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THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
THE TOP 10
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THE TOP 10

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  • 1. THE TOP 10WORLD'S LEADING DIAGNOSTIC IMAGING COMPANIES SAMPLE PAGES This report is based on data from sources considered to be reliable, but is not guaranteed as to accuracy and completeness. The information in this report is not intended to be used as the primary basis for decisions, and because of individual company objectives it should not be construed as advice designed to meet the particular business needs of any company. Subsequent developments may change opinions and conclusions in this report. Copyright 2005 VENTURE PLANNING GROUP This material is confidential for use by our clients only and may not be reprinted or reproduced. VENTURE PLANNING GROUP Sofia House, First Floor 350 Fifth Avenue, 48 Church Street Suite 3304 Hamilton HM 12, Bermuda New York, NY 10118 441.296.9500 212.564.2838 441.295.1209 Fax 212.564.8133 Fax info@vpgcorp.com
  • 2. CONTENTS Page INTRODUCTION . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I-1 MARKET OVERVIEW . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . MO-1 ALOKA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . AL-1 ANALOGIC . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . AN-1 ESAOTE . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . ES-1 GENERAL ELECTRIC . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . GE-1 HITACHI . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . HI-1 HOLOGIC . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . HO-1 PHILIPS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . PH-1 SHIMADZU . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . SH-1 SIEMENS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . SI-1 TOSHIBA . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . TO-1 COMPARATIVE ANALYSIS . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . CA-1
  • 3. INTRODUCTION "The Top 10 World's Leading Diagnostic Imaging Companies" is VENTURE PLANNING GROUP's regularly-updated report on the performance, capabilities and strategies of the major competitors in the diagnostic imaging industry worldwide. The report is based on personal and telephone interviews with the TOP 10 companies' executives, customers, suppliers, joint venture partners, financial analysts, advertising agencies, recruiting firms, as well as experts from trade associations, media and others knowledgeable of the companies' current operations and future strategic direction. Additional information was obtained from diagnostic imaging industry shows, marketing conferences and scientific symposia that occurred during the course of the study. In addition to primary sources, the TOP 10 report is based on the information retrieved from VENTURE PLANNING GROUP's proprietary data files, which contain current information on numerous diagnostic imaging companies, technologies, products and executives, and have been developed in the course of the firm's continuous monitoring of the industry and previous single-client assignments. Moreover, a comprehensive review of the TOP 10 companies' product and financial literature, local press, business and technical periodicals, trade and professional association surveys, marketing and technical meeting presentations, patents, antitrust records, government documents and pertinent industry analyst reports was conducted.
  • 4. We trust that the results of this report will help current diagnostic imaging product suppliers, companies planning to enter the market, and the financial community to assess the competitive environment, identify opportunities and develop successful business expansion strategies.
  • 5. diagnostic methods for Alzheimer’s are fairly reliable and the incentive for PET to confirm the diagnosis is not great. With procedure volume increasing but still limited in its clinical reach, mobile PET will likely continue as an important avenue for positron imaging, allowing wider use of PET than would otherwise be possible. The number of mobile unit sales will continue to be about 20% of that for sales of fixed installations. The average price of mobile PET systems of about $1.4 million will likely increase slightly in keeping with the shift toward PET/CT. Mobile PET/CT will make up a much lower proportion of the total mobile PET sales than fixed PET/CT versus PET installations because of the difficulty in recovering CT costs for mobile operators. Mobile PET sales in the US should reach $0.3 million in five years. The larger mobile operators will continue to expand, absorbing smaller companies. This expansion will be supported by an abundance of venture capital. The grafting of CT onto PET has shifted the modality towards mainstream radiology, although it will take a transposition to CT/PET for it to have truly left the domain of nuclear medicine. GE and CTI Molecular Imaging dominate the market for PET scanners and cyclotrons. CTI primarily markets through worldwide marketing partner Siemens, but also via Toshiba and Hitachi. The number of PET systems in the US has risen from fewer than 100 in 1997 to over 900 in 2004. In Europe, over the same period, system growth has also been impressive, increasing almost four-fold to 270 systems. While PET has
