, Eckelman WC, Garcia EV, Holman BL, Kung HF, Mattrey RF, Piwnica- Worms D, Wahl RL, Watson JT. Contrast Media And Radiopharmaceutical Agent: Regulatory Issues. Acad Radiol 2:S92-S93, 1995 228.Eckelman WC. Positron Emission Tomography Radiochemistry. Acad Radiol 2: 1-2, 1995. (Proceedings Of The Conference On Developing A Long-Term Plan For Imaging Research. Nov 5-8, 1994). 229.Arai T, Wakabayashi S, Freed Lm, Channing MA, Dunn BB, Der MG, Bell JM, Herscovitch P, Eckelman WC, Rapoport SI, Chang MCJ. Incorporation Of [1-11C] Palmitate In Monkey Brain Using PET. J Nucl Med 36: 2261-2267,1995. 230.Kawai K; Ohta H; Channing MA; Kubodera A; Eckelman WC. Synthesis Of Polymer- Bound 6-Mercuric Carboxylate DOPA Precursors And Solid Phase Labelling Method Of 6-Radioiodinated L-DOPA. Appl Radiat Isot 47(1):37-44, 1996. 231.K. Kawai, H. Ohta, A. Kubodera, M.A. Channing And W.C. Eckelman Synthesis And Evaluation Of Radioiodinated 6-Iodo-L-Dopa As A Cerebral L-Amino Acid Transport Marker. Nucl Med Biol 23: 251-256, 1996. 232.Book:Eckelman WC, Steigman J, Paik CH. Ch.10 Radiopharmaceutical Chemistry. In NIH Textbook Of Nuclear Medicine, 3rd Edition (Ed. J Harbert, R. Neumann, WC Eckelman), Thieme Press, New York, NY. 1996 233.Lang L, Choi CW, Lee JT, Webber KO, Yoo TM, Chang HK, Le N, Jagoda E, Paik CH, Pastan I, Carrasquillo JA, And Eckelman WC. Identification Of Metabolites Of F-18 Labeled Anti-Tac Disulfide Stabilized Monoclonal Antibody Variable-Region Fragments In Mice. J Labelled Cpd Radiopharm. 37:554-556, 1996 (Abst). 234.De Bartolomeis A, Der MG, Jagoda E, Schmall B, Saunders R, Su T, Breier A, Carson RE, And Eckelman WC. Development And Validation Of A High-Performance Liquid Chromatographic Method For The Determination Of Raclopride In Plasma. J Labelled Cpd Radiopharm. 37: 697-699, 1996 (Abst). 235.Schmall B, Shoaf SE, Carson RE, Herscovitch P, Sha L, Eckelman WC. Separation Of Racemic a-Methyl-Tryptophan Into Its L-And D-Isomers And Synthesis Of a-C-11- Methyl-L-Tryptophan. J Labelled Cpd Radiopharm. 37:689-691, 1996 (Abst). 28
  • 236.L. Lang And W.C. Eckelman. Improved One Step Synthesis Of N-Succinimidyl 4- [F-18] Fluoromethylbenzoate For Protein Labeling. J Labelled Cpd Radiopharm 37: 551-553, 1996 (Abst). 237.Aloj L, Lang L, Jagoda E, And Eckelman WC. Evaluation Of Transferrin Radiolabeled With [18 F]-Succinimidyl 4-(Fluoromethyl) Benzoate. J Nucl Med 37:1408-12, 1996. 238.Kiesewetter DO, Paik CH, Flippen-Anderson JL, Eckelman WC. Stereochemical Assignment Of (R,R)-[125I]IQNB. J Labelled Cpd Radiopharm. 37:686-688, 1996 (Abst). 239.H. Kobayashi, T.M. Yoo, I.S. Kim, M.-K. Kim, N. Le, K.O. Webber, I. Pastan, C.H. Paik, W.C. Eckelman, J.A. Carrasquillo. L-Lysine Effectively Blocks Renal Uptake Of I-125 Or Tc-99m-Labeled Anti-Tac Disulfide-Stabilized Fv Fragment. Cancer Res. 56: 3788-3795,1996. 240.L. Lang, L. Aloj, D.O. Kiesewetter, E. Jagoda, J.T. Lee, C.H. Paik, J.A. Carrasquillo, And W. C. Eckelman. A Review Of New Oncotropic Tracers For Pet Imaging. Nucl Med Biol 23:669-672, 1996. 241.S.F. Boulay, D.O. Kiesewetter, V.K. Sood, M.R. Rayeq, B.R. Zeeberg, W.C. Eckelman. Autoradiographic Evidence That (R)-3-Quinuclidinyl (S)-4-Fluoromethylbenzilate ((R,S)-FMeQNB) Displays In Vivo Selectivity For The Muscarinic M2 Subtype. Nucl Med Biol 7:889-896, 1996. 242.Z. Bi, L. Lang, E. Jagoda, D. Williams, W.D. Hankins, S. Shapiro, W.C. Eckelman. The Development Of Diagnostic And Therapeutic Radiopharmaceuticals Using Growth Factors. Radiat. Res., 1997. 243.Chang MCJ, Arai T, Freed LM, Wakabayashi S, Channing MA, Dunn BB, Der MG, Bell JM, Herscovitch P, Eckelman WC, Rapoport SI: Brain Incorporation Of [1-11C]Arachidonate In Normocapnic And Hypercapnic Monkeys, Measured With PET. Brain Res 755:74-83, 1997. 244.T.M. Yoo, H.K. Chang, C.W. Choi, K.O. Webber, N. Le, V.K. Sood, W.C. Eckelman, I. Pastan, J.A. Carrasquillo, Ch Paik. Tc-99m Labeling And Biodistribution Of Anti-Tac Disulfide-Stabilized Fv Fragment. J Nucl Med 38:294-300, 1997. 245.D.O. Kiesewetter, R.E. Carson, E. Jagoda, C.J. Endres, M.G. Der, P. Herscovitch And W.C. Eckelman. In Vivo Muscarinic Binding Selectivity Of R,S-[F-18] Fluoromethyl QNB. Biol. Med. Chem. 5(8), 1555-1567, 1997. 246.L. Lang, W.C. Eckelman. Labeling Proteins At High Specific Activity Using N- Succinimidyl 4-[F-18] Fluoromethylbenzoate. Appl Radiat. Isot 48:169-174, 1997. 247.Breier, T.-P. Su, R. Saunders, R.E. Carson, B.S. Kolchana, A. De Bartolomeis, N. Weisenfeld, A.K. Malhotra, W.C. Eckelman, D. Pickar. Schizophrenia Is Associated 29
