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Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
Pavlovian and Skinnerian Processes are Genetically Separable
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Pavlovian and Skinnerian Processes are Genetically Separable

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Keynote lecture at the 2014 Winter Conference on Animal Learning and Behavior

Keynote lecture at the 2014 Winter Conference on Animal Learning and Behavior

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  • 1. Björn Brembs Universität Regensburg http://brembs.net
  • 2. “operant” “classical”
  • 3. Press Lever Tone Food Food
  • 4. Eric Kandel
  • 5. US p UR a CS CS/US convergence UR
  • 6. Before: After: US CS UR pre-synapse post-synapse AP Broadening: a pre-synaptic mechanism
  • 7. UR US AP-Broadening CS Molecular CS/US convergence point (coincidence detection)
  • 8. Press Lever Food
  • 9. Behavioral variability in a constant stimulus situation: Actions, not responses
  • 10. Generate spontaneous actions (trying out)
  • 11. Shape behavior by evaluating sensory feedbac
  • 12. Action – Outcome Evaluation
  • 13. Torque operant self Colors classical world Heat
  • 14. Aplysia (Mollusks) Nt rutabaga cAMP Drosophila (Arthropods) Mouse (Chordates) Longterm memory PKA CREB > 530 Mya DNA CRE Nucleus Cytoplasm Modified from: "Comparative psychology: Evolution and development of behavior" (2nd Edition, Psychology Press, 2008)
  • 15. rut-AC dependent Synaptic Plasticity Protein Kinase C Torque Colors Heat world rut2080 wtb HS noHS PKCi PKCi Torque self Heat rut2080 wtb Brembs & Plendl (2008) HS noHS PKCi PKCi
  • 16. Torque Heat
  • 17. Jack Byrne Romuald Nargeot
  • 18. Generate spontaneous actions (trying out)
  • 19. Nargeot & Simmers, 2012
  • 20. Shape behavior by evaluating sensory feedbac
  • 21. Nargeot R and Simmers J (2012) Functional organization and adaptability of a decision-making network in Aplysia. Front. Neurosci. 6:113. doi: 10.3389/fnins.2012.00113
  • 22. Brembs et al. (2002)
  • 23. Brembs et al. (2002)
  • 24. Brembs et al. (2002)
  • 25. Brembs et al. (2002) Lorenzetti et al. (2008)
  • 26. Nargeot & Simmers, 2012
  • 27. Nargeot R and Simmers J (2012) Functional organization and adaptability of a decision-making network in Aplysia. Front. Neurosci. 6:113. doi: 10.3389/fnins.2012.00113
  • 28. Nargeot R and Simmers J (2012) Functional organization and adaptability of a decision-making network in Aplysia. Front. Neurosci. 6:113. doi: 10.3389/fnins.2012.00113
  • 29. AFTER BEFORE Nargeot & Simmers, 2012
  • 30. Nargeot & Simmers, 2012
  • 31. PKC involved in self-motion learning Rochefort C, Arabo A, André M, Poucet B, Save E, Rondi-Reig L. (2011) Science 334(6054):385-389
  • 32. Aplysia (Mollusks) Drosophila (Arthropods) Mouse (Chordates) > 530 Mya
  • 33. Generate spontaneous actions (trying out)
  • 34. Shape behavior by evaluating sensory feedbac
  • 35. FoxP2 Action – Outcome Evaluation
  • 36. Torque self Colors Heat world Torque self Heat WT FoxP RNAi ctrl.
  • 37. (to E.O. Wilson in 1987) “The only genetic contribution providing a behavioral disposition is bringing the vocal musculature under operant control” E.O. Wilson and B.F. Skinner: A Dialogue Between Sociobiology and Radical Behaviorism (Developments in Primatology: Progress and Prospects), Springer, 2009, Paul Naour
  • 38. Nt Type II cyclase PKC Humans/mice/birds (Chordates) Drosophila (Arthropods) cAMP PKA FoxP DNA ??? Nucleus Cytoplasm > 530 Mya Aplysia (Mollusks)
  • 39. Why have more than one learning system?
  • 40. Training Test turning composite: turning + color
  • 41. Training Test Self-Learning Test WT composite: turning + color MB Impaired turning WT 16min OK OK
  • 42. Training Test Self-Learning Test WT WT 16min MB Impaired OK OK turning World-Learning Test WT WT 16min OK Impaire Impaire d d composite: turning + color color MB
  • 43. Training Test Self-Learning Test WT 8min Impaired WT 16min OK habit formation turning MB OK World-Learning Test WT 8min composite: turning + color OK color WT 16min MB Impaire Impaired d
  • 44. Training Test Self-Learning Test WT 8min Impaired WT FoxP 16min 16min OK Impaired turning World-Learning Test WT 8min composite: turning + color OK color WT 16min MB Impaire Impaired d
  • 45. Training Test Self-Learning Test WT 8min Impaired WT 16min MB 8min OK OK turning World-Learning Test WT 8min composite: turning + color OK Brembs, 2009 WT 16min MB 8min Impaired Impaired MB247 or 17D driving TNT color
  • 46. Brembs (2009) Curr Biol Colomb & Brembs (2010) Commun Integr Biol Brembs (2010) Proc Roy Soc Brembs (2011) Behav Proc
  • 47. FoxP PCR: Ezequiel Mendoza and Constance Scharff (FU Berlin). FoxP mutants: Troy Zars, University of Missouri-Columbia.
  • 48. 16 minutes training 2 minutes test
  • 49. Modified from: Lorenzetti FD, Baxter DA, Byrne JH (2008): Molecular mechanisms underlying a cellular analog of operant reward learning. Neuron 59(5):815-28.

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