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Dr. Ferrari's power poin Presentation Transcript

  • 1. Using Chemistry in Medicine Norman Ferrari, MD West Virginia University School of Medicine
  • 2. West Virginia University Eberly College of Arts and Sciences Bennett Department of Chemistry Lecture 2008
    • Professor and Senior Associate Dean
    • Board Certified in two specialties
    • Pediatrics
    • Internal Medicine
  • 3. How did I get there …….
    • Completed the 24 th grade
      • 8 primary, 4 high school, 4 college, 4 med school, 4 residency
    • Years 13 to 16 were studying chemistry
    • Years 17 to 24 refining my use of chemistry
    • Beyond the 24 th grade
      • Using chemistry to improve health of patients
      • Using chemistry to prepare future physicians
  • 4.  
  • 5. Medical Education
    • Long process
    • College experience
      • At least 90 credit hours
      • 44 hours are for specific content
      • 16 hours are chemistry
        • 8 each of inorganic and organic
    • Doctoral Degree
      • 4 years
    • Post graduate Residency Training
      • Specialty specific
      • 3 years to 8 years
  • 6. Question
    • What is the most important academic preparation for a career in medicine ?
  • 7. Requirements for admission to MD Programs ……..
    • Chemistry is the most required undergraduate subject area
      • Inorganic and Organic
  • 8. Requirements for admission to MD programs …….
    • Do NOT require Chem
      • Northwestern
      • SIU
      • U Miss – KC
      • NEOCOM
      • U Cincinatti
      • U Penn
      • MUSC
    • Do NOT require Org Ch
      • Northwestern
      • SIU
      • U Miss – KC
      • U Cincinnati
      • U Penn
      • MUSC
    Have NO course requirements NEOCOM does require Org Ch and Physics
  • 9. Requirements for admission to MD programs ….
    • MCAT ……… PS section
      • 4 schools do not require MCAT
        • U Miss – KC
        • Dartmouth
        • Brown
        • Meharry
  • 10. MCAT results ……….
    • MCAT ……… PS section
        • U Miss – KC [no data]
        • Dartmouth 8 to 15, mean 11
        • Brown 8 to 15, mean 12
        • Meharry 5 to 12, mean 7
  • 11. MCAT results
    • Scores for schools that do not require Chem
      • Northwestern …….. 12
      • SIU …………………. 10
      • U Miss – KC ……… NR
      • NEOCOM …………. 9
      • U Cincinnati ………. 11
      • U Penn ……………. 12
      • MUSC ……………… 9
  • 12. Uses of Chemistry in Practice of Medicine
    • Stoichiometry
    • Electrochemistry
    • Gas laws and diffusion
    • Solubility
    • Kinetics
    • Acid-Base
    • Metals
    • Nuclear Chemistry
  • 13. Stoichiometry
    • Management of fluids and electrolytes
    • Solutions
      • Normal Saline: 154 mEq Na + / L
      • D10W: 10% glucose solution
    • Volume of fluids
      • 100 cc/Kg/day for first 10 Kg ……
    • Electrolytes
      • Current concentrations to needed concentrations
  • 14. Electrochemistry
    • Na+ ions have higher concentrations outside cell membrane via Na+/K+ pump
    • Electrical gradient across the cell membrane of -70 mV
    • Nerve conduction and action potentials
  • 15. Gas laws and diffusion
    • O 2 and CO 2 diffuse in alveoli in lungs and the capillary beds in tissues until they reach equilibrium
  • 16. Solubility
    • Will certain chemicals be able to diffuse through the cell membrane lipid bilayer
    • How will the concentration of chemicals (drugs) be distributed through body tissues that are aqueous verses lipid
    • What tissues do you want the drug to be highly concentrated …..
  • 17. Kinetics
    • How rapidly are chemicals we give patients degraded in the body
    • Half life of drugs
  • 18. Acid-Base
    • pH balance to maintain homestasis
    • Buffers in the body
      • HCO 3 -
  • 19. Metals
    • Iron
      • Hemoglobin and O 2 transport
    • Copper
      • Immune system health
    • Zinc
      • Wound healing, smell and taste
  • 20. Nuclear chemistry
    • Isotopes used for imaging studies
      • Technetium Tc 99
        • Emission of gamma rays
    • Isotopes used for therapy
      • Radioactive Iodine I 131
  • 21. Hidden Curriculum in Chemistry
    • Problem solving skills
    • Data gathering skills
    • Critical thinking skills
    • Time management skills
    • Good work ethic
  • 22. In my humble opinion ……
    • Chemistry is the most important science in the preparation for a career in medicine ……….