  • With Elevated Amphetamine-Induced Synaptic Dopamine Concentrations: Evidence From A Novel Positron Emission Tomography Method. PNAS, 94,2569-257 , 1997. 248.T. Sasaki, M.C.J. Chang, T. Hayakawa, B.K. Vuong, J.M. Bell, S.I. Rapoport, W.C. Eckelman. Analysis Of 1-[C-11] Arachidonic Acid In Rat And Monkey Plasma. J Nucl Med In Preparation 249.L. Aloj, R.E. Carson, L. Lang, P. Herscovitch, W.C. Eckelman. Measurement Of Transferrin Receptor Kinetics In The Liver Using Dynamic 3D PET And [F-18] Holo- Transferrin. Hepatology 25:986-990, 1997. 250.C. Wu, E. Jagoda, M. Brechbiel, K.O. Webber, I. Pastan, O. Gansow, W. C. Eckelman. The Biodistribution And Catabolism Of Ga-67 Labeled Anti-Tac DsFv Fragment. Bioconjugate Chemistry 8: 365-369, 1997. 251.Endres, B.S. Kolachana, R.C. Saunders T. Su, D. Weinberger, W. C. Eckelman, R. E. Carson. Kinetic Modeling Of [11C] Raclopride: Combined Pet-Microdialysis Studies. J Cereb Blood Flow Metab 17:932-942, 1997. 252.R.E. Carson, A. Breier, A. De Bartolomeis, R.C. Saunders, T.-P. Su, B. Schmall, M.G. Der, D. Pickar, W.C. Eckelman. Quantification Of Amphetamine-Induced Changes In [11C] Raclopride Binding With Continuous Infusion. J Cereb Blood Flow Metab. 17:437-447, 1997. 253.P. Plascjak, K. Kim, W. Meyer, Jr., J. Divel, M. Der, And W. C. Eckelman. An Automated Radiopharmaceutical Dispenser. Appl Radiat Isot 48: 345-348, 1997 254.L Lang, E Jagoda, C Wu, M W Brechbiel, O A Gansow, I Pastan, C H Paik, J A Carrasquillo, W C Eckelman. Factors Influencing The In Vivo Pharmacokinetics Of Peptides And Antibody Fragments: The Pharmacokinetics Of Two PET-Labeled Low Molecular Weight Proteins. Quart J Nucl Med 41, 53-63, 1997. 255.Schwarz UP, Plascjak P, Beitzel MP, Gansow OA, Eckelman WC, Waldmann TA. Production Of 211At Labeled Humanized Anti-Tac Using An Internal And External Bismuth Target. J Labelled Cpd Radiopharm 312-313, 1997 (Abst). 256.Lang L, Schmall B, Jagoda E, Carson RE, Eckelman WC. Derivatives Of Way100635 As Potential 5HT1a Receptor Binding Radiotracers. J Labelled Cpd Radiopharm. 534-535, 1997 (Abst). 257.Schmall B, Vuong B-K, Kiesewetter DO, Panico MR, Adams HR, Eckelman WC. Synthesis And Analysis Of Intermediate Compounds In The Production Of a11C- Methyl]-L-Tryptophan (AMT). J Labelled Cpd Radiopharm 746-748, 1997 (Abst). 258.Kapp OH, Siemion J, Eckelman WC, Cohen VI, And Reba RC. Comparison Of Agonist And Antagonist Binding In The Muscarinic M2 Receptor. Receptors & Signal Transduction. 7(3):177-203, 1997 30
  • 259.Caraco’, L. Aloj, W.C. Eckelman. The Gallium-Deferoxamine Complex: Stability With Different Deferoxamine Concentrations And Incubation Conditions. Appl Radiat Isot. 49, 1477-1480, 1998 260.Schwarz UP, Plascjak P, Beitzel MP, Gansow OA, Eckelman WC, Waldmann TA. Production Of At-211 Labeled Humanized Anti-Tac Using An Internal And External Bismuth Target. Nucl Med Biol. 25, 89-94, 1998. 261.Szajek LP, Channing MA, Eckelman WC. Automated Synthesis Of 6-[18F]Fluoro-L- DOPA Using Modified Polystyrene Supports With Bound 6-Mercuric DOPA Precursors. Appl Radiat Isot. 49: 795-804, 1998. 262.Moody TW, Leyton J, Unsworth E, John C, Lang L, And Eckelman WC. (Arg15, Arg21)VIP: A VIP Agonist For Localizing Breast Cancer Tumors. Peptides 19, 585-592, 1998. 263.Eckelman WC. Minireview: Sensitivity Of New Radiopharmaceuticals. Nucl Med Biol 25:169-174, 1998. 264.Carrasquillo JA, Lang L, Whatley M, Pastan I, Choyke P, Eckelman WC. Aminosyn II Effectively Blocks Renal Uptake Of 18F Labeled Anti-Tac DsFv. Cancer Res. 58:2612-2617, 1998. 265.Carson RE, Kiesewetter DO, Jagoda E, Der MG, Herscovitch P, Eckelman WC. Muscarinic Cholinergic Receptor Measurements With [18F]FP-TZTP: Control And Competition Studies, J Cereb Blood Flow Metab, 18:1130-1142, 1998. 266.Shoaf SE, Carson RE, Hommer D, Williams W, Higley JD, Schmall B, Herscovitch P, Eckelman WC, Linnoila M. Brain Serotonin Synthesis Rates In Rhesus Monkeys Determined By [11C] Alpha-Methyl-L-Tryptophan And Positron Emission Tomography Compared To CSF 5-Hydroxyindole-3-Acetic Acid Concentrations. Neuropsychopharmacology 19:345-353, 1998. 267.Sassaman MB, Giovanelli J, Sood VK, Eckelman WC. Synthesis And Screening Of Conformationally Restricted And Conformationally Free N-(Tertiaryaminoalkyl) Dithiocarbamic Acids And Esters As Inhibitors Of Neuronal Nitric Oxide . Bioorgan Med Chem 6: (10) 1759-1766, 1998. . 268.Siegel S, Vaquero JJ, Aloj L, Seidel J, Jagoda E, Gandler WR, Eckelman WC, Green MV. Initial Results From A PET/Planar Small Animal Imaging System. IEEE Transactions On Nuclear Science 46, 571-575, 1999. 269.Kiesewetter DO, Carson RE, Jagoda EM, Herscovitch P, Eckelman WC. In Vivo Muscarinic Binding Of 3-(Alkylthio)-3-Thiadiazolyl Tetrahydropyridines. Synapse 31, 29-40, 1999. 270.L Aloj, E Jagoda, L Lang, C Caraco, Rd Neumann, Cynthia Sung, Robert L. Dedrick, WC Eckelman. Targeting Of Transferrin Receptors In Nude Mice Bearing A431 And 31
  • LS 174t Xenografts With [18F]Holo-Transferrin: Permeability And Receptor Dependence. J Nucl Med 40: 1547-1555, 1999 271.Moody TW, Leyton J, Gozes I, Land L, Eckelman WC. VIP And Breast Cancer. Ann N Y Acad Sci 865:290-6, 1999 272.Lang L, Jagoda E, Schmall B, Vuong Bk, Adams HR, Nelson DL, Carson RE, Eckelman WC. The Development Of F-18 Labeled 5-HT1a Antagonists. J Med Chem. 42,1576-1586, 1999 273.Szajek L, Plascjak P, Daube-Witherspoon ME, Smith MF, Territo PR, Bacharach SL, Eckelman WC. Tc-94m As An Alternative To Tc-99m In Instant Kits. In Technetium, Rhenium And Other Metals In Chemistry And Nuclear Medicine. (Ed. M Nicolini And U Mazzi), Sge Editoriali, Padova, Italy 1999 P. 59-63. 274.Daube-Witherspoon ME, Carrasquillo J, Plascjak P, Wu C, Green SL, Whatley M, Pastan I, Brechbiel M, Eckelman WC. Imaging The Distribution Of Low Molecular Weight Proteins (LMWP) Using Ga-66. In Technetium, Rhenium And Other Metals In Chemistry And Nuclear Medicine. (Ed. M Nicolini And U Mazzi), Sge Editoriali, Padova, Italy 1999 P. 575-580. 