  • 6. TABLE MO-2 WORLDWIDE DIAGNOSTIC IMAGING MARKET ESTIMATED SALES BY MODALITY/BUSINESS AND GEOGRAPHIC REGION 2004 ($ billions) Modality/Business North Other America Countries World X-Ray Ultrasound MRI CT PACS Nuclear Medicine PET/PET-CT Others Service Total
  • 7. TABLE MO-3 WORLDWIDE DIAGNOSTIC IMAGING MARKET ESTIMATED SALES BY GEOGRAPHIC REGION 2004-2009 ($ billions) Annual Growth 2004-2009 Modality/Business 2004 2009 (%) X-Ray Ultrasound MRI CT PACS Nuclear Medicine PET/PET-CT Others Service Total
  • 8. HITACHI MEDICAL 1-1-14 Uchi-Kanda Chiyodaku, Tokyo 101 Japan Table of Contents Page I. Executive Summary . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . HI-1 II. Business Organization . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . HI-11 III. Senior Management . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . HI-17 IV. Facilities and Employees . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . HI-21 V. Technological Know-How . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . HI-24 VI. Product Portfolio . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . HI-29 VII. Marketing Tactics . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . HI-42 VIII. Sales and Profit Growth, 2001-2005 . . . . . . . . . . . . . . . . . . . . . . . HI-48 IX. R&D Expenditures and Major Programs . . . . . . . . . . . . . . . . . . . . . . HI-59 X. Collaborative Arrangements . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . HI-65 XI. Strategic Direction . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . HI-70
  • 9. I. EXECUTIVE SUMMARY A. Business Organization 1. Current and Recent Developments ! Organized into: Lighting, Consumer Electronics, Components, Semiconductors, Origin ( Enterprise Solutions, Managed Services and Professional Services, Domestic Appliances and Personal Care, Medical Systems. ! Medical Systems consists of X-ray equipment, computed tomography, magnetic resonance, ultrasound and healthcare services. ! In 2000, acquired ADAC Laboratories for approximately $426 million. ! In 2001, acquired Agilent Technologies’ Healthcare Solutions Group (HSG) for approximately $2.2 billion. ! In 2004, Philips sold its 80% interest in HeartCare Telemedicine to SHL Telemedicine International, sold most of X-Ray analytical business to Egham, sold 80% interest in HeartCare Telemedicine to the other owner, SHL Telemedicine, sold most of X-Ray analytical business to Egham. ! In 2004, acquired Richardson Electronics’ medical glassware business. ! In 2004, acquired Richardson Electronics’ medical glassware business. 2. History ! Established in 1891.
  • 10. TABLE AN-7 ANALOGIC ESTIMATED SALES GROWTH BY MAJOR CUSTOMER 2002-2004 ($ millions) Annual Growth 2002-2004 Customer 2002 2003 2004 (%) Toshiba GE Siemens L-3 Communications Philips Others Total
  • 11. In 2004, the company introduced its next generation Infinia nuclear medicine system offering a five millimeter CT axial resolution with Hawkeye enhanced SPECT/CT lesion detection; fan-beam collimation for enhanced brain SPECT scanning and a camera-based PET option. E. Nuclear Medicine 1. Millennium The Millennium nuclear imaging system incorporates specially designed Digital CSE (correlated signal enhancement) detectors, which improve both the count rate and uniformity. The Millennium system has been designed for use with the Genie acquisition workstation, which handles location, archiving and retrieval of patient files. The Millennium MG is a variable-angle dual-head; Millennium MT is an opposable-angle dual-head; Millennium MPR is a rectangular- detector single-head; and Millennium MPS is a square-detector single-head. The MG heads adjust from 101 degrees to 180 degrees to gain maximum sensitivity close to the collimators, while reducing the dead space normally associated with variable-head cameras. With a gantry footprint of about 20 square feet, MG is one of the most compact cameras in its class. It is equipped with two Digital CSE detectors employing a summation technique to generate additional diagnostic information from distant, small signals. A significant feature of the MPS system is its CSE detector which is based on square photomultiplier tubes. The detector gathers and sums form rows and columns of PMTs before any signal processing is performed using signals that
  • 12. TABLE GE-7 GENERAL ELECTRIC DIAGNOSTIC IMAGING ESTIMATED WORLDWIDE SALES BY MODALITY/BUSINESS 2004 Sales Percent Modality/Business ($ millions) Of Total Ultrasound X-Ray MRI CT PACS PET & PET/CT Service Others Total
