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DIAGNOSTIC IMAGING PROGRAM
NATIONAL CANCER INSTITUTE
National Institutes of Health
National Cancer Institute
Diagnostic Imaging Program
Diagnostic Imaging
Program: Update
• Money
• Organizational comments
• Current Programs
• Future Plans
• Concluding commen...
NIH Funding for Imaging
$0
$50
$100
$150
$200
$250
$300
$350
FY 96 FY 97 FY 98 FY 99
DIP
NIH-RAD
NIHImaging
$Millions
DIP Grant Funding
$0
$10
$20
$30
$40
$50
$60
$70
$80
FY 96 FY 97 FY 98 FY 99
$M
Diagnostic Imaging Program(DIP)
Diagnostic
Imaging
Branch
Functional
Imaging
Branch
Image-guided
Therapy
Branch
Office of
...
Organization
• 10 FTE’s
– D Sullivan, L Clarke, J Hoffman, A
Menkens, B Croft, M Torres, J Smith, L
Cooley, S Bowles, L Ba...
Positions available
(of importance to imaging)
• NCRR Director of Bioengineering
• NHLBI Program Director
• NCI Scientific...
Radiology 1999; 212:609-614
Recent Programs
Programs Awards Amount
RFA: CA-97-020:
Cooperative Trials in
Diagnostic Imaging (ACRIN)
2 U01 $ 3.0 M yr. ...
Current Programs(1)
Program Awards Amount
RFA: CA –99- 002 – Planning
Grants – Molecular and
Cellular Imaging Centers (Pre...
Current Programs(2)
Program Awards Amount
PA: 99-082/ 083: Development and Testing of
Digital Mammography Displays and Wor...
Collaborative Programs
Program Awards Amount
PA 98-092: Shared Resources for
Scientists Outside NCI Cancer Centers
R01 or ...
CTEP Collaborative
Programs
Program Awards
CTEP Protocol Review Contracts
U01’s
CA-98-007: Pediatric Brain Tumor Clinical
...
DIP Standards Activities
• DICOM / Working Group on Clinical
Trials Data
• RSNA - IHE / RSNA - image archive
collaboration...
NCI - Imaging Industry
Relations Forum
• Clear description of HCFA decision
rules
• Policy for conditional coverage of
eme...
NCI Training Activities
R 25
Cancer Education and
Career Development
Program
R 25 Cancer Education and Career
Development Program
• Multidisciplinary
• Institutional award
• Salary support for PI and...
K07 / K08 / K23
• K 07 Epidemiology
(limited use by radiology)
• K 08 Clinician: Bench science
(limited use by radiology)
...
T32 Training Grants -
Imaging
From 1/97-10/99 (6 NCI deadlines)
• 6.5% of applications submitted were
imaging-related
• 57...
T32 Training Grants -
Imaging
Yrs PI Title
24 Kuhl, David Cancer Research Training in Nuclear Medicine
17 Wagner, Henry Re...
Research Training Grant
Information
• Call Brian Kimes
301 496 8537
• email:
bk34t@nih.gov
Future Plans - Devices
• Proposed PA: R21/R33 for imaging
technology development
• RFP for ultrasound research interface
•...
Future Plans -
Pharmaceuticals
(Imaging agents)
Pharmaceutical categories of interest:
– 1. Non-PET tracers
– 2. PET trace...
Future Plans -
Pharmaceuticals
(Imaging agents)
• Proposed program to support
development of novel imaging
probes.
• Propo...
Concluding Comments
• Molecular imaging is future priority
• DIP funding increased 40 %
• More applications lead to more
f...
Sources of NCI imaging
information to public
• Website: URL = www.nci.nih.gov/dip/
• Email Newsletter
Handouts available
• URLs of interest
• Training program information
• Copy of Acad Rad article: Radiologic
Sciences Resea...