275.Shoaf SE, Hommer D, Williams W, Higley JD, Carson RE, Herscovitch P, Eckelman WC. Response To Letter: The Validity Of The PET [11C]Methyl-L-Tryptophan Method For Measuring Rates Of Serotonin Synthesis In The Human Brain By Benkelfat et al.. Neuropsychopharmacology 21, 156-157, 1999. 276.Szajek L, Kung H, Plascjak P, Plossl K, Acton PC, Herscovitch P, Eckelman WC. Comparison Of Tc-94m And Tc-99m TRODAT1 As Imaging Agents For The Dopamine Transporter. J Labelled Cpd Radiopharm 42, S45-S47, 1999(Abst). 277.Ma Y, Lang L, Kiesewetter DO, Jagoda EM, Eckelman WC. The LC-MS Identification Of Metabolites Of Fluorine-18 Labeled Radiopharmaceuticals Produced By Rat Hepatocytes. J Labelled Cpd Radiopharm 42, S216-S218, 1999(Abst). 278.John CS, Geyer BC, Plascjak P, Lim BB, Garmestani K, Eckelman WC. Preparation And Evaluation Of 3-[At-211]Astato-N-[2-(1’piperidinyl)Ethyl]-4-Methoxybenzamide, P[At-211]MBA. J Labelled Cpd Radiopharm 42, S297-299, 1999(Abst). 279.Jagoda E, Sassaman Mb, Schmall B, Panico M, Eckelman WC. The Biodistribution Of A Putative Nitric Oxide Synthase (N-NOS) Inhibitor In Rat Models. J Labelled Cpd Radiopharm 42, S646-648, 1999(Abst). 280.Aloj L, Caraco C, Jagoda E, Eckelman WC, Neumann RD. Glut-1 And Hexokinase Expression: Relationship With FDG Uptake In A431 And T47D Cells In Culture. Cancer Res. 59:4709-4714, 1999. 281.Eckelman William C., Gibson Raymond E. Guest Editors - A Society Of Nuclear Imaging In Drug Development (SNIDD) Sponsored Symposium – September 1998, 32
  • National Institutes Of Health, Bethesda, MD – Introduction. In Proceedings: Use Of Imaging In Drug R&D. J Clin Pharmacol 39: 4s-5s Suppl. S Aug 1999 282.Sassaman MB, Panico M, Schmall B, Eckelman WC (1999) [11C]Diazepam Synthesis: N-[11C]Methylation Of Desmethyldiazepam Is Facilitated By A Preformed Sodium Salt/ Benzo-15-Crown-5 Complex. J Labelled Compd Radiopharm 42: (13) 1229-1233, 1999 283.Aloj L, Jagoda E, Lang L, Caracò C, Neumann RD, Sung C, Dedrick RL, Eckelman WC (1999) Targeting Of Transferrin Receptors In Nude Mice Bearing A431 And LS 174t Xenografts With [18F]Holo-Transferrin: Permeability And Receptor Dependence. J Nucl Med 40: (9) 1547-1555, 1999 284.Eckelman WC And Collins JM. Pharmacology. Positron Emission Tomography. In report Of The Joint Working Group On Quantitative In Vivo Functional Imaging In Oncology. Academic Radiology 6: S291-S292, 1999 285.Kiesewetter DO, Carson RE, Jagoda EM, Herscovitch P, Eckelman WC. Using Single Photon Emission Tomography (SPECT) And Positron Emission Tomography (PET) To Trace The Distribution Of Muscarinic Acetylcholine Receptor (MAChR) Binding Radioligands. Life Sciences 64, 511-518, 1999. 286.Kiesewetter DO, Sassaman Mb, Robbins J, Jagoda EM, Carson RE, Nathan Nm, Sutkowski E, Herscovitch P, Braun A, Eckelman WC. Synthesis And Evaluation Of An F-18 Analogue Of Forskolin For Imaging Adenylyl Cyclase. J Fluorine Chem. 101(2), 297-304, 2000 287.Magata Y, Lang L, Kiesewetter DO, Jagoda EM, Channing MA, Eckelman WC. Biologically Stable [F-18] Labeled Benzylfluoride Derivatives. Nucl Med Biol. 27: 163-168, 2000 288.Caraco C, Aloj L, Chou JY, Eckelman WC. Cellular [F-18]-2-Fluoro-2-Deoxyglucose Release As A Function Of Glucose-6-Phosphatase Activity. J Biol . Chem. 275: (24) 18489-18494, 2000. 289.Carson RE, Lang L, Watabe H, Der MG, Adams HR, Jagoda E, Herscovitch P, Eckelman WC, PET Evaluation Of [18F]FCWAY, An Analog Of The 5-HT1a Antagonist Way 100635 , Nucl Med Biol, 27: (5) 493-497, 2000 290.Lang L, Jagoda E, Schmall B, Sassaman M, Ma Y, Eckelman WC, Fluoro Analogs Of Way 100635 With Varying Pharmacokinetic Properties. Nucl Med Biol, 27: (5) 457-462, 2000 291.Shoaf SE, Carson RE, Hommer D, Williams WA, Higley JD, Schmall B, Herscovitch P, Eckelman W (1999) The Suitability Of [C-11]-α-Methyl-L-Tryptophan As A Tracer For Serotonin Synthesis: Studies With Dual Administration Of [C-11] And [C-14] Labeled Tracer. J Cereb Blood Flow Metab 20: (2) 244-252, 2000. 33
  • 292.Watabe H, Endres CJ, Breier A, Schmall B, Eckelman WC, Carson RE (1999) Measurement Of Dopamine Release With Continuous Infusion Of [C-11]Raclopride: Optimization And Signal-To-Noise Considerations. J Nucl Med 41: (3) 522-530, 2000 293.Watabe H, Channing MA, Der MG, Adams HR, Jagoda E, Herscovitch P, Eckelman WC, Carson RE (1999) Kinetic Analysis Of The 5-HT2a Ligand [C-11]MDL 100,907. J Cereb Blood Flow Metab 20:899-909, 2000 294.Hsin LW, Webster EL, Chrousos GP, Gold PW, Eckelman WC, Contoreggi C, Rice KC. Synthesis And Biological Activity Of Fluoro-Substituted Pyrrolo[2,3-D]Pyrimidines: The Development Of Potential Positron Emission Tomography Imaging Agents For The Corticotropin-Releasing Hormone Type 1 Receptor. Bioorganic & Medicinal Chemistry Letters 10: (8) 707-710, 2000. 295.Hsin L-W, Webster EL, Chrousos GP, Gold P, Eckelman WC, Contoreggi C, Rice KC. Synthesis Of [3H](4-Fluorobutyl)Propyl[2,5,6-Trimethyl-7-(2,4,6- Trimethylphenyl)Pyrrolo[2,3-D]Pyrimidin-4-yl]Amine: A Potent Radioligand For Corticotropin-Releasing Hormone Type 1 Receptor. J Labelled Cpd. Radiopharm. 43, 899-908, 2000. 