  • 13. IX. R&D EXPENDITURES AND MAJOR PROGRAMS In 2004, GE invested approximately $3.1 billion, or 2.0% of total sales in R&D. Medical Systems Division R&D expenditures account for $530 million, or 5.4% of the division sales. Medical Systems Division works closely with GE’s central R&D in Schenectady, NY. Several technologies, including MRI and ultrasound, were jointly developed by the two R&D groups. GE succeeded in closely coordinating corporate R&D resources with those of Medical Systems headquarters in Milwaukee and other GE divisions with related technology. In 2004, GE opened a 10,000 square meter European Global Research Center in Garching, Germany on the campus of the Technical University of Munich. The facility is part of a $4 billion technology development effort. The main research areas of the new center include MRI and molecular imaging, as well as non-medical activities. Other R&D facilities include the Global Research Center in Niskayuna, NY. The sited employs approximately 1,800 persons working on technologies for all GE businesses. The John F. Welch Technology Center, located in Bangalore, India was the first GE R&D facility outside the US. Also, the company performs research activities at the China Technology Center in Shanghai. Imaging research programs cover 3D ultrasound, high field MRI, advanced medical applications and molecular imaging. Overall, GE’s major R&D activities in
  • 14. decoded and processed. The camera stops analyzing events with unacceptable z levels, remaining open for reception of another valid event. In 1998, Hitachi offered an upgrade which increased the counting performance form a minimum of two times the current rate to five times the current rate. F. PET In 2002, Hitachi added the Sceptre and Sceptre XLPET system to CTI PET systems. They come with the Avia multi-modality workstation. The Sceptre uses a partial-ring detector composed of LSO. The detector rotates around the patient using slip ring technology. The Avia was designed for processing and viewing data from any diagnostic imaging facility. The company offers software upgrades for the Avia that include the Fusion7D non-rigid/deformable fusion, enhanced display functionality and tele-radiology sharing to deliver real-time Lan/Wan synchronization. In 2004, Hitachi released Rtist software package for use with the Avia. It allows contouring of tumors and exports contours in DICOM RT format to therapy planning systems. The RTist was developed with English software company Mirada Solutions. In 2004, Hitachi introduced the Sceptre P3, an LSO-based rotational PET scanner outfitted with a quad-slice CT. The CT data are used to create attenuation correction maps for the PET images as well as diagnostic anatomic images. Dual Attenuation Correction allows the combination of both CT and sealed
  • 15. TABLE HI-8 HITACHI IMAGING SYSTEMS ESTIMATED SALES BY MODALITY/BUSINESS AND GEOGRAPHIC REGION 2005 Other Modality/Business U.S. Countries World MRI CT X-Ray Ultrasound Nuclear Medicine Service Others Total
  • 16. TABLE HI-9 HITACHI IMAGING SYSTEMS ESTIMATED SYSTEM PLACEMENTS AND INSTALLED BASE BY MODALITY AND GEOGRAPHIC REGION 2005 (units) Placements Installed Base Modality/Business U.S. Other Countries World U.S. Other Countries World MRI CT Utrasound X-Ray Nuclear Medicine
  • 17. In 2005, Hitachi invested approximately $3.6 billion, or 4.3% of total corporate sales, in R&D. Approximately 65% of the R&D expenses are devoted to semiconductors and computers. The company’s investment in Imaging Systems is estimated at $65 million, or 5.9% of sales. In Tarrytown, NY, Hitachi’s R&D division operates three laboratories where scientists are collaborating on a number of advanced research projects. In the San Francisco laboratory, efforts are focused on large-scale integrated high-speed digital signal processing chips for next-generation applications in communications, image processing and enhanced computer graphics. The company's laboratory in Princeton, NJ, opened in July 1991, is focusing on the development of the next-generation TV receiver with sophisticated digital signal processing for higher picture quality and wider screen. The R&D division is also responsible for long-range planning and pursuing international research projects. In the area of CT, Hitachi is collaborating with Tokai University's School of Medicine on the development of an optical CT system that offers a higher resolution oxygen-saturation image. The resolution was improved by reducing image blurring and distortion caused by strong light scattering in tissues. The optical CT produces images of the tissues of interest by irradiating a target area of a patient with a pair of near-infrared laser beams and processing the light that passes through the tissue using a streak camera. Optical CT can be used to obtain functional images of organs, by measuring the distribution of
  • 18. TABLE HO-5 HOLOGIC ESTIMATED OPERATING PROFIT GROWTH BY PRODUCT LINE 2002-2004 ($ millions) Annual Growth 2002-2004 Product Line 2002 2003 2004 (%) Mammography Osteoporosis Assessment Mini C-Arm, General General and Radiography Digital Detectors Total