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  1. 1. DIAGNOSTIC IMAGING PROGRAM NATIONAL CANCER INSTITUTE
  2. 2. National Institutes of Health National Cancer Institute Diagnostic Imaging Program
  3. 3. Diagnostic Imaging Program: Update • Money • Organizational comments • Current Programs • Future Plans • Concluding comments
  4. 4. NIH Funding for Imaging $0 $50 $100 $150 $200 $250 $300 $350 FY 96 FY 97 FY 98 FY 99 DIP NIH-RAD NIHImaging $Millions
  5. 5. DIP Grant Funding $0 $10 $20 $30 $40 $50 $60 $70 $80 FY 96 FY 97 FY 98 FY 99 $M
  6. 6. Diagnostic Imaging Program(DIP) Diagnostic Imaging Branch Functional Imaging Branch Image-guided Therapy Branch Office of Imaging Technology Division of Cancer Treatment and Diagnosis (DCTD) Cancer Diagnosis Program (CDP) Develop- mental Therapeutics Program (DTP) Cancer Therapy Evaluation Program (CTEP) Radiation Research Program (RRP) NCI
  7. 7. Organization • 10 FTE’s – D Sullivan, L Clarke, J Hoffman, A Menkens, B Croft, M Torres, J Smith, L Cooley, S Bowles, L Banh • 3 Part-time – E Staab, J Tatum, C Langlotz • Further expansion is space limited
  8. 8. Positions available (of importance to imaging) • NCRR Director of Bioengineering • NHLBI Program Director • NCI Scientific Review Administrator
  9. 9. Radiology 1999; 212:609-614
  10. 10. Recent Programs Programs Awards Amount RFA: CA-97-020: Cooperative Trials in Diagnostic Imaging (ACRIN) 2 U01 $ 3.0 M yr. 1 $ 22 M Tot RFA: CA-98-024: Development And Application of Imaging In Therapeutic Studies 9 R01’s $ 2.8 M yr. 1 $ 11.6 M Tot CA-98-023: Small Animal Imaging Resource Programs (SAIRPs) 5 U01’s $ 5.3 M yr. 1 $ 15.3 M Tot
  11. 11. Current Programs(1) Program Awards Amount RFA: CA –99- 002 – Planning Grants – Molecular and Cellular Imaging Centers (Pre- ICMICs): 6-8 P20’s $ 2.4 yr. 1 $ 7.2 M Tot RFA: CA –99- 004: Molecular and Cellular Imaging Centers: (ICMICs) 2 P50’s per year $4.0 M yr. 1 $48.0 M Tot RFA CA-99-015: Diagnostic Imaging and Guided Therapy in Prostate Cancer (Phased Innovation Award) 6-8 R21/R33 $1.6 M yr.1 $13.6Tot PAR-99-149: Diagnostic Imaging and Guided Therapy in Prostate Cancer: SBIR/STTR Initiative R43/R44 Payline
  12. 12. Current Programs(2) Program Awards Amount PA: 99-082/ 083: Development and Testing of Digital Mammography Displays and Workstations R0I/ SBIR/STTR). Payline PA: 98-008: Exploratory/Developmental Grants for Diagnostic Cancer Imaging R21’s $5.7 M yr. 1 PAR-99-101: Innovative Technologies for the Molecular Analysis of Cancer: Phase Innovation Award R21/R33 SBIR/STTR (PAR-99-100) Payline PAR-99-102: Applications Of Innovative Technologies For The Molecular Analysis Of Cancer: Phased Technology Application Award R21/R33 SBIR/STTR (PAR-99-103) Payline PAR-99-010: Bioengineering Research Partnership Programs (BRP) R01’s Payline PAR-99-009: Bioengineering Research Grants (BRG) R01’s Payline BAA No. N01-CM-97065-32 Novel Technologies for Noninvasive Detection, Diagnosis and Treatment of Cancer Contracts $ 4 M yr.1 $16 M Tot
  13. 13. Collaborative Programs Program Awards Amount PA 98-092: Shared Resources for Scientists Outside NCI Cancer Centers R01 or P01 Payline NLM 99-103: Visible Human Project Image Processing Tools (NLM) Contracts RFA: AI-99-004: New Imaging Technologies For Autoimmune Diseases R01’s $3.5 M yr. 1 $17.5 M Tot RFA: CA-99-013: Cancer Intervention and Surveillance Modeling Network (CISNET) U01’s $1.5 M yr. 1 $6.0 M Tot
  14. 14. CTEP Collaborative Programs Program Awards CTEP Protocol Review Contracts U01’s CA-98-007: Pediatric Brain Tumor Clinical Trials Consortium U01, imaging required RFA for new Centers U54’s imaging required RFP for Phase I & II clinical trials Contracts imaging required
  15. 15. DIP Standards Activities • DICOM / Working Group on Clinical Trials Data • RSNA - IHE / RSNA - image archive collaborations • Structured reporting collaborations: DICOM, SNOMED, ACR, RSNA • Image database standards: RFA
  16. 16. NCI - Imaging Industry Relations Forum • Clear description of HCFA decision rules • Policy for conditional coverage of emerging imaging technologies • Re-evaluation of FDA policies, esp. re: tracers or procedures of low risk • Assure full range of NCI support mechanisms for imaging science.