296.Eckelman WC, Tatum Jl, Kurdziel KA, Croft BY. Quantitative Analysis Of Tumor Biochemistry Using PET And SPECT. Nucl Med Biol.27, 633-635, 2000. 297.Blankenberg FG, Eckelman WC, Strauss W, Welch MJ, Alavi A, Anderson C, Bacharach S, Blasberg RG, Graham MM, Weber W. Role Of Radionuclide Imaging In Trials Of Antiangiogenic Therapy. Academic Radiology 7: (10) 851-867, 2000 298.M Kling, L. Borg, A Zametlin, R. Carson, J. Matochik, R. Maslansky, E. Khuri, A. Wells, S. Lampert, L. Lefter, J. Kreuter, P. Herscovitch, W. Eckelman, K. Rice, A. Ho, And M.J. Kreek. Opioid Receptor Binding In Long-Term Methadone Maintained Former Heroin Addicts By PET [Imaging] Using [18F]Cyclofoxy. J Pharmacol Exp Ther. 1;295(3):1070-1076, 2000. 299.Carson RE, Channing MA, Vuong BK, Watabe H, Herscovitch P, Eckelman WC, Amphetamine-Induced Dopamine Release: Duration Of Action Assessed With [11C]Raclopride In Anesthetized Monkeys, Physiological Imaging Of The Brain With PET, Eds. Gjedde A, Hansen SB, Knudsen Gm, Paulson Ob, Academic Press, San Diego, CA, 2000, 205-209. 300.Green MV, Seidel J, Vaquero JJ, Jagoda E, Lee I, Eckelman WC. High Resolution PET, SPECT, And Projection Imaging In Small Animals. Computerized Medical Imaging And Graphics To Be Published In A Special Conference Issue Devoted To "Frontiers In Nuclear Medicine Technology", A Symposium Held in Mol, Belgium in May, 1999, Computed Medical Imaging And Graphics 25, 79-86, 2001. 301.Tian X., Hsin L-W, Webster El, Contoreggi C, Chrousos GP, Gold P, Habib K, Ayala A, Eckelman WC, Jacobson AE , Rice KC. The Development Of A Potential Single Positron Emission Computed Tomography (SPECT) Imaging Agent For The 34
  • Corticotropin-Releasing Hormone Receptor Type 1. Bioorganic & Medicinal Chem Letters 11:331-333, 2001 302.Zimmerman BE, Kubicek GJ, Cessna JT, Plascjak PS, Eckelman WC. Radioassays And Experimental Evaluation Of Dose Calibrator Settings For 18F. Appl Radiat Isot. 54, 113-122, 2001 303.Channing MA, Huang BX, Eckelman WC. Analysis Of Residual Solvents In 2- [F-18]FDG By GC. Nucl Med Biol. 28(4):469-71, 2001. 304.MF Smith, ME Daube-Witherspoon, PS Plascjak, LP Szajek, RE Carson, JR Everett, Sl Green, PR Territo, RS Balaban, SL Bacharach, WC Eckelman. Device-Dependent Activity Estimation And Decay Correction Of Radionuclide Mixtures With Application To Tc-94m PET Studies. Medical Physics 28, 36-45, 2001. 305.Ma Y, Lang L, Kiesewetter D, Jagoda E, Sassaman M, Der M, Eckelman WC. Liquid Chromatography – Tandem Mass Spectrometry Identification Of Metabolites Of Two 5- HT1a Antagonists, N-{2-[4-(2-Methoxyphenyl)Piperazino]Ethyl}-N-(2-Pyridyl) Trans- And Cis-4-Fluorocyclohexanecarboximide, Produced By Human And Rat Hepatocytes. J Of Chromatography B, 755, 47-56, 2001. 306.Eckelman WC. Radiolabeled Muscarinic Radioligands For In Vivo Studies. Nucl Med Biol 28: 485-492, 2001. 307.Vera D, Eckelman WC. Receptor 1980 And Receptor 2000: Twenty Years Of Progress In Receptor-Binding Radiotracers. Nucl Med Biol.28:475-476, 2001. 18 308.Kiesewetter DO, Eckelman WC. Radiochemical Synthesis of [ F]Fluoropaclitaxel 18 ([ F]FPAC). J Labelled Cpd Radiopharm 44:S903-S905, 2001. 309.Lee Y-H C, Kiesewetter DO, Lang L, Jagoda EM, Shirani J, Dilsizian V, Eckelman WC. 18 Synthesis Of 4-[ F]Fluorobenzoyllisinopril: A Radioligand For Angiotensin Converting Enzyme (Ace) Imaging With Positron Emission Tomography. J Labelled Cpd Radiopharm 44:S268-S270, 2001 310.Lang L, Jagoda EM, Eckelman WC. The Development Of Additional Radioligands Of Varying Pharmacokinetics For The 5-HT1a Receptor. J Labelled Cpd Radiopharm. 44:S21-S23, 2001 311.Waki A, Sassaman MB, Kao CK, Jagoda EM, Ma Y, Szajek LP, Eckelman WC. Synthesis Of [76Br] 1-(2-Fluoro-2-Deoxy-3,5-O-Dibenzoyl-D-Arabinofuranosyl)-5- Bromouracil ([76Br]FBAU 3’,5’ Dibenzoate) And Its Evaluation As A Tracer For Imaging Brain Cell Proliferation. J Labelled Cpd Radiopharm. 44:S102-103, 2001 35
  • 312.Ma Y, Lang L, Kiesewetter DO, Sassaman Bb , Eckelman WC. Metabolites Of Three Phenylcarboxyl Derivatives Of The 5-HT1a Antagonists, Way 100635, Produced By Human And Rat Hepatocytes. J Labelled Cpd Radiopharm 44:S459-S461, 2001. 313.Szajek LP, Der M, Plascjak P, Eckelman WC. Production And Radioassay Of Tc-94m For PET Studies. J Labelled Cpd Radiopharm 44: S764-S766, 2001. 314.Panico M, Lang L, Sassaman MB, Eckelman WC. Radiolabeling Of Unprotected Octreotide With F-18. J Labelled Cpd Radiopharm 44: S922-S924, 2001 315.Zaret, B. L., Leppo, J. A., Bender, J. R., Carrio, I., Eckelman, WC, Gambhir, S., Green, A. M., Narula, J. Molecular Imaging. Journal Of Nuclear Cardiology, 8;2;256-266, 2001. 316.Jagoda EM, Kiesewetter DO, Shimoji K, Gomeza J, Wess J, And Eckelman WC. Regional Brain Uptake Of The Muscarinic Ligand, [18F]FP-TZTP, Is Decreased In M2 Knockout But Not In M4 Knockout Mice. Life Sciences Life Sci 68: 2634-2634, 2001 317.Book: Finn R, Balatoni J, Kothare P, Pentlow K, Sheh Y, Lom C, Dahl J, Eckelman W, Plascjak P, Adams HR, Larson SM. Cyclotron Production And Potential Clinical Application Of Iodine-124 Labeled Radiotracers. Applications Of Accelerators In Research And Industry-Sixteenth International Conference (Edited By JL Duggan And IL Morgan), 849-852, 2001 318.Libutti SK, Alexander, JR MD, Choyke P, Bartlett DL, Bacharach SL, Whatley M, Jousse F, Eckelman WC, Kranda K, Neumann RD, Carrasquillo JA. Fluoro-2-Deoxy-D- Glucose/Positron Emission Tomography Scan, 99mTc-Labeled Arcitumomab (CEA-Scan), And Blind Second-Look Laparotomy For Detecting Colon Cancer Recurrence In Patients With Increasing Carcinoembryonic Antigen Levels. Annals Of Surgical Oncology 8(10), 2001. 