  • 19. ! Aquilion In 2003, Philips introduced the Aquilion, a 32-slice scanner. The system increases patient through-put, reduces the need for invasive diagnostic techniques and adds such applications as enhanced perfusion studies, coronary artery imaging and critical care without adding radiation dose to the patient. ! Brilliance The Brilliance CT, in 64-, 40-, 16–, 10- and 6-slice varieties, offers DoseWise dosing for optimal efficiency, RapidView reconstruction techniques, as well as a scalable platform for growth and future applications. The 40-slice configuration allows for organ perfusion studies, coronary artery imaging and pulmonary imaging. In 2004, Philips introduced the Precedence SPECT/CT which combines the Skylight gamma camera and the Brilliance multislice CT platform. ! Tomoscan Series The Tomoscan Series has been marketed by Philips under a distribution and assembly agreement with Hitachi. The Tomoscan LX was designed for high-volume imaging departments, such as teaching hospitals and university medical centers. The console has two displays: a 14 inch, high resolution monitor for image viewing, and a plasma screen for operator/system communications. The image monitor tilts and swivels for convenient viewing from any vantage point. The LX gantry, with its 70 cm aperture and maximum 48 cm field of view, provides convenient positioning access and accommodates large
  • 20. emergency care, cardiology, and radiation oncology. The company plans to move to a common IT architecture for workstations, departmental, enterprise systems and user interface. In 2004, Phillips entered into a contract to provide Fletcher Allen Health Care with cardiovascular imaging equipment and software, enterprise-wide PACS, radiology equipment and patient monitoring systems. In 2005, Phillips contracted with John Hopkins and Lenox Hill Hospitals to provide SPECT/CT systems. Outside the US, Philips markets through a direct sales force of approximately 825 persons and selected distributors. The company employs approximately 585 sales persons in Europe, 95 in Japan and 145 in the rest of the world. In 1997, ATL established a Chinese subsidiary, ATL China, based in Beijing. The subsidiary is responsible for marketing, service and support activities of the company’s products in China. The Apogee 800 plus is sold in China by Shantou Institute of Ultrasonic Instruments (SIUI). Philips is actively expanding both domestically and overseas. Thus, the company has won a $25 million order for the supply of medical equipment and services to Zimbabwe. The company installed X-ray equipment and ultrasound systems in 77 small Government-owned and mission hospitals and clinics, as well as more advanced equipment in city hospitals. As part of the seven-year contract, Philips has been providing equipment maintenance and training. The Dutch Government funded 40% of the project, the remainder coming from a Dutch and German bank loan.
  • 21. specialists. A separate dedicated sales force was marketing cardiology products. In international markets, ATL had fifteen subsidiaries and an extensive distributor network. Outside the US, ATL marketed through direct sales in Argentina, Australia, Austria, Belgium, Canada, France, Germany, Italy, the Netherlands, the UK and Singapore. In 2005, the company set up a regional distribution center in Singapore that employs a staff of 45. In India, ATL sells through a joint venture with Indchem Electronics. In the rest of the world, the company sells through distributors. The Pacific Rim, Latin American and South American distribution network is managed from the US headquarters. The network of European, Middle Eastern and African distributors is coordinated from German headquarters. The company's worldwide marketing organization reaches over 100 countries. PACS Acquisitions of ADAC, ATL and Marconi have given Philips a broad spectrum of channels through which to market PACS and develop electronic image archiving and distribution strategies for specific modalities, as well as enterprise-wide systems for the workflow environment. Philips determined, for example, that postprocessing applications optimized for the Marconi Mx8000 and MxView workstations are compatible with EasyVision workstations. Philips provides an upgrade path to digital cardiac cath imaging labs. The company's Integris H, for example, allows users to upgrade systems gradually. To mammography users, Philips offers a quality assurance kit to help customers seeking accreditation from the American College of Radiology. The kit
  • 22. TABLE PH-7 PHILIPS MEDICAL SYSTEMS ESTIMATED WORLDWIDE SALES GROWTH BY GEOGRAPHIC REGION 2002-2004 ($ millions) Annual Growth 2002-2004 Geographic Region 2002 2003 2004 (%) North America Europe & Africa Asia Pacific Latin America Total