  17. 17. NCI Training Activities
  18. 18. R 25 Cancer Education and Career Development Program
  19. 19. R 25 Cancer Education and Career Development Program • Multidisciplinary • Institutional award • Salary support for PI and core faculty • Trainee salary up to $75,000 • Research support up to $20,000 per trainee • 5 yr. grant, renewable • 8% indirect
  20. 20. K07 / K08 / K23 • K 07 Epidemiology (limited use by radiology) • K 08 Clinician: Bench science (limited use by radiology) • K23 Clinician: Patient-oriented (hands-on; obtain consent form) (no imaging applications yet) • Salary $75,000/ Research $30,000
  21. 21. T32 Training Grants - Imaging From 1/97-10/99 (6 NCI deadlines) • 6.5% of applications submitted were imaging-related • 57.1% of imaging-related T32s were funded • 54.2% of T32 applications submitted to NCI were funded
  22. 22. T32 Training Grants - Imaging Yrs PI Title 24 Kuhl, David Cancer Research Training in Nuclear Medicine 17 Wagner, Henry Res. Training in Use of Tracer Principles in Oncology 14 Brady, Thomas Nuclear Magnetic Research 10 Zerhouni, Elias Research Training in Oncology Imaging 7 Glazer, Gary Advanced Techniques for Cancer Imaging 5 Clouse, Melvin Deaconess Research Training in Cancer Radiology 4 Baum, Stanley Training in Innovative Cancer Imaging Technologies 3 Hawkins, Randall Research Training in Diagnostic Oncology 2 Wehrli, Felix Training in Quantitative Magnetic Resonance Imaging 23 Hoffman, Edward Research Training in Biomedical Physics 23 Bedford, Joel Radiological Sciences Basic to Cancer Research 21 DeLuca, Paul U.W. Radiological Sciences Training Program 18 Alpert, Nathaniel Postgraduate Program in Radiological Science 10 Doi, Kunio Research Training in Medical Physics
  23. 23. Research Training Grant Information • Call Brian Kimes 301 496 8537 • email: bk34t@nih.gov
  24. 24. Future Plans - Devices • Proposed PA: R21/R33 for imaging technology development • RFP for ultrasound research interface • RFA for spiral CT image database • Proposed program to support production of beta units for clinical trials • Proposed additional Centers with technology development component
  25. 25. Future Plans - Pharmaceuticals (Imaging agents) Pharmaceutical categories of interest: – 1. Non-PET tracers – 2. PET tracers – 3. Bulk agents (pharmacologic effect) – 4. Radiolabeled therapeutic agents (non-sealed-source agents)
  26. 26. Future Plans - Pharmaceuticals (Imaging agents) • Proposed program to support development of novel imaging probes. • Proposed program to support R & D necessary for IND, and provide supply needed for clinical trials.
  27. 27. Concluding Comments • Molecular imaging is future priority • DIP funding increased 40 % • More applications lead to more funding • Patient accrual needs attention • Rewards for team science need attention • Think R25 for research training grants
  28. 28. Sources of NCI imaging information to public • Website: URL = www.nci.nih.gov/dip/ • Email Newsletter
  29. 29. Handouts available • URLs of interest • Training program information • Copy of Acad Rad article: Radiologic Sciences Research in the Next Century • DIP Newsletter • Everything you ever wanted to know … • Cancer information pamphlets
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