319.Kao C-H K, Sassaman MB, Szajek LP, Ma Y, Waki A, Eckelman WC. The Sequential Synthesis Of ([76Br]FBAU 3’,5’ Dibenzoate And ([76Br]FBAU. J Labelled Cpd Radiopharm 44: 889-898, 2001. 320.Channing MA, Huang BX, Eckelman WC. Analysis Of Residual Solvents In 2- [F-18]FDG By GC. Nucl Med Biol 28: (4) 469-471, 2001. 321.Yordanov AT, Garmestani K, Zhang M, Zhang Z, Yao Z, Phillips KE, Herring B, Horak E, Beitzel MP, Schwarz UP, Gansow OA, Plascjak PS, Eckelman WC, Waldmann TA, Brechbiel MW. Preparation And In Vivo Evaluation Of Linkers For 211At Labeling Of Humanized Anti-Tac. Nucl Med Biol. 28:845-856, 2001 322.Yao Zs, Garmestani K, Wong KJ, Park LS, Dadachova E, Yordanov A, Waldmann TA, Eckelman WC, Paik CH, Carrasquillo JA Comparative Cellular Catabolism And Retention Of Astatine-, Bismuth-, And Lead-Radiolabeled Internalizing Monoclonal Antibody. J Nucl Med 42: (10) 1538-1544 Oct 2001 36
  • 323.Eckelman WC, Waterhouse R, Frank R Nuclear Imaging And Biomarkers In Drug Development Using Approved Radiopharmaceuticals. J Clin Pharmacol 4s-6s Suppl. S Jul 2001 324.Chih-Hao K. Kao, Mark B. Sassaman, Lawrence P. Szajek, Ying Ma, Atsuo Waki, William C. Eckelman. The Sequential Syntheses Of [76br]FBAU 3,5-Dibenzoate And [76Br]FBAU. Journal Of Labelled Compounds And Radiopharmaceuticals 2001: 44(13):889-898. 325.Ling-Wei Hsin, Xinrong Tian, Elizabeth L. Webster, Andrew Coop, Timothy M. Caldwell, Arthur E. Jacobson, George P. Chrousos, Philip W. Gold, Kamal E. Habib, Alejandro Ayala, William C. Eckelman, Carlo Contoreggi And Kenner C. Rice. CRHR1 Receptor Binding And Lipophilicity Of Pyrrolopyrimidines, Potential Nonpeptide Corticotropin-Releasing Hormone Type 1 Receptor Antagonists. Bioorg. Med. Chem 10, 175-183, 2002. 326.Olasz E, Lang L, Seidel H, Green MV, Eckelman WC, Katz SI. Fluorine-18 Labeled Mouse Bone Marrow-Derived Dendritic Cells Can Be Detected In Vivo Detection By High Resolution Projection Imaging. Journal Of Immunological Methods 260: 137-148, 2001. 327.Kiesewetter DO, Jagoda EM, Starrett, Jr. J, Gribkoff VK, Hewawasam P, Srinivas N, Salazar D, Eckelman WC. Radiochemical Synthesis And Biodistribution Of A Novel Maxi-K Potassium Channel Opener. Nucl Med Biol 29:55-59, 2002. 328.Greiner E, Atkinson AJ, Jr., Ayala A, Chrousos GP, Contoreggi C, Eckelman WC, Gold PW, Habib KE, Jacobson AE, Whittaker N, Webster EL, Rice KC. Synthesis Of Doubly 13 C-Labelled Antalarmin Isotopomers For Pharmacokinetic Studies. J Labelled Compd and Radiopharm 45, 637-645, 2002. 329.Giovacchini G, Chang MCJ, Channing MA, Toczek M, Mason A, Bokde ALW, Connolly C, Vuong B-K, Ma Y, Der MG, Doudet DJ, Herscovitch P, Eckelman WC, Rapoport SI, Carson RE, Brain Incorporation Of [11C]Arachidonate In Young Healthy Humans Measured With Positron Emission Tomography, J Cereb Blood Flow Metab, 2002:22,1453-1462. 330.Zingone A, Seidel J, Aloj L, Caraco C, Vaquero JJ, Jagoda EM, Chou JY, Green MV, Eckelman WC. Monitoring The Correction Of Glycogen Storage Disease Type 1a In A Mouse Model Using [18F]FDG And A Dedicated Animal Scanner. Life Sci ;71:1293-301, 2002. 331.Kao CH, Waki A, Sassaman MB, Jagoda EM, Szajek LP, Ravasi L, Shimoji K, Eckelman WC. Evaluation Of [76Br]FBAU 3',5'-Dibenzoate As A Lipophilic Prodrug For Brain Imaging. Nucl Med Biol. 2002:29(5):527-35. 332.Kennel SJ, Mirzadeh S, Eckelman WC, Waldmann TA, Garmestani K, Yordanov At, Stabin Mg, Brechbiel Mw. Vascular-Targeted Radioimmunotherapy With The Alpha- Particle Emitter 211-At. Radiat Res. 2002 Jun;157(6):633-41. 37
  • 333.Eckelman WC, Frank JA, Brechbiel M. Theory And Practice Of Imaging Saturable Binding Sites. Invest Radiol. 2002;37(3):101-6. 334.Ma Y, Kiesewetter DO, Jagoda EM, Huang BX, Eckelman WC. Identification Of Metabolites Of Fluorine-18-Labeled M2 Muscarinic Receptor Agonist, 3-(3-[(3- Fluoropropyl)Thio]-1,2,5-Thiadiazol-4-yl)-1,2,5,6-Tetrahydro-1-Methylpyridine, Produced By Human And Rat Hepatocytes. J Chromatogr B Analyt Technol Biomed Life Sci. 2002;766(2):319-29. 335.Ma Y, Huang BX, Channing MA, Eckelman WC. Quantification Of Kryptofix 2.2.2 In 2-[18FFDG And Other Radiopharmaceuticals By LC/MS/MS. Nucl Med Biol. 2002;29(1):125-9. 336.Jagoda E, Aloj L, Seidel J, Lang L, Moody T, Green S, Caraco C, Daube-Witherspoon M, Green MV, Eckelman WC. Comparison Of F-18 Labeled Derivative Of Vasoactive Intestinal Peptide (DVIP) To Fluorine-18-2-Deoxy-2-Fluoro-D-Glucose (F-18-FDG) In Xenograft Mouse Models Of Breast Cancer. Molecular Imaging And Biology 4, 369-379, 2002.. 337.Ma Y, Lang L, Kiesewetter DO, Eckelman WC. Liquid Chromatography-Tandem Mass Spectrometry Identification of Metabolites Of 5-HT1a Antagonists, 3 Phenylcarboxamide Derivatives Of Way100635, Produced By Human And Rat Hepatocytes. J Chromatography B. 780,99-110, 2002. 