  • 23. ! Neusoft In 2004, Philips signed a joint venture agreement with Chinese technology group Neusoft. The deal with Neusoft’s digital medical products arm is intended to help Philips build its presence in the economy- to mid-range medical systems. Philips holds 51% of the joint venture, which is focusing on R&D and manufacturing. It is based at Neusoft Digital Medical’s existing site in Shenyang, northeastern China, where an additional facility is being built. Initially, the two firms intend to develop and manufacture low- to mid-range CT and x-ray equipment, and will expand the focus to ultrasound, MRI and PACS. The companies will sell and service the products arising from the venture independently. ! Oldelft In the US, Philips has been marketing the Advanced Multiple Beam Equalization (Amber) system, an automatic film changer developed by the Oldelft Corporation of America (Fairfax, VA). The Amber is Oldelft's radiography chest X- ray system. Philips evaluated Amber's automatic film changer, spurred by the interest of high-volume clinical sites, which have a need for improved quality in the system while requiring faster throughput capability. The Amber can benefit patients undergoing thoracic imaging procedures by improving clarity and lowering the rate of false negatives experienced in conventional X-ray imaging. ! PAION In 2004, Phillips entered into an agreement to provide PAION with brain perfusion CT software for use in clinical trials for the investigational drug
  • 24. the diagnostic imaging area. It has the rights to market, license, and develop new products in collaboration with third parties.. ! Cassling In 2000, the company signed an agreement with Cassling Diagnostic Imaging, for distribution of mammography and mobile X-ray systems. ! Catholic Health Systems In 2005, Siemens agreed to provide Catholic Health Systems (CHS) with equipment and services for ten years. CHS is composed of five hospitals, ten primary care centers, nine diagnostic and treatment centers, a freestanding surgery center and eleven long-term care facilities. ! CompuRad Siemens has been selling CompuRad's MagicView 50 teleradiology systems on an OEM basis worldwide. ! Data Critical Systems Siemens and Data Critical Systems agreed to jointly sell wireless telemedical systems for patient monitoring. ! Digital/Apple Siemens and Digital Equipment have a collaboration in the PACS field, allowing Digital computers to tap into Siemens installed base of CT and MR scanners. Siemens has a similar agreement with Apple, utilizing Macintosh computers in image workstations. Thus, the Litebox computer is produced under the Apple agreement.
  • 25. agreement whereby Merge is translating proprietary image data from scanners into ACR/NEMA-based Mergecom output. Mergecom is an open protocol that can be used on standard networks, such as Ethernet or Token Ring. ! National Cancer Institute In 2002, the National Cancer Institute awarded a $2 million dollar grant to Siemens for ultrasound research. The grant is intended to help in the development of a software interface that uses manuals for its Sonoline Antares platform, giving researchers access to advanced capabilities. ! National Geographic Since 2005, Siemens is supporting a research project on mummies by Egypt’s Supreme Council of Antiquities. The company has donated a trailer- mounted Somatom Emotion 6 to scan mummies found in Egypt. ! NextGen In 2005, Siemens entered into an agreement with NextGen Healthcare Information Systems, a provider of ambulatory Electronic Medical Records, whereby the companies market enterprise IT systems and imaging technologies for acute and specialty environments. The agreement also includes worldwide distribution rights. ! Novametrix Siemens and Novametrix Medical have been developing a combination flow and carbon dioxide module for patient monitoring products. ! Nucletron Systems Siemens’ Oncology Division entered into an agreement to sell
  • 26. Aquilion and Asteion systems. The software allows helical CT images to be used to quantify calcium deposits in coronary arteries. Toshiba licenses the Vitrea workstation and software package and the Vscore application from Vital Images. In 2005, Vital Images introduced ViTALCardia, a technology designed specifically for cardiologists. It includes software for diagnosis as well as a Web-based thin-client distribution technology to provide access to images throughout the cardiology enterprise. In 2001, Toshiba launched the Asteion Multi 60 system, designed for multiple applications, including CT angiography, cardiac and whole body scanning. The system features the Quantum Detector, a dose management tool. D. MRI Toshiba's MRI systems combine the company's proprietary technologies with the acquired Diasonics technical expertise. Diasonics MRI Division had been the mid-field leader in the US, offering a 0.35-tesla system, while Toshiba has been the leader in Japan, offering a 0.5-tesla system. Toshiba has a strong market position in low-, mid- and high-field market segments. !! Opart The Opart is a 0.35 tesla superconducting open-style scanner that operates without cryogens. The Opart has the dual distinction of being an open-style superconducting scanner and a cryogen-less superconducting magnet. The Opart's open design provides patient access from all four sides and allows scanning while the patient is still connected to ancillary MRI-compatible monitoring
  • 27. TABLE CA-2 THE TOP 10 WORLD'S LEADING DIAGNOSTIC IMAGING COMPANIES ESTIMATED TOTAL SALES BY MODALITY/BUSINESS 2004/2005 ($ millions) Company Ultrasound X-Ray MRI CT Nuclear PACS Service Others Total Analogic Aloka Esaote General Electric Hitachi Hologic Philips Shimadzu Siemens Toshiba Total

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