Pavlovian and Skinnerian Processes are Genetically Separable
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Pavlovian and Skinnerian Processes are Genetically Separable

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Keynote lecture at the 2014 Winter Conference on Animal Learning and Behavior

Keynote lecture at the 2014 Winter Conference on Animal Learning and Behavior

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Pavlovian and Skinnerian Processes are Genetically Separable Pavlovian and Skinnerian Processes are Genetically Separable Presentation Transcript

  • Björn Brembs Universität Regensburg http://brembs.net
  • “operant” “classical”
  • Press Lever Tone Food Food
  • Eric Kandel
  • US p UR a CS CS/US convergence UR
  • Before: After: US CS UR pre-synapse post-synapse AP Broadening: a pre-synaptic mechanism
  • UR US AP-Broadening CS Molecular CS/US convergence point (coincidence detection)
  • Press Lever Food
  • Behavioral variability in a constant stimulus situation: Actions, not responses
  • Generate spontaneous actions (trying out)
  • Shape behavior by evaluating sensory feedbac
  • Action – Outcome Evaluation
  • Torque operant self Colors classical world Heat
  • Aplysia (Mollusks) Nt rutabaga cAMP Drosophila (Arthropods) Mouse (Chordates) Longterm memory PKA CREB > 530 Mya DNA CRE Nucleus Cytoplasm Modified from: "Comparative psychology: Evolution and development of behavior" (2nd Edition, Psychology Press, 2008)
  • rut-AC dependent Synaptic Plasticity Protein Kinase C Torque Colors Heat world rut2080 wtb HS noHS PKCi PKCi Torque self Heat rut2080 wtb Brembs & Plendl (2008) HS noHS PKCi PKCi
  • Torque Heat
  • Jack Byrne Romuald Nargeot
  • Generate spontaneous actions (trying out)
  • Nargeot & Simmers, 2012
  • Shape behavior by evaluating sensory feedbac
  • Nargeot R and Simmers J (2012) Functional organization and adaptability of a decision-making network in Aplysia. Front. Neurosci. 6:113. doi: 10.3389/fnins.2012.00113
  • Brembs et al. (2002)
  • Brembs et al. (2002)
  • Brembs et al. (2002)
  • Brembs et al. (2002) Lorenzetti et al. (2008)
  • Nargeot & Simmers, 2012
  • Nargeot R and Simmers J (2012) Functional organization and adaptability of a decision-making network in Aplysia. Front. Neurosci. 6:113. doi: 10.3389/fnins.2012.00113
  • Nargeot R and Simmers J (2012) Functional organization and adaptability of a decision-making network in Aplysia. Front. Neurosci. 6:113. doi: 10.3389/fnins.2012.00113
  • AFTER BEFORE Nargeot & Simmers, 2012
  • Nargeot & Simmers, 2012
  • PKC involved in self-motion learning Rochefort C, Arabo A, André M, Poucet B, Save E, Rondi-Reig L. (2011) Science 334(6054):385-389
  • Aplysia (Mollusks) Drosophila (Arthropods) Mouse (Chordates) > 530 Mya
  • Generate spontaneous actions (trying out)
  • Shape behavior by evaluating sensory feedbac
  • FoxP2 Action – Outcome Evaluation
  • Torque self Colors Heat world Torque self Heat WT FoxP RNAi ctrl.
  • (to E.O. Wilson in 1987) “The only genetic contribution providing a behavioral disposition is bringing the vocal musculature under operant control” E.O. Wilson and B.F. Skinner: A Dialogue Between Sociobiology and Radical Behaviorism (Developments in Primatology: Progress and Prospects), Springer, 2009, Paul Naour
  • Nt Type II cyclase PKC Humans/mice/birds (Chordates) Drosophila (Arthropods) cAMP PKA FoxP DNA ??? Nucleus Cytoplasm > 530 Mya Aplysia (Mollusks)
  • Why have more than one learning system?
  • Training Test turning composite: turning + color
  • Training Test Self-Learning Test WT composite: turning + color MB Impaired turning WT 16min OK OK
  • Training Test Self-Learning Test WT WT 16min MB Impaired OK OK turning World-Learning Test WT WT 16min OK Impaire Impaire d d composite: turning + color color MB
  • Training Test Self-Learning Test WT 8min Impaired WT 16min OK habit formation turning MB OK World-Learning Test WT 8min composite: turning + color OK color WT 16min MB Impaire Impaired d
  • Training Test Self-Learning Test WT 8min Impaired WT FoxP 16min 16min OK Impaired turning World-Learning Test WT 8min composite: turning + color OK color WT 16min MB Impaire Impaired d
  • Training Test Self-Learning Test WT 8min Impaired WT 16min MB 8min OK OK turning World-Learning Test WT 8min composite: turning + color OK Brembs, 2009 WT 16min MB 8min Impaired Impaired MB247 or 17D driving TNT color
  • Brembs (2009) Curr Biol Colomb & Brembs (2010) Commun Integr Biol Brembs (2010) Proc Roy Soc Brembs (2011) Behav Proc
  • FoxP PCR: Ezequiel Mendoza and Constance Scharff (FU Berlin). FoxP mutants: Troy Zars, University of Missouri-Columbia.
  • 16 minutes training 2 minutes test
  • Modified from: Lorenzetti FD, Baxter DA, Byrne JH (2008): Molecular mechanisms underlying a cellular analog of operant reward learning. Neuron 59(5):815-28.