338.Hsin L-W, Tian Xinrong, Webster EL, Coop A, Chrousos GP, Gold P, Eckelman WC, Contoreggi C, Rice KC. CRHR1 Receptor Binding And Lipophilicity Of Pyrrolopyrimidines, Potential Nonpeptide Corticotropin-Releasing Hormone Type 1 Receptor Antagonists. Bioorganic And Medicinal Chemistry 10, 175-183, 2002 339.Eckelman WC. Accelerating Drug Discovery and Development Through In Vivo Imaging. Nucl Med Biol. 2002 Nov;29(8):777-82. 340.Carson RE, Channing MA, Der MG, Herscovitch P, Eckelman WC. Scatchard Analysis With Bolus/Infusion Administration Of [11C]Raclopride: Amphetamine Effects In Anesthetized Monkeys, Brain Imaging Using PET, Eds. Senda M, Kimura Y, Herscovitch P, Academic Press, San Diego, Ca, 2002, 63-69. 341.Kiesewetter DO, Kao C-HK, Jagoda EM, Ma Y, Szajek LP, Eckelman WC. Fluoro-, Bromo-, and Iodo-Paclitaxel Derivatives: Synthesis and Biological Evaluation. Nucl Med Biol 30, 11–24 (2003) 342.Podruchny, T.A., Connolly, C., Bokde, A, Herscovitch, P., Eckelman, W.C., Kiesewetter, D.O., Sunderland, T., Carson, R.E., and Cohen, R.M. In Vivo Muscarinic 2 Receptor Imaging In Cognitively Normal Young And Older Volunteers. Synapse, 48:39-44, 2003. 38
  • 343.Cohen, R.M., Podruchny, T.A., Bokde, A. L. W. Bokde, Carson, R.E., Herscovitch, P., Kiesewetter, D.O., Eckelman, W.C., Sunderland, T. Higher In Vivo Muscarinic-2 Receptor Distribution Volumes In Aging Subjects With An Apolipoprotein E-Epsilon4 Allele. Synapse 2003;49(3):150-6. 344.Jagoda EM, Kiesewetter DO, Shimoji K, Rasavi L, Yamada M, Gomeza J, Wess J, Eckelman WC. Regional Brain Uptake Of The Muscarinic Ligand, [18F]FP-TZTP, Is Decreased In M2 Knockout Mice, But Not in M1, M3, or M4 Knockout Mice. Neuropharmacology 44 (5): 653-661, 2003 345.Carson RE, Wu Y, Lang L, Ma Y, Der MG, Herscovitch P, Eckelman WC. Brain Uptake Of The Acid Metabolites Of F-18-Labeled WAY 100635 Analogs. J Cereb Blood Flow Metab 23(2):249-60, 2003 346.Ma Y, Kiesewetter DO, Lang L, Der M, Huang B, Carson RE, Eckelman WC. Determination Of [(18)F]FCWAY, [(18)F]FP-TZTP, And Their Metabolites In Plasma Using Rapid And Efficient Liquid-Liquid And Solid Phase Extractions. Nucl Med Biol. 2003;30(3):233-240. 347.Toczek MT, Carson RE, Lang L, Ma Y, Spanaki MV, Der MG, Fazilat S, Kopylev L, Herscovitch P, Eckelman WC, Theodore WH. PET Imaging Of 5-HT1a Receptor Binding In Patients With Temporal Lobe Epilepsy. Neurology. 2003:11;60(5):749-56. 348.Eckelman WC. The Use of PET And Knockout Mice In The Drug Discovery Process. Drug Discov Today. 2003 May 1;8(9):404-10. 349.Book: Eckelman WC. Labeled Agents as Tracers And Carriers: Theory And Practice. For “Molecular Nuclear Medicine: The Challenge From The Human Genome” Edited By L.E. Feinendegen, W.W. Shreeve, W.C. Eckelman, Y-W Bahk, H.N. Wagner, Jr. Published By Springer Verlag, Germany. 85-98, 2003 350.Kurdziel KA, Kiesewetter DO, Carson RE, Eckelman WC, Herscovitch P. Biodistribution, Radiation Dose Estimates And In Vivo Pgp Modulation Studies Of 18F- Paclitaxel In Nonhuman Primates. J Nucl Med. 44:1330-1339, 2003 351.Contoreggi C, Higley J. Dee, Hommer D, Pushkus J, Carson RE, Grant S, Bonson K, Chrousos G, Gold P, Ayala A, Rice K, Eckelman WC. Administration Of The Corticotrophin-Releasing Hormone Receptor Type 1 (CRHR1) Non-Peptide Antagonist, Antalarmin, To Macaque Monkeys Reduces Binding Of The Serotonin Type 2A (5-HT2a) Positron Emitting Ligand, MDL 100,907. PNAS 352.Elaine Jagoda, Carlo Contoreggi, Mei-Jing Lee, Chih-Hao K. Kao, Lawrence P. Szajek, Sam Listwak, Philip Gold, George Chrousos, Elisabeth Greiner, Moon B. Kim, Arthur E. Jacobson, Kenner C. Rice, William Eckelman. Autoradiographic Visualization Of Corticotropin Releasing Hormone Type 1 Receptors With A Non-Peptide Ligand: Synthesis Of [76Br]MJL-1-109-2. J Med Chem 2003, 46, 3559-3562. 39
  • 353.Shimoji K, Esaki T, Itoh Y, Ravasi L, Cook M, Jehle J, Jagoda EM, Kiesewetter DO, Schmidt K, Sokoloff L, Eckelman WC. Inhibition Of [18F]FP-TZTP Binding By Loading Doses Of Muscarinic Agonists P-TZTP Or FP-TZTP In Vivo Is Not Due To Agonist- Induced Reduction In Cerebral Blood Flow. Synapse. 2003; 50(2):151-63. 354.Book: Eckelman WC. Mechanism Of Target Specific Uptake. Handbook Of Radiopharmaceuticals: Radiochemistry And Applications. Edited By Michael J Welch & Carol Redvanly. John Wiley & Sons, Ltd, West Sussex, England. 2003. 355.Book Eckelman WC. The Use of Positron Emission Tomography (PET) In Drug Discovery and Development. Positron Emission Tomography: Principles & Practice. Edited By Dale L Bailey, David W Townsend, Peter E Valk And Michael N Maisey (Eds). Springer-Verlag (London) Ltd., 2003. 356.Eckelman WC. The Use Of Gene-Manipulated Mice In The Validation Of Receptor Binding Radiotracer. Nucl Med Biol. 2003;30(8):851-60. 357.Eckelman WC, Vera Dr. From Bench to Bedside. Nucl Med Biol. 2003;30(8):793-4. 358.Ma Y, Kiesewetter D, Lang L, Eckelman WC. Application of LC-MS to the Analysis of New Radiopharmaceuticals. Mol Imaging Biol. 2003;5(6):397-403. 359.Jagoda EM, Aloj L, Seidel J, Lang L, Moody TW, Green S, Caraco C, Daube- Witherspoon M, Green MV, Eckelman WC. Comparison Of An 18F Labeled Derivative Of Vasoactive Intestinal Peptide And 2-Deoxy-2-[18F]Fluoro-D-Glucose In Nude Mice Bearing Breast Cancer Xenografts. Mol Imaging Biol. 2002;4(5):369-79. 360.Huang Bx, Channing MA, Plascjak PS, Kiesewetter DO, Der M, Ma Y, Eckelman WC. Routine Quality Control of Recycled Target [18O]Water by Capillary Electrophoresis and Gas Chromatography. Nucl Med Biol. 2003 Oct;30(7):785-90. 361.Ma Y, Kiesewetter D, Lang L, Eckelman WC. Application of LC-MS to the Analysis of New Radiopharmaceuticals. Mol Imaging Biol. 2003;5(6):397-403. 362.Ma Y, Lang L, Kiesewetter DO, Vuong B-K, Channing M, Ito Y, Eckelman WC. Purification of the Precursor for the Automated Radiosynthesis of [18F]FCWAY by Counter-Current Chromatography Journal of Chromatography A, 2004:1034, 149-153. 363.Benson BE, Carson RE, Kiesewetter DO, Herscovitch P, Eckelman WC, Post RM, Ketter TA. A Potential Cholinergic Mechanism of Procaine's Limbic Activation. Neuropsychopharmacology. 2004: 29(7):1239-50. 364.Giovacchini G, Lerner A, Toczek M, Fraser C, Ma K, Demar JC, Herscovitch P, Eckelman WC, Rapoport SI, Carson RE, Brain Incorporation Of [11C]Arachidonate, Blood Volume, And Blood Flow In Healthy Aging: A Study With Partial Volume Correction J Nucl Med, 2004;45(9):1471-9. 40
  • 365.Shimoji K, Ravasi L, Schmidt K, Soto-Montenegro ML, Esaki T, Seidel J, Jagoda E, Sokoloff L, Green MV, Eckelman WC. Measurement Of Cerebral Glucose Metabolic Rates In The Anesthetized Rat By Dynamic Scanning With (18)F-FDG, The Atlas Small Animal PET Scanner, And Arterial Blood Sampling. J Nucl Med. 2004;45(4):665-672. 366.Wesley JN, Mcgee EC, Garmestani K, Brechbiel MW, Yordanov AT, Wu C, Gansow OA, Eckelman WC, Bacher JD, Flynn M, Goldman CK, Maclin M, Schwartz UP, Jackson-White T, Phillip CM, Decker J, Waldmann TA. Systemic Radioimmunotherapy Using A Monoclonal Antibody, Anti-Tac Directed Toward The Alpha Subunit Of The IL-2 Receptor Armed With The Alpha-Emitting Radionuclides (212)Bi Or (211)At. Nucl Med Biol. 2004 Apr;31(3):357-64. 367.Eckelman WC, Jagoda EM, Vaquero JJ, Seidel J, Green MV. Experimental Assessment Of Mass Effects In The Rat: Implications For Small Animal PET Imaging. Nucl Med Biol. 2004: 31, 771-779. 368.Park LS, Szajek LP, Wong KJ, Plascjak PS, Garmestani K, Googins S, Eckelman WC, Carrasquillo JA, Paik CH. Semi-Automated (86)Y Purification Using A Three-Column System. Nucl Med Biol. 2004 Feb;31(2):297-301. 369.Eckelman WC, Rice KC, Contoreggi C. New Tools To Monitor Stress Using Non- Invasive PET Imaging. Ann N Y Acad Sci. 2004;1018:487-494. 370.Jagoda EM, Vaquero JJ, Seidel J, Green MV, Eckelman WC. Experiment Assessment Of Mass Effects In The Rat: Implications For Small Animal PET Imaging. Nucl Med Biol. 2004;31(6):771-9. 371.Yao Z, Zhang M, Garmestani K, Axworthy DB, Mallett RW, Fritzberg AR, Theodore LJ, Plascjak PS, Eckelman WC, Waldmann TA, Pastan I, Paik CH, Brechbiel MW, Carrasquillo JA. Pretargeted Alpha Emitting Radioimmunotherapy Using (213)Bi 1,4,7,10-Tetraazacyclododecane-N,N',N",N"'-Tetraacetic Acid-Biotin. Clin Cancer Res. 2004;10(9):3137-46. 372.Szajek LP, Kao C-HK, Kiesewetter DO, Sassaman MB, Lang L, Plascjak P, Eckelman WC. Semi-Remote Production Of Br-76 And Preparation Of High Specific Activity Radiobrominated Pharmaceuticals For PET Studies. Radiochim. Acta 2004:92, 291-295. 373.Neumeister A, Bain E, Nugent AC, Carson RE, Bonne OM, Luckenbaugh, Eckelman W, Herscovitch P, Charney DS, Drevets WC. Reduced Serotonin Type 1A Receptor Binding In Panic Disorder. J Neurosci 2004:24, 589-591. 374.Talanov VS, Yordanov AT, Garmestani K, Milenic DE, Arora HC, Plascjak PS, Eckelman WC, Waldmann TA, Brechbiel MW. Preparation And In Vivo Evaluation Of Novel Linkers For 211at Labeling Of Proteins. Nucl Med Biol. 2004;31(8):1061-71. 375.Eckelman WC. Obituary: Joseph Steigman. Nucl Med Biol. 2004;31(7):971-2. 41
  • 376.Kiesewetter DO, Eckelman WC. Utility Of Azetidinium Methanesulfonates For Radiosynthesis Of 3-[18F]Fluoropropyl Amines. J Labelled Compd Radiopharm 2004:47 (13): 953-969. 377.Pascali G, Kiesewetter DO, Salvadori PA, Eckelman WC. Sintesi e studio delle proprietà decarbossilative di fluoroformiati: applicazioni alla sintesi di [18F]- fluorocomposti. Journal Label Compd Radiopharm. 2004:45(8): 637-645. 378.Bonne O, Bain E, Neumeister A, Nugent AC, Vythilingam M, Carson RE, Luckenbaugh DA, Eckelman W, Herscovitch P, Drevets WC, Charney DS. No Change In Serotonin Type 1a Receptor Binding In Patients With Posttraumatic Stress Disorder. Am J Psychiatry. 2005;162(2):383-5. 379.Smith CB, Schmidt KC, Qin M, Burlin TV, Cook MP, Kang J, Saunders RC, Bacher JD, Carson RE, Channing MA, Eckelman WC, Herscovitch P, Laverman P, Vuong BK. Measurement Of Regional Rates Of Cerebral Protein Synthesis With L-[1-(11)C]Leucine And PET With Correction For Recycling Of Tissue Amino Acids: Ii. Validation In Rhesus Monkeys. J Cereb Blood Flow Metab. 2005;25(5):629-40. 380.Giovacchini G, Lang L, Ma, Ying, Herscovitch P, Eckelman WC, Carson RE. Differential Effects Of Paroxetine On Raphe And Cortical 5-HT1a Binding: A PET Study In Monkeys. Neuroimage. 2005;28(1):238-48. 381.Wei L, Babich J, Eckelman WC, Zubieta J. Rhenium Tricarbonyl Core Complexes Of Thymidine And Uridine Derivatives. Inorg Chem. 2005;44(7):2198-209. 382.Giovacchini G, Toczek MT, Bonwetsch R, Bagic A, Lang L, Fraser C, Reeves-Tyer P, Herscovitch P, Eckelman WC, Carson RE, Theodore WH. 5-HT1A Receptors Are Reduced In Temporal Lobe Epilepsy After Partial-Volume Correction. J Nucl Med. 2005;46(7):1128-35. 383.Eckelman WC, Rohatagi S, Krohn KA, Vera DR. Are There Lessons To Be Learned From Drug Development That Will Accelerate The Use Of Molecular Imaging Probes In The Clinic? Nucl Med Biol. 2005;32(7):657-62. 384.Shirani J, Loredo ML, Eckelman WC, Jagoda EM, Dilsizian V. Imaging The Renin- Angiotensin- Aldosterone System In The Heart. Curr Heart Fail Rep. 2005;2(2):78-86 385.Scheibe PO, Vera Dr, Eckelman WC. What Is To Be Gained By Imaging The Same Animal Before And After Treatment? Nucl Med Biol. 2005 Oct;32(7):727-32. 386.Cho SY, Ravasi L, Szajek LP, Seidel J, Green MV, Fine HA, Eckelman WC. Evaluation Of 76Br-FBAU As A PET Reporter Probe For HSV1-Tk Gene Expression Imaging Using Mouse Models Of Human Glioma. J Nucl Med. 2005 Nov;46(11):1923-30. 387.Ravasi L, Kiesewetter DO, Shimoji K, Lucignani G, Eckelman WC. Why Does The Agonist [(18)F]FP-TZTP Bind Preferentially To The M(2) Muscarinic Receptor? Eur J Nucl Med Mol Imaging. 2006:33(3):292-300. 42
  • 388.Kelloff GJ, Krohn KA, Larson SM, Weissleder R, Mankoff DA, Hoffman JM, Link JM, Guyton KZ, Eckelman WC, Scher HI, O'Shaughnessy J, Cheson BD, Sigman CC, Tatum JL, Mills GQ, Sullivan DC, Woodcock J. The Progress And Promise Of Molecular Imaging Probes In Oncologic Drug Development. Clin Cancer Res. 2005 Nov 15;11(22):7967-85. 389.Jagoda EM, Lang L, Tokugawa J, Simmons A, Ma Y, Contoreggi C, Kiesewetter D, Eckelman WC. Development Of 5-HT(1a) Receptor Radioligands To Determine Receptor Density And Changes In Endogenous 5-HT. Synapse. 2006:59(6):330-341. 390.Moustapha ME, Ehrhardt GJ, Smith CJ, Szajek LP, Eckelman WC, Jurisson SS. Preparation Of Cyclotron-Produced (186)Re And Comparison With Reactor-Produced (186)Re And Generator-Produced (188)Re For The Labeling Of Bombesin. Nucl Med Biol. 2006;33(1):81-9. 391.Eckelman WC, Mathis CA. Molecular Targets. Nucl Med Biol. 2006;33(1):1. 392.Eckelman WC, Mathis CA. Targeting Proteins In Vivo: In Vitro Guidelines. Nucl Med Biol. 2006: Feb;33(2):161-4 393.Lang L, Jagoda E, Ma Y, Sassaman MB, Eckelman WC. Synthesis And In Vivo Biodistribution Of F-18 Labeled 3-Cis, 3-Trans, 4-Cis-, And 4-Trans-Fluorocyclohexane Derivatives Of Way 100635. Bioorg Med Chem. 2006 Jun 1;14(11):3737-48. 394.James S, Maresca KP, Allis DG, Valliant JF, Eckelman W, Babich JW, Zubieta J. Extension of the Single Amino Acid Chelate Concept (SAAC) to Bifunctional Biotin Analogues for Complexation of the M(CO)(3)(+1) Core (M = Tc and Re): Syntheses, Characterization, Biotinidase Stability, and Avidin Binding. Bioconjug Chem. 2006 May-Jun;17(3):579-89. 395.Bankiewicz KS, Forsayeth J, Eberling JL, Sanchez-Pernaute R, Pivirotto P, Bringas J, Herscovitch P, Carson RE, Eckelman W, Reutter B, Cunningham J. Long-Term Clinical Improvement in MPTP-Lesioned Primates after Gene Therapy with AAV-hAADC. Mol Ther. 2006:14(4):564-70, Jul 6; [Epub ahead of print] 396.Cannon DM, Carson RE, Nugent AC, Eckelman WC, Kiesewetter DO, Williams J, Rollis D, Drevets M, Gandhi S, Solorio G, Drevets WC. Reduced Muscarinic Type 2 Receptor Binding in Subjects With Bipolar Disorder. Arch Gen Psychiatry. 2006;63(7):741-747. 397.Eckelman WC, Kilbourn MR, Mathis CA. Discussion of targeting proteins in vivo: in vitro guidelines. Nucl Med Biol. 2006 May;33(4):449-51. 398.Eckelman WC, Kilbourn MR, Mathis CA. Radiopharmaceutical space. Nucl Med Biol. 2006;33(7):829 43
  • 399.Tokugawa J, Ravasi L, Nakayama T, Lang L, Schmidt KC, Seidel J, Green MV, Sokoloff L, Eckelman WC. Distribution of the 5-HT(1A) receptor antagonist [(18)F]FPWAY in blood and brain of the rat with and without isoflurane anesthesia. Eur J Nucl Med Mol Imaging. 2006 Sep 22; [Epub ahead of print] 400.Eckelman WC. Imaging of muscarinic receptors in the central nervous system. Curr Pharm Des. 2006;12(30):3901-13. 401.Ma Y, Lang L, Kiesewetter D, Jagoda E, Eckelman WC. Species differences in metabolites of PET ligands: serotonergic 5-HT(1A) receptor antagonists 3-trans-FCWAY and 3-cis- FCWAY. Nucl Med Biol. 2006 Nov;33(8):1013-9. 402.Kalen JD, Hirsch JI, Kurdziel KA, Eckelman WC, Kiesewetter DO. Automated synthesis of (18)F analogue of paclitaxel (PAC): [(18)F]Paclitaxel (FPAC). Appl Radiat Isot. 2006 Dec 9; [Epub ahead of print] Papers In Process 403.Carson RC, Lang L, Wu Y, Ma Y, Der MG, Herscovitch P, Eckelman WC. Scatchard Analysis With Bolus/Infusion Administration Of [11C]Raclopride: Amphetamine Effects In Anesthetized Monkeys. 404.Carson RE, Kiesewetter DO, Connelly K, Mentis MJ, Cohen RM, Herscovitch P, Sunderland T, Eckelman WC. Kinetic Analysis Of The Muscarinic Cholinergic Ligand [F-18]FP-TZTP In Humans. J Cereb Blood Flow Metab. 405.Carson RE, Lang L, Spanaki M, Ma Y, Der MG, Herscovitch P, Theodore WH, Eckelman WC. Human 5-HT1a PET Studies With [18F]FCWAY. 406.Carson RE, Lang L, Ma Y, Der MG, Herscovitch P, Eckelman WC. PET Evaluation Of Three [18F] Labeled 5-HT1a Antagonists With Intermediate Affinity. 407.Lang L, Channing MA, Vera D, Eckelman WC. The Synthesis, In Vitro Stability And In Vivo Biodistribution Of [18F]-Labeled Biotin Derivatives. 44